The Gut-Immune-Brain Axis in Autism Spectrum Disorders; A Focus on Amino Acids

Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice

(2018) Johanna Pott et al.   Cell Host & Microbe

Oral exposure to the free amino acid glycine inhibits the acute allergic response in a model of cow's milk allergy in mice

(2018) Jeroen van Bergenhenegouwen et al.   NUTRITION RESEARCH

Possible correlation between gut microbiota and immunity among healthy middle-aged and elderly people in southwest China

(2018) Xi Shen et al.   Gut Pathogens

Effects of dietary lysine restriction on inflammatory responses in piglets

(2018) Hui Han et al.   Scientific Reports

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

(2018) Jing Gao et al.   Frontiers in Cellular and Infection Microbiology

An In-Depth Characterization of a Large Cohort of Adults Patients with Eosinophilic Esophagitis

(2018) Lyvia Y. Leigh et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

BCAP links IL-1R to the PI3K–mTOR pathway and regulates pathogenic Th17 cell differentiation

(2018) Krystin Deason et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Maternal immune activation, central nervous system development and behavioral phenotypes

(2018) Elena Minakova et al.   Birth Defects Research

Anti-inflammatory and anti-genotoxic activity of branched chain amino acids (BCAA) in lipopolysaccharide (LPS) stimulated RAW 264.7 macrophages

(2017) Jae Hoon Lee et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

Dysfunctional mTORC1 Signaling: A Convergent Mechanism between Syndromic and Nonsyndromic Forms of Autism Spectrum Disorder?

(2017) Juliana Magdalon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases

(2017) Min-Hyun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Follicular helper T cells mediate IgE antibody response to airborne allergens

(2017) Takao Kobayashi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Insulin-like Growth Factor II Targets the mTOR Pathway to Reverse Autism-like Phenotypes in Mice

(2017) Adam B. Steinmetz et al.   JOURNAL OF NEUROSCIENCE

Chromatographic analysis of tryptophan metabolites

(2017) Ilona Sadok et al.   JOURNAL OF SEPARATION SCIENCE

Kynurenine Pathway in Autism Spectrum Disorders in Children

(2017) Vesna Bryn et al.   NEUROPSYCHOBIOLOGY

The Gut Microbiota and Autism Spectrum Disorders

(2017) Qinrui Li et al.   Frontiers in Cellular Neuroscience

L-Glutamine Supplementation Alleviates Constipation during Late Gestation of Mini Sows by Modifying the Microbiota Composition in Feces

(2017) Yuanyuan Zhang et al.   Biomed Research International

Proteobacteria: A Common Factor in Human Diseases

(2017) G. Rizzatti et al.   Biomed Research International

Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis

(2017) Ran Huo et al.   Frontiers in Cellular and Infection Microbiology

Novel metabolic and physiological functions of branched chain amino acids: a review

(2017) Shihai Zhang et al.   Journal of Animal Science and Biotechnology

New evidences on the altered gut microbiota in autism spectrum disorders

(2017) Francesco Strati et al.   Microbiome

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

(2017) Anna V. Golubeva et al.   EBioMedicine

Autism Spectrum Disorders and Mastocytosis

(2017) Theoharis C. Theoharides   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Immune dysfunction and neuroinflammation in autism spectrum disorder

(2016) Geir Bjørklund et al.   ACTA NEUROBIOLOGIAE EXPERIMENTALIS

Metabolic shifts and structural changes in the gut microbiota upon branched-chain amino acid supplementation in middle-aged mice

(2016) Zhan Yang et al.   AMINO ACIDS

Body fluid levels of neuroactive amino acids in autism spectrum disorders: a review of the literature

(2016) Hui-Fei Zheng et al.   AMINO ACIDS

A preliminary investigation on the relationship between gut microbiota and gene expressions in peripheral mononuclear cells of infants with autism spectrum disorders

(2016) Ryo Inoue et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

PI3K/AKT/mTOR-mediated autophagy in the development of autism spectrum disorder

(2016) Jun Zhang et al.   BRAIN RESEARCH BULLETIN

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

(2016) Deborah C.I. Goberdhan et al.   Cell Metabolism

mTOR, a Potential Target to Treat Autism Spectrum Disorder

(2016) Atsushi Sato   CNS & Neurological Disorders-Drug Targets

Mast cells, brain inflammation and autism

(2016) Theoharis C. Theoharides et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

The Role of the Immune System in Autism Spectrum Disorder

(2016) Amory Meltzer et al.   NEUROPSYCHOPHARMACOLOGY

Elevated plasma levels of glutamate in children with autism spectrum disorders

(2016) Jing Cai et al.   NEUROREPORT

Lower Level of Bacteroides in the Gut Microbiota Is Associated with Inflammatory Bowel Disease: A Meta-Analysis

(2016) Yingting Zhou et al.   Biomed Research International

Atopic diseases and inflammation of the brain in the pathogenesis of autism spectrum disorders

(2016) T C Theoharides et al.   Translational Psychiatry

Human Intestinal Barrier Function in Health and Disease

(2016) Julia König et al.   Clinical and Translational Gastroenterology

Altered kynurenine pathway metabolism in autism: Implication for immune-induced glutamatergic activity

(2015) Chai K. Lim et al.   Autism Research

Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study

(2015) Kristen Lyall et al.   Autism Research

Reduced prefrontal dopaminergic activity in valproic acid-treated mouse autism model

(2015) Yuta Hara et al.   BEHAVIOURAL BRAIN RESEARCH

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

(2015) Myka L. Estes et al.   NATURE REVIEWS NEUROSCIENCE

Restoration of Normal Cerebral Oxygen Consumption with Rapamycin Treatment in a Rat Model of Autism–Tuberous Sclerosis

(2015) Oak Z. Chi et al.   NEUROMOLECULAR MEDICINE

mTOR plays an important role in cow's milk allergy-associated behavioral and immunological deficits

(2015) Jiangbo Wu et al.   NEUROPHARMACOLOGY

Gastrointestinal microbiota in children with autism in Slovakia

(2015) Aleksandra Tomova et al.   PHYSIOLOGY & BEHAVIOR

Proteobacteria: microbial signature of dysbiosis in gut microbiota

(2015) Na-Ri Shin et al.   TRENDS IN BIOTECHNOLOGY

The Role of Microbial Amino Acid Metabolism in Host Metabolism

(2015) Evelien Neis et al.   Nutrients

Explaining the Increase in the Prevalence of Autism Spectrum Disorders

(2015) Stefan N. Hansen et al.   JAMA Pediatrics

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

(2015) Kathleen E. Fischer et al.   PLoS One

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Efficacy of Fetal Stem Cell Transplantation in Autism Spectrum Disorders: An Open-Labeled Pilot Study

(2014) James Jeffrey Bradstreet et al.   CELL TRANSPLANTATION

Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis

(2014) Stefano Gabriele et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Activation and Function of the mTORC1 Pathway in Mast Cells

(2014) M.-S. Kim et al.   JOURNAL OF IMMUNOLOGY

GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders

(2014) Afaf El-Ansary et al.   Journal of Neuroinflammation

Dietary Arginine Supplementation of Mice Alters the Microbial Population and Activates Intestinal Innate Immunity

(2014) Wenkai Ren et al.   JOURNAL OF NUTRITION

The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?

(2014) Giada De Palma et al.   JOURNAL OF PHYSIOLOGY-LONDON

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

Gastrointestinal Symptoms in Autism Spectrum Disorder: A Meta-analysis

(2014) B. O. McElhanon et al.   PEDIATRICS

Impairment of innate immune responses in cirrhotic patients and treatment by branched-chain amino acids

(2014) Ikuo Nakamura   WORLD JOURNAL OF GASTROENTEROLOGY

Autistic-like behavioural and neurochemical changes in a mouse model of food allergy

(2013) Caroline G.M. de Theije et al.   BEHAVIOURAL BRAIN RESEARCH

Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals

(2013) Roberta De Simone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rapamycin improves sociability in the BTBR T+Itpr3tf/J mouse model of autism spectrum disorders

(2013) Jessica A. Burket et al.   BRAIN RESEARCH BULLETIN

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia

(2013) Daniel J. Ham et al.   CLINICAL NUTRITION

Is a Subtype of Autism an Allergy of the Brain?

