Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease

Lys203 and Lys382 are Essential for the Proteasomal Degradation of BACE1

(2014) Rong Wang et al.   Current Alzheimer Research

Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization

(2013) Jeong-Eun Lee et al.   MOLECULES AND CELLS

Ubiquilin-1 and protein quality control in Alzheimer disease

(2013) Amina El Ayadi et al.   Prion

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

(2012) Michela Guglielmotto et al.   AGING CELL

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Crosstalk between the ubiquitin–proteasome system and autophagy in a human cellular model of Alzheimer's disease

(2012) Valentina Cecarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Possible Involvement of Ubiquitin Ligase HRD1 Insolubilization in Amyloid β Generation

(2012) Masayuki Kaneko et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Ubiquitin Ligase Synoviolin Up-regulates Amyloid β Production by Targeting a Negative Regulator of γ-Secretase, Rer1, for Degradation

(2012) Chiaki Tanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis

(2012) T. Watanabe et al.   JOURNAL OF NEUROSCIENCE

Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Possible Involvement of HRD1, a Novel Molecule Related to Endoplasmic Reticulum Stress, in Alzheimer’s Disease

(2012) Masayuki Kaneko et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Calpain 2 Activated through N-Methyl-D-Aspartic Acid Receptor Signaling Cleaves CPEB3 and Abrogates CPEB3-Repressed Translation in Neurons

(2012) C.-F. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer’s disease

(2012) Paula van Tijn et al.   NEUROCHEMISTRY INTERNATIONAL

Neuronal Expression of F-Box and Leucine-Rich-Repeat Protein 2 Decreases over Braak Stages in the Brains of Alzheimer’s Disease Patients

(2012) Tomomichi Watanabe et al.   Neurodegenerative Diseases

The role of the ubiquitin proteasome system in Alzheimer's disease

(2011) Beat M Riederer et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated A  in AD models

(2011) P. J. Khandelwal et al.   HUMAN MOLECULAR GENETICS

Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein

(2011) Emily S. Stieren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPR imaging biosensor for the 20S proteasome: sensor development and application to measurement of proteasomes in human blood plasma

(2011) Ewa Gorodkiewicz et al.   MICROCHIMICA ACTA

Review: Unchained maladie - a reassessment of the role of Ubb+1-capped polyubiquitin chains in Alzheimer's disease

(2011) L. Chadwick et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Amyloid-β Peptide Is a Substrate of the Human 20S Proteasome

(2010) Xiaobei Zhao et al.   ACS Chemical Neuroscience

SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synaptic function

(2010) Bing Gong et al.   AGING CELL

Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation

(2010) Eri Himeno et al.   ANNALS OF NEUROLOGY

Structural Basis of E2–25K/UBB+1Interaction Leading to Proteasome Inhibition and Neurotoxicity

(2010) Sunggeon Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin-proteasome pathway and synaptic plasticity

(2010) A. N. Hegde   LEARNING & MEMORY

Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation

(2010) Jayashree Viswanathan et al.   TRAFFIC

Protection against amyloid beta cytotoxicity by sulforaphane: Role of the proteasome

(2009) Hyun-Min Park et al.   ARCHIVES OF PHARMACAL RESEARCH

Parkin promotes intracellular A 1-42 clearance

(2009) M. P. Burns et al.   HUMAN MOLECULAR GENETICS

Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

(2009) Kenneth M. Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Disease-Associated Mutant Ubiquitin Causes Proteasomal Impairment and Enhances the Toxicity of Protein Aggregates

(2009) Elizabeth M. H. Tank et al.   PLoS Genetics

Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin

(2008) David F. Fischer et al.   NEUROBIOLOGY OF AGING

Affinity Makes the Difference: Nonselective Interaction of the UBA Domain of Ubiquilin-1 with Monomeric Ubiquitin and Polyubiquitin Chains

(2007) Daoning Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY