Article
Geriatrics & Gerontology
Suhang Song, Alexandra. M. M. Gaynor, Yunglin Gazes, Seonjoo Lee, Qianhui Xu, Christian Habeck, Yaakov Stern, Yian Gu
Summary: Physical activity may help maintain reasoning, speed, and vocabulary abilities in the face of white matter hyperintensity burden.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Tae Kim, Howard J. Aizenstein, Beth E. Snitz, Yu Cheng, Yue-Fang Chang, Rebecca E. Roush, Theodore J. Huppert, Annie Cohen, Jack Doman, James T. Becker
Summary: This study found that white matter hyperintensities (WMHs) are associated with cognitive decline, and the relationships between WM microstructural changes and structural and functional connectivity are important for understanding the pathophysiological processes of cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Qing Zhao, Xinxin Du, Wenhong Chen, Ting Zhang, Zhuo Xu
Summary: Alzheimer's disease is a global health issue with significant negative impacts. PET/CT and neuropsychological scales are useful for early identification and diagnosis, as well as offering early therapies. There is a lack of large-scale investigations focusing on the pathology of AD and MCI, hence further research is needed to understand the interaction between neuropsychological test scales and PET/CT measurements of disease progression.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Nira Cedres, Patricia Diaz-Galvan, Lucio Diaz-Flores, J-Sebastian Muehlboeck, Yaiza Molina, Jose Barroso, Eric Westman, Daniel Ferreira
Summary: The study found that subjective cognitive decline (SCD) is associated with neurodegeneration in both gray matter and white matter, involving brain areas beyond those typically targeted by Alzheimer's disease. This suggests that SCD may be a sensitive behavioral marker of heterogeneous brain pathologies in individuals recruited from the community.
Article
Geriatrics & Gerontology
Hyun Song, Pradyumna K. Bharadwaj, David A. Raichlen, Christian G. Habeck, Matthew J. Huentelman, Georg A. Hishaw, Theodore P. Trouard, Gene E. Alexander
Summary: In this study, a network pattern was identified, using multivariate scaled subprofile model analysis, that reflected the association of plasma Hcy with subcortical gray matter volumes. This pattern was related to other health risk factors and cognition in healthy older adults.
NEUROBIOLOGY OF AGING
(2023)
Article
Multidisciplinary Sciences
Ana Coelho, Henrique M. Fernandes, Ricardo Magalhaes, Pedro Silva Moreira, Paulo Marques, Jose M. Soares, Liliana Amorim, Carlos Portugal-Nunes, Teresa Castanho, Nadine Correia Santos, Nuno Sousa
Summary: Previous studies suggest a link between cognitive decline and white matter integrity in aging, supporting the disconnection hypothesis. Changes in white matter microstructure are associated with decline in cognitive abilities, particularly affecting memory, executive function, and general cognition.
SCIENTIFIC REPORTS
(2021)
Article
Green & Sustainable Science & Technology
Lan Lin, Yue Jin, Min Xiong, Shuicai Wu, Shen Sun
Summary: Sustainable cognitive health is affected by cognitive reserve, which delays or reduces cognitive decline by enhancing cognitive function. This study explores whether cognitive reserve moderates the relationship between white matter integrity and cognitive function in older adults. The findings reveal that early fluid intelligence has a significant independent and moderating impact on cognitive performance, making it a suitable individual proxy for cognitive reserve. Additionally, a composite proxy of early fluid intelligence and physical activity shows promise in promoting sustainable cognitive health.
Article
Geriatrics & Gerontology
Emma L. Ducca, Gabriela T. Gomez, Priya Palta, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, Rebecca F. Gottesman, Jeremy Walston, B. Gwen Windham, Keenan A. Walker
Summary: The study found a strong association between cerebral white matter structure and current and future frailty. Specifically, white matter hyperintensity volume was significantly associated with frailty. However, measures of white matter microstructure were not generally associated with progression from nonfrail to frail status.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Bonnie Yin Ka Lam, Brian Yiu, Encarnita Ampil, Christopher Li-Hsian Chen, Yustiani Dikot, Jacqueline C. Dominguez, Patel Vishal Ganeshbhai, Saima Hilal, Nagaendran Kandiah, SangYun Kim, Jun-Young Lee, Anam Paulus Ong, Vorapun Senanarong, Kam Tat Leung, Huali Wang, Yuan-Han Yang, Tingting Yong, Faheem Arshad, Suvarna Alladi, Samuel Wong, Ho Ko, Alexander Yuk Lun Lau, Vincent Chung Tong Mok
Summary: This study aimed to investigate the burden of WML and its associated risk factors in different Asian societies. The prevalence of moderate-to-severe WML was highest in stroke/TIA patients, with Bandung Indonesia showing the highest prevalence. Hypertension and hyperlipidemia were significant risk factors for WML, which was negatively associated with cognitive performance in all groups.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Keenan A. Walker, Noah Silverstein, Yun Zhou, Timothy M. Hughes, Clifford R. Jack, David S. Knopman, A. Richey Sharrett, Dean F. Wong, Thomas H. Mosley, Rebecca F. Gottesman
Summary: White matter hyperintensity volume is modestly positively associated with elevated amyloid in older adults without dementia, with a stronger association observed among Black participants. However, there was no association between white matter microstructure and elevated amyloid. These findings need to be further validated in larger, multiethnic cohorts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
S. Yla-Herttuala, M. Hakulinen, P. Poutiainen, J. Lotjonen, M. Kononen, H. Grohn, R. Vanninen, H. Mussalo, T. Laitinen, E. Mervaala
Summary: Cognitively normal middle-aged adults with severe obstructive sleep apnea (OSA) were found to have decreased gray matter-white matter contrast in cortical amyloid-beta deposits. This decrease was associated with smoking and higher Apnea-Hypopnea Index, highlighting the detrimental effect of OSA on amyloid clearance and suggesting dysfunction of the brain glymphatic system.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Medicine, Research & Experimental
Shanzeh M. Ahmed, Nina L. Fransen, Hanane Touil, Iliana Michailidou, Inge Huitinga, Jennifer L. Gommerman, Amit Bar-Or, Valeria Ramaglia
Summary: Meningeal inflammation may play a significant role in subpial cortical injury in multiple sclerosis, and it is related to white matter lesion activity.
