标题
Role of Post‐translational Modifications in Alzheimer's Disease
作者
关键词
-
出版物
CHEMBIOCHEM
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2019-12-22
DOI
10.1002/cbic.201900573
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Regulation of AβPP Glycosylation Modification and Roles of Glycosylation on AβPP Cleavage in Alzheimer’s Disease
- (2019) Peng-Fei Tao et al. ACS Chemical Neuroscience
- Small Molecule Inhibit Metal-Dependent and Independent Multifaceted Toxicity of Alzheimer’s Disease
- (2019) Sourav Samanta et al. ACS Chemical Neuroscience
- Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13
- (2019) Cristina Cariulo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hybrid Multifunctional Modulators Inhibit Multifaceted Aβ Toxicity and Prevent Mitochondrial Damage
- (2018) K. Rajasekhar et al. ACS Chemical Neuroscience
- SUMO1-conjugation is altered during normal aging but not by increased amyloid burden
- (2018) Trayana Stankova et al. AGING CELL
- 2018 Alzheimer's disease facts and figures
- (2018) Alzheimers & Dementia
- Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults
- (2018) Takuma Maruyama et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase
- (2018) Mohammad Moniruzzaman et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Tau Proteins and Tauopathies in Alzheimer’s Disease
- (2018) Fong Ping Chong et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics
- (2018) Ibraheem Ali et al. CHEMICAL REVIEWS
- Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease
- (2018) Angela Jeong et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains
- (2018) Liang Qiang et al. CURRENT BIOLOGY
- Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead
- (2018) Devendra Kumar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Acetylation Disfavors Tau Phase Separation
- (2018) Josephine Ferreon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Amyloid-β Induces AMPA Receptor Ubiquitination and Degradation in Primary Neurons and Human Brains of Alzheimer’s Disease
- (2018) Yanmin Zhang et al. JOURNAL OF ALZHEIMERS DISEASE
- Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
- (2018) Mahmood Haj-Yahya et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Protein S-Nitrosylation: Enzymatically Controlled, but Intrinsically Unstable, Post-translational Modification
- (2018) Ivan Gusarov et al. MOLECULAR CELL
- Tau-targeting therapies for Alzheimer disease
- (2018) Erin E. Congdon et al. Nature Reviews Neurology
- Isoprenoids and tau pathology in sporadic Alzheimer's disease
- (2018) Sandra Pelleieux et al. NEUROBIOLOGY OF AGING
- SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model
- (2018) Erin Knock et al. NEUROBIOLOGY OF DISEASE
- An overview of the possible therapeutic role of SUMOylation in the treatment of Alzheimer’s disease
- (2018) S. Marcelli et al. PHARMACOLOGICAL RESEARCH
- A mathematical model of multisite phosphorylation of tau protein
- (2018) Alexander Stepanov et al. PLoS One
- BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease
- (2018) Jian Bao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Near-atomic model of microtubule-tau interactions
- (2018) Elizabeth H. Kellogg et al. SCIENCE
- Protein arginine methylation: an emerging regulator of the cell cycle
- (2018) Anita E. Raposo et al. Cell Division
- Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease
- (2018) K. Rajasekhar et al. RSC Advances
- Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
- (2018) Masha G. Savelieff et al. CHEMICAL REVIEWS
- Loss of HDAC5 Impairs Memory Function: Implications for Alzheimer's Disease
- (2018) Roberto Carlos Agis-Balboa et al. JOURNAL OF ALZHEIMERS DISEASE
- Identification of a Novel Complex AβPP:Fe65:PP1 that Regulates AβPP Thr668 Phosphorylation Levels
- (2018) Sandra Rebelo et al. JOURNAL OF ALZHEIMERS DISEASE
- L-Dopa and dopamine conjugated naphthalenediimides modulate amyloid β toxicity
- (2018) T. Govindaraju et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding
- (2018) Doris Ellmer et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Functions and mechanisms of non-histone protein acetylation
- (2018) Takeo Narita et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)
- (2017) Fatima Ardito et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Protein Phosphorylation is a Key Mechanism in Alzheimer’s Disease
- (2017) Joana Oliveira et al. JOURNAL OF ALZHEIMERS DISEASE
