Progress and Challenges in PEGylated Proteins Downstream Processing: A Review of the Last 8 Years
出版年份 2019 全文链接
标题
Progress and Challenges in PEGylated Proteins Downstream Processing: A Review of the Last 8 Years
作者
关键词
Proteins, Poly(ethylene) glycol, Separation method, Scalability
出版物
International Journal of Peptide Research and Therapeutics
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2019-03-28
DOI
10.1007/s10989-019-09840-4
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- The Pharmaceutical Industry in 2018. An Analysis of FDA Drug Approvals from the Perspective of Molecules
- (2019) Beatriz G. de la Torre et al. MOLECULES
- Characterization of singly and multiply PEGylated insulin isomers by reversed-phase ultra-performance liquid chromatography interfaced with ion mobility mass spectrometry
- (2018) Selim Gerislioglu et al. ANALYTICA CHIMICA ACTA
- Preparation and characterization of calcium alginate-chitosan complexes loaded with lysozyme
- (2018) Tiantian Wu et al. JOURNAL OF FOOD ENGINEERING
- Large-scale purification of unstable, water-soluble secologanic acid using centrifugal partition chromatography
- (2018) Sung Hum Yeon et al. PHYTOCHEMICAL ANALYSIS
- Understanding the effect of ionic liquids as adjuvants in the partition of biomolecules in aqueous two-phase systems formed by polymers and weak salting-out agents
- (2018) Catarina M.S.S. Neves et al. BIOCHEMICAL ENGINEERING JOURNAL
- Multistep purification of cytochrome c PEGylated forms using polymer-based aqueous biphasic systems
- (2017) João H. P. M. Santos et al. GREEN CHEMISTRY
- Optimized purification of mono-PEGylated lysozyme by heparin affinity chromatography using response surface methodology
- (2017) Luis Alberto Mejía-Manzano et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Self-Assembly PEGylation Retaining Activity (SPRA) Technology via a Host–Guest Interaction Surpassing Conventional PEGylation Methods of Proteins
- (2017) Tatsunori Hirotsu et al. MOLECULAR PHARMACEUTICS
- In situ PEGylation of recombinant hirudin on an anion exchange chromatography column
- (2017) Xudong Wang et al. PROCESS BIOCHEMISTRY
- Model-Based Investigation on the Mass Transfer and Adsorption Mechanisms of Mono-Pegylated Lysozyme in Ion-Exchange Chromatography
- (2017) Josefine Morgenstern et al. Biotechnology Journal
- Characterization of the Reversed-Phase Chromatographic Behavior of PEGylated Peptides Based on the Poly(ethylene glycol) Dispersity
- (2016) Eun Ji Park et al. ANALYTICAL CHEMISTRY
- Integrated process for high conversion and high yield protein PEGylation
- (2016) David Pfister et al. BIOTECHNOLOGY AND BIOENGINEERING
- An integrated practical implementation of continuous aqueous two-phase systems for the recovery of human IgG: From the microdevice to a multistage bench-scale mixer-settler device
- (2016) Edith Espitia-Saloma et al. Biotechnology Journal
- PEGylated protein separation using different hydrophobic interaction supports: Conventional and monolithic supports
- (2016) Karla Mayolo-Deloisa et al. BIOTECHNOLOGY PROGRESS
- Separation of mono- and di-PEGylate of exenatide and resolution of positional isomers of mono-PEGylates by preparative ion exchange chromatography
- (2016) Ngoc-Thanh Thi Nguyen et al. JOURNAL OF CHROMATOGRAPHY A
- Separation of pegylated recombinant proteins and isoforms on CIM ion exchangers
- (2016) Jernej Gašperšič et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs
- (2016) Peter L. Turecek et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Pegylated-asparaginase during induction therapy for adult acute lymphoblastic leukaemia: toxicity data from the UKALL14 trial
- (2016) B Patel et al. LEUKEMIA
- An integrated practical implementation of continuous aqueous two-phase systems for the recovery of human IgG: From the microdevice to a multistage bench-scale mixer-settler device
- (2016) Edith Espitia-Saloma et al. Biotechnology Journal
- A reactive continuous chromatographic process for protein PEGylation
- (2016) Oliver Ingold et al. Reaction Chemistry & Engineering
- Model-based development of an on-column PEGylation process
- (2016) David Pfister et al. Reaction Chemistry & Engineering
- Monolith disk chromatography separates PEGylated protein positional isoforms within minutes at low pressure
- (2015) Yu Isakari et al. Biotechnology Journal
- Dielectrophoretic behavior of PEGylated RNase A inside a microchannel with diamond-shaped insulating posts
- (2015) Marco A. Mata-Gómez et al. ELECTROPHORESIS
- What is the future of PEGylated therapies?
