Article
Microbiology
Haixia Wei, Shuizhen Wu, Liying Mai, Lili Yang, Weihao Zou, Hongjuan Peng
Summary: This study reveals the important role of Cbl-b in Toxoplasma gondii infection. Knockout of Cbl-b significantly inhibits T. gondii proliferation and reduces parasitic burden. In Cbl-b KO mice, the proportion of B cells increases, while the proportion of macrophages decreases. The levels of interferon-gamma and interleukin-6 in the serum are higher, indicating that Cbl-b negatively regulates the host's immune response through the TLR/MyD88 pathway.
MICROBIOLOGY SPECTRUM
(2023)
Article
Agriculture, Dairy & Animal Science
Raquel Vallejo, Julio Benavides, Noive Arteche-Villasol, Mercedes Fernandez-Escobar, Maria Del Carmen Ferreras, Valentin Perez, Daniel Gutierrez-Exposito
Summary: This study aimed to investigate the effects of different genetic variants of T. gondii isolates on ovine monocyte-derived macrophages. The results showed that type III isolates had a higher internalization/infection rate and induced more pro-inflammatory cytokines and Th1 immune response. These findings suggest significant differences in the parasite-macrophage relationship between different genotypes.
Article
Immunology
Md. Taibur Rahman, Izabela J. Swierzy, Bryan Downie, Gabriela Salinas, Martin Blume, Malcolm J. McConville, Carsten G. K. Lueder
Summary: The study revealed that redox homeostasis and central carbohydrate metabolism are closely related to the formation of dormant bradyzoites in Toxoplasma gondii. Infected myoblast precursors and myotubes exhibited distinct metabolic pathways, showing different redox states.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Ragab M. Fereig, Mosaab A. Omar, Abdullah F. Alsayeqh
Summary: Toxoplasmosis and neosporosis are important protozoan diseases worldwide, and controlling these diseases is currently challenging. Understanding host-parasite interactions and host strategies to combat infections can aid in developing effective control measures, including vaccines. Macrophages and the production of interleukin-12 (IL-12) and interferon gamma (IFN-gamma) play a crucial role in successful vaccine candidates. However, identifying potential vaccine candidates is a time-consuming process.
Article
Cell Biology
Na Zhou, Weijiang Liu, Wei Zhang, Yuanlin Liu, Xue Li, Yang Wang, Rongxiu Zheng, Yi Zhang
Summary: This study reveals the crucial role of Wip1 in modulating the immunosuppressive capacities of MSCs in T1DM mice, showing that Wip1(-/-)MSCs have weaker therapeutic effects and immunosuppressive capabilities. The findings suggest that Wip1 is essential for regulating the immunomodulation properties of MSCs in T1DM treatment.
CELL DEATH DISCOVERY
(2021)
Article
Microbiology
Kai Dong, Ziyang Jiang, Jianhui Zhang, Hanxiao Qin, Jianping Chen, Qiwei Chen
Summary: Toxoplasma gondii is a protozoan parasite that can infect various warm-blooded animals, including humans, and it has the ability to evade immune response. This study aimed to examine the role of SIRT1 in T. gondii infection of macrophages and found that inhibiting SIRT1 can reduce the number of intracellular parasites, potentially through upregulation of IRGM1 and activation of autophagy.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Parasitology
Dingzeyang Su, Shifan Zhu, Zhaofeng Hou, Fuxing Hao, Kangzhi Xu, Fan Xu, Yuyang Zhu, Dandan Liu, Jinjun Xu, Jianping Tao
Summary: Toxoplasma gondii infection leads to upregulation of miR-185 and downregulation of ARAF, which is independent of the strain of T. gondii and the host cells. T. gondii infection regulates host cell apoptosis through the miR-185/ARAF axis, representing an additional strategy used by T. gondii to counteract host-cell apoptosis and ensure survival and reproduction in the host cells.
