Article
Biochemistry & Molecular Biology
Paul Ashwood
Summary: Autism spectrum disorder (AU) is a condition that affects approximately 2% of the population and is often accompanied by gastrointestinal (GI) symptoms. A study found that children with AU and GI symptoms had increased levels of various immune cytokines, indicating an imbalance in immune response. This finding could potentially lead to the development of therapeutic strategies for GI issues in AU.
Article
Immunology
Lin Zou, Junyun He, Lili Gu, Rami A. Shahror, Yun Li, Tuoxin Cao, Sheng Wang, Jing Zhu, Huang Huang, Fengqian Chen, Xiaoxuan Fan, Junfang Wu, Wei Chao
Summary: The study found that sepsis survivors may develop encephalopathy and neurological dysfunction, which are associated with extracellular miRNAs and the TLR7 sensor. Experimental results showed that sepsis can lead to BBB disruption, excessive neuroinflammatory responses in the brain, and impaired motor coordination and neurological function in neurobehavioral testing.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Immunology
Na Zhang, Fei Wang, Gaomeng Zhang, Qi Zhang, Yuhong Liu, Qiao Wang, Mohamed Shafey Elsharkawy, Maiqing Zheng, Jie Wen, Guiping Zhao, Qinghe Li
Summary: Toll-like receptors (TLRs) are important immune sensors involved in host defense. In this study, the researchers discovered that the deubiquitinase USP7 interacts with MyD88 protein, regulating its expression and participating in bacteria-induced inflammation. This finding contributes to our understanding of the regulatory mechanisms in immune signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Sophie A. I. Sanford, Lauren V. C. Miller, Marina Vaysburd, Sophie Keeling, Benjamin J. Tuck, Jessica Clark, Michal Neumann, Victoria Syanda, Leo C. James, William A. Mcewan
Summary: This study demonstrates the critical role of IFN-I in promoting tau aggregation, suggesting IFN-I as a potential therapeutic target in Alzheimer's disease and other tauopathies.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Nur Azizah A. Rahman, Vinod R. M. T. Balasubramaniam, Wei Boon Yap
Summary: The IL-12 family consists of cytokines that play a crucial role in activating host antiviral immunity and preventing excessive immune reactions. IL-12 and IL-23 stimulate T cell proliferation and effector cytokine release, leading to host defense against virus infections. IL-27 and IL-35 have dual functions in regulating cytokine synthesis, T cell proliferation, and viral antigen presentation to enhance virus clearance. The multitasking nature of the IL-12 family makes it a highly important target for antiviral therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Aminata P. Coulibaly
Summary: Behavior and cognition are influenced by genetics, synaptic plasticity, and neuronal connectivity. Peripheral inflammation and immune cells have been shown to play important roles in the preservation and deterioration of behavior and cognition. This review summarizes the current knowledge on the effects of immune cell activation on various behaviors and cognitive processes.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Biology
Eva M. Szego, Laura Malz, Nadine Bernhardt, Angela Roesen-Wolff, Bjoern H. Falkenburger, Hella Luksch
Summary: This study demonstrates that chronic activation of the STING pathway is sufficient to cause degeneration of dopaminergic neurons, which could be significant in Parkinson's disease and other neurodegenerative diseases.
Article
Cell Biology
Harry J. Hurley, Hannah Dewald, Zachary S. Rothkopf, Sukhwinder Singh, Frank Jenkins, Pratik Deb, Saurav De, Betsy J. Barnes, Patricia Fitzgerald-Bocarsly
Summary: The study indicates that AMP-activated protein kinase is a key driver of metabolic reprogramming in pDCs, with influenza activation leading to increased oxygen consumption and mitochondrial membrane potential, ultimately promoting IFN-alpha production.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stefano Sorrentino, Roberto Ascari, Emanuela Maderna, Marcella Catania, Bernardino Ghetti, Fabrizio Tagliavini, Giorgio Giaccone, Giuseppe Di Fede
Summary: The research suggests that microglial cells play a key role in the heterogeneous involvement of Alzheimer's disease (AD) and the neuroinflammation is significantly relevant in the pathogenesis of AD. By measuring brain levels of inflammatory factors, AD patients can be stratified into different neuroinflammatory clusters, contributing to the understanding of the disease diversity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Yuechi Fu, Jiaying Hu, Heng-wei Cheng
Summary: High ambient temperature can cause gut microbiota dysbiosis and increase gut permeability, resulting in neuroinflammation in various animals. This study found that dietary supplementation of the probiotic Bacillus subtilis reduced neuroinflammation in heat-stressed broiler chickens by decreasing the levels of inflammatory markers in the hippocampus. These results suggest the potential use of probiotics as a management strategy for reducing the impact of heat stress on poultry production.