- (2015) Magdalena Swierczewska et al. EXPERT OPINION ON EMERGING DRUGS
- Site-Specific PEGylation of Therapeutic Proteins
- (2015) Jonathan Dozier et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Effect of lysozyme solid-phase PEGylation on reaction kinetics and isoform distribution
- (2015) Benjamin Maiser et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Continuous enzyme aqueous two-phase extraction using a novel tubular mixer-settler in multi-step counter-current arrangement
- (2015) Patricia Vázquez-Villegas et al. SEPARATION AND PURIFICATION TECHNOLOGY
- Monolith disk chromatography separates PEGylated protein positional isoforms within minutes at low pressure
- (2015) Yu Isakari et al. Biotechnology Journal
- Separation of PEGylated variants of ribonuclease A and apo-α-lactalbumin via reversed phase chromatography
- (2014) Mayra Cisneros-Ruiz et al. JOURNAL OF CHROMATOGRAPHY A
- Chemical grafting of Sepharose 6B and its use in the purification of PEGylated RNase A
- (2014) Agustín Hernández-Martínez et al. SEPARATION AND PURIFICATION TECHNOLOGY
- Incorporation of heparin into biomaterials
- (2013) Shelly E. Sakiyama-Elbert Acta Biomaterialia
- PEG chain length impacts yield of solid-phase protein PEGylation and efficiency of PEGylated protein separation by ion-exchange chromatography: Insights of mechanistic models
- (2013) Noriko Yoshimoto et al. Biotechnology Journal
- Continuous aqueous two-phase systems devices for the recovery of biological products
- (2013) Edith Espitia-Saloma et al. FOOD AND BIOPRODUCTS PROCESSING
- Advances and trends in the design, analysis, and characterization of polymer–protein conjugates for “PEGylaided” bioprocesses
- (2012) José González-Valdez et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Characterization of a Protein Conjugate Using an Asymmetrical-Flow Field-Flow Fractionation and a Size-Exclusion Chromatography with Multi-Detection System
- (2012) Katja Rebolj et al. ANALYTICAL CHEMISTRY
- PEGylated protein separations: Challenges and opportunities
- (2012) Noriko Yoshimoto et al. Biotechnology Journal
- Continuous purification of antibodies from cell culture supernatant with aqueous two-phase systems: From concept to process
- (2012) Paula A. J. Rosa et al. Biotechnology Journal
- Practical non-chromatography strategies for the potential separation of PEGylated RNase A conjugates
- (2012) Miriam Galindo-López et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Hydrophobic interaction chromatography for purification of monoPEGylated RNase A
- (2012) Karla Mayolo-Deloisa et al. JOURNAL OF CHROMATOGRAPHY A
- Isoform separation and binding site determination of mono-PEGylated lysozyme with pH gradient chromatography
- (2012) Benjamin Maiser et al. JOURNAL OF CHROMATOGRAPHY A
- Aqueous two-phase systems for protein separation: Phase separation and applications
- (2012) Juan A. Asenjo et al. JOURNAL OF CHROMATOGRAPHY A
- Functional gigaporous polystyrene microspheres facilitating separation of poly(ethylene glycol)–protein conjugate
- (2011) Yanqin Zhai et al. ANALYTICA CHIMICA ACTA
- Two-dimensional gel electrophoresis in proteomics: A tutorial
- (2011) Thierry Rabilloud et al. Journal of Proteomics
- Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics
- (2011) Matthias Barz et al. Polymer Chemistry
- Capillary electrophoretic separation of poly(ethylene glycol)-modified granulocyte-colony stimulating factor
- (2010) Kyung Soo Lee et al. ARCHIVES OF PHARMACAL RESEARCH
- Purification of singly PEGylated α-lactalbumin using charged ultrafiltration membranes
- (2010) Krisada Ruanjaikaen et al. BIOTECHNOLOGY AND BIOENGINEERING
- Interaction mechanism of mono-PEGylated proteins in electrostatic interaction chromatography
- (2010) Mitsuyo Abe et al. Biotechnology Journal
- PEGylation of therapeutic proteins
- (2010) Simona JevsÌevar et al. Biotechnology Journal
- Current advances in the non-chromatographic fractionation and characterization of PEGylated proteins
- (2010) Karla Mayolo-Deloisa et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Potential application of aqueous two-phase systems for the fractionation of RNase A and α-Lactalbumin from their PEGylated conjugates
- (2010) José González-Valdez et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Solubility and binding properties of PEGylated lysozyme derivatives with increasing molecular weight on hydrophobic-interaction chromatographic resins
- (2010) Egbert Müller et al. JOURNAL OF CHROMATOGRAPHY A
- Product development issues for PEGylated proteins
- (2010) Robert W. Payne et al. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
- PEG-modified biopharmaceuticals
- (2009) Pascal Bailon et al. Expert Opinion on Drug Delivery
- Analytical and preparative separation of PEGylated lysozyme for the characterization of chromatography media
- (2009) Anna Moosmann et al. JOURNAL OF CHROMATOGRAPHY A
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