- SIRT1 Deacetylates SC35 and Suppresses Its Function in Tau Exon 10 Inclusion
- (2017) Xiaomin Yin et al. JOURNAL OF ALZHEIMERS DISEASE
- Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage
- (2017) Rebecca L. Williamson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An acetylation–phosphorylation switch that regulates tau aggregation propensity and function
- (2017) Yari Carlomagno et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glycation of Lys-16 and Arg-5 in amyloid-β and the presence of Cu2+ play a major role in the oxidative stress mechanism of Alzheimer’s disease
- (2017) Sebastian M. Fica-Contreras et al. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
- The Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer's disease
- (2017) Kumar Nikhil et al. JOURNAL OF CELL SCIENCE
- Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease
- (2017) Hye-Jin Park et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease
- (2017) Sheng Wang et al. JOURNAL OF PATHOLOGY
- Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends
- (2017) Sergey O. Bachurin et al. MEDICINAL RESEARCH REVIEWS
- Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease
- (2017) Veena Theendakara et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer’s Disease
- (2017) Zhi-Hao Wang et al. MOLECULAR CELL
- Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport
- (2017) Heesun Choi et al. Molecular Neurodegeneration
- The winding path of protein methylation research: milestones and new frontiers
- (2017) Jernej Murn et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies
- (2017) Juan Carlos Polanco et al. Nature Reviews Neurology
- Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease
- (2017) Ana L. Santos et al. Oxidative Medicine and Cellular Longevity
- Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease
- (2017) Robert J. Andrew et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of the Tau phosphorylation pattern that drives its aggregation
- (2017) Clément Despres et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of ubiquitin proteasomal system and autophagy-lysosome pathway in Alzheimer’s disease
- (2017) Yuan Zhang et al. REVIEWS IN THE NEUROSCIENCES
- Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease
- (2017) Zhong-Can Chen et al. Science Signaling
- Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets
- (2017) Thomas Lanyon-Hogg et al. TRENDS IN BIOCHEMICAL SCIENCES
- Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease
- (2017) Zhong-Can Chen et al. Science Signaling
- S-Nitrosylation of DRP1 Does Not Affect Enzymatic Activity and is Not Specific to Alzheimer's Disease
- (2017) Blaise Bossy et al. JOURNAL OF ALZHEIMERS DISEASE
- Natural Tripeptide-Based Inhibitor of Multifaceted Amyloid β Toxicity
- (2016) K. Rajasekhar et al. ACS Chemical Neuroscience
- O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease
- (2016) Shutao Xie et al. AGING CELL
- Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways
- (2016) M. Perluigi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Aβ-affected pathogenic induction of S-nitrosylation of OGT and identification of Cys-NO linkage triplet
- (2016) In-Hyun Ryu et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- The world of protein acetylation
- (2016) Adrian Drazic et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Ubiquitin modifications
- (2016) Kirby N Swatek et al. CELL RESEARCH
- Chemical and semisynthetic approaches to study and target deubiquitinases
- (2016) Pushparathinam Gopinath et al. CHEMICAL SOCIETY REVIEWS
- Protein Folding and Misfolding, Endoplasmic Reticulum Stress in Neurodegenerative Diseases: in Trace of Novel Drug Targets
- (2016) Botond Penke et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Nitrosylation of Vesicular Transporters in Brain of Amyloid Precursor Protein/Presenilin 1 Double Transgenic Mice
- (2016) Ying Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation
- (2016) Eniola Funmilayo Aduke Yeates et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBNand Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration
- (2016) Dolores Del Prete et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxidative stress induces transient O-GlcNAc elevation and tau dephosphorylation in SH-SY5Y cells
- (2016) Emese Kátai et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- A 40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway
- (2016) A. M. S. Hartz et al. JOURNAL OF NEUROSCIENCE
