标题
Cytosolic nucleic acid sensors and innate immune regulation
作者
关键词
-
出版物
INTERNATIONAL REVIEWS OF IMMUNOLOGY
Volume 36, Issue 2, Pages 74-88
出版商
Informa UK Limited
发表日期
2017-03-24
DOI
10.1080/08830185.2017.1298749
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity
- (2017) Yuichi Kitai et al. JOURNAL OF IMMUNOLOGY
- Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response
- (2016) Karen J Mackenzie et al. EMBO JOURNAL
- Chitosan: An Adjuvant with an Unanticipated STING
- (2016) Nicolas Riteau et al. IMMUNITY
- Recognition of Endogenous Nucleic Acids by the Innate Immune System
- (2016) Axel Roers et al. IMMUNITY
- The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons
- (2016) Elizabeth. C. Carroll et al. IMMUNITY
- RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice
- (2016) Vladislav Pokatayev et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity
- (2016) Daniela Anghelina et al. JOURNAL OF VIROLOGY
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
- (2016) Pengyan Xia et al. NATURE IMMUNOLOGY
- Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4
- (2016) Warrison A. Andrade et al. Cell Reports
- The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent
- (2016) Kirsten E. Wiens et al. PLoS Pathogens
- Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome
- (2015) Mi-Ae Jang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- A Specific IFIH1 Gain-of-Function Mutation Causes Singleton-Merten Syndrome
- (2015) Frank Rutsch et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Unusual cutaneous features associated with a heterozygous gain-of-function mutation inIFIH1: overlap between Aicardi-Goutières and Singleton-Merten syndromes
- (2015) A.-C. Bursztejn et al. BRITISH JOURNAL OF DERMATOLOGY
- Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection
- (2015) Rajendra Karki et al. Cell Host & Microbe
- Type I interferonopathies: Mendelian type I interferon up-regulation
- (2015) Yanick J Crow CURRENT OPINION IN IMMUNOLOGY
- Viral RNA detection by RIG-I-like receptors
- (2015) Mitsutoshi Yoneyama et al. CURRENT OPINION IN IMMUNOLOGY
- Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development
- (2015) Kathleen Pestal et al. IMMUNITY
- MDA5 plays a critical role in interferon response during hepatitis C virus infection
- (2015) Xuezhi Cao et al. JOURNAL OF HEPATOLOGY
- cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response toFrancisellaInfection
- (2015) Kelly M. Storek et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome
- (2015) Elizabeth E. Gray et al. JOURNAL OF IMMUNOLOGY
- Mitochondrial DNA stress primes the antiviral innate immune response
- (2015) A. Phillip West et al. NATURE
- Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
- (2015) Anna-Maria Herzner et al. NATURE IMMUNOLOGY
- STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
- (2015) Olivier Demaria et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
- (2015) Daxing Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
- (2015) B. J. Liddicoat et al. SCIENCE
- Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC
- (2015) Seamus R. Morrone et al. Nature Communications
- Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
- (2015) Gil Ju Seo et al. Cell Reports
- TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING
- (2015) Yanming Wang et al. PLoS Pathogens
- Brief Report:IFIH1Mutation Causes Systemic Lupus Erythematosus With Selective IgA Deficiency
- (2015) Lien Van Eyck et al. Arthritis & Rheumatology
- Aicardi-Goutières Syndrome Is Caused by IFIH1 Mutations
- (2014) Hirotsugu Oda et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
- (2014) Alvin Lu et al. CELL
- A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
- (2014) R. C. Ferreira et al. DIABETES
- Cytosolic RNA:DNA hybrids activate the cGAS–STING axis
- (2014) Arun K Mankan et al. EMBO JOURNAL
- Listeria monocytogenes induces IFN expression through an IFI16-, cGAS- and STING-dependent pathway
- (2014) K. Hansen et al. EMBO JOURNAL
- STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
- (2014) Seng-Ryong Woo et al. IMMUNITY
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
- (2014) Liufu Deng et al. IMMUNITY
- Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5
- (2014) Masahide Funabiki et al. IMMUNITY
- Association of innate immuneIFIH1gene polymorphisms with dilated cardiomyopathy in a Chinese population
- (2014) Qingyu Dou et al. IMMUNOLOGICAL INVESTIGATIONS
- Critical role for the AIM2 inflammasome during acute CNS bacterial infection