Article
Clinical Neurology
Megan McMahon, Yoshita Malneedi, Darrell A. Worthy, David M. Schnyer
Summary: This study found a significant association between rest-activity rhythm stability and white matter microstructure in healthy adults across different age groups, suggesting that rest-activity rhythm may serve as a biomarker of brain health throughout the adult lifespan.
Article
Clinical Neurology
Eric E. Abrahamson, Julia K. Kofler, Carl R. Becker, Julie C. Price, Kathy L. Newell, Bernardino Ghetti, Jill R. Murrell, Catriona A. McLean, Oscar L. Lopez, Chester A. Mathis, William E. Klunk, Victor L. Villemagne, Milos D. Ikonomovic
Summary: In a post-mortem study, it has been found that the amyloid PET radioligand Pittsburgh compound B (PiB) interacts poorly with cotton wool plaques, which are common in familial Alzheimer's disease but rare in sporadic Alzheimer's disease. This limited interaction may lead to an underestimation of total amyloid burden in patients with familial Alzheimer's disease.
Article
Geriatrics & Gerontology
Meng Li, Mohamad Habes, Hans Grabe, Yan Kang, Shouliang Qi, John A. Detre
Summary: This study estimated changes in the structural connectome caused by age-related white matter hyperintensities (WMH) using a virtual lesion approach. The results showed that WMH led to disruptions in multiple brain connections with increasing age, which may contribute to cognitive and sensorimotor decline.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Jenna L. Wells, Casey L. Brown, Alice Y. Hua, Peter D. Soyster, Kuan-Hua Chen, Deepika R. Dokuru, Giovanni Coppola, Claudia M. Haase, Robert W. Levenson
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2019)
Meeting Abstract
Neurosciences
Tina Gupta, Katherine S. F. Damme, Claudia M. Haase, Vijay A. Mittal
BIOLOGICAL PSYCHIATRY
(2019)
Article
Clinical Neurology
Miranka Wirth, Claudia Schwarz, Gloria Benson, Nora Horn, Ralph Buchert, Catharina Lange, Theresa Koebe, Stefan Hetzer, Marta Maglione, Eva Michael, Stefanie Maerschenz, Knut Mai, Ute Kopp, Dietmar Schmitz, Ulrike Grittner, Stephan J. Sigrist, Slaven Stekovic, Frank Madeo, Agnes Floeel
ALZHEIMERS RESEARCH & THERAPY
(2019)
Article
Geriatrics & Gerontology
Miranka Wirth, Catharina Lange, Willem Huijbers
NEUROBIOLOGY OF AGING
(2019)
Article
Psychiatry
Claire Yee, Tina Gupta, Vijay A. Mittal, Claudia M. Haase
SCHIZOPHRENIA RESEARCH
(2020)
Article
Neurosciences
Kuan-Hua Chen, Alice Y. Hua, Sandy J. Lwi, Claudia M. Haase, Howard J. Rosen, Bruce L. Miller, Robert W. Levenson
Summary: This study examined the neuroanatomical correlates of subjective experience of non-target emotions in patients with neurodegenerative diseases. The findings indicated that smaller volume in left hemisphere regions was associated with greater experience of negative non-target emotions, with effects being left-lateralized. No correlates were found for positive non-target emotions.
Article
Psychology, Multidisciplinary
Emily F. Hittner, Jacquelyn E. Stephens, Nicholas A. Turiano, Denis Gerstorf, Margie E. Lachman, Claudia M. Haase
PSYCHOLOGICAL SCIENCE
(2020)
Article
Psychology, Experimental
Alice Verstaen, Claudia M. Haase, Sandy J. Lwi, Robert W. Levenson
Article
Psychology, Experimental
Emily F. Hittner, Katie L. Rim, Claudia M. Haase
Article
Psychology, Experimental
Sandy J. Lwi, Claudia M. Haase, Michelle N. Shiota, Scott L. Newton, Robert W. Levenson
Article
Psychiatry
Claire Yee, Gregory P. Strauss, Daniel N. Allen, Claudia M. Haase, David Kimhy, Vijay A. Mittal
Article
Geriatrics & Gerontology
Alice Y. Hua, Jenna L. Wells, Claudia M. Haase, Kuan-Hua Chen, Howard J. Rosen, Bruce L. Miller, Robert W. Levenson
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2019)
Article
Psychology, Clinical
Tina Gupta, Claudia M. Haase, Gregory P. Strauss, Alex S. Cohen, Vijay A. Mittal
JOURNAL OF ABNORMAL PSYCHOLOGY
(2019)
Meeting Abstract
Psychology, Biological
David Rompilla, Emily Hittner, Jacquelyn Stephens, Claudia Haase
Article
Communication
Sarah R. Holley, Claudia M. Haase, Irene Chui, Lian Bloch
JOURNAL OF SOCIAL AND PERSONAL RELATIONSHIPS
(2018)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