- Targeting SUMO-1ylation Contrasts Synaptic Dysfunction in a Mouse Model of Alzheimer’s Disease
- (2016) Serena Marcelli et al. MOLECULAR NEUROBIOLOGY
- Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
- (2016) Peter Dongmin Sohn et al. Molecular Neurodegeneration
- Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
- (2016) Somasekhar Bondalapati et al. Nature Chemistry
- A comprehensive compilation of SUMO proteomics
- (2016) Ivo A. Hendriks et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Bad Ac-etylated Tau
- (2016) Jane C. Hettinger et al. NEURON
- Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss
- (2016) Tara E. Tracy et al. NEURON
- Simvastatin inhibits protein isoprenylation in the brain
- (2016) Stephen M. Ostrowski et al. NEUROSCIENCE
- Palmitoylation in Alzheimers disease and other neurodegenerative diseases
- (2016) Eunsil Cho et al. PHARMACOLOGICAL RESEARCH
- Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer’s disease
- (2016) Eleonora Gatta et al. PHARMACOLOGICAL RESEARCH
- Modulating epigenetic HAT activity for reinstating acetylation homeostasis: A promising therapeutic strategy for neurological disorders
- (2016) Shabir Ahmad Ganai et al. PHARMACOLOGY & THERAPEUTICS
- Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation
- (2016) Todd J. Cohen et al. PLoS One
- PP2A methylation controls sensitivity and resistance to β-amyloid–induced cognitive and electrophysiological impairments
- (2016) Russell E. Nicholls et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice
- (2016) Arne Ittner et al. SCIENCE
- Protein S -Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases
- (2016) Tomohiro Nakamura et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Elevated glucose and oligomeric β-amyloid disrupt synapses via a common pathway of aberrant protein S-nitrosylation
- (2016) Mohd Waseem Akhtar et al. Nature Communications
- Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock
- (2016) James Park et al. Frontiers in Neuroscience
- Phosphorylation of amyloid beta (Aβ) peptides – A trigger for formation of toxic aggregates in Alzheimer's disease
- (2016) Sathish Kumar et al. Aging-US
- Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo
- (2016) Marianna Karina Gorsky et al. Scientific Reports
- CHIP stabilizes amyloid precursor protein via proteasomal degradation and p53-mediated trans-repression of β-secretase
- (2015) Amir Kumar Singh et al. AGING CELL
- Threonine 576 residue of amyloid-β precursor protein regulates its trafficking and processing
- (2015) Yoon Sun Chun et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions
- (2015) Y. Kizuka et al. BIOCHEMICAL JOURNAL
- Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease
- (2015) K. Rajasekhar et al. CHEMICAL COMMUNICATIONS
- An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
- (2015) Y. Kizuka et al. EMBO Molecular Medicine
- Mitochondrial ATP synthase activity is impaired by suppressedO-GlcNAcylation in Alzheimer's disease
- (2015) Moon-Yong Cha et al. HUMAN MOLECULAR GENETICS
- Amyloid β-abrogated TrkA ubiquitination in PC12 cells analogous to Alzheimer's disease
- (2015) Chen Zheng et al. JOURNAL OF NEUROCHEMISTRY
- Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD
- (2015) P. Regan et al. JOURNAL OF NEUROSCIENCE
- Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer’s Disease
- (2015) Hui-Chung Liang et al. JOURNAL OF PROTEOME RESEARCH
- Tau and neurodegenerative disease: the story so far
- (2015) Khalid Iqbal et al. Nature Reviews Neurology
- Tau in physiology and pathology
- (2015) Yipeng Wang et al. NATURE REVIEWS NEUROSCIENCE
- Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain
- (2015) Pritika J. Narayan et al. NEUROBIOLOGY OF DISEASE
- Battling Alzheimer’s Disease: Targeting SUMOylation-Mediated Pathways
- (2015) Wagner Carbolin Martins et al. NEUROCHEMICAL RESEARCH
- Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid
- (2015) Margherita Eufemi et al. NEUROCHEMISTRY INTERNATIONAL
- Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
- (2015) Harindranath Kadavath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation
- (2015) Sean J. Humphrey et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease
- (2015) Xi Lu et al. Frontiers in Cellular Neuroscience
- SUMO1 Affects Synaptic Function, Spine Density and Memory
- (2015) Shinsuke Matsuzaki et al. Scientific Reports
- SUMOylation: Novel Neuroprotective Approach for Alzheimer’s Disease?
- (2015) Juliana B Hoppe et al. Aging and Disease
- Protein S-nitrosylation: specificity and identification strategies in plants
- (2015) Olivier Lamotte et al. Frontiers in Chemistry
- Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer’s Disease
- (2015) Woo-Joo Song et al. PLoS One
- Rationally Designed Peptidomimetic Modulators of Aβ Toxicity in Alzheimer's Disease
- (2015) K. Rajasekhar et al. Scientific Reports
- Mass Spectrometry-Based Detection and Assignment of Protein Posttranslational Modifications
- (2014) Sophia Doll et al. ACS Chemical Biology
- Traceless Purification and Desulfurization of Tau Protein Ligation Products
- (2014) Oliver Reimann et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Increased O-GlcNAc levels correlate with decreased O-GlcNAcase levels in Alzheimer disease brain
- (2014) Sarah Förster et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding
- (2014) Katharina Flach et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A
- (2014) Stéphanie Chasseigneaux et al. BMC NEUROSCIENCE
- O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau Monomers
- (2014) Scott A. Yuzwa et al. JOURNAL OF MOLECULAR BIOLOGY
- Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells
- (2014) W. Li et al. Journal of Nutrition Health & Aging
- Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation
- (2014) Yin Luo et al. Journal of Physical Chemistry Letters
- S-Nitrosylation in Alzheimer's disease
- (2014) Qing-Fei Zhao et al. MOLECULAR NEUROBIOLOGY
- Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease
- (2014) David A. Hottman et al. MOLECULAR NEUROBIOLOGY
- 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond
- (2014) Eric Verdin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Uncovering global SUMOylation signaling networks in a site-specific manner
- (2014) Ivo A Hendriks et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Epigenetic Regulation of Memory by Acetylation and Methylation of Chromatin: Implications in Neurological Disorders, Aging, and Addiction
- (2014) Nilkantha Sen NEUROMOLECULAR MEDICINE
- Histone Acetyltransferase p300 Mediates Histone Acetylation of PS1 and BACE1 in a Cellular Model of Alzheimer's Disease
- (2014) Xi Lu et al. PLoS One
- SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination
- (2014) Hong-Bin Luo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo
- (2014) Mingming Zhang et al. Scientific Reports
- Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease
- (2014) Linda Lee et al. Scientific Reports
- Protein phosphorylation in neurodegeneration: friend or foe?
- (2014) Sandra Tenreiro et al. Frontiers in Molecular Neuroscience
- The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution
- (2014) Nico P. Dantuma et al. Frontiers in Molecular Neuroscience
- Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons
- (2013) Ruishan Wang et al. Cell Metabolism
- The role of protein glycosylation in Alzheimer disease
- (2013) Sophia Schedin-Weiss et al. FEBS Journal
- Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
- (2013) Casey Cook et al. HUMAN MOLECULAR GENETICS
- Isomerase Pin1 Stimulates Dephosphorylation of Tau Protein at Cyclin-dependent Kinase (Cdk5)-dependent Alzheimer Phosphorylation Sites
- (2013) Taeko Kimura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Farnesyltransferase Haplodeficiency Reduces Neuropathology and Rescues Cognitive Function in a Mouse Model of Alzheimer Disease
- (2013) Shaowu Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucine Carboxyl Methyltransferase 1 (LCMT1)-dependent Methylation Regulates the Association of Protein Phosphatase 2A and Tau Protein with Plasma Membrane Microdomains in Neuroblastoma Cells
- (2013) Jean-Marie Sontag et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Protein Function and Signaling by Reversible CysteineS-Nitrosylation
- (2013) Neal Gould et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance
- (2013) Irina Lonskaya et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro
- (2013) Jhoana Mendoza et al. JOURNAL OF PROTEOME RESEARCH
- Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease
- (2013) Liang Hong et al. NEUROLOGICAL RESEARCH
- SUMO and Alzheimer’s Disease
- (2013) Linda Lee et al. NEUROMOLECULAR MEDICINE
- Differential S-nitrosylation of proteins in Alzheimer’s disease
- (2013) S. Zahid et al. NEUROSCIENCE
- Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+Cells Through PPARγ Involvement
- (2013) Caterina Scuderi et al. PHYTOTHERAPY RESEARCH
- Rab GTPase Prenylation Hierarchy and Its Potential Role in Choroideremia Disease
- (2013) Monika Köhnke et al. PLoS One
- HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
- (2013) Y. Xiong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Glycation exacerbates the neuronal toxicity of β-amyloid
- (2013) X-H Li et al. Cell Death & Disease
- Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer’s disease
- (2012) Michael P. Walker et al. AGE
- Tau protein kinases: Involvement in Alzheimer's disease
- (2012) Ludovic Martin et al. AGEING RESEARCH REVIEWS
- The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System
- (2012) Hwan-Ching Tai et al. AMERICAN JOURNAL OF PATHOLOGY
- Alzheimer Mechanisms and Therapeutic Strategies
- (2012) Yadong Huang et al. CELL
- The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization
- (2012) I. W. Hamley CHEMICAL REVIEWS
- Role of APP and Aβ in Synaptic Physiology
- (2012) Zilai Wang et al. Current Alzheimer Research
- Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
- (2012) Nambirajan Govindarajan et al. EMBO Molecular Medicine
- Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated byN-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation
- (2012) Siddhartha Mondragón-Rodríguez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BACE1 Protein Endocytosis and Trafficking Are Differentially Regulated by Ubiquitination at Lysine 501 and the Di-leucine Motif in the Carboxyl Terminus
- (2012) Eugene L. Kang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Isoprenoids and Related Pharmacological Interventions: Potential Application in Alzheimer’s Disease
- (2012) Ling Li et al. MOLECULAR NEUROBIOLOGY
- Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
- (2012) Scott A Yuzwa et al. Nature Chemical Biology
- S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
- (2012) Andrea Fuso et al. NEUROBIOLOGY OF AGING
- O-linked β-N-acetylglucosaminidase inhibitor attenuates β-amyloid plaque and rescues memory impairment
- (2012) Chaeyoung Kim et al. NEUROBIOLOGY OF AGING
- S-nitrosylation of Cdk5
- (2012) Jing Qu et al. Prion
- Targeted proteomics for quantification of histone acetylation in Alzheimer's disease
- (2012) Kangling Zhang et al. PROTEOMICS
- Phospho-dependent ubiquitination and degradation of PAR-1 regulates synaptic morphology and tau-mediated Aβ toxicity in Drosophila
- (2012) Seongsoo Lee et al. Nature Communications
- Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant
- (2012) Kazumi Motoki et al. Brain and Behavior
- Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach
- (2011) Stefani N. Thomas et al. ACTA NEUROPATHOLOGICA
- Amyloid Precursor Protein Processing and Alzheimer's Disease
- (2011) Richard J. O'Brien et al. Annual Review of Neuroscience
- S-Nitrosylation of ApoE in Alzheimer’s Disease
- (2011) Alexander J. Abrams et al. BIOCHEMISTRY
- Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics and neuronal synaptic damage in neurodegenerative diseases
- (2011) T Nakamura et al. CELL DEATH AND DIFFERENTIATION
- Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease
- (2011) Sathish Kumar et al. EMBO JOURNAL
- Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A in AD models
- (2011) P. J. Khandelwal et al. HUMAN MOLECULAR GENETICS
- Regulation byS-Nitrosylation of Protein Post-translational Modification
- (2011) Douglas T. Hess et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects
- (2011) Fabio Di Domenico et al. Journal of Proteomics
- Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation
- (2011) Caroline Smet-Nocca et al. Molecular BioSystems
- Post-translational modifications of tau protein: Implications for Alzheimer's disease
- (2011) Ludovic Martin et al. NEUROCHEMISTRY INTERNATIONAL
- Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model
- (2011) Laura E. McMillan et al. NEUROSCIENCE LETTERS
- S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by -amyloid peptide
- (2011) J. Qu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The acetylation of tau inhibits its function and promotes pathological tau aggregation
- (2011) Todd J. Cohen et al. Nature Communications
- APP processing in Alzheimer's disease
- (2011) Yun-wu Zhang et al. Molecular Brain
- SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function
- (2010) Bing Gong et al. AGING CELL
- Isoprenoids, small GTPases and Alzheimer's disease
- (2010) Gero P. Hooff et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Brain Endothelial Cells Produce Amyloid β from Amyloid Precursor Protein 770 and Preferentially Secrete theO-Glycosylated Form
- (2010) Shinobu Kitazume et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61
- (2010) P. Kurup et al. JOURNAL OF NEUROSCIENCE
- Reduced Alzheimer's Disease -Amyloid Deposition in Transgenic Mice Expressing S-Palmitoylation-Deficient APH1aL and Nicastrin
- (2010) X. Meckler et al. JOURNAL OF NEUROSCIENCE
- S-Nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration
- (2010) Tomohiro Nakamura et al. MITOCHONDRION
- Modulation of Cholesterol, Farnesylpyrophosphate, and Geranylgeranylpyrophosphate in Neuroblastoma SH-SY5Y-APP695 Cells: Impact on Amyloid Beta-Protein Production
- (2010) Gero P. Hooff et al. MOLECULAR NEUROBIOLOGY
- Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated
- (2010) Sandra I Vieira et al. Molecular Neurodegeneration
- Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity
- (2010) F. Duclot et al. NEUROSCIENCE
- Dysregulation of Insulin Signaling, Glucose Transporters, O -GlcNAcylation, and Phosphorylation of Tau and Neurofilaments in the Brain
- (2009) Yanqiu Deng et al. AMERICAN JOURNAL OF PATHOLOGY
- The Chemical Biology of Protein Phosphorylation
- (2009) Mary Katherine Tarrant et al. Annual Review of Biochemistry
- PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity
- (2009) Nobuhisa Aoyagi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Protein carboxyl methylation and the biochemistry of memory
- (2009) Zhu Li et al. BIOLOGICAL CHEMISTRY
- Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease
- (2009) F. Liu et al. BRAIN
- Ubiquitination and cysteine nitrosylation during aging and Alzheimer's disease
- (2009) Irène M. Riederer et al. BRAIN RESEARCH BULLETIN
- Protective effect of N-glycan bisecting GlcNAc residues on -amyloid production in Alzheimer's disease
- (2009) K. Akasaka-Manya et al. GLYCOBIOLOGY
- Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients
- (2009) Gunter P. Eckert et al. NEUROBIOLOGY OF DISEASE
- Immunoreactivity to Lys63-linked polyubiquitin is a feature of neurodegeneration
- (2009) Simon Paine et al. NEUROSCIENCE LETTERS
- S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
- (2009) Dong-Hyung Cho et al. SCIENCE
- Sumoylation and human disease pathogenesis
- (2009) Kevin D. Sarge et al. TRENDS IN BIOCHEMICAL SCIENCES
- Sumoylation of amyloid precursor protein negatively regulates Aβ aggregate levels
- (2008) Yu-Qian Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A Closer Look at α-Secretase
- (2008) Rolf Postina Current Alzheimer Research
- Sugar Chains of Cerebrospinal Fluid Transferrin as a New Biological Marker of Alzheimer’s Disease
- (2008) Miyako Taniguchi et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1
- (2008) Mary Cabell Jonas et al. EMBO REPORTS
- S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1
- (2008) Haipeng Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases
- (2008) C. Hugh Reynolds et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alzheimer Disease Aβ Production in the Absence ofS-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts
- (2008) Kulandaivelu S. Vetrivel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Two Endoplasmic Reticulum (ER)/ER Golgi Intermediate Compartment-based Lysine Acetyltransferases Post-translationally Regulate BACE1 Levels
- (2008) Mi Hee Ko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elucidation of O-Glycosylation Structures of the β-Amyloid Precursor Protein by Liquid Chromatography−Mass Spectrometry Using Electron Transfer Dissociation and Collision Induced Dissociation
- (2008) Irina Perdivara et al. JOURNAL OF PROTEOME RESEARCH
- Consequences of Individual N-glycan Deletions and of Proteasomal Inhibition on Secretion of Active BACE
- (2008) Omar Vanoni et al. MOLECULAR BIOLOGY OF THE CELL
- A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
- (2008) Scott A Yuzwa et al. Nature Chemical Biology
- Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
- (2008) Xin-Wen Zhou et al. NEUROBIOLOGY OF DISEASE
- SUMO-1 immunoreactivity co-localizes with phospho-Tau in APP transgenic mice but not in mutant Tau transgenic mice
- (2008) Kaoru Takahashi et al. NEUROSCIENCE LETTERS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search