- (2014) Richa Hanamsagar et al. JOURNAL OF NEUROCHEMISTRY
- Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients
- (2014) Alexander Varzari et al. JOURNAL OF NEUROIMMUNOLOGY
- Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
- (2014) Delphine Goubau et al. NATURE
- Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling
- (2014) Gillian I Rice et al. NATURE GENETICS
- Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production
- (2014) Susanne Roth et al. NATURE IMMUNOLOGY
- Activated STING in a Vascular and Pulmonary Syndrome
- (2014) Yin Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity
- (2014) K. Kuniyoshi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors
- (2014) Surya Pandey et al. Cold Spring Harbor Perspectives in Biology
- The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
- (2014) Xu Zhang et al. Cell Reports
- Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria
- (2014) Parisa Kalantari et al. Cell Reports
- Functional characterization of the Thr946Ala SNP at the type 1 diabetesIFIH1locus
- (2013) Hana Zouk et al. AUTOIMMUNITY
- Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
- (2013) Pu Gao et al. CELL
- Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
- (2013) Hiroyasu Konno et al. CELL
- Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
- (2013) Xin Li et al. IMMUNITY
- Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling
- (2013) Effi Wies et al. IMMUNITY
- The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome
- (2013) Hiroki Mitoma et al. IMMUNITY
- Critical Role of ASC Inflammasomes and Bacterial Type IV Secretion System in Caspase-1 Activation and Host Innate Resistance to Brucella abortus Infection
- (2013) M. T. R. Gomes et al. JOURNAL OF IMMUNOLOGY
- Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors
- (2013) K. A. Horan et al. JOURNAL OF IMMUNOLOGY
- USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I
- (2013) L. Wang et al. JOURNAL OF VIROLOGY
- The Essential, Nonredundant Roles of RIG-I and MDA5 in Detecting and Controlling West Nile Virus Infection
- (2013) J. S. Errett et al. JOURNAL OF VIROLOGY
- Structural mechanism of cytosolic DNA sensing by cGAS
- (2013) Filiz Civril et al. NATURE
- Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
- (2013) John W. Schoggins et al. NATURE
- Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
- (2013) Peter Liehl et al. NATURE MEDICINE
- RIG-I Detects Triphosphorylated RNA of Listeria monocytogenes during Infection in Non-Immune Cells
- (2013) Cristina Amparo Hagmann et al. PLoS One
- PNAS Plus: From the Cover: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
- (2013) M. R. Jakobsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy
- (2013) S. R. Morrone et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
- (2013) T. Kondo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
- (2013) X.-D. Li et al. SCIENCE
- Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
- (2013) Philip J. Kranzusch et al. Cell Reports
- Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5
- (2012) Bin Wu et al. CELL
- RIG-I detects infection with liveListeriaby sensing secreted bacterial nucleic acids
- (2012) Zeinab Abdullah et al. EMBO JOURNAL
- Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease
- (2012) Alevtina Gall et al. IMMUNITY
- Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor
- (2012) Tengchuan Jin et al. IMMUNITY
- Critical role of AIM2 in Mycobacterium tuberculosis infection
- (2012) H. Saiga et al. INTERNATIONAL IMMUNOLOGY
- TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination
- (2012) Jing Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- STING and the innate immune response to nucleic acids in the cytosol
- (2012) Dara L Burdette et al. NATURE IMMUNOLOGY
- Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
- (2012) M. H. Orzalli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16
- (2012) T. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells
- (2012) Qian Feng et al. Cell Reports
- Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA
- (2011) Eva Kowalinski et al. CELL
- Structural Insights into RNA Recognition by RIG-I
- (2011) Dahai Luo et al. CELL
- MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
- (2011) Fajian Hou et al. CELL
- IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
- (2011) Nagaraj Kerur et al. Cell Host & Microbe
- Immune Signaling by RIG-I-like Receptors
- (2011) Yueh-Ming Loo et al. IMMUNITY
