Article
Food Science & Technology
Zhipeng Kan, Yijun Wang, Qian Chen, Xiaoyu Tang, Henry J. Thompson, Jinbao Huang, Jinsong Zhang, Feng Gao, Yong Shen, Xiaochun Wan
Summary: In this study, it was found that green tea extract treatment significantly improved spatial learning and memory ability in 5XFAD mice, reduced the formation of A beta, and decreased the levels of related proteins. GTE also suppressed glial cell activation and inflammatory responses, while increasing synaptic protein levels.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Madhumathi Gnanaprakash, Agnieszka Staniszewski, Hong Zhang, Rose Pitstick, Michael P. Kavanaugh, Ottavio Arancio, Russell E. Nicholls
Summary: The study demonstrated that overexpression of PP2A methyltransferase LCMT-1 prevented cognitive and electrophysiological impairments caused by chronically elevated Aβ levels, while overexpression of PME-1 showed some negative effects.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Nutrition & Dietetics
Yacoubou Abdoul Razak Mahaman, Jun Feng, Fang Huang, Maibouge Tanko Mahamane Salissou, Jianzhi Wang, Rong Liu, Bin Zhang, Honglian Li, Feiqi Zhu, Xiaochuan Wang
Summary: Alzheimer's disease is a global health problem with no effective single therapy. Nutraceutical agents like Moringa oleifera (MO), which have multiple effects, show promise in treating AD. This study found that MO treatment improved behavioral and cognitive deficits, reduced A beta burden, and improved synaptic plasticity and neurodegeneration in AD mice.
Review
Immunology
Nobufumi Sekino, Magdy Selim, Amjad Shehadah
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It induces cerebral dysfunction, disruption of the blood-brain barrier, neuroinflammation, hypoperfusion, and accumulation of amyloid beta and tau protein in the brain. However, there is currently no specific treatment for cognitive impairments in sepsis. Antibiotics, targeting proinflammatory cytokines, and preventing ischemic injuries and hypoperfusion are suggested for the acute phase, while targeting neuroinflammation, blood-brain barrier dysfunction, protein phosphorylation, and specific receptors are suggested for the late phase of sepsis.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Mingxi Dang, Qian Chen, Xiaobin Zhao, Kewei Chen, Xin Li, Junying Zhang, Jie Lu, Lin Ai, Yaojing Chen, Zhanjun Zhang
Summary: The study investigates the spatial distribution of ATN biomarkers and their relationship with cognitive impairment and NPS in AD patients. The results show that tau deposition occurs mainly in the inferior temporal lobes of AD and overlaps extensively with hypometabolic regions. In contrast, A beta deposition is unique and hypometabolism is widely distributed. Tau and hypometabolism increase monotonically with worsening cognitive impairment in the late stages of AD. NPS in AD is closely associated with tau deposition, followed by hypometabolism, but not with A beta. Hypometabolism and tau have higher accuracy in distinguishing AD patients from controls than A beta, and the combination of all three has the highest accuracy.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Madhura P. Dixit, Shubham N. Rahmatkar, Prachi Raut, Milind J. Umekar, Brijesh G. Taksande, Nandkishor R. Kotagale
Summary: Alzheimer's disease is a progressive neurodegenerative disorder characterized by decline in cognitive functions. The study found that cognitive impairment in Aβ(1-42) injected mice was associated with alterations in agmatine metabolism.
NEUROSCIENCE LETTERS
(2021)
Review
Neurosciences
Leslie C. Norins
Summary: Substantial evidence supports the clinical testing of FDA-approved drugs for repurposing to treat Alzheimer's disease, including drug mechanisms of action, in vivo testing, and epidemiological data. Investigating already-approved compounds can be faster and more cost-effective than un-approved compounds in the drug pipeline. With the increasing prevalence of AD due to longer life expectancy, the lack of an effective drug for treatment is a pressing public health concern.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aleksandar Jovalekic, Nuria Roe-Vellve, Norman Koglin, Mariana Lagos Quintana, Aaron Nelson, Markus Diemling, Johan Lilja, Juan Pablo Gomez-Gonzalez, Vincent Dore, Pierrick Bourgeat, Alex Whittington, Roger Gunn, Andrew W. Stephens, Santiago Bullich
Summary: The purpose of this study was to demonstrate the robustness of FBB PET quantification. The results showed that quantitative methods provided comparable results to visual assessments, indicating their potential in early detection, disease monitoring, and treatment evaluation for amyloid deposition.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Neurosciences
Roland Nicsanu, Carlo Cervellati, Luisa Benussi, Rosanna Squitti, Roberta Zanardini, Valentina Rosta, Alessandro Trentini, Clarissa Ferrari, Claudia Saraceno, Antonio Longobardi, Sonia Bellini, Giuliano Binetti, Orazio Zanetti, Giovanni Zuliani, Roberta Ghidoni
Summary: This study investigated the role of serum BACE1 activity as a biomarker for Alzheimer's disease (AD). Results showed that BACE1 levels were increased in AD and MCI-AD patients and could accurately discriminate patients with high sensitivity and specificity. High BACE1 levels were associated with worse cognitive performance and earlier disease onset.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Lihong Zhu, Qiongru Yuan, Zhaohao Zeng, Ruiyi Zhou, Rixin Luo, Jiawei Zhang, Chi Kwan Tsang, Wei Bi
Summary: The study demonstrates that rifampicin improves cognitive impairment induced by LPS by enhancing autophagy, inhibiting Aβ(1-42) accumulation, and enhancing neurological function in the hippocampus.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Orthopedics
Peng Zhang, Yi Zhou, Gang Chen, Jun Li, Bangjun Wang, Xinyan Lu
Summary: This study aims to investigate the relationship between markers of bone loss and cognitive performance in older adults. The results showed that participants with osteopenia had lower bone mineral density, cognitive performance, and plasma A beta 42 levels. The plasma A beta 42/40 ratio mediated the association between bone mineral density and cognitive function in osteopenia participants. Alzheimer's disease participants had reduced bone mineral density, and the interactive effects of bone mineral density and CSF A beta 42/40 ratio on cognitive function were found. Bone mineral density can serve as a promising biomarker for distinguishing Alzheimer's disease and cognitive impairment.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Kaori Tsukakoshi, Rikako Kubo, Kazunori Ikebukuro
Summary: In this study, a fusion protein called PrP-ALP was developed as a sensing element to detect toxic A beta oligomers. PrP-ALP showed strong affinity towards high molecular weight oligomers and has potential for detecting A beta oligomers. This study is important for understanding the pathogenesis of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Angie K. Torres, Claudia Jara, Han S. Park-Kang, Catalina M. Polanco, Diego Tapia, Fabian Alarcon, Adely de la Pena, Jesus Llanquinao, Gabriela Vargas-Mardones, Javiera A. Indo, Nibaldo C. Inestrosa, Cheril Tapia-Rojas
Summary: Alzheimer's disease is characterized by cognitive impairment and the presence of neurofibrillary tangles and senile plaques in the brain, caused by the accumulation of Aβ and abnormal tau proteins. Mitochondrial dysfunction plays a critical role in the neurotoxicity of AD, potentially leading to synaptic and memory impairment. Synaptic mitochondria are considered a primary target for Aβ toxicity and may be a predisposing factor for AD or an early marker of its onset.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Yorito Hattori, Satoshi Saito, Yuriko Nakaoku, Soshiro Ogata, Masashi Hattori, Mio Nakatsuji, Kunihiro Nishimura, Masafumi Ihara
Summary: This retrospective study investigated the association between TAX intake and cognitive changes. The results showed that TAX intake was significantly associated with changes in visuospatial/executive function, verbal fluency, and total score of MoCA, but not with ADAS-Cog. These findings provide a basis for TAX as a novel strategy for maintaining brain health.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Akram A. Hosseini, Thomas Brown, Luca Mannino, Bruno Gran, Kehinde Junaid, Elizabeta B. Mukaetova-Ladinska
Summary: This study conducted diagnostic lumbar puncture in patients with early onset Alzheimer's or related dementias and evaluated the measurements of amyloid-beta 42 (A beta(42)), total tau, and Thr181-phosphorylated tau (p-tau) in the cerebrospinal fluid (CSF). The results showed that low levels of CSF A beta(42) appear to be more sensitive than total and p-tau measures in differentiating AD MCI from other forms of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Fang Fang, Qing Yu, Ottavio Arancio, Doris Chen, Smruti S. Gore, Shirley ShiDu Yan, Shi Fang Yan
HUMAN MOLECULAR GENETICS
(2018)
Review
Neurosciences
Walter Gulisano, Daniele Maugeri, Marian A. Baltrons, Mauro Fa, Arianna Amato, Agostino Palmeri, Luciano D'Adamio, Claudio Grassi, D. P. Devanand, Lawrence S. Honig, Daniela Puzzo, Ottavio Arancio
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Geriatrics & Gerontology
Grazia Rutigliano, Martina Stazi, Ottavio Arancio, D. Martin Watterson, Nicola Origlia
NEUROBIOLOGY OF AGING
(2018)
Article
Geriatrics & Gerontology
Walter Gulisano, Marcello Melone, Domenica D. Li Puma, Maria Rosaria Tropea, Agostino Palmeri, Ottavio Arancio, Claudio Grassi, Fiorenzo Conti, Daniela Puzzo
NEUROBIOLOGY OF AGING
(2018)
Article
Neurosciences
Walter Gulisano, Maria Rosaria Tropea, Ottavio Arancio, Agostino Palmeri, Daniela Puzzo
Article
Multidisciplinary Sciences
Fabrizio Biundo, Dolores Del Prete, Hong Zhang, Ottavio Arancio, Luciano D'Adamio
SCIENTIFIC REPORTS
(2018)
Article
Geriatrics & Gerontology
Shaobin Yang, Sonia Pascual-Guiral, Rebeca Ponce, Lydia Gimenez-Llort, Maria A. Baltrons, Ottavio Arancio, Jose R. Palacio, Victoria M. Clos, Victor J. Yuste, Jose R. Bayascas
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Microbiology
Chao-Jiang Gu, Alejandra Borjabad, Eran Hadas, Jennifer Kelschenbach, Boe-Hyun Kim, Wei Chao, Ottavio Arancio, Jin Suh, Bruce Polsky, JoEllyn McMillan, Benson Edagwa, Howard E. Gendelman, Mary Jane Potash, David J. Volsky
Article
Clinical Neurology
Lucy P. Evans, Elizabeth A. Newell, MaryAnn Mahajan, Stephen H. Tsang, Polly J. Ferguson, Jolonda Mahoney, Christopher D. Hue, Edward W. Vogel, Barclay Morrison, Ottavio Arancio, Russell Nichols, Alexander G. Bassuk, Vinit B. Mahajan
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2018)
Correction
Psychiatry
F. Biundo, C. d'Abramo, M. D. Tambini, H. Zhang, D. Del Prete, F. Vitale, L. Giliberto, O. Arancio, L. D'Adamio
TRANSLATIONAL PSYCHIATRY
(2018)
Article
Chemistry, Medicinal
Saktimayee M. Roy, George Minasov, Ottavio Arancio, Laura W. Chico, Linda J. Van Eldik, Wayne F. Anderson, Jeffrey C. Pelletier, D. Martin Watterson
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Neurosciences
Agnieszka Staniszewski, Hong Zhang, Kesava Asam, Rose Pitstick, Michael P. Kavanaugh, Ottavio Arancio, Russell E. Nicholls
JOURNAL OF NEUROSCIENCE
(2020)
Correction
Chemistry, Medicinal
Saktimayee M. Roy, George Minasov, Ottavio Arancio, Laura W. Chico, Linda J. Van Eldik, Wayne F. Anderson, Jeffrey C. Pelletier, D. Martin Watterson
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Stephen D. Ginsberg, Suhasini Joshi, Sahil Sharma, Gianny Guzman, Tai Wang, Ottavio Arancio, Gabriela Chiosis
Summary: The adaptation to stress in central nervous system disorders involves a wide range of factors, including changes in homeostasis, protein connectivity, and disease-related pathologic scaffolds. These stressors may disrupt cellular homeostasis, leading to alterations in brain networks and potential therapeutic opportunities for neurodegenerative disorders like Alzheimer's disease.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Clinical Neurology
Domenica Donatella Li Puma, Cristian Ripoli, Giulia Puliatti, Francesco Pastore, Giacomo Lazzarino, Barbara Tavazzi, Ottavio Arancio, Roberto Piacentini, Claudio Grassi
Summary: This study found that ex-oTau affects the uptake of extracellular glutamate by astrocytes, leading to dysregulated glutamate signaling and impaired Na+-dependent transport. This is caused by reduced expression and altered function of glutamate-transporter-1 and mislocalization of NKA1A1 and NKA1A2.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)