(2013) Theoharis C. Theoharides   CLINICAL THERAPEUTICS

Functions and Imaging of Mast Cell and Neural Axis of the Gut

(2013) Michael Schemann et al.   GASTROENTEROLOGY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Beneficial Effects of an Amino Acid Mixture on Colonic Mucosal Healing in Rats

(2013) Xinxin Liu et al.   INFLAMMATORY BOWEL DISEASES

Effects of oral supplementation with glutamate or combination of glutamate and N-carbamylglutamate on intestinal mucosa morphology and epithelium cell proliferation in weanling piglets1

(2013) X. Wu et al.   JOURNAL OF ANIMAL SCIENCE

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reversing autism by targeting downstream mTOR signaling

(2013) Hansen Wang et al.   Frontiers in Cellular Neuroscience

The immune modifying effects of amino acids on gut-associated lymphoid tissue

(2013) Megan R Ruth et al.   Journal of Animal Science and Biotechnology

Leucine and mTORC1: a complex relationship

(2012) Kayleigh M. Dodd et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Global Prevalence of Autism and Other Pervasive Developmental Disorders

(2012) Mayada Elsabbagh et al.   Autism Research

Clinical Spectrum of Food Allergies: a Comprehensive Review

(2012) Marco H.-K. Ho et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Autism spectrum disorders

(2012) Alexis Tchaconas et al.   CURRENT OPINION IN PEDIATRICS

Elevated Fecal Short Chain Fatty Acid and Ammonia Concentrations in Children with Autism Spectrum Disorder

(2012) Lv Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells

(2012) Sandra Lechowski et al.   EUROPEAN JOURNAL OF NUTRITION

Bacteria, Colonic Fermentation, and Gastrointestinal Health

(2012) George T. Macfarlane et al.   JOURNAL OF AOAC INTERNATIONAL

Dampened dopamine-mediated neuromodulation in prefrontal cortex of fragile X mice

(2012) Kush Paul et al.   JOURNAL OF PHYSIOLOGY-LONDON

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

(2012) Tatsuo Hashimoto et al.   NATURE

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

(2012) John F. Cryan et al.   NATURE REVIEWS NEUROSCIENCE

Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host

(2012) Anne-Marie Davila et al.   PHARMACOLOGICAL RESEARCH

Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy

(2012) G. Novarino et al.   SCIENCE

Application of Novel PCR-Based Methods for Detection, Quantitation, and Phylogenetic Characterization of Sutterella Species in Intestinal Biopsy Samples from Children with Autism and Gastrointestinal Disturbances

(2012) B. L. Williams et al.   mBio

Prevalence of Autism Spectrum Disorders in a Total Population Sample

(2011) Young Shin Kim et al.   AMERICAN JOURNAL OF PSYCHIATRY

Amino Acid Signaling in TOR Activation

(2011) Joungmok Kim et al.   Annual Review of Biochemistry

Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats

(2011) Klaus-Peter Ossenkopp et al.   BEHAVIOURAL BRAIN RESEARCH

Mast cell–nerve axis with a focus on the human gut

(2011) Sabine Buhner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of immune dysfunction in the pathophysiology of autism

(2011) Charity Onore et al.   BRAIN BEHAVIOR AND IMMUNITY

Glutamine supplementation improves intestinal barrier function in a weaned piglet model of Escherichia coli infection

(2011) Julia B. Ewaschuk et al.   BRITISH JOURNAL OF NUTRITION

Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

(2011) Caroline G.M. de Theije et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amino acids exhibit anti-inflammatory effects in human monocytic leukemia cell line, THP-1 cells

(2011) Shunji Hasegawa et al.   INFLAMMATION RESEARCH

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances

(2011) Brent L. Williams et al.   PLoS One

Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity

(2011) Mechteld AR Vermeulen   WORLD JOURNAL OF GASTROENTEROLOGY

Glutamine as an Immunonutrient

(2011) Hyeyoung Kim   YONSEI MEDICAL JOURNAL

Brain?Gut?Microbe Communication in Health and Disease

(2011) Sue Grenham et al.   Frontiers in Physiology

Pyrosequencing study of fecal microflora of autistic and control children

(2010) Sydney M. Finegold et al.   ANAEROBE

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

(2010) Derrick F. MacFabe et al.   BEHAVIOURAL BRAIN RESEARCH

Mast cell activation and autism

(2010) Theoharis C. Theoharides et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

(2010) John T. Morgan et al.   BIOLOGICAL PSYCHIATRY

Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome

(2010) Paul Ashwood et al.   BRAIN BEHAVIOR AND IMMUNITY

Modulation of human lymphocyte proliferation by amino acids

(2010) J. C. CHUANG et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Amino acid metabolism in intestinal bacteria: links between gut ecology and host health

(2010) Zhao-Lai Dai   Frontiers in Bioscience-Landmark

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Guidelines for the Diagnosis and Management of Food Allergy in the United States: Report of the NIAID-Sponsored Expert Panel

(2010)   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders

(2010) Paul Ashwood et al.   JOURNAL OF NEUROIMMUNOLOGY

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives

(2010) Laura de Magistris et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Glycine transporter GLYT1 is essential for glycine-mediated protection of human intestinal epithelial cells against oxidative damage

(2010) Alison Howard et al.   JOURNAL OF PHYSIOLOGY-LONDON

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Immune dysfunction in autism: A pathway to treatment

(2010) Milo Careaga et al.   Neurotherapeutics

Medical comorbidities in autism: Challenges to diagnosis and treatment

(2010) Margaret L. Bauman   Neurotherapeutics

Mood and gut feelings

(2009) Paul Forsythe et al.   BRAIN BEHAVIOR AND IMMUNITY

m(en)TOR(ing) Differentiating T Helper Cells

(2009) I-Cheng Ho   IMMUNITY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Frequency of CD4+CD25high Regulatory T Cells in the Peripheral Blood of Egyptian Children With Autism

(2009) Gehan A. Mostafa et al.   JOURNAL OF CHILD NEUROLOGY

Visual attention in autism families: ‘unaffected’ sibs share atypical frontal activation

(2009) Matthew K. Belmonte et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Deregulation of EIF4E: a novel mechanism for autism

(2009) M Neves-Pereira et al.   JOURNAL OF MEDICAL GENETICS

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Intestinal Inflammation Increases Gastrointestinal Threonine Uptake and Mucin Synthesis in Enterally Fed Minipigs

(2009) Didier Rémond et al.   JOURNAL OF NUTRITION

l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis

(2009) Connie J. Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Genetics and neuropsychiatric disorders: Treatment during adulthood

(2009) Dan Ehninger et al.   NATURE MEDICINE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epidemiology of Pervasive Developmental Disorders

(2009) Eric Fombonne   PEDIATRIC RESEARCH

Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders

(2009) H. O. Atladottir et al.   PEDIATRICS

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

The critical contribution of TGF-β to the induction of Foxp3 expression and regulatory T cell function

(2008) Ethan M. Shevach et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dietary Histidine Ameliorates Murine Colitis by Inhibition of Proinflammatory Cytokine Production From Macrophages

(2008) Ayatoshi Andou et al.   GASTROENTEROLOGY

Negative effects of the amino acids Lys, His, and Thr on S6K1 phosphorylation in mammary epithelial cells

(2008) Rotem Ladovsky Prizant et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Low natural killer cell cytotoxic activity in autism: The role of glutathione, IL-2 and IL-15

(2008) Aristo Vojdani et al.   JOURNAL OF NEUROIMMUNOLOGY

Decreased transforming growth factor beta1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes

(2008) P ASHWOOD et al.   JOURNAL OF NEUROIMMUNOLOGY

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE

Malnutrition as an enteric infectious disease with long-term effects on child development

(2008) Richard L Guerrant et al.   NUTRITION REVIEWS

Altered amino acid excretion in children with autism

(2008) Craig Evans et al.   NUTRITIONAL NEUROSCIENCE