Article
Health Care Sciences & Services
Nikolaos Pyrpyris, Maria Kritikou, Xenofon Aggelidis, Ioanna Manolaraki, Michael Makris, Nikolaos G. Papadopoulos, Paraskevi Xepapadaki
Summary: This study analyzes the characteristics of anaphylaxis in a pediatric cohort in Greece and finds a low rate of adrenaline autoinjector administration by lay people. However, drug prescription and counseling after the reaction could help improve correct acute anaphylaxis management in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Giulia Costanzo, Annalisa Matolo, Laura Saderi, Maria Rita Messina, Davide Firinu, Maria Pina Barca, Paolo Serra, Nicoletta Corso, Giovanni Sotgiu, Stefano Del Giacco
Summary: The aim of this study was to clarify the impact of cofactors on allergic reactions in patients sensitized to LTP and omega-5-gliadin. The findings showed that exercise was the most common cofactor in FDEIAn and its involvement, along with alcohol and multiple cofactors, was more frequent in males than females. The study also revealed that exercise, pollen counts peaks, and multiple cofactors were more often associated with anaphylaxis than mild reactions.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Konstantinos Vamvakaris, Alkmini Koumpoura, Maria Farmaki, John Lakoumentas, Maria Pasioti, Nikolaos Papadopoulos, Paraskevi Xepapadaki
Summary: This study reviewed the compliance of a pediatric Allergy Department in diagnosing and treating food-induced allergic reactions, emphasizing the importance of following guidelines, organized documentation, and continuous staff training.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
Raymond James Mullins, Keith B. G. Dear, Mimi L. K. Tang
Summary: While overall rates of food anaphylaxis continue to increase, there is evidence of a slowed rate of increase in the age groups of 1-14 years after the introduction of updated infant feeding and allergy prevention guidelines. However, the rates of increase have accelerated in those younger than 1 year and in the age groups older than 15 years.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Tiago Azenha Rama, Diana Martins, Nuno Gomes, Jorge Pinheiro, Ana Nogueira, Luis Delgado, Jose Luis Placido, Alice Coimbra
Summary: Mastocytosis is a rare and heterogeneous group of disorders characterized by expansion and accumulation of clonal mast cells, presenting mainly with cutaneous lesions and anaphylaxis. Due to its unusual features, the diagnosis of mastocytosis may be delayed for several years.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pediatrics
Waheeda Samady, Christopher Warren, Lucy A. A. Bilaver, Justin Zaslavsky, Jialing Jiang, Ruchi Gupta
Summary: This study aimed to explore US caregivers' awareness, beliefs, practices, and outcomes around peanut introduction. The survey revealed disparities and shortcomings in the practice of peanut introduction, despite some caregivers being aware of the peanut allergy prevention guidelines. Therefore, future efforts should focus on increasing guideline adherence, providing support for medical providers, and educating about the true incidence of reactions.
Article
Nutrition & Dietetics
Sara Urbani, Arianna Aruanno, Antonio Gasbarrini, Alessandro Buonomo, Rossana Moroni, Caterina Sarnari, Angela Rizzi, Eleonora Nucera
Summary: Lipid transfer proteins (LTPs) are common allergens found in plant food and are the main cause of food allergies in adults in the Mediterranean basin. This study investigated the use of prescribed epinephrine auto-injectors in LTP patients and the appropriateness of their prescription. It also examined the occurrence of new food reactions, the need for emergency services, and possible predictive factors for further food reactions in these patients. The study found that most LTP patients experienced local symptoms in further reactions, with a small percentage requiring emergency care and only one patient using the epinephrine auto-injector. Patients with a history of anaphylaxis were more likely to seek emergency services during the follow-up period, and there was an association between platanus pollen sensitization and the severity of further reactions. The study also highlighted the need for follow-up to monitor patients over time and assess the actual use of prescribed epinephrine auto-injectors.
