Fingolimod for the treatment of neurological diseases—state of play and future perspectives
出版年份 2014 全文链接
标题
Fingolimod for the treatment of neurological diseases—state of play and future perspectives
作者
关键词
-
出版物
Frontiers in Cellular Neuroscience
Volume 8, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2014-09-12
DOI
10.3389/fncel.2014.00283
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Increased Ceramide in Brains with Alzheimer's and Other Neurodegenerative Diseases
- (2018) Valery Filippov et al. JOURNAL OF ALZHEIMERS DISEASE
- Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide
- (2014) Emanuela Colombo et al. ANNALS OF NEUROLOGY
- Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment
- (2014) Kazuya Fukumoto et al. BEHAVIOURAL BRAIN RESEARCH
- Fingolimod exerts neuroprotective effects in a mouse model of intracerebral hemorrhage
- (2014) Lei Lu et al. BRAIN RESEARCH
- The anticoagulant activated protein C (aPC) promotes metaplasticity in the hippocampus through an EPCR-PAR1-S1P1 receptors dependent mechanism
- (2014) Nicola Maggio et al. HIPPOCAMPUS
- Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond
- (2014) Christopher S. Garris et al. IMMUNOLOGY
- Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein
- (2014) Ilker Karaca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway
- (2014) Achilles Ntranos et al. JOURNAL OF NEUROIMMUNOLOGY
- FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation
- (2014) Stine Mencl et al. JOURNAL OF NEUROIMMUNOLOGY
- Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial
- (2014) Peter A Calabresi et al. LANCET NEUROLOGY
- Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory
- (2014) Nitai C Hait et al. NATURE NEUROSCIENCE
- Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease
- (2014) Michelle M. Mielke et al. NEUROBIOLOGY OF AGING
- Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model
- (2014) Daniel C. Anthony et al. NEUROPHARMACOLOGY
- Fingolimod for the Treatment of Intracerebral Hemorrhage
- (2014) Ying Fu et al. JAMA Neurology
- Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis
- (2014) Timothy A Couttas et al. Acta Neuropathologica Communications
- Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine
- (2013) Fatemeh Hemmati et al. BEHAVIOURAL BRAIN RESEARCH
- Second generation S1P pathway modulators: Research strategies and clinical developments
- (2013) Marc Bigaud et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Isoflurane Preconditioning Increases Survival of Rat Skin Random-Pattern Flaps by Induction of HIF-1a Expression
- (2013) Yu Sun et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- The astrocyte in multiple sclerosis revisited
- (2013) Celia F. Brosnan et al. GLIA
- FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease
- (2013) Alba Di Pardo et al. HUMAN MOLECULAR GENETICS
- FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats
- (2013) Masoumeh Asle-Rousta et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Fingolimod phosphate promotes the neuroprotective effects of microglia
- (2013) Hiromi Noda et al. JOURNAL OF NEUROIMMUNOLOGY
- Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
- (2013) Celina Wu et al. Journal of Neuroinflammation
- Lipopolysaccharide-induced cross-tolerance against renal ischemia–reperfusion injury is mediated by hypoxia-inducible factor-2α-regulated nitric oxide production
- (2013) Kang He et al. KIDNEY INTERNATIONAL
- Temporal profile of lymphocyte counts and relationship with infections with fingolimod therapy
- (2013) G Francis et al. Multiple Sclerosis Journal
- Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells
- (2013) Cara N Skon et al. NATURE IMMUNOLOGY
- Epidemiology of stroke and its subtypes in Chinese vs white populations: A systematic review
- (2013) C.-F. Tsai et al. NEUROLOGY
- FTY720 for cancer therapy (Review)
- (2013) LI ZHANG et al. ONCOLOGY REPORTS
- Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons
- (2013) Yukiko Doi et al. PLoS One
- FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons
- (2013) Nobumasa Takasugi et al. PLoS One
- FTY720 Treatment in the Convalescence Period Improves Functional Recovery and Reduces Reactive Astrogliosis in Photothrombotic Stroke
- (2013) Robert Brunkhorst et al. PLoS One
- Fingolimod Reduces Hemorrhagic Transformation Associated With Delayed Tissue Plasminogen Activator Treatment in a Mouse Thromboembolic Model
- (2013) Francisco Campos et al. STROKE
- FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection
- (2013) Peter Kraft et al. STROKE
- Role of the Sphingosine Metabolism Pathway on Neurons Against Experimental Cerebral Ischemia in Rats
- (2013) Yu Hasegawa et al. Translational Stroke Research
- Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes
- (2012) Ruben van Doorn et al. ACTA NEUROPATHOLOGICA
- Myeloid microvesicles are a marker and therapeutic target for neuroinflammation
