标题
The autophagic paradox in cancer therapy
作者
关键词
-
出版物
ONCOGENE
Volume 31, Issue 8, Pages 939-953
出版商
Springer Nature
发表日期
2011-07-18
DOI
10.1038/onc.2011.295
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells
- (2014) Stefania Meschini et al. Autophagy
- Nucleolar p19ARF unlike mitochondrial smARF is incapable of inducing p53-independent autophagy
- (2014) Sharon Reef et al. Autophagy
- Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells
- (2014) Ugur Akar et al. Autophagy
- Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer
- (2014) Kwang Woon Kim et al. Autophagy
- Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation
- (2014) Takashi Ueno et al. Autophagy
- Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation
- (2014) Marie Stampe Ostenfeld et al. Autophagy
- Autophagy activation by NFκB is essential for cell survival after heat shock
- (2014) Mathieu Nivon et al. Autophagy
- Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics
- (2011) Tracey R. O’Donovan et al. Autophagy
- Mutant p53 protein localized in the cytoplasm inhibits autophagy
- (2011) Eugenia Morselli et al. CELL CYCLE
- Pancreatic cancers require autophagy for tumor growth
- (2011) S. Yang et al. GENES & DEVELOPMENT
- Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
- (2011) J. Y. Guo et al. GENES & DEVELOPMENT
- Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
- (2011) Mohamed Elgendy et al. MOLECULAR CELL
- Autophagy in immunity and inflammation
- (2011) Beth Levine et al. NATURE
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- High-resolution characterization of a hepatocellular carcinoma genome
- (2011) Yasushi Totoki et al. NATURE GENETICS
- The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels
- (2011) Jose-Andres C. Portillo et al. PLoS One
- LC3A-Positive Light Microscopy Detected Patterns of Autophagy and Prognosis in Operable Breast Carcinomas
- (2010) Efthimios Sivridis et al. AMERICAN JOURNAL OF PATHOLOGY
- Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells
- (2010) Robert Koesters et al. AMERICAN JOURNAL OF PATHOLOGY
- FYCO1: Linking autophagosomes to microtubule plus end-directing molecular motors
- (2010) Serhiy Pankiv et al. Autophagy
- Elevated Beclin 1 expression is correlated with HIF-1α in predicting poor prognosis of nasopharyngeal carcinoma
- (2010) Xiang-Bo Wan et al. Autophagy
- Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells
- (2010) William Ka Kei Wu et al. Autophagy
- RB-E2F1
- (2010) Hong Jiang et al. Autophagy
- Regulation of autophagy by transforming growth factor-β (TGF-β) signaling
- (2010) Hiroshi I. Suzuki et al. Autophagy
- Autophagy-independent LC3 function in vesicular traffic
- (2010) Cornelis A.M. de Haan et al. Autophagy
- Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells
- (2010) Shengbing Huang et al. Autophagy
- Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy
- (2010) Séverine Lorin et al. Autophagy
- Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors
- (2010) Zidong Li et al. BMC CANCER
- Activated mammalian target of rapamycin is a potential therapeutic target in gastric cancer
- (2010) Da-zhi Xu et al. BMC CANCER
- Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia
- (2010) M I Koukourakis et al. BRITISH JOURNAL OF CANCER
- Proteasome inhibition: A new therapeutic strategy to cancer treatment
- (2010) William Ka Kei Wu et al. CANCER LETTERS
- The RB-E2F1 Pathway Regulates Autophagy
- (2010) H. Jiang et al. CANCER RESEARCH
- PERK-Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24-Induced Killing of Primary Human Glioblastoma Multiforme Cells
- (2010) A. Yacoub et al. CANCER RESEARCH
- Inhibition of Autophagy Enhances Anticancer Effects of Atorvastatin in Digestive Malignancies
- (2010) P.-M. Yang et al. CANCER RESEARCH
- The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1 and Bcl-2 and Activating the Beclin 1/hVps34 Complex
- (2010) X. Li et al. CANCER RESEARCH
- Stimulation of autophagy by the p53 target gene Sestrin2
- (2010) Maria Chiara Maiuri et al. CELL CYCLE
- The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways
- (2010) Mustapha Kandouz et al. CELL CYCLE
- Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells
- (2010) P Bhoopathi et al. CELL DEATH AND DIFFERENTIATION
- A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum
- (2010) J Lian et al. CELL DEATH AND DIFFERENTIATION
- Autophagy regulation by p53
- (2010) Maria Chiara Maiuri et al. CURRENT OPINION IN CELL BIOLOGY
- Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy
- (2010) William K.K. Wu et al. DRUG RESISTANCE UPDATES
- Relative down-regulation of apoptosis and autophagy genes in colorectal cancer
- (2010) Ying-Tse Chang et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden
- (2010) Harald Stenmark FEBS Journal
- Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis
- (2010) Feifan Zhou et al. FEBS Journal
- Chromosome band 17q21 in breast cancer: Significant association between beclin 1 loss and HER2/NEU amplification
- (2010) Tiziana Negri et al. GENES CHROMOSOMES & CANCER
- Inhibition of Autophagosome Formation by the Benzoporphyrin Derivative Verteporfin
- (2010) Elizabeth Donohue et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells
- (2010) Ping Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TGF-β1 Protects against Mesangial Cell Apoptosis via Induction of Autophagy
- (2010) Yan Ding et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport
- (2010) Serhiy Pankiv et al. JOURNAL OF CELL BIOLOGY
- HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers
- (2010) J. J. Steffan et al. JOURNAL OF CELL SCIENCE
- Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors
- (2010) Xin Huang et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Expression of Beclin1 in osteosarcoma and the effects of down-regulation of autophagy on the chemotherapeutic sensitivity
- (2010) Zhicai Zhang et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Induction of Autophagy and Inhibition of Melanoma Growth In Vitro and In Vivo by Hyperactivation of Oncogenic BRAF
- (2010) Nityanand Maddodi et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- NF-κB as a common signaling pathway in ganglioside-induced autophagic cell death and activation of astrocytes
- (2010) Jaegyu Hwang et al. JOURNAL OF NEUROIMMUNOLOGY
- Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
- (2010) Rebecca Lock et al. MOLECULAR BIOLOGY OF THE CELL
- ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy
- (2010) Kathryn G Eby et al. Molecular Cancer
- The Pan-Bcl-2 Inhibitor (-)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma
- (2010) V. Voss et al. MOLECULAR CANCER RESEARCH
- RETRACTED: The Skp2 Promoter Integrates Signaling through the NF-κB, p53, and Akt/GSK3β Pathways to Regulate Autophagy and Apoptosis
- (2010) Benjamin Barré et al. MOLECULAR CELL
- Activation of autophagy during cell death requires the engulfment receptor Draper
- (2010) Christina K. McPhee et al. NATURE
- Mitochondria get a Parkin' ticket
- (2010) Philipp Wild et al. NATURE CELL BIOLOGY
- Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
- (2010) Ying Zhao et al. NATURE CELL BIOLOGY
- Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis
- (2010) B J Altman et al. ONCOGENE
- p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation
- (2010) R. Scherz-Shouval et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
- (2010) A. Alexander et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST)
- (2010) A. Gupta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
- (2010) D. F. Egan et al. SCIENCE
- Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma
- (2010) Q.-W. Fan et al. Science Signaling
- ARD1 Stabilization of TSC2 Suppresses Tumorigenesis Through the mTOR Signaling Pathway
- (2010) H.-P. Kuo et al. Science Signaling
- The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
- (2010) Zhaohui Feng et al. TRENDS IN CELL BIOLOGY
- mTOR Signaling Pathway Is a Target for the Treatment of Colorectal Cancer
- (2009) Yan-Jie Zhang et al. ANNALS OF SURGICAL ONCOLOGY
- Autophagy facilitates oncogene-induced senescence
- (2009) Masako Narita et al. Autophagy
- The prognostic role of Beclin 1 protein expression in high-grade gliomas
- (2009) Luigi Pirtoli et al. Autophagy
- The expression ofbeclin 1is associated with favorable prognosis in stage IIIB colon cancers
- (2009) Bao-Xiu Li et al. Autophagy
- Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells
- (2009) Keng-Fu Hsu et al. Autophagy
- Targeted Activation of Innate Immunity for Therapeutic Induction of Autophagy and Apoptosis in Melanoma Cells
- (2009) Damià Tormo et al. CANCER CELL
- Autophagy Is Activated by TGF- and Potentiates TGF- -Mediated Growth Inhibition in Human Hepatocellular Carcinoma Cells
- (2009) K. Kiyono et al. CANCER RESEARCH
- c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol-Treated Ewing Sarcoma Cells
- (2009) S. Lorin et al. CANCER RESEARCH
- Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis
- (2009) R. H. Kim et al. CANCER RESEARCH
- Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy
- (2009) L. Fu et al. CANCER RESEARCH
- PUMA- and Bax-induced autophagy contributes to apoptosis
- (2009) K S Yee et al. CELL DEATH AND DIFFERENTIATION
- Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
- (2009) E Laane et al. CELL DEATH AND DIFFERENTIATION
- Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer
- (2009) F. M. Platt et al. CLINICAL CANCER RESEARCH
- Combined Bcl-2/Mammalian Target of Rapamycin Inhibition Leads to Enhanced Radiosensitization via Induction of Apoptosis and Autophagy in Non-Small Cell Lung Tumor Xenograft Model
- (2009) K. W. Kim et al. CLINICAL CANCER RESEARCH
- Mammalian autophagy: core molecular machinery and signaling regulation
- (2009) Zhifen Yang et al. CURRENT OPINION IN CELL BIOLOGY
- TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells
- (2009) Griselda Herrero-Martín et al. EMBO JOURNAL
- The IKK complex contributes to the induction of autophagy
- (2009) Alfredo Criollo et al. EMBO JOURNAL
- Why do melanomas get so dark?
