Microbial Peptidyl-Prolyl cis/trans Isomerases (PPIases): Virulence Factors and Potential Alternative Drug Targets

A specific pathway inducing autophagic cell death is marked by an IP3R mutation

(2014) David Lam et al.   Autophagy

Characterization of three Arabidopsis thaliana immunophilin genes involved in the plant defense response against Pseudomonas syringae

(2014) Gennady V. Pogorelko et al.   GENE

Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore

(2013) John W. Elrod et al.   CIRCULATION JOURNAL

The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.

(2013) Lilach Sheiner et al.   CURRENT OPINION IN MICROBIOLOGY

Demarcating SurA Activities Required for Outer Membrane Targeting of Yersinia pseudotuberculosis Adhesins

(2013) Ikenna R. Obi et al.   INFECTION AND IMMUNITY

Identification of FkpA as a Key Quality Control Factor for the Biogenesis of Outer Membrane Proteins under Heat Shock Conditions

(2013) X. Ge et al.   JOURNAL OF BACTERIOLOGY

Secreted Trypanosome Cyclophilin Inactivates Lytic Insect Defense Peptides and Induces Parasite Calcineurin Activation and Infectivity

(2013) Manjusha M. Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure ofPlasmodium vivaxFK506-binding protein 25 reveals conformational changes responsible for its noncanonical activity

(2013) Sreekanth Rajan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Proteomic methods reveal cyclophilin a function as a host restriction factor against rotavirus infection

(2013) Haiyang He et al.   PROTEOMICS

Insights into the Roles of Cyclophilin A During Influenza Virus Infection

(2013) Xiaoling Liu et al.   Viruses-Basel

Cyclophilins as Modulators of Viral Replication

(2013) Stephen Frausto et al.   Viruses-Basel

Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent

(2013) Amaravadhi Harikishore et al.   Scientific Reports

The Caenorhabditis elegans parvulin gene subfamily and their expression under cold or heat stress along with the fkb subfamily

(2012) Michael K. Fasseas et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells

(2012) Eva Kaiser et al.   CELLULAR MICROBIOLOGY

Genome-wide analysis of immunophilin FKBP genes and expression patterns in Zea mays

(2012) W.-W. Wang et al.   GENETICS AND MOLECULAR RESEARCH

SurA Is Involved in the Targeting to the Outer Membrane of a Tat Signal Sequence-Anchored Protein

(2012) A. Rondelet et al.   JOURNAL OF BACTERIOLOGY

Microneme Protein 5 Regulates the Activity ofToxoplasmaSubtilisin 1 by Mimicking a Subtilisin Prodomain

(2012) Savvas Saouros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trypanosomatid Pin1-Type Peptidyl-Prolyl Isomerase Is Cytosolic and Not Essential for Cell Proliferation

(2012) Esteban D. Erben et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Cyclophilin A is required for efficient human cytomegalovirus DNA replication and reactivation

(2012) L. R. Keyes et al.   JOURNAL OF GENERAL VIROLOGY

Combination of the Human Prolyl Isomerase FKBP12 with Unrelated Chaperone Domains Leads to Chimeric Folding Enzymes with High Activity

(2012) Anne-Juliane Geitner et al.   JOURNAL OF MOLECULAR BIOLOGY

Pin1 Interacts with the Epstein-Barr Virus DNA Polymerase Catalytic Subunit and Regulates Viral DNA Replication

(2012) Y. Narita et al.   JOURNAL OF VIROLOGY

A family of cyclophilin-like molecular chaperones in Plasmodium falciparum

(2012) Alejandro Marín-Menéndez et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Top 10 plant pathogenic bacteria in molecular plant pathology

(2012) JOHN MANSFIELD et al.   MOLECULAR PLANT PATHOLOGY

PpiA, a Surface PPIase of the Cyclophilin Family in Lactococcus lactis

(2012) Nicolas Trémillon et al.   PLoS One

Solution Structural Analysis of the Single-Domain Parvulin TbPin1

(2012) Lifang Sun et al.   PLoS One

The OmpA family of proteins: Roles in bacterial pathogenesis and immunity

(2012) Anthony W. Confer et al.   VETERINARY MICROBIOLOGY

Identification of Two Legionella pneumophila Effectors that Manipulate Host Phospholipids Biosynthesis

(2012) Ram Viner et al.   PLoS Pathogens

Varying dependency of periplasmic peptidylprolylcis–transisomerases in promotingYersinia pseudotuberculosisstress tolerance and pathogenicity

(2011) Ikenna R. Obi et al.   BIOCHEMICAL JOURNAL

The structure of aBurkholderia pseudomalleiimmunophilin–inhibitor complex reveals new approaches to antimicrobial development

(2011) Isobel H. Norville et al.   BIOCHEMICAL JOURNAL

Collagen IV-derived peptide binds hydrophobic cavity of Legionella pneumophila Mip and interferes with bacterial epithelial transmigration

(2011) Can Ünal et al.   CELLULAR MICROBIOLOGY

The occurrence of Legionella species other than Legionella pneumophila in clinical and environmental samples in Denmark identified by mip gene sequencing and matrix-assisted laser desorption ionization time-of-flight mass spectrometry

(2011) C.W. Svarrer et al.   CLINICAL MICROBIOLOGY AND INFECTION

FKBP51 regulation of AKT/protein kinase B phosphorylation

(2011) Liewei Wang   CURRENT OPINION IN PHARMACOLOGY

Targeting FKBP isoforms with small-molecule ligands

(2011) Elizabeth A Blackburn et al.   CURRENT OPINION IN PHARMACOLOGY

Effect of interactions between Mip and PrtA on the full extracellular protease activity of Xanthomonas campestris pathovar campestris

(2011) Qing-Lin Meng et al.   FEMS MICROBIOLOGY LETTERS

Membrane Translocation of Binary Actin-ADP-Ribosylating Toxins from Clostridium difficile and Clostridium perfringens Is Facilitated by Cyclophilin A and Hsp90

(2011) Eva Kaiser et al.   INFECTION AND IMMUNITY

Surface Lipoprotein PpiA of Streptococcus mutans Suppresses Scavenger Receptor MARCO-Dependent Phagocytosis by Macrophages

(2011) Tadashi Mukouhara et al.   INFECTION AND IMMUNITY

A Burkholderia pseudomallei Macrophage Infectivity Potentiator-Like Protein Has Rapamycin-Inhibitable Peptidylprolyl Isomerase Activity and Pleiotropic Effects on Virulence

(2011) Isobel H. Norville et al.   INFECTION AND IMMUNITY

The Neisseria meningitidis Macrophage Infectivity Potentiator Protein Induces Cross-Strain Serum Bactericidal Activity and Is a Potential Serogroup B Vaccine Candidate

(2011) Miao-Chiu Hung et al.   INFECTION AND IMMUNITY

Posttranslocation Chaperone PrsA2 Regulates the Maturation and Secretion of Listeria monocytogenes Proprotein Virulence Factors

(2011) B. M. Forster et al.   JOURNAL OF BACTERIOLOGY

The Fimbrial Usher FimD Follows the SurA-BamB Pathway for Its Assembly in the Outer Membrane of Escherichia coli

(2011) C. Palomino et al.   JOURNAL OF BACTERIOLOGY

The Virulence Factor PEB4 (Cj0596) and the Periplasmic Protein Cj1289 Are Two Structurally Related SurA-like Chaperones in the Human PathogenCampylobacter jejuni

(2011) Avinash Kale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted SlyD from Helicobacter pylori: implication in [NiFe] hydrogenase maturation

(2011) Tianfan Cheng et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Mannheimia haemolytica leukotoxin binds cyclophilin D on bovine neutrophil mitochondria

(2011) Nicole A. Aulik et al.   MICROBIAL PATHOGENESIS

A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei

(2011) I. H. Norville et al.   MICROBIOLOGY-SGM

Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence

(2011) Francis Alonzo III et al.   MOLECULAR MICROBIOLOGY

Unraveling the Role of Peptidyl-Prolyl Isomerases in Neurodegeneration

(2011) Melanie Gerard et al.   MOLECULAR NEUROBIOLOGY

Overexpression of a cotton cyclophilin gene (GhCyp1) in transgenic tobacco plants confers dual tolerance to salt stress and Pseudomonas syringae pv. tabaci infection

(2011) Chuanfeng Zhu et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum

(2011) Alejandro Marín-Menéndez et al.   PROTEIN EXPRESSION AND PURIFICATION

Involvement of cyclophilin B in the replication of Japanese encephalitis virus

(2011) Hiroto Kambara et al.   VIROLOGY

Transcriptome Analysis of Neisseria meningitidis in Human Whole Blood and Mutagenesis Studies Identify Virulence Factors Involved in Blood Survival

(2011) Hebert Echenique-Rivera et al.   PLoS Pathogens

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

Role of Prolylcis/transIsomers in Cyclophilin-AssistedPseudomonas syringaeAvrRpt2 Protease Activation

(2010) Tobias Aumüller et al.   BIOCHEMISTRY

Identification of an atypical peptidyl-prolyl cis/trans isomerase from trypanosomatids

(2010) Esteban D. Erben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Restricted domain mobility in the Candida albicans Ess1 prolyl isomerase

(2010) Lynn McNaughton et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

PpiD is a player in the network of periplasmic chaperones in Escherichia coli

(2010) Yvonne Matern et al.   BMC MICROBIOLOGY

A Diacylglycerol-Dependent Signaling Pathway Contributes to Regulation of Antibacterial Autophagy

(2010) Shahab Shahnazari et al.   Cell Host & Microbe

Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen

(2010) Lydia Dmochewitz et al.   CELLULAR MICROBIOLOGY

Identification of Immunologically Relevant Proteins of Chlamydophila abortus Using Sera from Experimentally Infected Pregnant Ewes

(2010) P. X. Marques et al.   Clinical and Vaccine Immunology

Toxoplasma gondii Cyclophilin 18 Regulates the Proliferation and Migration of Murine Macrophages and Spleen Cells

(2010) H. M. Ibrahim et al.   Clinical and Vaccine Immunology

Antivirulence drugs to target bacterial secretion systems

(2010) Christian Baron   CURRENT OPINION IN MICROBIOLOGY

Leishmania infantum chagasi: A genome-based approach to identification of excreted/secreted proteins

(2010) Sruti DebRoy et al.   EXPERIMENTAL PARASITOLOGY

Functional characterization of two novel parvulins inTrypanosoma brucei

(2010) Jian Yuan Goh et al.   FEBS LETTERS

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

(2010) Herman O Sintim et al.   Future Medicinal Chemistry

Listeria monocytogenes PrsA2 Is Required for Virulence Factor Secretion and Bacterial Viability within the Host Cell Cytosol

(2010) F. Alonzo et al.   INFECTION AND IMMUNITY

Phospholipase PlaB is a new virulence factor of Legionella pneumophila

(2010) Eva Schunder et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The role of SurA factor in outer membrane protein transport and virulence

(2010) Susanne Behrens-Kneip   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Versatility of Trigger Factor Interactions with Ribosome-Nascent Chain Complexes

(2010) Sathish Kumar Lakshmipathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pipecolic Acid Derivatives As Small-Molecule Inhibitors of theLegionellaMIP Protein

(2010) Christina Juli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trigger factor of Streptococcus suis is involved in stress tolerance and virulence

(2010) Tao Wu et al.   MICROBIAL PATHOGENESIS

Penicillin-binding protein folding is dependent on the PrsA peptidyl-prolyl cis-trans isomerase in Bacillus subtilis

(2010) Hanne-Leena Hyyryläinen et al.   MOLECULAR MICROBIOLOGY

Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4+ T lymphocytes

(2010) Lara Manganaro et al.   NATURE MEDICINE

Cyclosporin A Treatment of Leishmania donovani Reveals Stage-Specific Functions of Cyclophilins in Parasite Proliferation and Viability

(2010) Wai-Lok Yau et al.   PLoS Neglected Tropical Diseases

Differential composition of culture supernatants from wild-type Brucella abortus and its isogenic virB mutants

(2009) M. Victoria Delpino et al.   ARCHIVES OF MICROBIOLOGY

NMR assignments of the FK506-binding domain of FK506-binding protein 35 from Plasmodium vivax

(2009) Reema Alag et al.   Biomolecular NMR Assignments

Shigella Induces Mitochondrial Dysfunction and Cell Death in Nonmyleoid Cells

(2009) Leticia A.M. Carneiro et al.   Cell Host & Microbe

Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication

(2009) Xiaoling Liu et al.   CELLULAR MICROBIOLOGY

Engineering of monomeric FK506-binding protein 22 with peptidyl prolylcis-transisomerase

(2009) Cahyo Budiman et al.   FEBS Journal

Highly expressed genes in a rough-colony-forming phenotype ofAggregatibacter actinomycetemcomitans: implication of amip-like gene for the invasion of host tissue

(2009) Takemasa Maeda et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The Posttranslocation Chaperone PrsA2 Contributes to Multiple Facets of Listeria monocytogenes Pathogenesis

(2009) F. Alonzo et al.   INFECTION AND IMMUNITY

Toxoplasma gondii Cyclophilin 18-Mediated Production of Nitric Oxide Induces Bradyzoite Conversion in a CCR5-Dependent Manner

(2009) H. M. Ibrahim et al.   INFECTION AND IMMUNITY

Roles of Periplasmic Chaperone Proteins in the Biogenesis of Serine Protease Autotransporters of Enterobacteriaceae

(2009) F. Ruiz-Perez et al.   JOURNAL OF BACTERIOLOGY

Development of a mariner-Based Transposon and Identification of Listeria monocytogenes Determinants, Including the Peptidyl-Prolyl Isomerase PrsA2, That Contribute to Its Hemolytic Phenotype

(2009) J. Zemansky et al.   JOURNAL OF BACTERIOLOGY

Role of Periplasmic Chaperones and BamA (YaeT/Omp85) in Folding and Secretion of Intimin from Enteropathogenic Escherichia coli Strains

(2009) G. Bodelon et al.   JOURNAL OF BACTERIOLOGY

Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering

(2009) Bernard Clantin et al.   JOURNAL OF STRUCTURAL BIOLOGY

Investigation of the role of the BAM complex and SurA chaperone in outer-membrane protein biogenesis and type III secretion system expression in Salmonella

(2009) Y. Fardini et al.   MICROBIOLOGY-SGM

Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner

(2009) L. E. Cron et al.   MICROBIOLOGY-SGM

In silico analysis of the cyclophilin repertoire of apicomplexan parasites

(2009) Jürgen Krücken et al.   Parasites & Vectors

Chaperone domains convert prolyl isomerases into generic catalysts of protein folding

(2009) R. P. Jakob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The prolyl isomerase domain of PpiD fromEscherichia colishows a parvulin fold but is devoid of catalytic activity

(2009) Ulrich Weininger et al.   PROTEIN SCIENCE

Characterization of the role of the Escherichia coli periplasmic chaperone SurA using differential proteomics

(2009) Didier Vertommen et al.   PROTEOMICS

Solution structure of the parvulin-type PPIase domain of Staphylococcus aureus PrsA – Implications for the catalytic mechanism of parvulins

(2009) Outi Heikkinen et al.   BMC STRUCTURAL BIOLOGY

Fiber Formation across the Bacterial Outer Membrane by the Chaperone/Usher Pathway

(2008) Han Remaut et al.   CELL

Novel strategies to combat bacterial virulence

(2008) Susan V Lynch et al.   Current Opinion in Critical Care

Dynamin-2-Dependent Targeting of Mannheimia haemolytica Leukotoxin to Mitochondrial Cyclophilin D in Bovine Lymphoblastoid Cells

(2008) D. N. Atapattu et al.   INFECTION AND IMMUNITY

Proteomic Characterization of the Whole Secretome of Legionella pneumophila and Functional Analysis of Outer Membrane Vesicles

(2008) F. Galka et al.   INFECTION AND IMMUNITY

Periplasmic chaperone FkpA is essential for imported colicin M toxicity

(2008) Julia Hullmann et al.   MOLECULAR MICROBIOLOGY

FKBP Family Proteins: Immunophilins with Versatile Biological Functions

(2008) Cong Bao Kang et al.   NEUROSIGNALS

Components of SurA Required for Outer Membrane Biogenesis in Uropathogenic Escherichia coli

(2008) Kristin M. Watts et al.   PLoS One

Structure-based classification of 45 FK506-binding proteins

(2008) J. A. Somarelli et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Solution structure of the Legionella pneumophila Mip-rapamycin complex

(2008) Andreas Ceymann et al.   BMC STRUCTURAL BIOLOGY

Functional analysis of Leishmania major cyclophilin

(2007) Vyacheslav Yurchenko et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Structural, Biochemical, and in Vivo Characterization of the First Virally Encoded Cyclophilin from the Mimivirus

(2007) Vu Thai et al.   JOURNAL OF MOLECULAR BIOLOGY

The Peptidyl–Prolyl Isomerase and Chaperone Par27 of Bordetella pertussis as the Prototype for a New Group of Parvulins

(2007) Hélène Hodak et al.   JOURNAL OF MOLECULAR BIOLOGY

The Inositol 1,4,5-Trisphosphate Receptor Is Required to Signal Autophagic Cell Death

(2007) David Lam et al.   MOLECULAR BIOLOGY OF THE CELL