Article
Neurosciences
Liisa Raud, Markus H. Sneve, Didac Vidal-Pineiro, Oystein Sorensen, Line Folvik, Hedda T. Ness, Athanasia M. Mowinckel, Hakon Grydeland, Kristine B. Walhovd, Anders M. Fjell
Summary: Memory encoding and retrieval are important processes in episodic memory, with the hippocampus playing a key role. However, the connectivity between the hippocampus and neocortex during memory processing in humans is not well understood. This study used data from two large-scale functional resonance imaging studies to identify hippocampal-cortical networks active during memory tasks. The functional connectivity maps were similar during resting state, encoding, and retrieval, and the connectivity profiles of the anterior and posterior hippocampus were stable across different states. During retrieval, the hippocampal connectivity with areas involved in recollection increased, while encoding connectivity likely reflected contextual factors.
Article
Neurosciences
Heung-Yeol Lim, Jae-Rong Ahn, Inah Lee
Summary: The perirhinal cortex (PER) and postrhinal cortex (POR) are two distinct systems that process nonspatial and spatial information, respectively. However, recent research suggests that these two regions may exhibit functional overlap in goal-directed behavior. In a study involving rats, it was found that both PER and POR showed selective firing for object and scene stimuli, with a higher proportion of cells in POR firing selectively for specific choice responses. The firing patterns of PER and POR were best explained when considering both stimulus and response components, indicating that stimulus-selective cells in POR were more modulated by response, while response-selective cells in PER were more influenced by object information.
Article
Neurosciences
Ueli Rutishauser, Leila Reddy, Florian Mormann, Johannes Sarnthein
Summary: Recordings from neurons in humans implanted with electrodes reveal the existence of different types of cells related to memory, including those encoding selective and invariant representations of abstract concepts, and memory-selective cells associated with familiarity and episodic retrieval. Insights derived from observing these cells include the activation of semantic representations before episodic representations, the segregation of memory content and memory strength, and the relationship between cell activity and subjective awareness in declarative memory.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Lisa Gillinder, Catherine Liegeois-Chauvel, Patrick Chauvel
Summary: Inappropriate familiarity illusions and hallucinatory recall of memories are reported in temporal lobe seizures. Recent data demonstrates a critical role for the sub-and para-hippocampal cortices. Better scrutiny of experiential phenomena is achieved through direct cortical stimulation to make precise correlations between illusion/hallucination and electrical discharge features and localization.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neuroimaging
Judith Machts, Marius Keute, Joern Kaufmann, Stefanie Schreiber, Elisabeth Kasper, Susanne Petri, Johannes Prudlo, Stefan Vielhaber, Mircea Ariel Schoenfeld
Summary: Memory impairment in motor neuron disease (MND) is a common cognitive dysfunction that may be involved early in the disease course. Atrophy of the hippocampus and parahippocampal gyrus related to memory performance suggests a widespread involvement of these non-motor cortical areas in disease pathology.
NEUROIMAGE-CLINICAL
(2021)
Article
Behavioral Sciences
Hikaru Sugimoto, Florin Dolcos, Takashi Tsukiura
Summary: The study demonstrates that social rewards play a role in enhancing memory through interactions between reward-related regions and memory-related regions. In the competition task, opponents' Angry faces as the Win outcome were rated positively and remembered more accurately, while activation in the medial orbitofrontal cortex paralleled the pattern of valence ratings, with greater activation for the Win condition.
Article
Neurosciences
Sachin S. Deshmukh
Summary: The study shows that the inputs from different regions in the proximal and distal CA1 areas cause differential representation responses. While pCA1 representation splits when faced with conflicting inputs, dCA1 is more influenced by global cues. Overall spatial selectivity is not significantly different, possibly due to the richer sensory information available in the behavioral environment.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Neal W. Morton, Ellen L. Zippi, Alison R. Preston
Summary: In this study, fMRI was used to track the reactivation and suppression of individual related memories during encoding of overlapping events. The results showed that reactivation of semantic knowledge related to a prior event in the posterior medial prefrontal cortex (pmPFC) supported memory integration, while the anterior hippocampus (aHPC) formed integrated representations combining the semantic features of overlapping events. Additionally, interactions between ventrolateral PFC and anterior mPFC were found to modulate aHPC integration on a trial-by-trial basis, with suppression of item-specific memory representations in anterior mPFC inhibiting hippocampal integration.
