De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements

(2017) Leila Pirhaji et al.   Nature Communications

Endoplasmic Reticulum Malfunction in the Nervous System

(2017) Joanna Jung et al.   Frontiers in Neuroscience

Metabolic profiling of presymptomatic Huntington’s disease sheep reveals novel biomarkers

(2017) Debra J. Skene et al.   Scientific Reports

Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease

(2017) Alba Di Pardo et al.   Scientific Reports

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease

(2017) Alba Di Pardo et al.   Scientific Reports

Endoplasmic reticulum stress: The cause and solution to Huntington's disease?

(2016) Yuwei Jiang et al.   BRAIN RESEARCH

FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice

(2016) Guadalupe Vidal-Martínez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential

(2016) Masayo Aoki et al.   MEDIATORS OF INFLAMMATION

Revealing disease-associated pathways by network integration of untargeted metabolomics

(2016) Leila Pirhaji et al.   NATURE METHODS

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

(2016) Timothy A. Couttas et al.   NEUROBIOLOGY OF AGING

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Rosa Luisa Potenza et al.   Neurotherapeutics

Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

(2016) Stefka D. Spassieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic disruption identified in the Huntington’s disease transgenic sheep model

(2016) Renee. R. Handley et al.   Scientific Reports

Impaired Levels of Gangliosides in the Corpus Callosum of Huntington Disease Animal Models

(2016) Alba Di Pardo et al.   Frontiers in Neuroscience

Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS

(2015) Abdul Basit et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells

(2015) Eva Bernhart et al.   BIOCHEMICAL PHARMACOLOGY

Membrane lipid domains in the nervous system

(2015) Sandro Sonnino   Frontiers in Bioscience-Landmark

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTRup-regulation and astrocyte-mediated inflammation

(2015) Andrés Miguez et al.   HUMAN MOLECULAR GENETICS

Dihydroceramides: From Bit Players to Lead Actors

(2015) Monowarul Mobin Siddique et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Availability of Mutant SPT Alters Neuronal Branching and Growth Cone Dynamics in Dorsal Root Ganglia

(2015) Byung Kyu Jun et al.   JOURNAL OF NEUROSCIENCE

Treating the whole body in Huntington's disease

(2015) Jeffrey B Carroll et al.   LANCET NEUROLOGY

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Impairment of ceramide synthesis causes a novel progressive myoclonus epilepsy

(2014) Nicola Vanni et al.   ANNALS OF NEUROLOGY

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

Sphingosine-1-Phosphate: Boon and Bane for the Brain

(2014) Gerhild van Echten-Deckert et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

La sphingosine 1-phosphate comme biomarqueur de la maladie d’Alzheimer ?

(2014) Johnatan Ceccom et al.   M S-MEDECINE SCIENCES

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

PMHT and acute pancreatitis risk

(2014) Joana Osório   Nature Reviews Endocrinology

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

(2014) Johnatan Ceccom et al.   Acta Neuropathologica Communications

Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine

(2013) Fatemeh Hemmati et al.   BEHAVIOURAL BRAIN RESEARCH

Sphingosine 1-phosphate signalling

(2013) K. Mendelson et al.   DEVELOPMENT

Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy

(2013) D.-H. Nguyen-Tran et al.   Disease Models & Mechanisms

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease

(2013) Alba Di Pardo et al.   HUMAN MOLECULAR GENETICS

Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest

(2013) Irina A. Gorshkova et al.   LIFE SCIENCES

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

(2013) Nobumasa Takasugi et al.   PLoS One

Huntington's disease: underlying molecular mechanisms and emerging concepts

(2013) John Labbadia et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sphingolipid Homeostasis in the Endoplasmic Reticulum and Beyond

(2013) D. K. Breslow   Cold Spring Harbor Perspectives in Biology

Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes

(2012) Christina Ginkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

(2012) A. Di Pardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles for cholesterol in Huntington's disease

(2011) Marta Valenza et al.   TRENDS IN NEUROSCIENCES

A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation

(2011) Lihong Zhao et al.   PLoS Genetics

Dihydrosphingosine-1 phosphate has a potent anti-fibrotic effect in Scleroderma fibroblasts via normalization of PTEN levels

(2010) Shizhong Bu et al.   ARTHRITIS AND RHEUMATISM

Neurons and Oligodendrocytes Recycle Sphingosine 1-Phosphate to Ceramide

(2010) Jingdong Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Ganglioside Metabolism in Huntington's Disease and Neuroprotective Role of GM1

(2010) V. Maglione et al.   JOURNAL OF NEUROSCIENCE

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

(2009) Evgeny V. Berdyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

The vascular S1P gradient—Cellular sources and biological significance

(2008) T HLA   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY