Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

(2011) Jason S. White et al.   CELL CYCLE

In Aged Mice, Outgrowth of Intraocular Melanoma Depends on Proangiogenic M2-Type Macrophages

(2010) L. V. Ly et al.   JOURNAL OF IMMUNOLOGY

Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences

(2010) M. Kodama et al.   MOLECULAR AND CELLULAR BIOLOGY

RITA Inhibits Multiple Myeloma Cell Growth through Induction of p53-Mediated Caspase-Dependent Apoptosis and Synergistically Enhances Nutlin-Induced Cytotoxic Responses

(2010) M. N. Saha et al.   MOLECULAR CANCER THERAPEUTICS

The ATM Inhibitor KU-55933 Suppresses Cell Proliferation and Induces Apoptosis by Blocking Akt In Cancer Cells with Overactivated Akt

(2010) Y. Li et al.   MOLECULAR CANCER THERAPEUTICS

Role of Mdm4 in drug sensitivity of breast cancer cells

(2010) S Lam et al.   ONCOGENE

Effectiveness of Treatments for Metastatic Uveal Melanoma

(2009) James J. Augsburger et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53

(2009) Martin Enge et al.   CANCER CELL

HIPK2 Regulation by MDM2 Determines Tumor Cell Response to the p53-Reactivating Drugs Nutlin-3 and RITA

(2009) C. Rinaldo et al.   CANCER RESEARCH

Nutlin-3, an Hdm2 antagonist, inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated inactivation of HIF-1α

(2009) Yoon-Mi Lee et al.   CARCINOGENESIS

Topotecan Triggers Apoptosis in p53-Deficient Cells by Forcing Degradation of XIAP and Survivin Thereby Activating Caspase-3-Mediated Bid Cleavage

(2009) M. T. Tomicic et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Small-Molecule Activation of p53 Blocks Hypoxia-Inducible Factor 1  and Vascular Endothelial Growth Factor Expression In Vivo and Leads to Tumor Cell Apoptosis in Normoxia and Hypoxia

(2009) J. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY