Article
Peripheral Vascular Disease
Moritz Brandt, Hendrik Doerschmann, Sana'a Khraisat, Tanja Knopp, Julia Ringen, Sanela Kalinovic, Venkata Garlapati, Svenja Siemer, Michael Molitor, Sebastian Goebel, Roland Stauber, Susanne Helena Karbach, Thomas Muenzel, Andreas Daiber, Philip Wenzel
Summary: This study reveals that cardiomyocyte telomere shortening and oxidative damage in heart failure with reduced ejection fraction are induced by excess neurohormonal activation and depend on NOX2-derived superoxide. The findings suggest that telomere length in cardiomyocytes could be used as a predictor for the recovery of cardiac function and may help to stratify HF therapy.
Review
Cell Biology
Wenhui Jia, Chunling Dong, Bo Li
Summary: Peroxiredoxin 6 (PRDX6) is a protein that is widely distributed in multiple organs, especially the lungs. Over the past 20 years, research on the role of PRDX6 in oxidative stress has shown contradictory results. It can have both antioxidant and pro-oxidant effects in different diseases, and even exhibit these effects simultaneously in the same disease. The conflicting regulatory effects of PRDX6 on oxidative stress in respiratory diseases are attributed to its multifunctional enzyme activity. PRDX6's peroxidase and phospholipase A2 activity are closely related to its antioxidant and pro-oxidant effects, and it can interfere with cell proliferation and apoptosis by interacting with multiple redox signaling pathways. Due to its important regulatory role in oxidative stress, PRDX6 has become a new target in respiratory disease research. This paper reviews the role of PRDX6 in oxidative stress in respiratory diseases and the progress in targeting PRDX6.
Review
Pharmacology & Pharmacy
Jianglei Li, Meihong Yu, Shifeng Fu, Deliang Liu, Yuyong Tan
Summary: This review summarizes the research progress and underlying mechanism of ACY-1215 in cancer and other human diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Kai-Cheng Hsu, Jung-Chun Chu, Hui-Ju Tseng, Chia- Liu, Hao-Ching Wang, Tony Eight Lin, Hong-Sheng Lee, Ling-Wei Hsin, Andrew H-J Wang, Chien-Huang Lin, Wei-Jan Huang
Summary: The study showed that modifying the acridine ring with phenothiazine derivatives can effectively inhibit the activity of class II HDACs, with compound 4f exhibiting the strongest inhibitory effect and promoting neurite outgrowth.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Zhongqing Wen, Yanwen Duan, Yi Xiong, Yong Huang
Summary: Platensic alcohol was semisynthesized from platensimycin and used as an adamantane surrogate in anticancer drug lead adaphostin, demonstrating similar cytotoxic activity with adaphostin but stronger ROS generation and synergy with vorinostat. Density functional theory calculation suggests certain stacking interaction in 4b, which explains its similar serum stability with adaphostin. This study showcases a simple scaffold hopping strategy to harvest lipophilic scaffolds from natural products and identifies 4b as a potent ROS generating agent.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Immunology
Martina Mazzocchi, Susan R. Goulding, Noelia Morales-Prieto, Tara Foley, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The peripheral administration of Class IIa-specific HDIs may have neuroprotective effects in Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Jakub Ptacek, Ivan Snajdr, Jiri Schimer, Zsofia Kutil, Jana Mikesova, Petra Baranova, Barbora Havlinova, Werner Tueckmantel, Pavel Majer, Alan Kozikowski, Cyril Barinka
Summary: This article compares hydroxamate-based HDAC6-selective inhibitors commonly used in the treatment of neurological and psychiatric disorders with a novel HDAC6 inhibitor containing the difluoromethyl-1,3,4-oxadiazole function (compound 7). In vitro screening revealed HDAC10 as a primary off-target for hydroxamate-based HDAC6 inhibitors, while compound 7 showed exquisite selectivity over all other HDAC isoforms. Cell-based assays showed lower potency for all compounds when using tubulin acetylation as a surrogate readout. Additionally, the limited selectivity of some HDAC6 inhibitors was shown to be linked to cytotoxicity in RPMI-8226 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Xin-Hui Zhang, Qin-Ma, Hui-Pan Wu, Mussa Yussuf Khamis, Yi-Han Li, Li-Ying Ma, Hong-Min Liu
Summary: In this translation, the essential role of HDACs in maintaining homeostasis is discussed, with a focus on the unique characteristics and diverse functions of HDAC6. HDAC6 inhibitors have shown promising potential in treating various diseases with reduced toxicity. Progress has been made in defining the crystal structures of HDAC6 catalytic domains, which can inform the development of HDAC6 inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Aron B. Fisher, Chandra Dodia, Jian-Qin Tao, Sheldon I. Feinstein, Shampa Chatterjee
Summary: The study shows that inhibiting NOX2-derived ROS production with PIP-2 helps partially mitigate lung injury in ALI associated with bacterial infection, while concurrent antibiotic treatment eliminates the negative effects of PIP-2 on lung bacterial clearance.
Review
Biochemistry & Molecular Biology
Chanchal Sharma, Sang Ryong Kim
Summary: Proteinopathy and excessive production of reactive oxygen species are key factors contributing to neuronal toxicity in Alzheimer's disease. Beta-amyloid and tau proteins play a significant role in proteinopathy in AD, which is closely related to ROS production. The mechanisms of proteinopathy and ROS production work together to drive the pathology observed in aging brains, ultimately leading to oxidative stress and neurodegeneration.
Article
Biochemistry & Molecular Biology
Naoki Yoshida, Yugo Kato, Hirokatsu Takatsu, Koji Fukui
Summary: Many neurodegenerative disorders, including Alzheimer's disease (AD), are associated with oxidative damage accumulation. This study used transgenic mice as an AD model and found that cognitive impairment in AD mice occurs in an age-dependent manner. The hippocampus showed higher oxidative stress compared to other brain regions, potentially leading to mitochondrial dysfunction through oxidative damage.
Article
Biochemistry & Molecular Biology
Mars G. G. Sharapov, Ruslan G. G. Goncharov, Svetlana B. B. Parfenyuk, Olga V. Glushkova, Vladimir L. I. Novoselov
Summary: Peroxiredoxin 6 (Prdx6) is a multifunctional eukaryotic antioxidant enzyme with peroxidase and phospholipase A2 (aiPLA2) activities. The phospholipase activity plays a vital role in promoting the penetration of Prdx6 into cells. Overoxidation suppresses the peroxidase activity and increases aiPLA2 activity of Prdx6, enhancing its transmembrane transport efficiency. The phospholipase activity is important in the radioprotective effects of Prdx6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tianyi Zhang, Xiaoyan Zhao, Xiangpei Sun, Wei Tian, Chongqing Wang, Mingping Wang, Yi Zhang, Xin Chen, Canhui Zheng
Summary: This study aimed to discover novel HDAC6 selective inhibitors, and a new class of compounds with excellent inhibitory activities and selectivity was obtained through structural optimization of the previously reported inhibitor 7g. These compounds showed inhibitory effects on HDAC6, a protein associated with diseases such as cancer, and may have lower toxicity to normal cells and tissues.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2022)
Review
Cell Biology
Renren Bai, Jianan Guo, Xiang-Yang Ye, Yuanyuan Xie, Tian Xie
Summary: As the number of Alzheimer's disease (AD) patients increases, it poses great challenges to their families and society as a whole. While significant efforts have been made to understand the pathology of AD, the main pathogenesis remains elusive. Oxidative stress, as a crucial factor, plays a critical role in this disease by connecting different hypotheses and mechanisms.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Mauro Palmieri, Alessandro Frati, Antonio Santoro, Paola Frati, Vittorio Fineschi, Alessandro Pesce
Summary: Identifying clinical prognostic factors for diffuse axonal injury (DAI) is crucial, including glycemia, early GCS, oxygen saturation, blood pressure, and time to recover consciousness. Severity of the lesion, based on cerebral anatomical structures involved, is strongly correlated with survival after DAI. Additionally, biomarkers such as GFAP, pNF-H, NF-L, tau, and A beta 42 may be potential targets for future pharmaceutical treatments to prevent DAI-related damages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dobeen Hwang, Aerin Yoon, Soohyun Kim, Hyori Kim, Junho Chung
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2017)
Article
Multidisciplinary Sciences
Aerin Yoon, Jung Won Shin, Soohyun Kim, Hyori Kim, Junho Chung
Article
Biochemistry & Molecular Biology
Soohyun Kim, Hyunho Lee, Jinsung Noh, Yonghee Lee, Haejun Han, Duck Kyun Yoo, Hyori Kim, Sunghoon Kwon, Junho Chung
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemical Research Methods
Soohyun Kim, Hyori Kim, Dong Hyun Jo, Jeong Hun Kim, Su Ree Kim, Dongmin Kang, Dobeen Hwang, Junho Chung
Article
Medicine, Research & Experimental
Jinsung Noh, Okju Kim, Yushin Jung, Haejun Han, Jung-Eun Kim, Soohyun Kim, Sanghyub Lee, Jaeseong Park, Rae Hyuck Jung, Sang Il Kim, Jaejun Park, Jerome Han, Hyunho Lee, Duck Kyun Yoo, Amos C. Lee, Euijin Kwon, Taehoon Ryu, Junho Chung, Sunghoon Kwon
Article
Biochemistry & Molecular Biology
Jung Won Shin, Soohyun Kim, Suji Ha, Byungsan Choi, Seongyeong Kim, Seock-Ah Im, Tae-Young Yoon, Junho Chung
Article
Biochemistry & Molecular Biology
Duck Kyun Yoo, Seung Ryul Lee, Yushin Jung, Haejun Han, Hwa Kyoung Lee, Jerome Han, Soohyun Kim, Jisu Chae, Taehoon Ryu, Junho Chung
Article
Biochemistry & Molecular Biology
Seohee Chang, Soohyun Kim, Jerome Han, Suji Ha, Hyunho Lee, Seo Woo Song, Daewon Lee, Sunghoon Kwon, Junho Chung, Junhoi Kim
Article
Virology
Soohyun Kim, Maria V. Filsinger V. Interrante, Peter S. S. Kim
Summary: The trimeric glycoprotein Env on the surface of HIV-1 is the target of broadly neutralizing antibodies and vaccine development efforts. Antibodies that target the membrane proximal external region (MPER) of Env show lipid-binding characteristics and increasing their local concentration through binding to the Fc receptor Fc gamma RI can potentiate their ability to prevent viral entry. This study shows that lipid-binding activity and Fc gamma RI-mediated potentiation work together to improve the potency of MPER-directed antibodies by increasing their local concentration near the site of viral fusion.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wonjun Yang, Aerin Yoon, Sanghoon Lee, Soohyun Kim, Jungwon Han, Junho Chung
EXPERIMENTAL AND MOLECULAR MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Junyeong Jin, Gunwoo Park, Jong Bae Park, Soohyun Kim, Hyori Kim, Junho Chung
EXPERIMENTAL AND MOLECULAR MEDICINE
(2018)