- (2012) Claudia Verderio et al. ANNALS OF NEUROLOGY
- Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase
- (2012) Oliver Holmes et al. BIOCHEMISTRY
- Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
- (2012) C. Kleinschnitz et al. BLOOD
- Molecular Targets of FTY720 (Fingolimod)
- (2012) M.R. Pitman et al. CURRENT MOLECULAR MEDICINE
- Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage
- (2012) William B. Rolland et al. EXPERIMENTAL NEUROLOGY
- Ceramide Synthase 6 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis
- (2012) S. Schiffmann et al. JOURNAL OF IMMUNOLOGY
- Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway
- (2012) Bradley K. Wacker et al. JOURNAL OF NEUROCHEMISTRY
- A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome
- (2012) D. A. Schmid et al. JOURNAL OF NEUROSCIENCE
- Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma
- (2012) A. Estrada-Bernal et al. NEURO-ONCOLOGY
- Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model
- (2012) Fei Gao et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome
- (2012) R. Deogracias et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice
- (2012) A. Di Pardo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of sphingosine kinase 2 is an endogenous protective mechanism in cerebral ischemia
- (2011) Waltraud Pfeilschifter et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Brain inflammation as a biomarker in epilepsy
- (2011) Annamaria Vezzani et al. Biomarkers in Medicine
- Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis
- (2011) S Rossi et al. BRITISH JOURNAL OF PHARMACOLOGY
- Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model
- (2011) Hye Jung Kim et al. FASEB JOURNAL
- FTY720 Analogues as Sphingosine Kinase 1 Inhibitors
- (2011) Keng G. Lim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pharmacodynamic Effects of Steady-State Fingolimod on Antibody Response in Healthy Volunteers: A 4-Week, Randomized, Placebo-Controlled, Parallel-Group, Multiple-Dose Study
- (2011) Craig Boulton et al. JOURNAL OF CLINICAL PHARMACOLOGY
- BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate
- (2011) N. Takasugi et al. JOURNAL OF NEUROSCIENCE
- Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo
- (2011) Yinghui Hu et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Biology and pathophysiology of the amyloid precursor protein
- (2011) Hui Zheng et al. Molecular Neurodegeneration
- Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS
- (2011) M. C. Kowarik et al. NEUROLOGY
- Inflammation and prevention of epileptogenesis
- (2011) Teresa Ravizza et al. NEUROSCIENCE LETTERS
- Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice
- (2011) Mattia Maroso et al. Neurotherapeutics
- FTY720 Reduces Post-Ischemic Brain Lymphocyte Influx but Does Not Improve Outcome in Permanent Murine Cerebral Ischemia
- (2011) Arthur Liesz et al. PLoS One
- Sphingosine Kinase 2 Mediates Cerebral Preconditioning and Protects the Mouse Brain Against Ischemic Injury
- (2011) Lai Ming Yung et al. STROKE
- FTY720 Regulates Bone Marrow Egress of Eosinophils and Modulates Late-Phase Skin Reaction in Mice
- (2010) Kazunari Sugita et al. AMERICAN JOURNAL OF PATHOLOGY
- Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices
- (2010) Veronique E. Miron et al. AMERICAN JOURNAL OF PATHOLOGY
- Fingolimod provides long-term protection in rodent models of cerebral ischemia
- (2010) Ying Wei et al. ANNALS OF NEUROLOGY
- Distinct Properties of Circulating CD8+ T Cells in FTY720-Treated Patients With Multiple Sclerosis
- (2010) Trina A. Johnson et al. ARCHIVES OF NEUROLOGY
- Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants
- (2010) Glyn Dawson et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
- (2010) C. Kleinschnitz et al. BLOOD
- Neurons and Oligodendrocytes Recycle Sphingosine 1-Phosphate to Ceramide
- (2010) Jingdong Qin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
- (2010) Shobha Thangada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells
- (2010) Adriana Estrada-Bernal et al. JOURNAL OF NEURO-ONCOLOGY
- Differential responses of human microglia and blood-derived myeloid cells to FTY720
- (2010) Bryce A. Durafourt et al. JOURNAL OF NEUROIMMUNOLOGY
- Impaired Ganglioside Metabolism in Huntington's Disease and Neuroprotective Role of GM1
- (2010) V. Maglione et al. JOURNAL OF NEUROSCIENCE
- Fibrillar Amyloid- -Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for Alzheimer's Disease
- (2010) A. Jana et al. JOURNAL OF NEUROSCIENCE
- Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth
- (2010) S. Rauskolb et al. JOURNAL OF NEUROSCIENCE
- Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials
- (2010) Kennedy R Lees et al. LANCET
- Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
- (2010) Sergio E. Alvarez et al. NATURE
- Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
- (2010) Volker Brinkmann et al. NATURE REVIEWS DRUG DISCOVERY
- Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus
- (2010) T. Kanno et al. NEUROSCIENCE
- A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
- (2010) Ludwig Kappos et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis
- (2010) Jeffrey A. Cohen et al. NEW ENGLAND JOURNAL OF MEDICINE
- FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
- (2010) J. W. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting the correct HDAC(s) to treat cognitive disorders
- (2010) André Fischer et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- The immunomodulatory sphingosine 1-phosphate analog FTY720 reduces lesion size and improves neurological outcome in a mouse model of cerebral ischemia
- (2009) Bozena Czech et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Blockade of adrenoreceptors inhibits the splenic response to stroke
- (2009) Craig T. Ajmo et al. EXPERIMENTAL NEUROLOGY
- The Serine Protease Plasmin Cleaves the Amino-terminal Domain of the NR2A Subunit to Relieve Zinc Inhibition of theN-Methyl-d-aspartate Receptors
- (2009) Hongjie Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-de pend ent Manner
- (2009) Sujoy Lahiri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
- (2009) Eric Camerer et al. JOURNAL OF CLINICAL INVESTIGATION
- Modulation of Cannabinoid Receptor Activation as a Neuroprotective Strategy for EAE and Stroke
- (2009) Ming Zhang et al. Journal of Neuroimmune Pharmacology
- FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses
- (2009) Dimitrios Papadopoulos et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Sphingosine-1-Phosphate Regulates Glioblastoma Cell Invasiveness through the Urokinase Plasminogen Activator System and CCN1/Cyr61
- (2009) Nicholas Young et al. MOLECULAR CANCER RESEARCH
- Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3-year results
- (2009) G. Comi et al. Multiple Sclerosis Journal
- Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury
- (2009) Takashi Shichita et al. NATURE MEDICINE
- Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
- (2009) N. C. Hait et al. SCIENCE
- Hypoxic Preconditioning-Induced Cerebral Ischemic Tolerance
- (2009) Bradley K. Wacker et al. STROKE
- Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats
- (2009) Yu Hasegawa et al. STROKE
- Cyclical and Dose-Dependent Responses of Adult Human Mature Oligodendrocytes to Fingolimod
- (2008) Veronique E. Miron et al. AMERICAN JOURNAL OF PATHOLOGY
- Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells
- (2008) Stephanie Schwalm et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets
- (2008) Andrea Huwiler et al. BIOCHEMICAL PHARMACOLOGY
- Adaptive immunity affects learning behavior in mice
- (2008) Anna Brynskikh et al. BRAIN BEHAVIOR AND IMMUNITY
- FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage
- (2008) Carolyn A. Foster et al. BRAIN PATHOLOGY
- Sphingosine Kinase 1: A New Modulator of Hypoxia Inducible Factor 1 during Hypoxia in Human Cancer Cells
- (2008) I. Ader et al. CANCER RESEARCH
- Experimentally induced various inflammatory models and seizure: Understanding the role of cytokine in rat
- (2008) R.S. Rao et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- S1P1 Receptor Signaling Overrides Retention Mediated by Gαi-Coupled Receptors to Promote T Cell Egress
- (2008) Trung H.M. Pham et al. IMMUNITY
- Plasmin Potentiates SynapticN-Methyl-D-aspartate Receptor Function in Hippocampal Neurons through Activation of Protease-activated Receptor-1
- (2008) Guido Mannaioni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment
- (2008) Pamela Osenkowski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid phosphate phosphatases and signaling
- (2008) David N. Brindley et al. JOURNAL OF LIPID RESEARCH
- Thrombin Induces Long-Term Potentiation of Reactivity to Afferent Stimulation and Facilitates Epileptic Seizures in Rat Hippocampal Slices: Toward Understanding the Functional Consequences of Cerebrovascular Insults
- (2008) N. Maggio et al. JOURNAL OF NEUROSCIENCE
- Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
- (2008) Emyr Lloyd-Evans et al. NATURE MEDICINE
- Principles of bioactive lipid signalling: lessons from sphingolipids
- (2008) Yusuf A. Hannun et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Deregulation of sphingolipid metabolism in Alzheimer's disease
- (2008) Xingxuan He et al. NEUROBIOLOGY OF AGING
- FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis
- (2008) M. Mehling et al. NEUROLOGY
- The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors
- (2008) A. Kawahara et al. SCIENCE
- Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis
- (2007) John S. Tzartos et al. AMERICAN JOURNAL OF PATHOLOGY
- Brain-Derived Neurotrophic Factor Levels in the Nervous System of Wild-Type and Neurotrophin Gene Mutant Mice
- (2003) Roland Kolbeck et al. JOURNAL OF NEUROCHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More