Sphingolipid Metabolism Is Dysregulated at Transcriptomic and Metabolic Levels in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis

Hypermetabolism is a deleterious prognostic factor in patients with amyotrophic lateral sclerosis

(2017) P. Jésus et al.   EUROPEAN JOURNAL OF NEUROLOGY

Fingolimod induces neuronal-specific gene expression with potential neuroprotective outcomes in maturing neuronal progenitor cells exposed to HIV

(2017) Rebeca Geffin et al.   JOURNAL OF NEUROVIROLOGY

Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice

(2017) Céline Desseille et al.   Frontiers in Molecular Neuroscience

Lipid Involvement in Neurodegenerative Diseases of the Motor System: Insights from Lysosomal Storage Diseases

(2017) James C. Dodge   Frontiers in Molecular Neuroscience

Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets

(2017) James K. T. Wang et al.   Frontiers in Neuroscience

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

(2017) Sara Pinto et al.   Frontiers in Neuroscience

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

(2017) Johnathan Cooper-Knock et al.   Acta Neuropathologica Communications

Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis

(2017) Alexandre Henriques et al.   Scientific Reports

Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis

(2016) Hajer El Oussini et al.   ACTA NEUROPATHOLOGICA

Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis

(2016) Pauline Vercruysse et al.   BRAIN

Immune response in peripheral axons delays disease progression in SOD1G93A mice

(2016) Giovanni Nardo et al.   Journal of Neuroinflammation

Runx1 contributes to the functional switching of bone morphogenetic protein 4 (BMP4) from neurite outgrowth promoting to suppressing in dorsal root ganglion

(2016) Masaaki Yoshikawa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

The potential of endurance exercise-derived exosomes to treat metabolic diseases

(2016) Adeel Safdar et al.   Nature Reviews Endocrinology

Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

(2016) Franck Patin et al.   Neurotherapeutics

Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation

(2016) Tomer Halevy et al.   Stem Cell Reports

Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis

(2015) Jae Keun Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Contribution of the Runx1 transcription factor to axonal pathfinding and muscle innervation by hypoglossal motoneurons

(2015) Masaaki Yoshikawa et al.   Developmental Neurobiology

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

(2015) L. Palamiuc et al.   EMBO Molecular Medicine

Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase

(2015) Alexandre Henriques et al.   HUMAN MOLECULAR GENETICS

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTRup-regulation and astrocyte-mediated inflammation

(2015) Andrés Miguez et al.   HUMAN MOLECULAR GENETICS

Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis: a prospective observational study

(2015) Johannes Dorst et al.   JOURNAL OF NEUROLOGY

Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions

(2015) Rohini Raman et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

DGIdb 2.0: mining clinically relevant drug–gene interactions

(2015) Alex H. Wagner et al.   NUCLEIC ACIDS RESEARCH

Blood Cell Palmitoleate-Palmitate Ratio Is an Independent Prognostic Factor for Amyotrophic Lateral Sclerosis

(2015) Alexandre Henriques et al.   PLoS One

Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis

(2015) James C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression changes in spinal motoneurons of the SOD1G93A transgenic model for ALS after treatment with G-CSF

(2015) Alexandre Henriques et al.   Frontiers in Cellular Neuroscience

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics

(2014) Oscar G. Vidaurre et al.   BRAIN

Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial

(2014) Anne-Marie Wills et al.   LANCET

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis

(2014) Aline Xavier da Silveira dos Santos et al.   MOLECULAR BIOLOGY OF THE CELL

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

TLR4 Accessory Molecule RP105 (CD180) Regulates Monocyte-Driven Arteriogenesis in a Murine Hind Limb Ischemia Model

(2014) Antonius J. N. M. Bastiaansen et al.   PLoS One

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A plural role for lipids in motor neuron diseases: energy, signaling and structure

(2014) Florent Schmitt et al.   Frontiers in Cellular Neuroscience

A mental retardation gene, motopsin/prss12, modulates cell morphology by interaction with seizure-related gene 6

(2013) Shinichi Mitsui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity

(2013) J. Druker et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release

(2013) Ceren Korkut et al.   NEURON

Electrophysiologic Biomarkers for Assessing Disease Progression and the Effect of Riluzole in SOD1 G93A ALS Mice

(2013) Jia Li et al.   PLoS One

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

(2013) Takashi Nonaka et al.   Cell Reports

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

(2013) Erin J. McAllum et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

High-caloric food supplements in the treatment of amyotrophic lateral sclerosis: A prospective interventional study

(2013) Johannes Dorst et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Can Transcriptomics Cut the Gordian Knot of Amyotrophic Lateral Sclerosis?

(2012) Alexandre Henriques et al.   CURRENT GENOMICS

Clostridium perfringensAlpha-toxin Recognizes the GM1a-TrkA Complex

(2012) Masataka Oda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis

(2012) Jin Hee Shin et al.   JOURNAL OF NEUROCHEMISTRY

Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract

(2012) Makoto Minamiyama et al.   NATURE MEDICINE

Integrated pathway-level analysis of transcriptomics and metabolomics data with IMPaLA

(2011) Atanas Kamburov et al.   BIOINFORMATICS

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases

(2011) Daniel Canals et al.   BRITISH JOURNAL OF PHARMACOLOGY

Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis

(2011) Sabrina Paganoni et al.   MUSCLE & NERVE

Calcitonin gene-related peptide expression levels predict motor neuron vulnerability in the superoxide dismutase 1-G93A mouse model of amyotrophic lateral sclerosis

(2011) Cornelia Ringer et al.   NEUROBIOLOGY OF DISEASE

Lipid Pathway Alterations in Parkinson's Disease Primary Visual Cortex

(2011) Danni Cheng et al.   PLoS One

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

Runx Regulation of Sphingolipid Metabolism and Survival Signaling

(2010) A. Kilbey et al.   CANCER RESEARCH

Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells

(2010) Anders Enjin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

CNS-targeted Viral Delivery of G-CSF in an Animal Model for ALS: Improved Efficacy and Preservation of the Neuromuscular Unit

(2010) Alexandre Henriques et al.   MOLECULAR THERAPY

ConsensusPathDB: toward a more complete picture of cell biology

(2010) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

High metabolic level in patients with familial amyotrophic lateral sclerosis

(2008) Benoit Funalot et al.   Amyotrophic Lateral Sclerosis

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice

(2008) Steven J. Del Signore et al.   Amyotrophic Lateral Sclerosis

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice

(2008) Hidefumi Ito et al.   EXPERIMENTAL NEUROLOGY

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

(2008) L. Dupuis et al.   NEUROLOGY

ConsensusPathDB—a database for integrating human functional interaction networks

(2008) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle

(2007) Marika Zanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY