Article
Fisheries
Yan Gao, Chen Li, Lin Shi, Fang Wang, Jing Ye, Yuan-An Lu, Xue-Qin Liu
Summary: Our study demonstrates that SVCV replication can be inhibited by viperin_sv1, which promotes RIG-I protein expression and activates type-1 interferon response. The SAM domain of viperin_sv1 plays an essential role in regulating RIG-I expression and inducing IFN production, suggesting a conserved antiviral mechanism across different species.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Virology
Zhen Wang, Shaotang Ye, Congwen Yao, Ji Wang, Jianwei Mao, Liang Xu, Yongbo Liu, Cheng Fu, Gang Lu, Shoujun Li
Summary: In this study, the RIG-I gene of beagle dogs was cloned and characterized for its expression and subcellular localization. Overexpression of canine RIG-I suppressed CIV replication, but CIV's NS1 protein strongly inhibited RIG-I-mediated immune response. Novel interactions between CIV matrix proteins (M1 and M2) and canine RIG-I were identified.
Review
Immunology
Jing Liu, Qinglu Ji, Feng Cheng, Dengwang Chen, Tingting Geng, Yueyue Huang, Jidong Zhang, Yuqi He, Tao Song
Summary: This paper comprehensively analyzes the regulatory role of long non-coding RNAs (lncRNAs) in the RIG-I signaling pathway, studying the specific mechanisms during viral infections and cancer. It provides a solid foundation for further research on lncRNAs and RIG-I in the future, and contributes to clinical drug development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Enrico Palermo, Magdalini Alexandridi, Daniele Di Carlo, Michela Muscolini, John Hiscott
Summary: Virus-Like Particles (VLPs) produced in this study by co-expressing VSV glycoprotein and HIV structural proteins, incorporated an RNA agonist M8 and showed antiviral and therapeutic effects as well as selective blocking of viral infection. These results suggest the potential of VLPs-M8 as a therapeutic and prophylactic vaccine platform.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Fisheries
Lin Shi, Chen Li, Yan Gao, Jing Ye, Yuanan Lu, Xueqin Liu
Summary: This study demonstrates for the first time that STUB1 enhances the expression of IFN and ISGs in fish by promoting the expression of RIG-I and inhibiting viral replication. These findings provide an important foundation for the development of antiviral targets and drugs.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Xue Jiang, Yanping Xiao, Wen Hou, Jingge Yu, Tian-Sheng He, Liang-Guo Xu
Summary: Innate immunity is the first line of defense against infections. A study found that the RNA-binding protein ZFP36 acts as a positive regulator in antiviral innate immunity by promoting K63-linked ubiquitination of RIG-I. This finding improves our understanding of the activation mechanism of RIG-I.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Immunology
Huasong Chang, Peili Hou, Xuefeng Wang, Aibiao Xiang, Hao Wu, Wenjing Qi, Rukun Yang, Xue Wang, Xingyu Li, Wenqi He, Guimin Zhao, Weiyang Sun, Tiecheng Wang, Daniel Chang He, Hongmei Wang, Yuwei Gao, Hongbin He
Summary: This study reveals that CD97 acts as a negative regulator of RIG-I in the antiviral immune response. Overexpression of CD97 promotes the degradation of RIG-I, leading to the suppression of IFN-I signaling pathway and enhancing RNA virus replication. These findings provide insights into the functional mechanism of CD97 in antiviral immunity and offer a molecular basis for the development of new therapeutic strategies and targeted antiviral agents.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Virology
Jian Deng, Sheng-Nan Zheng, Yang Xiao, Mei-Ling Nan, Jing Zhang, Lulu Han, Yi Zheng, Yanying Yu, Qiang Ding, Chengjiang Gao, Pei-Hui Wang
Summary: SARS-CoV-2 NSP8 inhibits the production of type I and III interferons by targeting RIG-I/MDA5, TRIF, and STING signaling molecules. It disrupts the assembly of RIG-I/MDA5-MAVS complex, resulting in impaired phosphorylation and nuclear translocation of IRF3. NSP8 also directly interacts with TRIF and STING to suppress their signaling transduction.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oyahida Khatun, Mansi Sharma, Rohan Narayan, Shashank Tripathi
Summary: Evasion and antagonism of host cellular immunity provide replication advantage to SARS-CoV-2. ORF6 protein was found to mitigate type-I interferon induction and signaling. ORF6 directly interacts with RIG-I and reduces K63-linked ubiquitinated RIG-I, blocking downstream type-I interferon induction and signaling. These findings contribute to understanding how SARS-CoV-2 evades the host immune response.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Yuan Qiao, Shan Zhu, Shuanglin Deng, Shan-Shan Zou, Bao Gao, Guoxia Zang, Jing Wu, Yuxue Jiang, Yong-Jun Liu, Jingtao Chen
Summary: Human epithelial cancer cells respond to cytosolic RNA through the RIG-I-MAVS pathway but only sense cytosolic DNA through the cGAS-STING pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Microbiology
Jie Tong, Wuchao Zhang, Yuran Chen, Qiaoling Yuan, Ning-Ning Qin, Guosheng Qu
Summary: This review summarizes the impacts of RNA epigenetic marks, including N6-methyladenosine (m(6)A), 5-methylcytidine (m(5)C), on viral RNAs and their roles in antiviral innate immunity and relevant signaling pathways. It highlights the significance of antiviral innate immune responses during virus infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Jian Wang, Hui Zheng, Chunsheng Dong, Sidong Xiong
Summary: This study identifies a human deubiquitinase, OTUD6B, as a positive regulator of IRF3-mediated antiviral immune response. OTUD6B enhances cellular antiviral responses and overexpression of OTUD6B in mice increases resistance to RNA virus infection.
Article
Microbiology
Boyu Zhai, Lanlan Liu, Xiang Li, Xinru Lv, Jinyan Wu, Jing Li, Shengze Lin, Yuxiang Yin, Jiaqi Lan, Jianan Du, Chenwei Wu, Yi Wen, Yajun Wang, Yulong Wang, Zhijun Hou, Yanbing Li, Hongliang Chai, Xiangwei Zeng
Summary: This study examined the innate immune responses of ducks to avian influenza infection using wild-bird-origin viruses H5N8 and H4N6. The expression levels of RIG-I and interferon beta (IFN-beta) fluctuated during infection, with the viruses exhibiting varying degrees of inhibition on the immune response. The highly pathogenic H5N8 virus had a stronger inhibitory effect on RIG-I, particularly in the lungs. RIG-I and IFN-beta were found to play important roles in the innate immune response to H5N8 infection, especially in the lungs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Cheng Wang, Wenkai Zhou, Yin Liu, Yue Xu, Xuan Zhang, Chengyu Jiang, Minghong Jiang, Xuetao Cao
Summary: This study reveals a non-canonical role of nuclear RIG-I in the induction of cellular apoptosis, besides its activation of IFN-I expression as the cytosolic innate sensor. The interaction between nuclear RIG-I and APEX1 provides new insight into the regulation of infection, IFN-I, and autoimmune diseases.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Immunology
Zeyin Jiang, Zhichao Sun, Jihuan Hu, Dongming Li, Xiaowen Xu, Meifeng Li, Zhiqing Feng, Shanshan Zeng, Huiling Mao, Chengyu Hu
Summary: This study demonstrated that grass carp Mex3A interacts with RIG-I in the endoplasmic reticulum following poly(I:C) stimulation, facilitating the ubiquitination and degradation of RIG-I to inhibit IRF3-mediated innate antiviral immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Qian Zhang, Kai Zhao, Qicong Shen, Yanmei Han, Yan Gu, Xia Li, Dezhi Zhao, Yiqi Liu, Chunmei Wang, Xiang Zhang, Xiaoping Su, Juan Liu, Wei Ge, Ross L. Levine, Nan Li, Xuetao Cao
Article
Immunology
Dan Wang, Songlin Yu, Yening Zhang, Lingmin Huang, Ruiheng Luo, Yiting Tang, Kai Zhao, Ben Lu
CLINICAL IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Songlin Yu, Dan Wang, Lingmin Huang, Yening Zhang, Ruiheng Luo, Dickson Adah, Yiting Tang, Kai Zhao, Ben Lu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)