Review
Cell Biology
Marta Campillo Poveda, Collette Britton, Eileen Devaney, Tom N. Mcneilly, Francois Gerbe, Philippe Jay, Rick M. Maizels
Summary: Tuft cells are chemosensory cells in the intestinal tract that play a crucial role in activating immune responses to parasitic infections. They not only participate in maintaining metabolic and tissue integrity, but also serve as the first sensors of parasite infection. Furthermore, Tuft cells are widely distributed in mucosal tissues and are connected to immune and neuronal cells.
Article
Immunology
Annemieke M. Peters van Ton, Guus P. Leijte, Gerben M. Franssen, Niklas Bruse, Jan Booij, Janine Doorduin, Mark Rijpkema, Matthijs Kox, Wilson F. Abdo, Peter Pickkers
Summary: This study investigated the trajectory of the immune response systemically and within the brain following repeated LPS challenges in healthy volunteers. The results showed that while the first LPS challenge induced systemic and cerebral inflammation, the second challenge led to a decrease in cerebral inflammation below baseline levels, indicating a neuroprotective mechanism of in vivo immunological reprogramming in the brain. These findings suggest further studies on immunotolerance in patients with systemic inflammation-induced cerebral dysfunction.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Ophthalmology
Andrew R. Griswold, Hsin-Che Huang, Daniel A. Bachovchin
Summary: The study demonstrates the functional role of NLRP1 inflammasome in human corneal epithelial cells and sheds light on the mechanism through which aberrant inflammasome activation causes corneal damage.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Immunology
Patricia Urban, Paola Italiani, Diana Boraschi, Sabrina Gioria
Summary: The study investigates the interaction of SARS-CoV-2 with the human immune system, finding that monocytes pre-exposed to the N protein exhibit a milder response to subsequent viral or bacterial challenges, potentially leading to a mild response to new infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Sadaf Noor, Yuliya Semenova, Alexandru Dosa, Joeri J. Pen, Alain Menzel, Salva Piscopo, Nicolas Wirth, Daniel-Ovidiu Costea
Summary: This article discusses alternative treatments for prostate disorders, with a particular focus on the role of nutrients. By providing an overview of the characteristics of the prostate organ and the most prevalent diseases, nutrition-based treatment methods are proposed, with an emphasis on their potential effectiveness in surgery. The article advocates for the recognition of this form of alternative treatment as a fully recognized therapy for prostate disorders.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Pediatrics
Khalid I. Elsayh, Khaled Saad, Helal F. Hetta, Mervat A. M. Youssef, Mostafa M. Embaby, Ismail L. Mohamed, Safwat M. Abdel-Aziz, Zeinab Albadry M. Zahran, Amira Elhoufey, Aliaa M. A. Ghandour, Asmaa M. Zahran
Summary: Hydroxyurea treatment can restore the immune parameters in children with sickle cell anemia, including increased CD3+, CD4+, Th1, and CD8+ T cells and decreased NK, Th2, and Tc2 cells, resulting in an increase in the Th1/Th2 and Tc1/Tc2 ratios.
PEDIATRIC RESEARCH
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel Ovidiu Costea
Summary: Bariatric surgery is an effective method for significant weight loss in patients who have not achieved weight loss through pharmacological interventions. Post-surgery, sustained weight loss offers metabolic advantages and improves glucose and lipid metabolism. However, bariatric surgery is associated with deficiencies in vitamins and minerals, requiring monitoring and supplementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Geir Bjorklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Joeri J. Pen, Asma Gasmi Benahmed, Daniel-Ovidiu Costea
Summary: Gut microbes play a crucial role in bariatric surgery outcomes, as they can be altered by the surgery and have beneficial effects on therapeutic results.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Amin Gasmi, Boukelia Boukhmis, Geir Bjorklund, Ibrahim H. Elkhidir, Yuliya Semenova, Alexandru Dosa, Salva Piscopo, Adekunle Hakeem Temitope, Sadaf Noor, Daniel-Ovidiu Costea
Summary: This systematic review and meta-analysis examined the effect of physical activity on weight loss in adults who underwent bariatric surgery. The study also compared biomarkers between individuals with different levels of physical activity after surgery. The results showed that BMI as a measure of physical activity had a positive impact on the target population. However, further larger-scale studies with stricter criteria are needed to confirm these findings.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pediatrics
Anas Elgenidy, Ahmed K. Awad, Khaled Saad, Mostafa Atef, Hatem Helmy El-Leithy, Ahmed A. Obiedallah, Emad M. Hammad, Faisal-Alkhateeb Ahmad, Ahmad M. Ali, Hamad Ghaleb Dailah, Amira Elhoufey, Samaher Fathy Taha
Summary: This study reveals the increase of pediatric DKA during the COVID-19 pandemic and finds an increase in the severe form of DKA among newly diagnosed T1DM children.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Nagwa A. Meguid, Heba S. Hashem, Mohamed H. Ghanem, Samia A. Helal, Yuliya Semenova, Saher Hashem, Adel Hashish, Salvatore Chirumbolo, Ahmed M. Elwan, Geir Bjorklund
Summary: This study aimed to identify metabolic abnormalities in BCAAs and investigate the presence of epileptiform discharges in ASD patients. Results showed that various types of seizures can occur in ASD children and that ASD children have lower levels of BCAAs compared to neurotypical controls. Further research is needed to better understand ASD and evaluate the association between ASD, EEG changes, seizures, and BCAAs more reliably.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Marina Izmailovich, Yuliya Semenova, Gulzada Abdushukurova, Ainur Mukhamejanova, Azhar Dyussupova, Raida Faizova, Meruert Gazaliyeva, Leila Akhvlediani, Natalya Glushkova, Sundetgali Kalmakhanov, Geir Bjorklund
Summary: A systematic review was conducted to explore the use of component-resolved diagnosis in identifying polysensitization in patients with seasonal allergic rhinitis. A total of 568 publications were identified and 12 were included in the review, with 3302 patients enrolled. The findings showed that component-resolved diagnostics changed the choice of relevant allergens for immunotherapy in at least 50% of cases and sensitization differed based on age, disease type, and disease duration.
