Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease

Fingolimod enhances myelin repair of hippocampus in pentylenetetrazol-induced kindling model

(2017) Mohammad Gol et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Neuroprotective effects of fingolimod in mouse models of Parkinson’s disease

(2017) Peng Zhao et al.   FASEB JOURNAL

Clinical characterization of an APP mutation (V717I) in five Han Chinese families with early-onset Alzheimer's disease

(2017) Guili Zhang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

S1PR1 drives a feedforward signalling loop to regulate BATF3 and the transcriptional programme of Hodgkin lymphoma cells

(2017) K Vrzalikova et al.   LEUKEMIA

Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases

(2017) Sinead O'Sullivan et al.   NEUROPHARMACOLOGY

BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells

(2017) Margaret E. Maes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Sphingolipids: membrane microdomains in brain development, function and neurological diseases

(2017) Anne S. B. Olsen et al.   Open Biology

Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling

(2017) Ioannis Serafimidis et al.   PLOS BIOLOGY

Sphingosine 1-phosphate receptor 1 (S1PR1) agonist CYM5442 inhibits expression of intracellular adhesion molecule 1 (ICAM1) in endothelial cells infected with influenza A viruses

(2017) Hao Jiang et al.   PLoS One

Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate

(2016) Arivarasu N. Anbazhagan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

GM1 Ganglioside Inhibits β-Amyloid Oligomerization Induced by Sphingomyelin

(2016) Mariana Amaro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

FTY720P inhibits hepatic Na+–K+ ATPase via S1PR2 and PGE2

(2016) Nadine Al Alam et al.   Biochemistry and Cell Biology

The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration

(2016) Sofia Anastasiadou et al.   EXPERIMENTAL NEUROLOGY

Effects of fingolimod administration in a genetic model of cognitive deficits

(2016) D. Becker-Krail et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Screening exons 16 and 17 of the amyloid precursor protein gene in sporadic early-onset Alzheimer's disease

(2016) Imelda S. Barber et al.   NEUROBIOLOGY OF AGING

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis

(2016) Rosa Luisa Potenza et al.   Neurotherapeutics

Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage

(2016) Rasoul Ghasemi et al.   PHARMACOLOGICAL RESEARCH

The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis

(2015) Samuel F. Hunter et al.   CNS DRUGS

Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy

(2015) Jason Newton et al.   EXPERIMENTAL CELL RESEARCH

Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice

(2015) AI Pogue et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Fingolimod induces neuroprotective factors in human astrocytes

(2015) Franziska S. Hoffmann et al.   Journal of Neuroinflammation

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells

(2014) Marthe-Susanna Wegner et al.   BIOCHEMICAL PHARMACOLOGY

Original article Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein

(2014) Henryk Jesko et al.   FOLIA NEUROPATHOLOGICA

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

Sphingosine-1-Phosphate Mediates COX-2 Expression and PGE2/IL-6 Secretion via c-Src-Dependent AP-1 Activation

(2014) Chih-Kai Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

Fingolimod for the treatment of neurological diseases—state of play and future perspectives

(2014) Robert Brunkhorst et al.   Frontiers in Cellular Neuroscience

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease

(2014) Johnatan Ceccom et al.   Acta Neuropathologica Communications

Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine

(2013) Fatemeh Hemmati et al.   BEHAVIOURAL BRAIN RESEARCH

AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose

(2013) Kaipeng Huang et al.   CELLULAR SIGNALLING

Unique functional roles for class I and class II histone deacetylases in central nervous system development and function

(2013) Michael J. Morris et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

FTY720 (Fingolimod) Attenuates Beta-amyloid Peptide (Aβ42)-Induced Impairment of Spatial Learning and Memory in Rats

(2013) Masoumeh Asle-Rousta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

(2013) Nobumasa Takasugi et al.   PLoS One

Lysophospholipids and their receptors in the central nervous system

(2012) Ji Woong Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type

(2011) Hayate Javed et al.   BRAIN RESEARCH

Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism

(2011) N Hagen et al.   CELL DEATH AND DIFFERENTIATION

Generation of reactive oxygen species (ROS) is a key factor for stimulation of macrophage proliferation by ceramide 1-phosphate

(2011) Lide Arana et al.   EXPERIMENTAL CELL RESEARCH

NF-кB-regulated micro RNAs (miRNAs) in primary human brain cells

(2011) Walter J. Lukiw   EXPERIMENTAL NEUROLOGY

BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

(2011) N. Takasugi et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Sphingosine 1-Phosphate Receptor 2 Protects against Renal Ischemia-Reperfusion Injury

(2011) S. Won Park et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology

(2010) Masakazu Hashimoto et al.   ACTA NEUROPATHOLOGICA

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells

(2010) Judith Mesicek et al.   CELLULAR SIGNALLING

Plasma membrane microdomains in aging and disease

(2010) Yoshiko Ohno-Iwashita et al.   Geriatrics & Gerontology International

Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

(2010) Jian Guo Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory, Apoptotic, and Survival Gene Signaling in Alzheimer’s Disease

(2010) Walter J. Lukiw et al.   MOLECULAR NEUROBIOLOGY

Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages

(2009) María H. Granado et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

(2009) Xiaoying Wang et al.   BRAIN RESEARCH BULLETIN

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Ceramide 1-phosphate (C1P) promotes cell migration

(2008) María H. Granado et al.   CELLULAR SIGNALLING

Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system

(2008) T OKADA et al.   CELLULAR SIGNALLING

Involvement of nitric oxide in the promotion of cell survival by ceramide 1-phosphate

(2008) Patricia Gangoiti et al.   FEBS LETTERS

N-Acetylcholinesterase-Induced Apoptosis in Alzheimer's Disease

(2008) Debra Toiber et al.   PLoS One