Article
Allergy
Riccardo Asero, Renato Ariano, Arianna Aruanno, Claudio Barzaghi, Paolo Borrelli, Moira Busa, Giorgio Celi, Massimo Cinquini, Gabriele Cortellini, Francesca D'Auria, Marco De Carli, Camilla Di Paolo, Giulia Garzi, Fabio Lodi Rizzini, Monica Magnani, Giuseppina Manzotti, Alessandro Marra, Stefano Miceli Sopo, Francesco Murzilli, Eleonora Nucera, Elena Pinter, Valerio Pravettoni, Federica Rivolta, Angela Rizzi, Nicoletta Saporiti, Enrico Scala, Danilo Villalta, Mona-Rita Yacoub, Giuliana Zisa
Summary: The study found that systemic reactions induced by PR-10 and profilin are facilitated by PPI, ingestion of large amounts of unprocessed foods, and fasting. Soybean beverages represent a risk for PR-10 hypersensitive patients.
Article
Allergy
Sing-Jill Chow, Vicki McWilliam, Jennifer J. Koplin, Kirsten P. Perrett
Summary: This study aimed to determine if the 2016 update of food allergy prevention guidelines led to an increase in emergency department presentations for food allergy or anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Allergy
Ralf Baumann, Eva Untersmayr, Ulrich M. Zissler, Stefanie Eyerich, Ian M. Adcock, Knut Brockow, Tilo Biedermann, Markus Ollert, Adam M. Chaker, Oliver Pfaar, Holger Garn, Ryan S. Thwaites, Alkis Togias, Marek L. Kowalski, Trevor T. Hansel, Constanze A. Jakwerth, Carsten B. Schmidt-Weber
Summary: Allergic diseases are increasing, and local sampling methods can improve sensitivity, reduce costs, and aid in prevention and treatment.
Article
Allergy
Torsten Zuberbier, Tamara Doerr, Werner Aberer, Montserrat Alvaro, Elizabeth Angier, Stefania Arasi, Hasan Arshad, Barbara Ballmer-Weber, Joan Bartra, Lisa Beck, Philippe Begin, Carsten Bindslev-Jensen, Jovanka Bislimovska, Jean Bousquet, Knut Brockow, Andrew Bush, Antonella Cianferoni, Michael J. Cork, Adnan Custovic, Ulf Darsow, Nicolette Jong, Diana Deleanu, Stefano Del Giacco, Antoine Deschildre, Audrey Dunn Galvin, Motohiro Ebisawa, Montserrat Fernandez-Rivas, Marta Ferrer, Alessandro Fiocchi, Roy Gerth van Wijk, Maia Gotua, Kate Grimshaw, Josefine Gruenhagen, Enrico Heffler, Michihiro Hide, Karin Hoffmann-Sommergruber, Cristoforo Incorvaia, Christer Janson, Swen Malte John, Carla Jones, Marek Jutel, Norito Katoh, Benjamin Kendziora, Tamar Kinaciyan, Edward Knol, Oksana Kurbacheva, Susanne Lau, Richard Loh, Carlo Lombardi, Mika Makela, Mary Jane Marchisotto, Michael Makris, Marcus Maurer, Rosan Meyer, Dragan Mijakoski, Jordan Minov, Joaquim Mullol, Caroline Nilsson, Anna Nowak-Wegrzyn, Bright Nwaru, Mikela Odemyr, Giovanni Battista Pajno, Sushil Paudel, Nikolaos G. Papadopoulos, Harald Renz, Giampaolo Ricci, Johannes Ring, Barbara Rogala, Hugh Sampson, Gianenrico Senna, Brigita Sitkauskiene, Peter Kenneth Smith, Katarina Stevanovic, Sasho Stoleski, Hania Szajewska, Akio Tanaka, Ana Todo-Bom, Fatih Alexander Topal, Erkka Valovirta, Ronald Van Ree, Carina Venter, Stefan Woehrl, Gary W. K. Wong, Zuotao Zhao, Margitta Worm
Summary: Based on a systematic review, it is unlikely that cross-contamination of major food allergens below 0.5 mg/100 g will endanger most food allergic patients when consuming a standard portion of food. The suggestion is to use a voluntary declaration on processed food packages stating that the product contains named allergens and may contain traces of other contaminations at concentrations less than 0.5 mg per 100 g of the product, which can be technically achieved in most processed foods. Further research on threshold levels is encouraged for a legally binding solution in the future.
