Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

Toxicity assessment of aggregated/agglomerated cerium oxide nanoparticles in an in vitro 3D airway model: The influence of mucociliary clearance

(2015) C. Frieke Kuper et al.   TOXICOLOGY IN VITRO

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

(2015) Panagiotis Mastorakos et al.   Advanced Healthcare Materials

Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo

(2014) Hugo Guerrero-Cázares et al.   ACS Nano

Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier

(2014) Jung Soo Suk et al.   JOURNAL OF CONTROLLED RELEASE

Overcoming the Cystic Fibrosis Sputum Barrier to Leading Adeno-associated Virus Gene Therapy Vectors

(2014) Benjamin S Schuster et al.   MOLECULAR THERAPY

Estimating the effective density of engineered nanomaterials for in vitro dosimetry

(2014) Glen DeLoid et al.   Nature Communications

Development of Poly(β-amino ester)-Based Biodegradable Nanoparticles for Nonviral Delivery of Minicircle DNA

(2013) Michael Keeney et al.   ACS Nano

Nanoparticle-based therapy for respiratory diseases

(2013) ADRIANA L. DA SILVA et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Use of Single-Site-Functionalized PEG Dendrons To Prepare Gene Vectors that Penetrate Human Mucus Barriers

(2013) Anthony J. Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoparticle diffusion in respiratory mucus from humans without lung disease

(2013) Benjamin S. Schuster et al.   BIOMATERIALS

Virus-mimetic polyplex particles for systemic and inflammation-specific targeted delivery of large genetic contents

(2013) S Kang et al.   GENE THERAPY

Mucus Penetrating Nanoparticles: Biophysical Tool and Method of Drug and Gene Delivery

(2012) Laura M. Ensign et al.   ADVANCED MATERIALS

Uptake and Transfection with Polymeric Nanoparticles Are Dependent on Polymer End-Group Structure, but Largely Independent of Nanoparticle Physical and Chemical Properties

(2012) Joel C. Sunshine et al.   MOLECULAR PHARMACEUTICS

In Vivo Gene Delivery by Nonviral Vectors: Overcoming Hurdles?

(2012) Yuan Zhang et al.   MOLECULAR THERAPY

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer

(2011) Uta Griesenbach et al.   BIOMATERIALS

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung

(2011) G McLachlan et al.   GENE THERAPY

Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice

(2011) Andrea Beyerle et al.   JOURNAL OF CONTROLLED RELEASE

Highly compacted DNA nanoparticles with low MW PEG coatings: In vitro, ex vivo and in vivo evaluation

(2011) Nicholas J. Boylan et al.   JOURNAL OF CONTROLLED RELEASE

N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles

(2011) Jung Soo Suk et al.   MOLECULAR THERAPY

Gene therapy finds its niche

(2011) Cormac Sheridan   NATURE BIOTECHNOLOGY

Common Gene Therapy Viral Vectors Do Not Efficiently Penetrate Sputum from Cystic Fibrosis Patients

(2011) Kaoru Hida et al.   PLoS One

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

(2010) B. Manicassamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles

(2009) Jung Soo Suk et al.   BIOMATERIALS

Progress and Prospects: prospects of repeated pulmonary administration of viral vectors

(2009) P L Sinn et al.   GENE THERAPY

Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages

(2009) Andrew A. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery

(2008) Jordan J. Green et al.   ACCOUNTS OF CHEMICAL RESEARCH

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Barrier properties of mucus

(2008) Richard A. Cone   ADVANCED DRUG DELIVERY REVIEWS

Extracellular barriers in respiratory gene therapy

(2008) Niek Sanders et al.   ADVANCED DRUG DELIVERY REVIEWS

Ciliated epithelial cell lifespan in the mouse trachea and lung

(2008) Emma L. Rawlins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS

Nanoparticle formulations in pulmonary drug delivery

(2008) Mark M. Bailey et al.   MEDICINAL RESEARCH REVIEWS