Novel metabolic and physiological functions of branched chain amino acids: a review

Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+/glucose co-transporter 1 (SGLT-1) and GLUT2

(2016) Shihai Zhang et al.   BRITISH JOURNAL OF NUTRITION

The effect of increasing the dietary valine-to-lysine ratio on sow metabolism, milk production, and litter growth1

(2016) A. V. Strathe et al.   JOURNAL OF ANIMAL SCIENCE

High Leucine Diets Stimulate Cerebral Branched-Chain Amino Acid Degradation and Modify Serotonin and Ketone Body Concentrations in a Pig Model

(2016) Anna G. Wessels et al.   PLoS One

Dietary l-leucine supplementation enhances intestinal development in suckling piglets

(2015) Yuli Sun et al.   AMINO ACIDS

Ten weeks of branched-chain amino acid supplementation improves select performance and immunological variables in trained cyclists

(2015) Wesley C. Kephart et al.   AMINO ACIDS

Leucine supplementation of a chronically restricted protein and energy diet enhances mTOR pathway activation but not muscle protein synthesis in neonatal pigs

(2015) Rodrigo Manjarín et al.   AMINO ACIDS

Effects of dietary leucine supplementation in low crude protein diets on performance, nitrogen balance, whole-body protein turnover, carcass characteristics and meat quality of finishing pigs

(2015) Shihai Zhang et al.   ANIMAL SCIENCE JOURNAL

Dietary leucine regulates the intestinal immune status, immune-related signalling molecules and tight junction transcript abundance in grass carp (Ctenopharyngodon idella)

(2015) Wei-Dan Jiang et al.   AQUACULTURE

Branched-chain Amino Acids are Beneficial to Maintain Growth Performance and Intestinal Immune-related Function in Weaned Piglets Fed Protein Restricted Diet

(2015) M. Ren et al.   ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES

Branched-chain amino acid and lysine deficiencies exert different effects on mammary translational regulation

(2015) John Doelman et al.   JOURNAL OF DAIRY SCIENCE

Branched-chain amino acids modulate the expression of hepatic fatty acid metabolism-related genes in female broiler chickens

(2015) Jie Bai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Impaired Function of Macrophages Induced by Strenuous Exercise Could Not Be Ameliorated by BCAA Supplementation

(2015) Weihua Xiao et al.   Nutrients

Dietary Leucine Supplementation Improves the Mucin Production in the Jejunal Mucosa of the Weaned Pigs Challenged by Porcine Rotavirus

(2015) Xiangbing Mao et al.   PLoS One

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(2015) Samad Rahimnejad et al.   Turkish Journal of Fisheries and Aquatic Sciences

Leucine acts in the brain to suppress food intake but does not function as a physiological signal of low dietary protein

(2014) Thomas Laeger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways

(2014) Shihai Zhang et al.   AMINO ACIDS

Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion

(2014) Sarah C. Brennan et al.   BRITISH JOURNAL OF NUTRITION

The impaired intestinal mucosal immune system by valine deficiency for young grass carp (Ctenopharyngodon idella) is associated with decreasing immune status and regulating tight junction proteins transcript abundance in the intestine

(2014) Jian-Bo Luo et al.   FISH & SHELLFISH IMMUNOLOGY

Effect of dietary isoleucine on the immunity, antioxidant status, tight junctions and microflora in the intestine of juvenile Jian carp (Cyprinus carpio var. Jian)

(2014) Juan Zhao et al.   FISH & SHELLFISH IMMUNOLOGY

The combination of arginine and leucine supplementation of reduced crude protein diets for boars increases eating quality of pork1

(2014) M. S. Madeira et al.   JOURNAL OF ANIMAL SCIENCE

Impairment of innate immune responses in cirrhotic patients and treatment by branched-chain amino acids

(2014) Ikuo Nakamura   WORLD JOURNAL OF GASTROENTEROLOGY

Production of free glutamate in milk requires the leucine transporter LAT1

(2013) Takuya Matsumoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs

(2013) Claire Boutry et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Functional amino acids in nutrition and health

(2013) Guoyao Wu   AMINO ACIDS

Supplementation with branched-chain amino acids to a low-protein diet regulates intestinal expression of amino acid and peptide transporters in weanling pigs

(2013) Shihai Zhang et al.   AMINO ACIDS

Leucine supplementation increases serum insulin-like growth factor 1 concentration and liver protein/RNA ratio in rats after a period of nutritional recovery

(2013) Rogerio G. Pedrosa et al.   Applied Physiology Nutrition and Metabolism

Potential Role of Branched-Chain Amino Acid Catabolism in Regulating Fat Oxidation

(2013) Heikki Kainulainen et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Effects of dietary isoleucine on the immune response, antioxidant status and gene expression in the head kidney of juvenile Jian carp (Cyprinus carpio var. Jian)