Article
Allergy
Ioana Maris, Sabine Doelle-Bierke, Jean-Marie Renaudin, Lars Lange, Alice Koehli, Thomas Spindler, Jonathan Hourihane, Kathrin Scherer, Katja Nemat, C. Kemen, Irena Neustaedter, Christian Vogelberg, Thomas Reese, Ismail Yildiz, Zsolt Szepfalusi, Hagen Ott, Helen Straube, Nikolaos G. Papadopoulos, Susanne Haemmerling, Ute Staden, Michael Polz, Tihomir Mustakov, Ewa Cichocka-Jarosz, Renata Cocco, Alessandro Giovanni Fiocchi, Montserrat Fernandez-Rivas, Margitta Worm
Summary: The study showed that peanut allergy is a major cause of severe allergic reactions in European children, with characteristics such as asthma comorbidity and a higher rate of biphasic reactions. The use of intramuscular adrenaline as first-line treatment is low and needs improvement. The European Anaphylaxis Registry provides a valuable tool for continuous assessment of anaphylactic reactions.
Article
Food Science & Technology
Cristina Bueno-Diaz, Laura Martin-Pedraza, Jorge Parron, Javier Cuesta-Herranz, Beatriz Cabanillas, Carlos Pastor-Vargas, Eva Batanero, Mayte Villalba
Summary: 2S albumins are major allergens from tree nuts and seeds, mainly affecting children and young people. This study analyzed the structural features of 12 2S albumins, showing that despite low amino acid sequence identity, they share structural features that explain cross-reactivity. Immunoblotting with allergic patients' sera revealed possible correlations between evolutionarily distant 2S albumins.
Article
Public, Environmental & Occupational Health
Swann Geoffroy, Yann Lambert, Alexis Fremery, Christian Marty, Nathalie Andre
Summary: This study reports a series of cases where 10 patients in French Guiana were simultaneously attacked by hundreds of killer bees and immediately treated by a prehospital medical team. The prompt medical interventions, including removal of stingers, treatment for anaphylaxis, and biological tests, led to all patients leaving the hospital without complications or sequelae after 44 hours of monitoring.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Review
Allergy
Hans C. Oettgen
Summary: Mast cells throughout the gastrointestinal tract play a crucial role in IgE-mediated allergic reactions to foods. Aside from immediate reactions, recent evidence suggests that mast cells are also important regulators of adaptive immunity to foods. They provide cytokines that initiate and consolidate immune responses to allergens in the gastrointestinal mucosa, as well as molecules that recruit leukocytes causing tissue inflammation. By counteracting the activating effects of IgE antibodies, food-specific IgG antibodies suppress both immediate allergic reactions and mast cell-mediated immune responses.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Dermatology
Carolina Iturriaga, Maria Francisca Bustos, Catalina Le Roy, Rocio Rodriguez, Lorena Cifuentes, Sergio Silva-Valenzuela, Cristian Vera-Kellet, Francisca Cristi, Guillermo Perez-Mateluna, Carolina Cabalin, Rodrigo Hoyos-Bachiloglu, Carlos A. Camargo, Arturo Borzutzky
Summary: This study evaluated the association of obesity with atopic dermatitis (AD) in children from Chile. The study found that children with AD had similar rates of obesity as healthy controls, but showed sex-specific associations of abdominal obesity and AD.
PEDIATRIC DERMATOLOGY
(2023)
Article
Pediatrics
Pornthep Tanpowpong, Sijia Li, Janice A. Espinola, Ludmilla Candido Santos, Kaitlyn E. James, Camille E. Powe, Carlos A. Camargo Jr
Summary: The study aimed to investigate the relationship between pregnancy and birth-related factors and the risk of celiac disease (CD) in a large US mother-child cohort. The results showed that being born by Caesarean delivery without labor was associated with a higher risk of CD, while infants born by Caesarean delivery with labor did not show a significant association.
