Article
Veterinary Sciences
Shenggang Yin, Ting You, Jiayong Tang, Longqiong Wang, Gang Jia, Guangmang Liu, Gang Tian, Xiaoling Chen, Jingyi Cai, Bo Kang, Hua Zhao
Summary: This study investigated the effects of dietary licorice flavonoids powder (LFP) supplementation on antioxidant capacity and immunity in weaned piglets. The results showed that LFP supplementation improved the liver index and antioxidant capacity, reduced serum cholesterol levels, and alleviated inflammation in immune organs of piglets.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Xiyuan Pang, Zhiqiang Miao, Yuanyang Dong, Huiyu Cheng, Xiangqi Xin, Yuan Wu, Miaomiao Han, Yuan Su, Jianmin Yuan, Yuxin Shao, Lei Yan, Jianhui Li
Summary: This study investigated the effects of dietary methionine restriction (MR) on antioxidant function and inflammatory responses in LPS-challenged broilers reared at high stocking density. The results showed that MR can improve antioxidant capacity, immunological stress, and liver health in LPS-challenged broilers.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Brooke Zanco, Christen K. Mirth, Carla M. Sgro, Matthew D. W. Piper
Summary: Research on fruit flies shows that the influence of protein and carbohydrates on lifespan is indirect, affecting the distribution of dietary sterols. Supplementing with cholesterol can rescue the shortened lifespan caused by high protein: carbohydrate diets. This highlights the complex and indirect effects of nutrient-dependent trade-offs on life histories.
Article
Nutrition & Dietetics
Hye-Yeon Lee, Bora Lee, Eun-Ji Lee, Kyung-Jin Min
Summary: Dietary restriction (DR) is a widely accepted strategy to increase lifespan and stress resistance in eukaryotic organisms. This study investigated the effects of parental DR on the fitness of their offspring and found that the offspring displayed increased body weight, stress resistance, and lifespan. However, the development and fecundity of the offspring were not affected. Interestingly, parental DR led to a reduction in the feeding rate of their offspring. These findings suggest that the effects of DR can extend to the offspring and should be considered in studies on aging.
Article
Nutrition & Dietetics
Marina Souza Matos, Bettina Platt, Mirela Delibegovic
Summary: With advancements in medical treatments, public health, improved housing, and dietary choices, there has been a significant increase in the aging population in developed countries, leading to a rise in chronic diseases among the elderly. Non-pharmacological dietary interventions such as energetic restriction and methionine restriction have shown promising outcomes in preventing and treating aging-related disorders.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Article
Agriculture, Dairy & Animal Science
Zhihua Ren, Xinyue Zhang, Haoyue Fan, Yueru Yu, Shuhua Yao, Yuqian Wang, Yanqiang Dong, Huidan Deng, Zhicai Zuo, Youtian Deng, Ya Wang, Zhiwen Xu, Junliang Deng
Summary: This study investigated the relationship between changes in intestinal aquaporins (AQPs) and nutritional diarrhea in piglets fed diets with different protein levels. The results showed that 20% crude protein (CP) diet is beneficial for the normal expression of AQP4 in the small intestine and AQP2, AQP4, and AQP9 in the colon of weaned piglets, maintaining the balance of intestinal water absorption and secretion.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Hannah Lail, Angela M. Mabb, Marise B. Parent, Filipe Pinheiro, Desiree Wanders
Summary: Dietary restriction of methionine has been shown to have unique metabolic protection and cognitive benefits, protecting against impairments in learning and memory induced by obesity, age, and Alzheimer's disease in animal models. These benefits are likely mediated by various mechanisms, including increases in fibroblast growth factor 21, alterations in methionine metabolism pathways, reductions in neuroinflammation and central oxidative stress, and potential changes in the gut microbiome, mitochondrial function, and synaptic plasticity.
Article
Cell Biology
Jing Gao, ZeMin Liu, ChenYu Wang, Li Ma, Yongzhong Chen, TieJun Li
Summary: This study investigates the relationship between dietary protein levels and changes in the intestinal microbiota of piglets. It was found that a high-protein diet leads to diarrhea in piglets and affects feed intake and body weight. The high-protein diet also influences the content of fatty acids in the colon and the relative abundance of gastrointestinal bacteria.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Agriculture, Dairy & Animal Science
Lei Hou, Li Wang, Yueqin Qiu, YunXia Xiong, Hao Xiao, Hongbo Yi, Xiaolu Wen, Zeling Lin, Zhikang Wang, Xuefen Yang, Zongyong Jiang
Summary: Protein restriction and subsequent realimentation in weaned piglets lead to compensatory growth and protein deposition, while also influencing gut microbiota and metabolite profiles to improve intestinal health.
