Senescence and aging: the critical roles of p53

Caloric restriction: is mammalian life extension linked to p53?

(2016) Paola Tucci   Aging-US

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

The critical role of catalase in prooxidant and antioxidant function of p53

(2012) M Y Kang et al.   CELL DEATH AND DIFFERENTIATION

Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

(2012) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

STAT3 can serve as a hit in the process of malignant transformation of primary cells

(2012) M Demaria et al.   CELL DEATH AND DIFFERENTIATION

SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH

(2012) L Pellegrini et al.   CELL DEATH AND DIFFERENTIATION

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism

(2012) Xiaohua Su et al.   Cell Metabolism

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

(2012) L. A. Carvajal et al.   GENES & DEVELOPMENT

TAp73 depletion accelerates aging through metabolic dysregulation

(2012) A. Rufini et al.   GENES & DEVELOPMENT

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

(2012) O. Aksoy et al.   GENES & DEVELOPMENT

SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

(2012) Chu-Xia Deng   International Journal of Biological Sciences

Sirtuin Catalysis and Regulation

(2012) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The many faces of insulin-like peptide signalling in the brain

(2012) Ana M. Fernandez et al.   NATURE REVIEWS NEUROSCIENCE

The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells

(2012) S Galavotti et al.   ONCOGENE

Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis

(2012) Z-H Wen et al.   ONCOGENE

Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells

(2012) H Yasaei et al.   ONCOGENE

p63-microRNA feedback in keratinocyte senescence

(2012) P. Rivetti di Val Cervo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

(2012) N Minois et al.   Cell Death & Disease

Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

(2012) M Michaelis et al.   Cell Death & Disease

Role of the promyelocytic leukaemia protein in cell death regulation

(2012) P Salomoni et al.   Cell Death & Disease

Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence

(2012) C Drullion et al.   Cell Death & Disease

Proliferation and tissue remodeling in cancer: the hallmarks revisited

(2012) E K Markert et al.   Cell Death & Disease

Paclitaxel resistance is associated with switch from apoptotic to autophagic cell death in MCF-7 breast cancer cells

(2012) G M A Ajabnoor et al.   Cell Death & Disease

Re-oxygenation causes hypoxic tumor regression through restoration of p53 wild-type conformation and post-translational modifications

(2012) R Gogna et al.   Cell Death & Disease

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition

(2012) D Dixit et al.   Cell Death & Disease

Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer

(2012) C C Cook et al.   Cell Death & Disease

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Regulation of p73 activity by post-translational modifications

(2012) F Conforti et al.   Cell Death & Disease

Resveratrol and life extension

(2011) Beamon Agarwal et al.   Annals of the New York Academy of Sciences

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Pseudo-DNA damage response in senescent cells

(2011) Tatyana V. Pospelova et al.   CELL CYCLE

A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts

(2011) R Faraonio et al.   CELL DEATH AND DIFFERENTIATION

Regulation of skin aging and heart development by TAp63

(2011) M Paris et al.   CELL DEATH AND DIFFERENTIATION

Chk2 mediates RITA-induced apoptosis

(2011) J de Lange et al.   CELL DEATH AND DIFFERENTIATION

E3 ubiquitin ligase Hades negatively regulates the exonuclear function of p53

(2011) J H Jung et al.   CELL DEATH AND DIFFERENTIATION

ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization

(2011) M K Leonard et al.   CELL DEATH AND DIFFERENTIATION

p73 is critical for the persistence of memory

(2011) E R Flores   CELL DEATH AND DIFFERENTIATION

Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

(2011) C Spinnler et al.   CELL DEATH AND DIFFERENTIATION

miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition

(2011) A Magenta et al.   CELL DEATH AND DIFFERENTIATION

Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics and neuronal synaptic damage in neurodegenerative diseases

(2011) T Nakamura et al.   CELL DEATH AND DIFFERENTIATION

Therapeutic targets in cancer cell metabolism and death

(2011) I Iaccarino et al.   CELL DEATH AND DIFFERENTIATION

Role of autophagy in disease resistance and hypersensitive response-associated cell death

(2011) D Hofius et al.   CELL DEATH AND DIFFERENTIATION

Biological functions of p53 isoforms through evolution: lessons from animal and cellular models

(2011) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs

(2011) L Y Peche et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival

(2011) E A Afanasyeva et al.   CELL DEATH AND DIFFERENTIATION

Roles of HAUSP-mediated p53 regulation in central nervous system development

(2011) N Kon et al.   CELL DEATH AND DIFFERENTIATION

Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

(2011) W-J Lu et al.   CELL DEATH AND DIFFERENTIATION

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

ΔNp63α Is an Oncogene that Targets Chromatin Remodeler Lsh to Drive Skin Stem Cell Proliferation and Tumorigenesis

(2011) William M. Keyes et al.   Cell Stem Cell

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

p73: A Multifunctional Protein in Neurobiology

(2011) Richard Killick et al.   MOLECULAR NEUROBIOLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The p53 family: guardians of maternal reproduction

(2011) Arnold J. Levine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming

(2011) C H Eng et al.   ONCOGENE

The autophagic paradox in cancer therapy

(2011) W K K Wu et al.   ONCOGENE

Targeting the Akt/mTOR pathway in Brca1-deficient cancers

(2011) T Xiang et al.   ONCOGENE

Transcriptional regulation of cellular senescence

(2011) F Lanigan et al.   ONCOGENE

MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63

(2011) L D Gamble et al.   ONCOGENE

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

(2011) U Weyemi et al.   ONCOGENE

Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer

(2011) M E Caldwell et al.   ONCOGENE

E2F1-dependent oncogenic addiction of melanoma cells to MDM2

(2011) M Verhaegen et al.   ONCOGENE

Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma

(2011) J de Lange et al.   ONCOGENE

p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors

(2011) C Romagosa et al.   ONCOGENE

Epigenetic regulation of aging stem cells

(2011) E A Pollina et al.   ONCOGENE

Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional

(2011) G Lossaint et al.   ONCOGENE

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

(2011) M V Astle et al.   ONCOGENE

Checkpoint control and cancer

(2011) R H Medema et al.   ONCOGENE

Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo

(2011) L Nogueira et al.   ONCOGENE

The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling

(2011) W van Veelen et al.   ONCOGENE

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-34a regulates neurite outgrowth, spinal morphology, and function

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

mTOR Signaling

(2011) M. Laplante et al.   Cold Spring Harbor Perspectives in Biology

Mechanism of cell death resulting from DNA interstrand cross-linking in mammalian cells

(2011) T Osawa et al.   Cell Death & Disease

Reactive oxygen species initiate luminal but not basal cell death in cultured human mammary alveolar structures: a potential regulator of involution

(2011) E Thomas et al.   Cell Death & Disease

Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors

(2011) A V Vaseva et al.   Cell Death & Disease

Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1

(2011) A Ahmed et al.   Cell Death & Disease

Neurodegenerative processes in Huntington's disease

(2011) D Bano et al.   Cell Death & Disease

Oxygen matters: tissue culture oxygen levels affect mitochondrial function and structure as well as responses to HIV viroproteins

(2011) L M Tiede et al.   Cell Death & Disease

NF-Y joins E2Fs, p53 and other stress transcription factors at the apoptosis table

(2011) R Gatta et al.   Cell Death & Disease

Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32

(2011) S P Francis et al.   Cell Death & Disease

Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

(2011) M Donadelli et al.   Cell Death & Disease

Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy

(2011) Y Kuwahara et al.   Cell Death & Disease

The role of reactive oxygen species and autophagy in safingol-induced cell death

(2011) L-U Ling et al.   Cell Death & Disease

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

(2011) D Nguyen et al.   Cell Death & Disease

Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway

(2011) R Koster et al.   Cell Death & Disease

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

Hydrogen peroxide: a Jekyll and Hyde signalling molecule

(2011) D R Gough et al.   Cell Death & Disease

Reciprocal influence of the p53 and the hypoxic pathways

(2011) A Sermeus et al.   Cell Death & Disease

Temporal Dissection of Tumorigenesis in Primary Cancers

(2011) Steffen Durinck et al.   Cancer Discovery

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Weak p53 permits senescence during cell cycle arrest

