Clinical experiences with systemically administered siRNA-based therapeutics in cancer
出版年份 2015 全文链接
标题
Clinical experiences with systemically administered siRNA-based therapeutics in cancer
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 14, Issue 12, Pages 843-856
出版商
Springer Nature
发表日期
2015-11-16
DOI
10.1038/nrd4685
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Physical Chemistry of Nanomedicine: Understanding the Complex Behaviors of Nanoparticles in Vivo
- (2015) Lucas A. Lane et al. Annual Review of Physical Chemistry
- Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model
- (2015) Gregory R. Robbins et al. Nanomedicine-Nanotechnology Biology and Medicine
- Safety and Activity of the First-in-Class Sym004 Anti-EGFR Antibody Mixture in Patients with Refractory Colorectal Cancer
- (2015) R. Dienstmann et al. Cancer Discovery
- Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency
- (2014) Edward A. Sykes et al. ACS Nano
- Beyond BRAF: where next for melanoma therapy?
- (2014) I V Fedorenko et al. BRITISH JOURNAL OF CANCER
- Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis
- (2014) Sonia A. Melo et al. CANCER CELL
- First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors
- (2014) Beate Schultheis et al. JOURNAL OF CLINICAL ONCOLOGY
- Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates
- (2014) Stephanie E. Barrett et al. JOURNAL OF CONTROLLED RELEASE
- Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
- (2014) Jayaprakash K. Nair et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Systemic Delivery of a miR34a Mimic as a Potential Therapeutic for Liver Cancer
- (2014) C. L. Daige et al. MOLECULAR CANCER THERAPEUTICS
- MicroRNA silencing for cancer therapy targeted to the tumour microenvironment
- (2014) Christopher J. Cheng et al. NATURE
- Time to deliver
- (2014) NATURE BIOTECHNOLOGY
- Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates
- (2014) Trinna L. Cuellar et al. NUCLEIC ACIDS RESEARCH
- Long-Distance Communication between Laryngeal Carcinoma Cells
- (2014) Ieva Antanavičiūtė et al. PLoS One
- Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA
- (2014) J. E. Zuckerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Investigating the optimal size of anticancer nanomedicine
- (2014) L. Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of RNA structure at 5′ untranslated region in microRNA-mediated gene regulation
- (2014) Wanjun Gu et al. RNA
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- RNAi Therapies: Drugging the Undruggable
- (2014) S. Y. Wu et al. Science Translational Medicine
- Antisense therapeutics in oncology: current status
- (2014) Ammad Ahmad Farooqi et al. OncoTargets and Therapy
- Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
- (2014) Kathryn A. Whitehead et al. Nature Communications
- Development of siRNA Payloads to Target KRAS-Mutant Cancer
- (2014) T. L. Yuan et al. Cancer Discovery
- Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
- (2013) Nicolas Bertrand et al. ADVANCED DRUG DELIVERY REVIEWS
- A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors
- (2013) Anthony W. Tolcher et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology
- (2013) U. Prabhakar et al. CANCER RESEARCH
- Vesicle Trafficking and RNA Transfer Add Complexity and Connectivity to Cell-Cell Communication
- (2013) C. T. Roberts et al. CANCER RESEARCH
- Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology
- (2013) Lígia Catarina Gomes-da-Silva et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Intercellular Communication by Exosome-Derived microRNAs in Cancer
- (2013) Bethany Hannafon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies
- (2013) Glen J. Weiss et al. INVESTIGATIONAL NEW DRUGS
- Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
- (2013) Kevin Fitzgerald et al. LANCET
- Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors
- (2013) Neil Senzer et al. MOLECULAR THERAPY
- Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics
- (2013) Martin A Maier et al. MOLECULAR THERAPY
- Heterogeneity in nanoparticles influences biodistribution and targeting
- (2013) Isaac M Adjei et al. Nanomedicine
- Delivery materials for siRNA therapeutics
- (2013) Rosemary Kanasty et al. NATURE MATERIALS
- Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
- (2013) Teresa Coelho et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prognostic Significance of Deregulated Dicer Expression in Breast Cancer
- (2013) Emer Caffrey et al. PLoS One
- Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle
- (2013) S. Eliasof et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The CRISPR Craze
- (2013) E. Pennisi SCIENCE
- First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement
- (2013) Josep Tabernero et al. Cancer Discovery
- Toxicity profiling of several common RNAi-based nanomedicines: a comparative study
- (2013) Dalit Landesman-Milo et al. Drug Delivery and Translational Research
- Safety profile of RNAi nanomedicines
- (2012) Scott A. Barros et al. ADVANCED DRUG DELIVERY REVIEWS
- Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models
- (2012) Atsushi Suetsugu et al. ADVANCED DRUG DELIVERY REVIEWS
- Cancer nanomedicines: So many papers and so few drugs!
- (2012) Vincent J. Venditto et al. ADVANCED DRUG DELIVERY REVIEWS
- In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier
- (2012) Broes Naeye et al. BIOMATERIALS
- RNA-Based Therapeutics: Current Progress and Future Prospects
- (2012) John C. Burnett et al. CHEMISTRY & BIOLOGY
- Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research
- (2012) Susana Patricia Egusquiaguirre et al. Clinical & Translational Oncology
- Factors affecting the pharmacokinetics and pharmacodynamics of liposomal drugs
- (2012) Gina Song et al. JOURNAL OF LIPOSOME RESEARCH
- Nanoparticle Hydrophobicity Dictates Immune Response
- (2012) Daniel F. Moyano et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Assessing the Heterogeneity Level in Lipid Nanoparticles for siRNA Delivery: Size-Based Separation, Compositional Heterogeneity, and Impact on Bioperformance
- (2012) Jingtao Zhang et al. MOLECULAR PHARMACEUTICS
- Fighting cancer with nanoparticle medicines―The nanoscale matters
- (2012) Mark E. Davis MRS BULLETIN
- Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
- (2012) J. E. Zuckerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
- (2012) Z. Cheng et al. SCIENCE
- Therapeutic Oligonucleotides: The Road Not Taken
- (2011) C. A. Stein et al. CLINICAL CANCER RESEARCH
- Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery
- (2011) L Li et al. GENE THERAPY
- Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors
- (2011) Dirk Strumberg et al. INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- Atelocollagen-mediated Systemic Delivery Prevents Immunostimulatory Adverse Effects of siRNA in Mammals
- (2011) Shinichiro Inaba et al. MOLECULAR THERAPY
- Progress Toward In Vivo Use of siRNAs-II
- (2011) Garrett R Rettig et al. MOLECULAR THERAPY
- Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
- (2011) H. Cabral et al. Nature Nanotechnology
- The Dicey Role of Dicer: Implications for RNAi Therapy
- (2010) William M. Merritt et al. CANCER RESEARCH
- Potential clinical applications of siRNA technique: benefits and limitations
- (2010) Shao-Hua Chen et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- siRNA Knockdown of Ribonucleotide Reductase Inhibits Melanoma Cell Line Proliferation Alone or Synergistically with Temozolomide
- (2010) Jonathan E. Zuckerman et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
- (2010) Mark E. Davis et al. NATURE
- Strategies in the design of nanoparticles for therapeutic applications
- (2010) Robby A. Petros et al. NATURE REVIEWS DRUG DISCOVERY
- Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice
- (2009) Adam D. Judge et al. JOURNAL OF CLINICAL INVESTIGATION
- siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury
- (2009) B. A. Molitoris et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic
- (2009) Mark E. Davis MOLECULAR PHARMACEUTICS
- Knocking down barriers: advances in siRNA delivery
- (2009) Kathryn A. Whitehead et al. NATURE REVIEWS DRUG DISCOVERY
- Challenges and Opportunities for Local and Systemic Delivery of siRNA and Antisense Oligonucleotides
- (2008) L Sepp-Lorenzino et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Nanoparticle therapeutics: an emerging treatment modality for cancer
- (2008) Mark E. Davis et al. NATURE REVIEWS DRUG DISCOVERY
- Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer
- (2008) William M. Merritt et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chemical Modification of siRNAs for In Vivo Use
- (2008) Mark A. Behlke OLIGONUCLEOTIDES
- Stability Study of Unmodified siRNA and Relevance to Clinical Use
- (2008) Robyn P. Hickerson et al. OLIGONUCLEOTIDES
- Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
- (2007) Derek W. Bartlett et al. BIOTECHNOLOGY AND BIOENGINEERING
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