Article
Biochemistry & Molecular Biology
Lida Fan, Wenzhe Yu, Beiang Zhang, Bin Cao, Mingfu Wang, Xiaoqian Hu
Summary: This study revealed the distinctive effects of various AGEs on glucose metabolism, with MGO-BSA being the most active in promoting insulin resistance and impacting glucose tolerance when consumed in the diet.
Article
Agriculture, Dairy & Animal Science
Lei Wang, Xian Tan, Huiru Wang, Qiye Wang, Pengfei Huang, Yali Li, Jianzhong Li, Jing Huang, Huansheng Yang, Yulong Yin
Summary: The present study evaluated the effect of dietary folic acid on growth performance, intestinal morphology, and intestinal epithelial cells renewal in post-weaning piglets. The results showed that folic acid supplementation improved villus height, VH-to-crypt depth ratio, villus surface area, lactase and sucrase activities in the jejunal mucosa, along with several other significant linear changes in gene expression and cell shedding rate. Overall, folic acid supplementation can enhance growth performance and intestinal morphology in weaned piglets by maintaining epithelial cell renewal balance.
Article
Agriculture, Dairy & Animal Science
Francesca Soglia, Marco Zampiga, Giulia Baldi, Yuwares Malila, Krittaporn V. Thanatsang, Yanee Srimarut, Nantawat Tatiyaborworntham, Onuma Unger, Annop Klamchuen, Luca Laghi, Massimiliano Petracci, Federico Sirri
Summary: The study assessed the impact of lysine restriction during different feeding phases on broilers' growth performances, meat quality traits, and technological properties. Lysine restriction had negligible effects on production performances, but increased anserine content in lysine-restricted birds suggested an increased energy requirement and potential reduced protein synthesis in the pectoral muscles.
Review
Biochemistry & Molecular Biology
Christy Yeung, Irisa Qianwen Shi, Hoon-Ki Sung
Summary: Dieting regimens such as calorie restriction and intermittent fasting are commonly practiced interventions for weight management and metabolic health, with the latter showing more flexibility and fewer post-dietary effects. Understanding the sustainability of dieting and developing more practical and effective interventions are crucial, particularly in the absence of substantial research on intermittent fasting post-dietary effects.
Article
Microbiology
Hui Diao, Jiayou Yan, Shuwei Li, Shengyao Kuang, Xiaolan Wei, Mengjia Zhou, Jinxiu Zhang, Chongbo Huang, Peng He, Wenjie Tang
Summary: The study showed that dietary supplementation with 100mg/kg of zinc sulfate, glycine zinc, or zinc lactate could improve the growth performance and gut barrier function of weaned piglets. Organic zinc supplementation, particularly zinc lactate, had the best effect.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Xiao-Long Wang, Zhu-Ying Liu, Ying-Hui Li, Ling-Yuan Yang, Jie Yin, Jian-Hua He, De-Xing Hou, Ya-Li Liu, Xing-Guo Huang
Summary: The study showed that dietary supplementation of Lactobacillus delbrueckii improved growth performance and increased serum HDL and insulin levels in piglets. It also modulated the microbiota community by decreasing the relative abundance of Bacteroidetes and increasing the relative abundance of Firmicutes. Furthermore, Lactobacillus delbrueckii improved intestinal morphology, leading to higher concentrations of beneficial acids in the colon and decreased intestinal pH.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Jing Gao, Md A. K. Azad, Hui Han, Dan Wan, TieJun Li
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Cell Biology
Jing Gao, Jie Yin, Kang Xu, Hui Han, ZeMin Liu, ChenYu Wang, Tiejun Li, Yulong Yin
MEDIATORS OF INFLAMMATION
(2020)
Article
Microbiology
Jie Yin, Yuying Li, Hui Han, Jie Ma, Gang Liu, Xin Wu, Xingguo Huang, Rejun Fang, Kenkichi Baba, Peng Bin, Guoqiang Zhu, Wenkai Ren, Bie Tan, Gianluca Tosini, Xi He, Tiejun Li, Yulong Yin
Article
Infectious Diseases
Shunfen Zhang, Ruqing Zhong, Hui Han, Bao Yi, Jie Yin, Liang Chen, Hongfu Zhang
Article
Agriculture, Dairy & Animal Science
Hao Li, Longteng Ma, Zhiqing Li, Jie Yin, Bie Tan, Jiashun Chen, Qian Jiang, Xiaokang Ma
Summary: The study described the evolution of gut microbiota of an indigenous pig breed, Ningxiang pigs (NXP), with dietary factors playing a major role. The response of fiber-degrading bacteria at different stages may help NXP better adapt to plant-derived feeds.
Article
Physiology
Hui Han, Zemin Liu, Jie Yin, Jing Gao, Liuqin He, Chenyu Wang, Ruoxin Hou, Xingguo He, Guoqiang Wang, Tiejun Li, Yulong Yin
Summary: The study found that treatment with 10 g/kg BW/day of D-galactose for 3 weeks induced chronic oxidative stress in weaned piglets, resulting in reduced growth performance and altered gut microbiota.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Food Science & Technology
Hui Han, Yi Jiang, Mengyu Wang, Mebratu Melaku, Lei Liu, Yong Zhao, Nadia Everaert, Bao Yi, Hongfu Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder that is closely related to gut dysfunction. The bidirectional communication between the gut and liver, mediated by metabolites, plays a role in the pathogenesis of NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Microbiology
Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Summary: Feelings of hunger and satiety play crucial roles in maintaining life; gut microbiota have been implicated in appetite control, potentially affecting host metabolic health and leading to various metabolic disorders.
Article
Biotechnology & Applied Microbiology
Hui Han, Shunfen Zhang, Ruqing Zhong, Chaohua Tang, Jie Yin, Junmin Zhang, Hongfu Zhang
Summary: The experiment with CTC showed that the drug did not affect growth performance in piglets, but could adjust intestinal structure. It seems that the colonic microbiota is no longer sensitive to CTC due to long-term use and low bioavailability.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hui Han, Mengyu Wang, Ruqing Zhong, Bao Yi, Martine Schroyen, Hongfu Zhang
Summary: This study investigates the mechanism through which the gut microbiota influences hepatic lipid metabolism in high-fat diet-fed mice. Gut microbiota depletion was found to reduce body weight, fat deposition, glucose levels, cholesterol levels, insulin levels, and leptin levels in these mice. Additionally, it inhibited excessive hepatic lipid accumulation and changed the expression of genes involved in cholesterol and fatty acid metabolism. The abundance of bacteria associated with abnormal metabolism and inflammation was also reduced. There was a strong correlation between the altered gut microbiota abundance and the serum cholesterol level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Mengyu Wang, Hui Han, Fan Wan, Ruqing Zhong, Yoon Jung Do, Sang-Ik Oh, Xuemeng Lu, Lei Liu, Bao Yi, Hongfu Zhang
Summary: This study found that DHQ improved lipid dysmetabolism in the body, especially in the liver, and was associated with altered gut flora.
Article
Biochemistry & Molecular Biology
Hui Han, Ruqing Zhong, Shunfen Zhang, Mengyu Wang, Xiaobin Wen, Bao Yi, Yong Zhao, Liang Chen, Hongfu Zhang
Summary: This study investigated the antioxidant effects of hydroxytyrosol (HT) administration in diquat (DQ)-challenged mice. The results showed that HT treatment alleviated DQ-induced oxidative stress, increased antioxidant enzyme activities, and decreased malondialdehyde concentration. HT also modulated colonic microbiota and enhanced Nrf2 signaling pathways. These findings suggest that HT may protect against oxidative stress through its effects on colonic microbiota and Nrf2 signaling pathways in DQ-challenged mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Tao Wang, Junquan Tian, Wenxuan Su, Fan Yang, Jie Yin, Qian Jiang, Yuying Li, Kang Yao, Tiejun Li, Yulong Yin
Summary: This study evaluated the optimal dosage of ornithine a-ketoglutarate (OKG) and explored its preventive effect on DSS-induced colitis in mice. Results showed that 1% OKG supplementation increased body weight, serum growth hormone (GH), insulin (INS), alkaline phosphatase (ALP), and certain amino acids, while decreasing urea nitrogen (BUN), NH3L, and Ile. Moreover, 1% OKG supplementation prevented DSS-induced colitis in mice by altering microbial compositions and reducing the secretion of inflammatory cytokines in serum.
Article
Agriculture, Dairy & Animal Science
Hongnan Liu, Li Wu, Hui Han, Yuying Li, Lijian Wang, Jie Yin, Wenjun Fan, Miaomiao Bai, Jiming Yao, Xingguo Huang, Tiejun Li
Article
Biochemistry & Molecular Biology
Yuying Li, Hui Han, Jie Yin, Xingguo He, Zhiyi Tang, Tiejun Li, Kang Yao, Yulong Yin