Article
Multidisciplinary Sciences
Ingvild Ulsaker-Janke, Torgeir Waaga, Tanja Waaga, Edvard I. Moser, May - Britt Moser
Summary: This study found that rats can develop grid-like neuron firing patterns in a specific environment, even without stable reference boundaries to guide them. After a few trials of training, these patterns become more clear. While some experience with external spatial boundaries is required for the expression of grid patterns in a new environment, this restricted spatial experience can be overcome with short-term training.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Nichole R. Bouffard, Ali Golestani, Iva K. Brunec, Buddhika Bellana, Jun Young Park, Morgan D. Barense, Morris Moscovitch
Summary: During navigation, there exist temporal dynamics gradients in the hippocampus and entorhinal cortex. The granularity of information represented in the hippocampus increases along its long axis. Signal stability in the anterior-medial hippocampus is modulated by navigational difficulty and is relevant to behavior.
Article
Neurosciences
Ece Boran, Peter Hilfiker, Lennart Stieglitz, Johannes Sarnthein, Peter Klaver
Summary: The involvement of the medial temporal lobe (MTL) in working memory is controversial, but recent research has found that persistent neural firing in the hippocampus during maintenance is related to workload. This study recorded single neuron firing in 13 epilepsy patients while they performed a visual working memory task. The results showed that performance was almost perfect for low workload and dropped at high workload, suggesting that high workload exceeded working memory capacity. Maintenance neurons in the MTL were identified, and more of them were found in the hippocampus for trials with correct performance compared to incorrect performance. Maintenance neurons showed increased firing in the hippocampus and entorhinal cortex for high workload. Population firing in the entorhinal cortex and hippocampus accurately predicted workload during the maintenance period. The data suggest that persistent neural firing in the MTL supports performance and workload of multiple items in working memory, beyond working memory capacity.
Article
Clinical Neurology
Emily A. Mankin, Zahra M. Aghajan, Peter Schuette, Michelle E. Tran, Natalia Tchemodanov, Ali Titiz, Guldamla Kalender, Dawn Eliashiv, John Stern, Shennan A. Weiss, Dylan Kirsch, Barbara Knowlton, Itzhak Fried, Nanthia Suthana
Summary: The study found that stimulation of the right entorhinal white matter during visual memory tasks had a beneficial effect on subsequent memory, while other stimulation methods were ineffective. This highlights the importance of precise stimulation site on modulation of human hippocampal-dependent memory.
Article
Clinical Neurology
Shinnosuke Shiono, Huayu Sun, Tamal Batabyal, Aleksandra Labuz, John Williamson, Jaideep Kapur, Suchitra Joshi
Summary: Activation of PRs in the EC and hippocampus increases neuronal excitability and worsens seizures. These receptors may play a role in catamenial epilepsy.
Article
Neurosciences
Emily T. Cowan, Matthew Fain, Ian O'Shea, Lauren M. Ellman, Vishnu P. Murty
Summary: The study shows that novelty has an impact on brain circuits, particularly the interactions between the hippocampal-VTA circuit and cortical networks. Following exposure to novelty, functional coupling is enhanced between the right anterior hippocampus and VTA, with distinct patterns of post-novelty functional coupling enhancements observed in the anterior hippocampus and VTA, targeting task-relevant regions and large-scale networks respectively.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Yujiro Kose, Yoichi Hatamoto, Rie Takae, Yuki Tomiga, Jun Yasukata, Takaaki Komiyama, Yasuki Higaki
Summary: While overall olfaction was not correlated with physical performance, cognitive function, or brain atrophy, the inability to identify the Japanese orange odor was independently associated with mild medial temporal atrophy in community-dwelling older adults.