Review
Infectious Diseases
Yernar Amangelsin, Yuliya Semenova, Maryam Dadar, Mohamad Aljofan, Geir Bjorklund
Summary: Tetracycline, a widely used antibiotic, has become a serious threat to the environment due to overuse and weak degradation ability. It accumulates in the food chain, causing toxicity to microbial communities, promoting antibiotic resistance, and disrupting human intestinal flora.
Review
Chemistry, Medicinal
Amin Gasmi, Mariia Shanaida, Oleksandra Oleshchuk, Yuliya Semenova, Pavan Kumar Mujawdiya, Yana Ivankiv, Olena Pokryshko, Sadaf Noor, Salva Piscopo, Stepan Adamiv, Geir Bjorklund
Summary: The immune system protects the body from infectious agents, and a well-balanced immunity is crucial for maintaining human health. Nutritional and micronutrient deficiencies can compromise the immune system, while certain bioactive compounds from plants, fungi, animals, microorganisms, and other natural sources have shown immunomodulatory properties and can enhance the immune response.
Review
Health Care Sciences & Services
Laura Kassym, Assiya Kussainova, Yuliya Semenova, Almas Kussainov, Damir Marapov, Marat Zhanaspayev, Zhanar Urazalina, Almira Akhmetova, Madi Tokanov, Yerbol Smail, Geir Bjorklund
Summary: Drunk driving is a significant risk factor for traffic accidents and their lethality. This meta-analysis provides estimates of the prevalence of drunk driving in non-lethally injured drivers, considering factors such as the world region, blood alcohol concentration, and study quality. The pooled prevalence of drunk driving in injured drivers was found to be 16.6%.
Article
Chemistry, Analytical
Vincenzo Caro Fuentes, Ariel Torres, Danny Luarte, Jorge E. Pezoa, Sebastian E. Godoy, Sergio N. Torres, Mauricio A. Urbina
Summary: This study proposes and implements an automated fish landing control system that can identify and classify different species in real time, considerably outperforming the current manual procedure.
Article
Chemistry, Analytical
Jorge E. Pezoa, Diego A. Ramirez, Cristofher A. Godoy, Maria F. Saavedra, Silvia E. Restrepo, Pablo A. Coelho-Caro, Christopher A. Flores, Francisco G. Perez, Sergio N. Torres, Mauricio A. Urbina
Summary: Fishing is an important industry that provides protein-rich food and labor for mankind, but it has also led to overexploitation of targeted fish species. This study proposes a deep learning-based method for classifying five fish species in the Chilean fishing industry, achieving better classification results than other techniques.
Article
Health Policy & Services
Valeriy Zub, Yuliya Semenova, Oleksandr Tolstanov, Andrii Kotuza, Taras Gutor, Oksana Matsyura, Roman Lysiuk, Geir Bjorklund
Summary: This study assessed the challenges faced by oncologists in providing cancer care in Ukraine after the armed conflict. The findings showed that physicians in regions occupied by the Russian army experienced a significant decline in patient numbers, while most physicians were satisfied with the availability of medicines and equipment.
INTERNATIONAL JOURNAL OF HEALTHCARE MANAGEMENT
(2023)
Article
Neurosciences
Neluwa-Liyanage R. Indika, Udara D. Senarathne, Antonio Malvaso, Dhanushka Darshana, Susan C. Owens, Borhan Mansouri, Yuliya Semenova, Geir Bjorklund
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social interaction and communication deficits, along with repetitive and restricted patterns of activities, behavior, and interests. Heavy metal exposure, abnormal metabolism, and genetic susceptibility may play a role in the pathogenesis of ASD. Altered porphyrin metabolism in ASD may be associated with deficiencies in vitamins and minerals, and potential metabolic therapies such as supplementation with vitamins, minerals, cofactors, and antioxidants need to be explored in future research.
MOLECULAR NEUROBIOLOGY
(2023)