(2010) Olga V. Leontieva et al.   CELL CYCLE

p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

(2010) F Talos et al.   CELL DEATH AND DIFFERENTIATION

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

(2010) S Lépine et al.   CELL DEATH AND DIFFERENTIATION

c-Abl tyrosine kinase in the DNA damage response: cell death and more

(2010) V Meltser et al.   CELL DEATH AND DIFFERENTIATION

ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis

(2010) R Shalom-Feuerstein et al.   CELL DEATH AND DIFFERENTIATION

SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

(2010) X D Wang et al.   CELL DEATH AND DIFFERENTIATION

A positive role for c-Abl in Atm and Atr activation in DNA damage response

(2010) X Wang et al.   CELL DEATH AND DIFFERENTIATION

SIRT1 stabilizes PML promoting its sumoylation

(2010) M Campagna et al.   CELL DEATH AND DIFFERENTIATION

PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation

(2010) J-J Lee et al.   CELL DEATH AND DIFFERENTIATION

Negative regulation of autophagy

(2010) C Liang   CELL DEATH AND DIFFERENTIATION

p53-family proteins and their regulators: hubs and spokes in tumor suppression

(2010) L Collavin et al.   CELL DEATH AND DIFFERENTIATION

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

(2010) A Lemarie et al.   CELL DEATH AND DIFFERENTIATION

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

(2010) Hui-Young Lee et al.   Cell Metabolism

Nuclear Receptor Corepressor SMRT Regulates Mitochondrial Oxidative Metabolism and Mediates Aging-Related Metabolic Deterioration

(2010) Shannon M. Reilly et al.   Cell Metabolism

TAp73 Acts via the bHLH Hey2 to Promote Long-Term Maintenance of Neural Precursors

(2010) Masashi Fujitani et al.   CURRENT BIOLOGY

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Isoform-specific p73 knockout mice reveal a novel role for  Np73 in the DNA damage response pathway

(2010) M. T. Wilhelm et al.   GENES & DEVELOPMENT

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Induction of Reactive Oxygen Species-mediated Autophagy by a Novel Microtubule-modulating Agent

(2010) Prasanthi Karna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial dysfunction as a cause of ageing

(2010) A. Trifunovic et al.   JOURNAL OF INTERNAL MEDICINE

Selective activation of p53-mediated tumour suppression in high-grade tumours

(2010) Melissa R. Junttila et al.   NATURE

Stage-specific sensitivity to p53 restoration during lung cancer progression

(2010) David M. Feldser et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Puma is required for p53-induced depletion of adult stem cells

(2010) Dongping Liu et al.   NATURE CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NRF2, cancer and calorie restriction

(2010) A Martín-Montalvo et al.   ONCOGENE

Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction

(2010) M Colombi et al.   ONCOGENE

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence

(2010) P Rai et al.   ONCOGENE

The p16INK4A tumor suppressor regulates cellular oxidative stress

(2010) N C Jenkins et al.   ONCOGENE

Negative regulation of the tumor suppressor p53 gene by microRNAs

(2010) M Kumar et al.   ONCOGENE

The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB–P53 pathways

(2010) N Alessio et al.   ONCOGENE

Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

(2010) K G Wiman   ONCOGENE

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

(2010) M L Marino et al.   Cell Death & Disease

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

(2010) Mirela Matecic et al.   PLoS Genetics

Expression ofp16INK4ain peripheral blood T-cells is a biomarker of human aging

(2009) Yan Liu et al.   AGING CELL

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

TAp63 Prevents Premature Aging by Promoting Adult Stem Cell Maintenance

(2009) Xiaohua Su et al.   Cell Stem Cell

Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice

(2009) Y.-F. Chen et al.   GENES & DEVELOPMENT

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

(2009) Stefania Gonfloni et al.   NATURE MEDICINE

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians

(2009) G. Atzmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity

(2009) Richard Tomasini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Regulation of Metabolic Pathways

(2009) E. Gottlieb et al.   Cold Spring Harbor Perspectives in Biology

A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression

(2008) Pradip K. Majumder et al.   CANCER CELL

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Autophagy in aging, disease and death: the true identity of a cell death impostor

(2008) B Levine et al.   CELL DEATH AND DIFFERENTIATION

miR-203 represses ‘stemness’ by repressing ΔNp63

(2008) A M Lena et al.   CELL DEATH AND DIFFERENTIATION

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

p63 in epithelial development

(2008) E. Candi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Free radicals and senescence

(2008) Teng Lu et al.   EXPERIMENTAL CELL RESEARCH

The wanderings of a free radical

(2008) Barry Halliwell   FREE RADICAL BIOLOGY AND MEDICINE

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

(2008) C. Nardella et al.   GENES & DEVELOPMENT

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

A skin microRNA promotes differentiation by repressing ‘stemness’

(2008) Rui Yi et al.   NATURE

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

p73 Regulates Neurodegeneration and Phospho-Tau Accumulation during Aging and Alzheimer's Disease

(2008) Monica K. Wetzel et al.   NEURON

Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense

(2008) Ivan A. Olovnikov et al.   SEMINARS IN CANCER BIOLOGY

Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence

(2003) Utz Herbig et al.   AGING CELL