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Khazar Ahmadi, Joana B. Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T. Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk J. M. M. Mutsaerts, Oskar Hansson
Summary: This study investigated the role of decreased cerebral blood flow in Alzheimer's disease and found that tau tangles and neurodegeneration are more closely connected with GM-CBF changes than A beta pathology.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biophysics
Johannes Petzold, Sebastian Schmitter, Berk Silemek, Lukas Winter, Oliver Speck, Bernd Ittermann, Frank Seifert
Summary: This study integrates the safety assessment of implant carriers in MRI with pTx technology. It proposes a comprehensive safety concept that combines real-time monitoring with physical sensors for quantifying implant-related heating. Simulation experiments and optimization algorithms are used to find the best excitation scheme that ensures both overall and local safety.
NMR IN BIOMEDICINE
(2023)
Article
Clinical Neurology
Anika Wuestefeld, Alexa Pichet Binette, David van Berron, Nicola Spotorno, Danielle van Westen, Erik Stomrud, Niklas Mattsson-Carlgren, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Trevor Glenn, Svenja Moes, Michael Honer, Konstantinos Arfanakis, Lisa L. Barnes, David A. Bennett, Julie A. Schneider, Laura E. M. Wisse, Oskar Hansson
Summary: This study found that tau pathology, independent of amyloid-beta, may exist outside of the medial temporal lobe and affect cognition and brain structures. These findings have implications for understanding the spread of tau in Alzheimer's disease and suggest the potential use of tau-targeting treatments.
Article
Neurosciences
Marion Rouault, Ines Pereira, Herman Galioulline, Stephen M. Fleming, Klaas Enno Stephan, Zina-Mary Manjaly
Summary: Numerous disorders are characterized by fatigue, particularly in multiple sclerosis (MS), where fatigue significantly impacts quality of life. However, empirical data on interoception and metacognition in relation to fatigue in MS are scarce. This study examined these factors in a sample of 71 individuals with MS and found associations between interoceptive awareness and fatigue, as well as autonomic function and metacognition. Additionally, machine learning showed that fatigue levels could be predicted from questionnaire-based measures of interoception and sleep quality.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychology
Andrew P. Yonelinas
Summary: The debate on whether working memory reflects a thresholded recollection process or a signal detection process is ongoing. A review of visual working memory studies suggests that both processes contribute to working memory, with their roles varying depending on the conditions. Furthermore, the results indicate that different types of tests require different processes, and these processes are related to different states of conscious awareness.
PSYCHOLOGICAL REVIEW
(2023)
Article
Clinical Neurology
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Goeerss, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Duezel, Gabriel Ziegler
Summary: This study used voxel-based morphometry to validate the classification system of Alzheimer's disease biomarkers. The results showed that early amyloid conversion is associated with brain volume loss, supporting the monotonic progression model of the amyloid-tau-neurodegeneration (ATN) system.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Zerrin Yildirim, Firuze Delen, David Berron, Hannah Baumeister, Gabriel Ziegler, Hartmut Schuetze, Wenzel Glanz, Laura Dobisch, Oliver Peters, Silka Dawn Freiesleben, Luisa-Sophie Schneider, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjoern-Hendrik Schott, Dix Meiberth, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael Heneka, Frederic Brosseron, Michael Wagner, Sandra Roeske, Alfredo Ramirez, Michael Ewers, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Steffen Wolfsgruber, Renat Yakupov, Matthias Schmid, Moritz Berger, Hakan Gurvit, Frank Jessen, Emrah Duzel
Summary: In preclinical Alzheimer's disease, individuals in stage 1 with amyloid pathology have larger brain volumes in memory-related regions compared to asymptomatic amyloid-negative older adults. In stage 2, individuals with subjective cognitive decline (SCD) have smaller brain volumes. This suggests the presence of a brain reserve mechanism that allows individuals with amyloid pathology to remain cognitively normal in stage 1.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Beatrice Barbazzeni, Oliver Speck, Emrah Duezel
Summary: Self-regulation of alpha frequency through neurofeedback does not improve working memory maintenance. However, changes in right parietal low-beta power are related to improved working memory accuracy. Working memory performance is influenced by motivational factors, which are associated with specific brain activities, including alpha suppression.
BRAIN COMMUNICATIONS
(2023)
Article
Computer Science, Artificial Intelligence
Philipp Ernst, Soumick Chatterjee, Georg Rose, Oliver Speck, Andreas Nuernberger
Summary: Computed tomography (CT) and magnetic resonance imaging (MRI) are widely used clinical imaging modalities for non-invasive diagnosis, but both have certain problems. This paper proposes a unified solution for sparse CT and undersampled radial MRI reconstruction and improves the accuracy and reconstruction speed of the Primal-Dual network.