(2013) Juan Zhao et al.   FISH & SHELLFISH IMMUNOLOGY

Food as a Hormone

(2013) K. K. Ryan et al.   SCIENCE

The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses

(2013) Ghada Soliman   Nutrients

Hormonal regulation of leucine catabolism in mammary epithelial cells

(2012) Jian Lei et al.   AMINO ACIDS

Regulation of leucine catabolism by metabolic fuels in mammary epithelial cells

(2012) Jian Lei et al.   AMINO ACIDS

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Leptin and leucine synergistically regulate protein metabolism in C2C12 myotubes and mouse skeletal muscles

(2012) Xiangbing Mao et al.   BRITISH JOURNAL OF NUTRITION

Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and α-keto acid concentrations in pigs1

(2012) M. Gloaguen et al.   JOURNAL OF ANIMAL SCIENCE

An amino acid mixture is essential to optimize insulin-stimulated glucose uptake and GLUT4 translocation in perfused rodent hindlimb muscle

(2012) Jeffrey R. Bernard et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effect of central and peripheral leucine on energy metabolism in the Djungarian hamster (Phodopus sungorus)

(2012) Christiane E. Koch et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Leucine Is Essential for Attenuating Fetal Growth Restriction Caused by a Protein-Restricted Diet in Rats

(2012) Gabriela Fullin Resende Teodoro et al.   JOURNAL OF NUTRITION

Isoleucine and Leucine Independently Regulate mTOR Signaling and Protein Synthesis in MAC-T Cells and Bovine Mammary Tissue Slices

(2012) J. A. D. Ranga Niroshan Appuhamy et al.   JOURNAL OF NUTRITION

Zn2+ and l-isoleucine induce the expressions of porcine β-defensins in IPEC-J2 cells

(2012) Xiangbing Mao et al.   MOLECULAR BIOLOGY REPORTS

Glutamine and Leucine Provide Enhanced Protective Immunity Against Mucosal Infection with Herpes Simplex Virus Type 1

(2012) Erdenebileg Uyangaa et al.   Immune Network

Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT

(2011) Ying Du et al.   AMINO ACIDS

Induction of β-defensins by l-isoleucine as novel immunotherapy in experimental murine tuberculosis

(2011) C. E. Rivas-Santiago et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo

(2011) Isabel M. González et al.   DEVELOPMENTAL BIOLOGY

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Utilization of amino acids by bacteria from the pig small intestine

(2010) Zhao-Lai Dai et al.   AMINO ACIDS

Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk

(2010) Riikka Kivelä et al.   FASEB JOURNAL

Isoleucine Prevents the Accumulation of Tissue Triglycerides and Upregulates the Expression of PPARα and Uncoupling Protein in Diet-Induced Obese Mice

(2010) Junko Nishimura et al.   JOURNAL OF NUTRITION

Leucine Supplementation of a Low-Protein Meal Increases Skeletal Muscle and Visceral Tissue Protein Synthesis in Neonatal Pigs by Stimulating mTOR-Dependent Translation Initiation

(2010) Roberto Murgas Torrazza et al.   JOURNAL OF NUTRITION

Leucine and α-Ketoisocaproic Acid, but Not Norleucine, Stimulate Skeletal Muscle Protein Synthesis in Neonatal Pigs

(2010) Jeffery Escobar et al.   JOURNAL OF NUTRITION

Leucine promotes leptin receptor expression in mouse C2C12 myotubes through the mTOR pathway

(2010) Xiangbing Mao et al.   MOLECULAR BIOLOGY REPORTS

Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes

(2010) Susan C. Connor et al.   Molecular BioSystems

Catabolism of nutritionally essential amino acids in developing porcine enterocytes

(2009) Lixiang Chen et al.   AMINO ACIDS

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

Leucine Deprivation Decreases Fat Mass by Stimulation of Lipolysis in White Adipose Tissue and Upregulation of Uncoupling Protein 1 (UCP1) in Brown Adipose Tissue

(2009) Y. Cheng et al.   DIABETES

Isocaloric high-protein diet as well as branched-chain amino acids supplemented diet partially alleviates adverse consequences of maternal undernutrition on fetal growth

(2009) Haruta Mogami et al.   GROWTH HORMONE & IGF RESEARCH

Stimulation of Muscle Protein Synthesis by Prolonged Parenteral Infusion of Leucine Is Dependent on Amino Acid Availability in Neonatal Pigs

(2009) Fiona A. Wilson et al.   JOURNAL OF NUTRITION

Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation

(2008) Agus Suryawan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

(2008) Micah J Drummond et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

(2008) Kirsi H Pietiläinen et al.   PLOS MEDICINE