期刊
CELL METABOLISM
卷 20, 期 4, 页码 560-562出版社
CELL PRESS
DOI: 10.1016/j.cmet.2014.09.012
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资金
- Korea Health Promotion Institute [HI13C1149000014] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Intramural NIH HHS [Z99 AG999999] Funding Source: Medline
Depression is associated with elevated kynurenine levels, a tryptophan metabolite generated under stress and inflammatory conditions. Agudelo et al. (2014) now reveal how PGC-1a1 overexpression in muscle mimics anti-depressant effects of exercise by promoting kynurenine aminotransferase expression, likely preventing kynurenine from crossing the blood brain barrier to disrupt neural plasticity.
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