Regulation of p73 activity by post-translational modifications

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism

(2011) S Al-Bahlani et al.   ONCOGENE

βA3/A1-Crystallin controls anoikis-mediated cell death in astrocytes by modulating PI3K/AKT/mTOR and ERK survival pathways through the PKD/Bit1-signaling axis

(2011) B Ma et al.   Cell Death & Disease

TRAIL promotes caspase-dependent pro-inflammatory responses via PKCδ activation by vascular smooth muscle cells

(2011) S Song et al.   Cell Death & Disease

WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells

(2011) A M Wasik et al.   Cell Death & Disease

WW domain interactions regulate the Hippo tumor suppressor pathway

(2011) Z Salah et al.   Cell Death & Disease

Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models

(2011) M Seervi et al.   Cell Death & Disease

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells

(2011) M Michaelis et al.   Cell Death & Disease

Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway

(2011) R Koster et al.   Cell Death & Disease

Serine 312 phosphorylation is dispensable for wild-type p53 functions in vivo

(2010) M K Lee et al.   CELL DEATH AND DIFFERENTIATION

GRAMD4 mimics p53 and mediates the apoptotic function of p73 at mitochondria

(2010) K John et al.   CELL DEATH AND DIFFERENTIATION

A positive role for c-Abl in Atm and Atr activation in DNA damage response

(2010) X Wang et al.   CELL DEATH AND DIFFERENTIATION

p53-family proteins and their regulators: hubs and spokes in tumor suppression

(2010) L Collavin et al.   CELL DEATH AND DIFFERENTIATION

SUMO-specific protease 2 in Mdm2-mediated regulation of p53

(2010) M Jiang et al.   CELL DEATH AND DIFFERENTIATION

Differential control of TAp73 and  Np73 protein stability by the ring finger ubiquitin ligase PIR2

(2010) B. S. Sayan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway

(2010) I. Dulloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Puma modulates its apoptotic function by regulating protein stability

(2010) M Fricker et al.   Cell Death & Disease

c-Abl downregulates the slow phase of double-strand break repair

(2010) V Meltser et al.   Cell Death & Disease

Novel p63 target genes involved in paracrine signaling and keratinocyte differentiation

(2010) C E Barton et al.   Cell Death & Disease

p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53

(2010) L Gonzalez-Cano et al.   Cell Death & Disease

Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis

(2010) K M E Chu et al.   Cell Death & Disease

Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2

(2010) W-W Lei et al.   Cell Death & Disease

The C-terminus of p63 contains multiple regulatory elements with different functions

(2010) W E Straub et al.   Cell Death & Disease

IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter

(2010) G C Mitchell et al.   Cell Death & Disease

Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells

(2010) N Bhatnagar et al.   Cell Death & Disease

A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

(2010) W J Placzek et al.   Cell Death & Disease

GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy

(2010) N Heidari et al.   Cell Death & Disease

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment

(2010) Y Wang et al.   Cell Death & Disease

An essential role for p73 in regulating mitotic cell death

(2009) W H Toh et al.   CELL DEATH AND DIFFERENTIATION

Conformational stability and activity of p73 require a second helix in the tetramerization domain

(2009) D Coutandin et al.   CELL DEATH AND DIFFERENTIATION

Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding

(2009) N D Marchenko et al.   CELL DEATH AND DIFFERENTIATION

Protein Kinase C-Dependent Phosphorylation Regulates the Cell Cycle-Inhibitory Function of the p73 Carboxy Terminus Transactivation Domain

(2009) U. Nyman et al.   MOLECULAR AND CELLULAR BIOLOGY

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis

(2008) A E Sayan et al.   ONCOGENE