Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors
出版年份 2011 全文链接
标题
Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors
作者
关键词
-
出版物
Cell Death & Disease
Volume 2, Issue 5, Pages e156-e156
出版商
Springer Nature
发表日期
2011-05-12
DOI
10.1038/cddis.2011.39
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The transcription-independent mitochondrial p53 program is a major contributor to Nutlin-induced apoptosis in tumor cells
- (2011) Angelina V. Vaseva et al. CELL CYCLE
- Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies
- (2010) I Goldstein et al. CANCER GENE THERAPY
- Blockade of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase and Murine Double Minute Synergistically Induces Apoptosis in Acute Myeloid Leukemia via BH3-Only Proteins Puma and Bim
- (2010) W. Zhang et al. CANCER RESEARCH
- Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method
- (2010) T.-C. Chou CANCER RESEARCH
- Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
- (2010) Grzegorz M. Popowicz et al. CELL CYCLE
- Identification and Characterization of the First Small Molecule Inhibitor of MDMX
- (2010) Damon Reed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis
- (2010) H. Wang et al. MOLECULAR CANCER THERAPEUTICS
- p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation
- (2010) M Xia et al. ONCOGENE
- Paradoxical suppression of cellular senescence by p53
- (2010) Z. N. Demidenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The p53 orchestra: Mdm2 and Mdmx set the tone
- (2010) Mark Wade et al. TRENDS IN CELL BIOLOGY
- Pharmacological activation of the p53 pathway in haematological malignancies
- (2009) M. N Saha et al. JOURNAL OF CLINICAL PATHOLOGY
- Pharmacologic p53 Activation Blocks Cell Cycle Progression but Fails to Induce Senescence in Epithelial Cancer Cells
- (2009) B. Huang et al. MOLECULAR CANCER RESEARCH
- Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma
- (2009) O. Ayrault et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells
- (2008) N. Zhu et al. MOLECULAR CANCER THERAPEUTICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now