Article
Emergency Medicine
Rebecca E. Cash, Christopher L. Bennett, Krislyn M. Boggs, Margaret E. Samuels-Kalow, Monica Saxena, Melissa Pasao, Ali S. Raja, Carlos A. Camargo Jr
Summary: This study examines the gender differences in first authorship and characteristics in the Society for Academic Emergency Medicine (SAEM) Annual Meeting abstracts and resulting manuscript publications. It found that a minority of abstracts and publications had female first authors, and abstracts with female first authors took longer to achieve manuscript publication. Moreover, a significant proportion of female first author abstracts resulted in male first author publications.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Ruby H. N. Nguyen, Emily A. Knapp, Xiuhong Li, Carlos A. Camargo, Elisabeth Conradt, Whitney Cowell, Karen J. Derefinko, Amy J. Elliott, Alexander M. Friedman, Gurjit K. Khurana Hershey, Julie A. Hofheimer, Barry M. Lester, Cindy T. McEvoy, Jenae M. Neiderhiser, Emily Oken, Steven J. Ondersma, Sheela Sathyanarayana, Meagan E. Stabler, Annemarie Stroustrup, Irene Tung, Monica McGrath
Summary: This study analyzed cross-sectional data from 21,905 pregnancies enrolled in the ECHO program in the United States. The study identified characteristics associated with opioid use during pregnancy, including race, pregnancy period, parity, tobacco use, illegal drug use, and maternal depression.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Immunology
Tadao Ooka, Zhaozhong Zhu, Liming Liang, Juan C. Celedon, Brennan Harmon, Andrea Hahn, Eugene P. Rhee, Robert J. Freishtat, Carlos A. Camargo Jr, Kohei Hasegawa
Summary: Through integrated genetics-metabolomics analysis, genetically driven metabolites associated with asthma development and genetic loci associated with both these metabolites and asthma susceptibility were identified in this high-risk population.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Dominique Lauque, Anna Khalemsky, Zoubir Boudi, Linda Ostlundh, Chang Xu, Mohammed Alsabri, Churchill Onyeji, Jacqueline Cellini, Geroge Intas, Kapil Dev Soni, Detajin Junhasavasdikul, Jose Javier Trujillano Cabello, Niels K. Rathlev, Shan W. Liu, Carlos A. Camargo, Anna Slagman, Michael Christ, Adam J. Singer, Charles-Henri Houze-Cerfon, Elhadi H. Aburawi, Karim Tazarourte, Lisa Kurland, Phillip D. Levy, James H. Paxton, Dionyssios Tsilimingras, Vijaya Arun Kumar, David G. Schwartz, Eddy Lang, David W. Bates, Gabriele Savioli, Shamai A. Grossman, Abdelouahab Bellou
Summary: This systematic review and meta-analysis aimed to determine the association between emergency department length of stay (EDLOS) and in-hospital mortality (IHM). The analysis of multiple studies showed a significant association between EDLOS over 24 hours and IHM in ICU-admitted patients, as well as a correlation between low EDLOS and IHM in non-ICU admitted patients. This highlights the importance of minimizing prolonged stays in the emergency department and providing special attention to patients admitted after a short ED stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Emergency Medicine
Krislyn M. Boggs, Rebecca E. Cash, Dorsey Glew, Piroz Bahar, Kohei Hasegawa, Ali S. Raja, Carlos A. Camargo Jr
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Nutrition & Dietetics
George Doumat, Geneva D. Mehta, Jonathan M. Mansbach, Kohei Hasegawa, Carlos A. Camargo Jr
Summary: This study found an association between serum 25-hydroxyvitamin D (25(OH)D) levels and lung function in children with severe bronchiolitis. Children with lower vitamin D status at age 3 had decreased FEV1pp and FVCpp at 6 years. However, there was no difference in FEV1pp/FVCpp across different serum 25(OH)D levels.
Article
Cardiac & Cardiovascular Systems
Kori S. Zachrison, Renee Y. Hsia, Lee H. Schwamm, Zhiyu Yan, Margaret E. Samuels-Kalow, Mathew J. Reeves, Carlos A. Camargo, Jukka-Pekka Onnela
Summary: This study aimed to explore the association between patient insurance and likelihood of transfer and transfer to a stroke center among ischemic stroke patients. The study found that compared to privately insured patients, all insurance groups had lower odds of transfer and transfer to a stroke center. Among the identified hospital clusters, disparities in transfer based on insurance varied, and one poorly performing cluster fully explained the insurance-based disparity in odds of stroke center transfer.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Geriatrics & Gerontology
Jeffrey M. Caterino, Julie A. Stephens, Randell Wexler, Carlos A. Camargo, Katherine M. Hunold, Lai Wei, David Hains, Lauren T. Southerland, Jason J. Bischof, Andrew Schwaderer
Summary: The study found that there were no significant differences in urinary antimicrobial peptide (AMPs) levels between older and younger adults, but older adults had lower levels of a specific AMP, hBD-2. This finding has implications for the potential use of urinary AMPs as diagnostic markers and will facilitate further exploration into the role of innate immunity in urinary tract infection susceptibility in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhaozhong Zhu, Yijun Li, Robert J. Freishtat, Juan C. Celedon, Janice A. Espinola, Brennan Harmon, Andrea Hahn, Carlos A. Camargo, Liming Liang, Kohei Hasegawa
Summary: This study investigates the role of DNA methylation in the severity of bronchiolitis in infants. The authors analyze blood DNA methylation data from hospitalized infants and identify differentially methylated CpGs associated with disease severity. These CpGs are found to be differentially methylated in blood immune cells and enriched in various tissues, cells, and pathways. Additionally, they are also associated with respiratory and immune traits. The study highlights the importance of DNA methylation in understanding the pathobiology of bronchiolitis and its severity.
NATURE COMMUNICATIONS
(2023)
Article
Public, Environmental & Occupational Health
Tehnaz Boyle, Krislyn Boggs, Jingya Gao, Maureen McMahon, Rachel Bedenbaugh, Lauren Schmidt, Kori Sauser Zachrison, Eric Goralnick, Paul Biddinger, Carlos A. Camargo Jr
Summary: The study aimed to identify the capabilities and willingness of hospitals in New England to respond to disaster health crises, in order to guide future implementation. The survey results showed that most hospitals and emergency departments have access to emergency notification systems, teleconsultation with experts, disaster credentialing requirements, reliable internet service, and willingness to use a disaster teleconsultation system. However, there are still issues with communication service instability and technological limitations in rural areas and some smaller hospitals.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Dermatology
Carolina Cabalin, Guillermo Perez-Mateluna, Carolina Iturriaga, Carlos A. Camargo, Arturo Borzutzky
Summary: This study investigated the effects of oral cholecalciferol supplementation on vitamin D receptor (vdr), Cathelicidin Antimicrobial Peptide (camp/LL-37), and Thymic Stromal Lymphopoietin (tslp) in children with atopic dermatitis (AD). The results showed that oral vitamin D3 supplementation improved serum 25-hydroxyvitamin D levels, AD severity, and increased the expression of vdr and camp in lesional skin of children with AD, providing mechanistic clues for its effects.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Meeting Abstract
Allergy
Zhaozhong Zhu, Robert Freishtat, Brennan Harmon, Andrea Hahn, Stephen Teach, Marcos Perez-Losada, Kohei Hasegawa, Carlos Camargo
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Emergency Medicine
Rebecca E. Cash, Anjali J. Kaimal, Margaret E. Samuels-Kalow, Krislyn M. Boggs, Maeve F. Swanton, Carlos A. Camargo Jr
Summary: This study examined out-of-hospital deliveries and high-risk complications treated by EMS clinicians in the U.S. Most out-of-hospital deliveries involved patients between the ages of 20-34 and occurred on weekdays. There were disparities in the level of care and access to definitive care based on maternal and community factors.
PREHOSPITAL EMERGENCY CARE
(2023)