Article
Neurosciences
Luisa Herrmann, Johanna Ade, Anne Kuehnel, Annina Widmann, Liliana Ramona Demenescu, Meng Li, Nils Opel, Oliver Speck, Martin Walter, Lejla Colic
Summary: High childhood emotional maltreatment (CM-EMO) is associated with an increased risk for psychopathology, potentially through alterations in gamma-Aminobutyric acid (GABA). The pregenual anterior cingulate cortex (pgACC) is an important brain region for emotion processing, and its' GABA levels are implicated in mood and anxiety disorders. This study examined the association between self-reported CM-EMO in adulthood and GABA+ levels in the pgACC, finding a negative relationship between CM-EMO-NEG and GABA+/tCr in the pgACC.
NEUROBIOLOGY OF STRESS
(2023)
Article
Psychology, Developmental
Thomas Gauduel, Camille Blondet, Sibylle Gonzalez-Monge, James Bonaiuto, Alice Gomez
Summary: Developmental coordination disorder (DCD) affects the quality of life and coordinated actions in 5% of school-aged children. This study found that children with DCD have lower accuracy in sensory tasks compared to motor tasks. Additionally, children with DCD exhibited larger errors or synkinesis in both tasks. The results support the hypothesis of imprecise body representations in DCD.
DEVELOPMENTAL SCIENCE
(2023)
Review
Clinical Neurology
Elisa Lancini, Lena Haag, Franziska Bartl, Maren Ruehling, Nicholas J. Ashton, Henrik Zetterberg, Emrah Duezel, Dorothea Haemmerer, Matthew J. Betts
Summary: The noradrenergic system undergoes pathological modifications in aging and neurodegenerative diseases, and significant neuronal loss in Alzheimer's disease and Parkinson's disease. A meta-analysis found that individuals with Parkinson's disease had decreased levels of CSF noradrenaline and 3-methoxy-4-hydroxyphenylglycol, as well as noradrenaline transporters availability in the hypothalamus. In Alzheimer's disease dementia, only 3-methoxy-4-hydroxyphenylglycol levels were increased compared to controls. Further studies are needed to understand the association between these biomarkers and clinical symptoms and pathology.
BRAIN COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johannes Petzold, Sebastian Schmitter, Berk Silemek, Lukas Winter, Oliver Speck, Bernd Ittermann, Frank Seifert
Summary: This study investigates the safety and performance aspects of parallel-transmit RF control modes for a body coil at B-0 <= 3T using electromagnetic simulations. The results show that PTx body coils can be used safely at B-0 <= 3T, but uncertainties in patient anatomy must be taken into account.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
A. Nemali, N. Vockert, D. Berron, A. Maas, J. Bernal, R. Yakupov, O. Peters, D. Gref, N. Cosma, L. Preis, J. Priller, E. Spruth, S. Altenstein, A. Lohse, K. Fliessbach, O. Kimmich, I. Vogt, J. Wiltfang, N. Hansen, C. Bartels, B. H. Schott, F. Maier, D. Meiberth, W. Glanz, E. Incesoy, M. Butryn, K. Buerger, D. Janowitz, R. Pernecky, B. Rauchmann, L. Burow, S. Teipel, I. Kilimann, D. Goeerss, M. Dyrba, C. Laske, M. Munk, C. Sanzenbacher, S. Mueller, A. Spottke, N. Roy, M. Heneka, F. Brosseron, S. Roeske, L. Dobisch, A. Ramirez, M. Ewers, P. Dechent, K. Scheffler, L. Kleineidam, S. Wolfsgruber, M. Wagner, F. Jessen, E. Duzel, G. Ziegler
Summary: This study explores and evaluates the optimal combinations of features based on MRIs for predicting cognitive status and biomarker positivity using a multi kernel learning Gaussian process framework. The evaluation suggests that a combination of neuroimaging markers, demographics, genetic information (ApoE4), and CSF biomarkers provides the best prediction of memory performance.
MEDICAL IMAGE ANALYSIS
(2023)
