Article
Mathematical & Computational Biology
Dipten Laskar, Rajkrishna Amenti, Rajkrishna Mondal
Summary: Juglone may inhibit the expression of PPiase in Staphylococcus aureus through a competitive inhibition mechanism, making it a potential drug against the bacteria.
Article
Infectious Diseases
Helle Brander Eriksen, Andreas Petersen, Michael Pedersen, Soren Overballe-Petersen, Anders Rhod Larsen, Barbara Juliane Holzknecht
Summary: This case report describes recurrent catheter-related bloodstream infections caused by Staphylococcus aureus, initially susceptible to penicillin but later developing resistance. Experimental findings showed that the loss of penicillin resistance correlated with the absence of the blaZ gene.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Zhenhua Wang, Hui Shen, Binbin He, Maikun Teng, Qiong Guo, Xu Li
Summary: Staphylococcus aureus infections have become a serious clinical problem due to the emergence of drug-resistant strains in recent years. The nucleotide phosphatase Ntdp plays a crucial role in the infection process. Through structural and biochemical studies, insights into the catalytic mechanism and regulatory pathways of Ntdp have been revealed.
Article
Food Science & Technology
Deyin Zhao, Qian Wang, Fengxia Lu, Xiaomei Bie, Haizhen Zhao, Zhaoxin Lu, Yingjian Lu
Summary: Plantaricin 827, a novel bacteriocin, has been found to effectively inhibit S. aureus and significantly extend the shelf life of skim milk. Its antibacterial mechanism involves increasing cell membrane permeability, inhibiting biofilm formation, and interacting with genomic DNA minor groove in AT-rich regions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing Wang, Zhicun Sheng, Yunying Liu, Xiaolan Chen, Shuaibing Wang, Haifeng Yang
Summary: This study analyzed the proteome and transcriptome of Staphylococcus aureus and found that tannic acid (TA) has an inhibitory effect on this pathogen. TA damaged the integrity of the cell membrane and affected the expression and abundance of key enzymes, leading to impaired growth and synthesis in S. aureus. These findings provide a theoretical basis for the application of TA as an antibacterial chemotherapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Marzieh Asadi, Mortaza Taheri-Anganeh, Maryam Ranjbar, Seyyed Hossein Khatami, Amir Maleksabet, Zohreh Mostafavi-Pour, Younes Ghasemi, Abdolkhalegh Keshavarzi, Amir Savardashtaki
Summary: This study evaluated the antibacterial activity of a novel exolysin containing an SH3b domain against MRSA. The results showed that the chimeric exolysin LYZ2-SH3b had a more inhibitory effect on MRSA compared to LYZ2 and vancomycin.
Article
Chemistry, Physical
Imran Khan Rind, Ahmet Sari, Mustafa Tuzen, Muhammad Farooque Lanjwani, Isa Karaman, Tawfik A. Saleh
Summary: In this study, graphene nanoplatelets (GNP) were coupled with Staphylococcus aureus (S. aureus) for the adsorption of antimony (Sb) from water. The optimum conditions for composite dosage, initial concentration, pH level, contact time, and temperature were determined. The GNP/S. aureus composite exhibited promising adsorption capacity for Sb(III) ions in wastewater.
SURFACES AND INTERFACES
(2023)
Article
Multidisciplinary Sciences
Ziqing Zhang, Jinrun Dong, Yibo Yang, Yuan Zhou, Yuang Chen, Yang Xu, Jiandong Feng
Summary: This study presents a direct investigation of chemiluminescent reaction dynamics of single molecules in solution. It demonstrates that double-substrate Michaelis-Menten type of catalytic kinetics governs the single-molecule reaction dynamics and reveals heterogeneity among catalyst particles and catalytic sites. The authors also show that single-molecule chemiluminescence imaging can be used to evaluate the thermodynamics of the catalytic system, resolving activation energy at the single-particle level.
NATURE COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Dina A. Mosselhy, Mhd Assad, Tarja Sironen, Mady Elbahri
Summary: Staphylococcus aureus is a problematic pathogen with resistant strains like MRSA causing issues in hospitals. Nanoparticles and nanofibers show potential in combating superbugs and biofilms, as well as diagnosing MRSA efficiently. Collaborative efforts and standard testing procedures are recommended to address challenges in nanotheranostics.
Article
Food Science & Technology
Mengyuan Qi, Qingyan Liu, Ying Liu, Haiyang Yan, Yan Zhang, Yuan Yuan
Summary: This study investigated the inhibitory effect and mechanism of high voltage prick electrostatic field (HVPEF) on Staphylococcus aureus biofilms. The results showed that HVPEF effectively inactivated established S. aureus biofilms and inhibited biofilm formation. HVPEF disintegrated established biofilms by killing bacteria and reduced the release of key compositions of extracellular polymeric substance. The study suggests that HVPEF can be used as a novel method to inhibit bacteria biofilm and prevent biofilm-associated contamination of S. aureus.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Microbiology
Bokyung Son, Minsuk Kong, Yoona Lee, Sangryeol Ryu
Summary: This study constructed a random domain swapping library of four different endolysins from phages infecting Staphylococcus aureus and screened to obtain engineered endolysins. The novel chimeric endolysin, Lys109, exhibited greater lytic activity against staphylococcal planktonic cells and biofilms, showing highly improved activity in eliminating S. aureus from milk and stainless steel surfaces. These results suggest that a novel chimeric endolysin with higher activity and solubility can be developed by random domain swapping, demonstrating great potential as an antimicrobial agent.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Megija Sede, Jekabs Fridmanis, Martins Otikovs, Jan Johansson, Anna Rising, Nina Kronqvist, Kristaps Jaudzems
Summary: The N-terminal domain of spider silk proteins plays a crucial role in storage and fiber formation. It has high solubility and pH-dependent assembly. Although the residues involved may differ, the pH dependency is conserved among different silk types. The N-terminal domain of tubuliform spidroin lacks key residues for dimerization. The structure and mutant studies suggest that tubuliform spidroin N-terminal domain assembles through elimination of intramolecular repulsive charge interactions.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Food Science & Technology
Jinming Dai, Mei Bai, Changzhu Li, Wai San Cheang, Haiying Cui, Lin Lin
Summary: This study aimed to investigate the impact of citral concentration on its antibacterial effect against Staphylococcus aureus. The results showed that citral at a concentration of 0.5 mg/mL significantly disturbed the cell membrane fluidity and permeability, leading to cell death. However, at a concentration of 0.25 mg/mL, the membrane damage was reduced and a complex interaction between citral and the membrane components was observed. Overall, this study provides valuable insights into the antibacterial mechanisms of natural compounds and expands the potential applications of citral as a natural antimicrobial.
