Can physical exercise in old age improve memory and hippocampal function?

Entorhinal volume, aerobic fitness, and recognition memory in healthy young adults: A voxel-based morphometry study

(2016) Andrew S. Whiteman et al.   NEUROIMAGE

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease

(2015) Kurt A. Jellinger et al.   ACTA NEUROPATHOLOGICA

PART is part of Alzheimer disease

(2015) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia

(2015) Anna-Maija Tolppanen et al.   Alzheimers & Dementia

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

(2015) Claudia Cooper et al.   AMERICAN JOURNAL OF PSYCHIATRY

Effect of pioglitazone medication on the incidence of dementia

(2015) Michael T. Heneka et al.   ANNALS OF NEUROLOGY

Physical Activity and Cognitive Vitality

(2015) Ruchika Shaurya Prakash et al.   Annual Review of Psychology

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Frequent Physical Activity May Not Reduce Vascular Disease Risk as Much as Moderate Activity: Large Prospective Study of Women in the United Kingdom

(2015) M. E. G. Armstrong et al.   CIRCULATION

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High-Intensity Interval Exercise and Cerebrovascular Health: Curiosity, Cause, and Consequence

(2015) Samuel JE Lucas et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

(2015) Géraldine Gontier et al.   JOURNAL OF NEUROSCIENCE

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

(2015) Tiia Ngandu et al.   LANCET

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions

(2015) Sandrine Andrieu et al.   LANCET NEUROLOGY

CAP—advancing the evaluation of preclinical Alzheimer disease treatments

(2015) Eric M. Reiman et al.   Nature Reviews Neurology

Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing

(2015) Carla J. Cox et al.   NEUROBIOLOGY OF AGING

Dangerous Leaks: Blood-Brain Barrier Woes in the Aging Hippocampus

(2015) Costantino Iadecola   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Adult neurogenesis: a substrate for experience-dependent change

(2015) Maya Opendak et al.   TRENDS IN COGNITIVE SCIENCES

Adult Neurogenesis in Humans

(2015) Olaf Bergmann et al.   Cold Spring Harbor Perspectives in Biology

Exercise-mimetic AICAR transiently benefits brain function

(2015) Davide Guerrieri et al.   Oncotarget

Functional subregions of the human entorhinal cortex

(2015) Anne Maass et al.   eLife

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

Plant-derived flavanol (−)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice

(2015) T P Stringer et al.   Translational Psychiatry

Beyond the temporal pole: limbic memory circuit in the semantic variant of primary progressive aphasia

(2014) Rachel H. Tan et al.   BRAIN

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

Muscle Over Mind

(2014) Hyo Youl Moon et al.   Cell Metabolism

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

(2014) Sam Norton et al.   LANCET NEUROLOGY

Vascular hippocampal plasticity after aerobic exercise in older adults

(2014) A Maass et al.   MOLECULAR PSYCHIATRY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults

(2014) Adam M Brickman et al.   NATURE NEUROSCIENCE

Neuroprotective pathways: lifestyle activity, brain pathology, and cognition in cognitively normal older adults

(2014) Miranka Wirth et al.   NEUROBIOLOGY OF AGING

Physical activity attenuates age-related biomarker alterations in preclinical AD

(2014) O. C. Okonkwo et al.   NEUROLOGY

CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation

(2014) Joshua P. Neunuebel et al.   NEURON

The A4 Study: Stopping AD Before Symptoms Begin?

(2014) R. A. Sperling et al.   Science Translational Medicine

Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding

(2014) Anne Maass et al.   Nature Communications

Dynamics of Hippocampal Neurogenesis in Adult Humans

(2013) Kirsty L. Spalding et al.   CELL

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Train the Vessel, Gain the Brain: Physical Activity and Vessel Function and the Impact on Stroke Prevention and Outcome in Cerebrovascular Disease

(2013) Wolf Schmidt et al.   CEREBROVASCULAR DISEASES

Death of developing neurons: New insights and implications for connectivity

(2013) Martijn P.J. Dekkers et al.   JOURNAL OF CELL BIOLOGY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Environmental Novelty Activates β2-Adrenergic Signaling to Prevent the Impairment of Hippocampal LTP by Aβ Oligomers

(2013) Shaomin Li et al.   NEURON

Architecture of spatial circuits in the hippocampal region

(2013) M. P. Witter et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Functional correlates of the lateral and medial entorhinal cortex: objects, path integration and local-global reference frames

(2013) J. J. Knierim et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Randomized Controlled Trial of Multicomponent Exercise in Older Adults with Mild Cognitive Impairment

(2013) Takao Suzuki et al.   PLoS One

Emergence of Individuality in Genetically Identical Mice

(2013) J. Freund et al.   SCIENCE

The Mental Activity and eXercise (MAX) Trial

(2013) Deborah E. Barnes et al.   JAMA Internal Medicine

Adult hippocampal neurogenesis reduces memory interference in humans: opposing effects of aerobic exercise and depression

(2013) Nicolas Déry et al.   Frontiers in Neuroscience

Exergaming and Older Adult Cognition

(2012) Cay Anderson-Hanley et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Age-Specific Effects of Voluntary Exercise on Memory and the Older Brain

(2012) Joyce Siette et al.   BIOLOGICAL PSYCHIATRY

In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer’s disease

(2012) Michael Hornberger et al.   BRAIN

Neurobiological markers of exercise-related brain plasticity in older adults

(2012) Michelle W. Voss et al.   BRAIN BEHAVIOR AND IMMUNITY

A community-based approach to trials of aerobic exercise in aging and Alzheimer's disease

(2012) Eric D. Vidoni et al.   Contemporary Clinical Trials

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Computer Activities, Physical Exercise, Aging, and Mild Cognitive Impairment: A Population-Based Study

(2012) Yonas E. Geda et al.   MAYO CLINIC PROCEEDINGS

Physical activity and amyloid-β plasma and brain levels: results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

(2012) B M Brown et al.   MOLECULAR PSYCHIATRY

Association between physical activity and brain health in older adults

(2012) Christian Benedict et al.   NEUROBIOLOGY OF AGING

Environmental and pharmacological modulations of cellular plasticity: Role in the pathophysiology and treatment of depression

(2012) Kristie T. Ota et al.   NEUROBIOLOGY OF DISEASE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generalization through the recurrent interaction of episodic memories: A model of the hippocampal system.

(2012) Dharshan Kumaran et al.   PSYCHOLOGICAL REVIEW

Monosynaptic inputs to new neurons in the dentate gyrus

(2012) Carmen Vivar et al.   Nature Communications

Intense physical activity is associated with cognitive performance in the elderly

(2012) B M Brown et al.   Translational Psychiatry

The association between aerobic fitness and executive function is mediated by prefrontal cortex volume

(2011) Andrea M. Weinstein et al.   BRAIN BEHAVIOR AND IMMUNITY

Episodic memory on the path to Alzheimer's disease

(2011) Michela Gallagher et al.   CURRENT OPINION IN NEUROBIOLOGY

Endurance factors improve hippocampal neurogenesis and spatial memory in mice

(2011) T. Kobilo et al.   LEARNING & MEMORY

Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging

(2011) J. Eric Ahlskog et al.   MAYO CLINIC PROCEEDINGS

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

(2011) Amar Sahay et al.   NATURE

Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood

(2011) Martin Lövdén et al.   NEUROBIOLOGY OF AGING

Cortical thickness changes following spatial navigation training in adulthood and aging

(2011) Elisabeth Wenger et al.   NEUROIMAGE

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern separation in the hippocampus

(2011) Michael A. Yassa et al.   TRENDS IN NEUROSCIENCES

Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice

(2010) Michael W. Marlatt et al.   BRAIN RESEARCH

The effects of physical activity, education, and body mass index on the aging brain

(2010) April J. Ho et al.   HUMAN BRAIN MAPPING

Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth

(2010) S. Rauskolb et al.   JOURNAL OF NEUROSCIENCE

BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory

(2010) Michael E. Hopkins et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Running enhances spatial pattern separation in mice

(2010) D. J. Creer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer Disease

(2009) Robyn A. Honea et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: a randomized controlled trial

(2009) Antonio Muscari et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

The anatomy of memory: an interactive overview of the parahippocampal–hippocampal network

(2009) N. M. van Strien et al.   NATURE REVIEWS NEUROSCIENCE

Exercise moderates age-related atrophy of the medial temporal lobe

(2009) Julie M. Bugg et al.   NEUROBIOLOGY OF AGING

Physical activity and memory functions: An interventional study

(2009) R. Ruscheweyh et al.   NEUROBIOLOGY OF AGING

Physical activity and memory functions: Are neurotrophins and cerebral gray matter volume the missing link?

(2009) A. Flöel et al.   NEUROIMAGE

Impaired recollection but spared familiarity in patients with extended hippocampal system damage revealed by 3 convergent methods

(2009) S. D. Vann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating insulin-like growth factor I and cognitive function: Neuromodulation throughout the lifespan

(2009) André Aleman et al.   PROGRESS IN NEUROBIOLOGY

Exercise and the brain: something to chew on

(2009) Henriette van Praag   TRENDS IN NEUROSCIENCES

Aerobic exercise effects on cognitive and neural plasticity in older adults

(2008) K I Erickson et al.   BRITISH JOURNAL OF SPORTS MEDICINE

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease

(2008) Nicola T. Lautenschlager et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A disproportionate role for the fornix and mammillary bodies in recall versus recognition memory

(2008) Dimitris Tsivilis et al.   NATURE NEUROSCIENCE

Neurogenesis and Exercise: Past and Future Directions

(2008) Henriette van Praag   NEUROMOLECULAR MEDICINE

What is the mammalian dentate gyrus good for?

(2008) A. Treves et al.   NEUROSCIENCE