- (2009) Rossitza Lazova et al. EXPERIMENTAL DERMATOLOGY
- Autophagy mediates the mitotic senescence transition
- (2009) A. R.J. Young et al. GENES & DEVELOPMENT
- Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions
- (2009) Clelia Miracco et al. HUMAN PATHOLOGY
- A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1
- (2009) Jianrong Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Immunohistochemical expression of MAP1LC3A and MAP1LC3B protein in breast carcinoma tissues
- (2009) Ekhlas Qaid Gazem Othman et al. JOURNAL OF CLINICAL LABORATORY ANALYSIS
- Autophagy in cutaneous malignant melanoma
- (2009) Rossitza Lazova et al. JOURNAL OF CUTANEOUS PATHOLOGY
- p65/RelA Modulates BECN1 Transcription and Autophagy
- (2009) T. Copetti et al. MOLECULAR AND CELLULAR BIOLOGY
- ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
- (2009) Chang Hwa Jung et al. MOLECULAR BIOLOGY OF THE CELL
- Discovery of Atg5/Atg7-independent alternative macroautophagy
- (2009) Yuya Nishida et al. NATURE
- Thiazolidinediones Induce Rab7-RILP-MAPK-Dependent Juxtanuclear Lysosome Aggregation and Reduce Tumor Cell Invasion
- (2009) Joshua J. Steffan et al. TRAFFIC
- Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy
- (2008) Q. Chen et al. BLOOD
- Differential RelA- and RelB-dependent gene transcription in LTβR-stimulated mouse embryonic fibroblasts
- (2008) Agnes Lovas et al. BMC GENOMICS
- Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization
- (2008) M. A. Qadir et al. BREAST CANCER RESEARCH AND TREATMENT
- A Molecule Targeting VHL-Deficient Renal Cell Carcinoma that Induces Autophagy
- (2008) Sandra Turcotte et al. CANCER CELL
- Mammalian Target of Rapamycin and S6 Kinase 1 Positively Regulate 6-thioguanine-Induced Autophagy
- (2008) X. Zeng et al. CANCER RESEARCH
- p53-Dependent and p53-Independent Activation of Autophagy by ARF
- (2008) W. M. Abida et al. CANCER RESEARCH
- Association of Autophagy Defect with a Malignant Phenotype and Poor Prognosis of Hepatocellular Carcinoma
- (2008) Z.-B. Ding et al. CANCER RESEARCH
- Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells
- (2008) Satoshi Fujii et al. CANCER SCIENCE
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias
- (2008) Y Kamitsuji et al. CELL DEATH AND DIFFERENTIATION
- Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
- (2008) F Scarlatti et al. CELL DEATH AND DIFFERENTIATION
- Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability
- (2008) Min Sung Kim et al. HUMAN PATHOLOGY
- Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis
- (2008) Hitomi Nomura et al. HUMAN PATHOLOGY
- Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells
- (2008) Takashi Shingu et al. INTERNATIONAL JOURNAL OF CANCER
- Bcl-xLand UVRAG Cause a Monomer-Dimer Switch in Beclin1
- (2008) Christian G. Noble et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells
- (2008) Jie Han et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation
- (2008) Hernan Roca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Brevinin-2R1 semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway
- (2008) Saeid Ghavami et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Akt Induces Apoptosis in Neuroblastoma Cells Expressing a C98X Vasopressin Mutant Following Autophagy Suppression
- (2008) R. Castino et al. JOURNAL OF NEUROENDOCRINOLOGY
- Frameshift mutations of autophagy-related genesATG2B, ATG5, ATG9BandATG12in gastric and colorectal cancers with microsatellite instability
- (2008) Mi Ran Kang et al. JOURNAL OF PATHOLOGY
- Autophagy Provides Nutrients but Can Lead to Chop-dependent Induction of Bim to Sensitize Growth Factor–deprived Cells to Apoptosis
- (2008) Brian J. Altman et al. MOLECULAR BIOLOGY OF THE CELL
- OSU-03012 Stimulates PKR-Like Endoplasmic Reticulum-Dependent Increases in 70-kDa Heat Shock Protein Expression, Attenuating Its Lethal Actions in Transformed Cells
- (2008) M. A. Park et al. MOLECULAR PHARMACOLOGY
- Autophagy fights disease through cellular self-digestion
- (2008) Noboru Mizushima et al. NATURE
- Regulation of autophagy by cytoplasmic p53
- (2008) Ezgi Tasdemir et al. NATURE CELL BIOLOGY
- E2F1 regulates autophagy and the transcription of autophagy genes
- (2008) S Polager et al. ONCOGENE
- Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival
- (2007) Christopher Fung et al. MOLECULAR BIOLOGY OF THE CELL
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