Article
Multidisciplinary Sciences
N'Toia C. Hawkins, James L. Kizziah, Asma Hatoum-Aslan, Terje Dokland
Summary: In this study, the structure of the complete virion of the Staphylococcus epidermidis-infecting phage Andhra was determined using high-resolution cryo-electron microscopy. The findings provide insights into critical features for virion assembly, host recognition, and penetration.
Article
Food Science & Technology
Weijun Leng, Xiaoyun Wu, Tong Shi, Zhiyu Xiong, Li Yuan, Wengang Jin, Ruichang Gao
Summary: The skin mucus extract of Channa argus possesses strong inhibitory action against Staphylococcus aureus, disrupting cell membrane functions to induce intracellular metabolic imbalance and affecting the normal physiological functions and growth of the bacteria. The antimicrobial mechanism involves inhibiting primary metabolic pathways of the bacteria such as the tricarboxylic acid cycle and amino acid biosynthesis.
Article
Biochemical Research Methods
Ivan Vuckovic, Marja-Leena Rapinoja, Matti Vaismaa, Paula Vanninen, Harri Koskela
PHYTOCHEMICAL ANALYSIS
(2016)
Article
Biochemical Research Methods
Harri Koskela, Ilkka Kilpelainen, Sami Heikkinen
JOURNAL OF MAGNETIC RESONANCE
(2016)
Article
Pharmacology & Pharmacy
Kirsi Harju, Harri Koskela, Anke Kremp, Sanna Suikkanen, Pablo de la Iglesia, Christopher O. Miles, Bernd Krock, Paula Vanninen
Article
Chemistry, Multidisciplinary
Harri Koskela, Boban Andelkovic
MAGNETIC RESONANCE IN CHEMISTRY
(2017)
Article
Chemistry, Analytical
Harri Koskela, Boban Andjelkovic, Annette Pettersson, Marja-Leena Rapinoja, Marja-Leena Kuitunen, Paula Vanninen
ANALYTICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Alistair W. T. King, Valtteri Makela, Stephanie A. Kedzior, Tiina Laaksonen, Gabriel J. Partl, Sami Heikkinen, Harri Koskela, Harri A. Heikkinen, Ashley J. Holding, Emily D. Cranston, Ilkka Kilpelainen
Article
Chemistry, Analytical
Harri Koskela
ANALYTICA CHIMICA ACTA
(2012)
Article
Chemistry, Analytical
Harri Koskela, Ullastiina Hakala, Paula Vanninen
ANALYTICAL CHEMISTRY
(2010)
Article
Chemistry, Analytical
Harri Koskela, Ullastiina Hakala, Leena Loiske, Paula Vanninen, Ilmari Szilvay
ANALYTICAL METHODS
(2011)
Article
Biochemical Research Methods
Harri Koskela
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2010)
Article
Biochemical Research Methods
Harri Koskela, Outi Heikkila, Ilkka Kilpelainen, Sami Heikkinen
JOURNAL OF MAGNETIC RESONANCE
(2010)
Article
Biochemical Research Methods
Daniel Girma Mulat, Harri Latva-Maenpaa, Harri Koskela, Pekka Saranpaa, Kristiina Wahala
PHYTOCHEMICAL ANALYSIS
(2014)
Article
Biochemistry & Molecular Biology
Antti Mattila, Rose-Marie Andsten, Mikael Jumppanen, Michele Assante, Jouni Jokela, Matti Wahlsten, Kornelia M. Mikula, Cihad Sigindere, Daniel H. Kwak, Muriel Gugger, Harri Koskela, Kaarina Sivonen, Xinyu Liu, Jari Yli-Kauhaluoma, Hideo Iwai, David P. Fewer
ACS CHEMICAL BIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Harri Koskela, Samir F. de A. Cavalcante, Samim Ahmed, Paula Vanninen
Summary: A study was conducted on a selection of acidic, alkaline, and neutral degradation products relevant to the Chemical Weapons Convention to determine their spin systems and spectral parameters under a wide range of pH conditions. The pH dependence of chemical shifts and J couplings was parameterized using Henderson-Hasselbalch-based functions, allowing for precise calculation of chemical shifts and J coupling constants in arbitrary pH conditions. The obtained spin system definitions and parameters were shown to be a valid source of quantum mechanically simulated reference data in chemical verification analysis.
MAGNETIC RESONANCE IN CHEMISTRY
(2021)
Meeting Abstract
Chemistry, Medicinal
Antti Mattila, Rose-Marie Andsten, Mikael Jumppanen, Michele Assante, Jouni Jokela, Matti Wahlsten, Kornelia M. Mikula, Muriel Gugger, Harri Koskela, Kaarina Sivonen, Jari Yli-Kauhaluoma, Hideo Iwasi, David P. Fewer