- Structural basis of RNA recognition and activation by innate immune receptor RIG-I
- (2011) Fuguo Jiang et al. NATURE
- STING is a direct innate immune sensor of cyclic di-GMP
- (2011) Dara L. Burdette et al. NATURE
- Pattern Recognition Receptors and the Innate Immune Response to Viral Infection
- (2011) Mikayla R. Thompson et al. Viruses-Basel
- Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity
- (2010) Evelyn Dixit et al. CELL
- Pattern Recognition Receptors and Inflammation
- (2010) Osamu Takeuchi et al. CELL
- Activation of the NLRP3 inflammasome by intracellular poly I:C
- (2010) Jayant V. Rajan et al. FEBS LETTERS
- The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
- (2010) Tetsuo Tsuchida et al. IMMUNITY
- The role of mitochondria in the mammalian antiviral defense system
- (2010) Iain Scott MITOCHONDRION
- Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency
- (2010) Ricardo C Ferreira et al. NATURE GENETICS
- The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
- (2010) Vijay A K Rathinam et al. NATURE IMMUNOLOGY
- The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
- (2010) Teresa Fernandes-Alnemri et al. NATURE IMMUNOLOGY
- IFI16 is an innate immune sensor for intracellular DNA
- (2010) Leonie Unterholzner et al. NATURE IMMUNOLOGY
- Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I
- (2010) Yanli Wang et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
- (2010) T. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses
- (2010) T. Satoh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain
- (2010) Cheng Lu et al. STRUCTURE
- Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5
- (2009) Xiaojun Li et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease
- (2009) Shinji Sato et al. ARTHRITIS AND RHEUMATISM
- RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway
- (2009) Yu-Hsin Chiu et al. CELL
- Extracellular and Intracellular Pattern Recognition Receptors Cooperate in the Recognition of Helicobacter pylori
- (2009) Roland Rad et al. GASTROENTEROLOGY
- Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity
- (2009) Y. J. Crow et al. HUMAN MOLECULAR GENETICS
- The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA
- (2009) Bo Zhong et al. IMMUNITY
- Solution Structures of Cytosolic RNA Sensor MDA5 and LGP2 C-terminal Domains
- (2009) Kiyohiro Takahasi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of MDA5 Requires Higher-Order RNA Structures Generated during Virus Infection
- (2009) A. Pichlmair et al. JOURNAL OF VIROLOGY
- AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
- (2009) Teresa Fernandes-Alnemri et al. NATURE
- AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
- (2009) Veit Hornung et al. NATURE
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- (2009) Hiroki Ishikawa et al. NATURE
- RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate
- (2009) Andrea Ablasser et al. NATURE IMMUNOLOGY
- Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
- (2009) Hendrik Poeck et al. NATURE IMMUNOLOGY
- An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
- (2009) Tilmann Bürckstümmer et al. NATURE IMMUNOLOGY
- Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
- (2009) T. Saitoh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody
- (2009) Ran Nakashima et al. RHEUMATOLOGY
- HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
- (2009) T. L. Roberts et al. SCIENCE
- Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
- (2009) S. Nejentsev et al. SCIENCE
- Identification of Host Cytosolic Sensors and Bacterial Factors Regulating the Type I Interferon Response to Legionella pneumophila
- (2009) Kathryn M. Monroe et al. PLoS Pathogens
- The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response
- (2008) Constantin S Friedman et al. EMBO REPORTS
- Structural Mechanism of RNA Recognition by the RIG-I-like Receptors
- (2008) Mitsutoshi Yoneyama et al. IMMUNITY
- TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway
- (2008) Marie-Cécile Michallet et al. IMMUNITY
- Structures of Human Cytochrome P-450 2E1
- (2008) Patrick R. Porubsky et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
- (2008) Hiroki Kato et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I
- (2008) Sheng Cui et al. MOLECULAR CELL
- Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses
- (2008) Kiyohiro Takahasi et al. MOLECULAR CELL
- TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
- (2008) Ken J. Ishii et al. NATURE
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started