PARASITES & VECTORS
(2023)
Article
Immunology
Ahlam Elmasry, Wafaa A. Aboukamar, Heba Hany, Manar S. Elmehankar
Summary: The study found that Roflumilast has a potential effect on the tachyzoite-bradyzoite transition in toxoplasmosis. The group treated earlier with 10 mg/kg of Roflumilast showed the best results, significantly reducing T. gondii cyst count, size, and IL-12 level.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Filippo Favretto, Eva Jimenez-Faraco, Carolina Conter, Paola Dominici, Juan A. Hermoso, Alessandra Astegno
Summary: This study characterized a conserved and a more divergent cyclophilin isoform from Toxoplasma gondii. The conserved isoform showed high activity and affinity for CsA, while the divergent isoform had low activity and was less sensitive to CsA inhibition. Structural studies revealed differences in the CsA-binding site between the two isoforms, suggesting distinct functions in the parasite.
ACS INFECTIOUS DISEASES
(2023)
Article
Cell Biology
Jili Zhang, Hongfei Si, Kun Lv, Yanhua Qiu, Jichao Sun, Yubin Bai, Bing Li, Xuzheng Zhou, Jiyu Zhang
Summary: Licarin-B from nutmeg exhibited excellent anti-Toxoplasma gondii activity both in vitro and in vivo, potentially functioning by damaging mitochondria and activating autophagy, leading to parasite death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Xiaoyuan Bai, Wenxian Yang, Heqiao Li, Yuna Zhao, Wenhui Fan, He Zhang, Wenjun Liu, Lei Sun
Summary: CsA regulates macrophage polarization and attenuates influenza virus-induced inflammatory responses by decreasing pro-inflammatory cytokines expression, increasing anti-inflammatory cytokines expression, and altering the polarization of macrophages from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype. These effects depend on the binding of CsA to CypA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Jessica H. Chern, Rebecca R. Pasquarelli, Andy S. Moon, Allan L. Chen, Jihui Sha, James A. Wohlschlegel, Peter J. Bradley
Summary: The cytoskeleton of Toxoplasma gondii contains a novel protein that localizes to discrete puncta in the IMC sutures, impacting various functions such as cytoskeletal integrity and host cell invasion. Additionally, this protein interacts with other proteins implicated in membrane trafficking, indicating a potential role in transporting molecules across the IMC structure.
Article
Parasitology
Dawei Wang, Mengen Xing, Saeed El-Ashram, Yingying Ding, Xiao Zhang, Xiaoyu Sang, Ying Feng, Ran Chen, Xinyi Wang, Ning Jiang, Qijun Chen, Na Yang
Summary: The study found that lumefantrine inhibits the proliferation of T. gondii in Vero cells without being toxic. In mice, lumefantrine at a concentration of 50 μg L-1 prolonged survival by 3 days and reduced parasite burden in tissues. High-dose lumefantrine increased IFN-γ production, while low-dose lumefantrine increased IL-10 and IL-4 levels in mice.
Article
Biotechnology & Applied Microbiology
Kayla L. Menard, Lijing Bu, Eric Y. Denkers
Summary: The study identified differential gene expression in host cells infected with highly virulent RH strain versus less virulent PTG strain, with more immune response-related genes being upregulated in response to RH strain. Additionally, non-coding RNAs showed differential expression between infection with RH and PTG strains. The results provide insights into the immune response mechanisms and the role of long noncoding RNAs during Toxoplasma gondii infection.
Article
Immunology
Keon-Woong Yoon, Ki-Back Chu, Hae-Ji Kang, Min-Ju Kim, Gi-Deok Eom, Jie Mao, Su-Hwa Lee, Md Atique Ahmed, Fu-Shi Quan
Summary: This study found that oral immunization with Toxoplasma gondii vaccines induced a similarly effective immune response as intranasal or intramuscular immunizations, providing a protective effect against lethal infections in mice.
Article
Cell Biology
Badr Mohamed Badr, Nadia Ahmed Moustafa, Heba M. Saad Eldien, Amany O. Mohamed, Hany M. Ibrahim, Ibrahim A. El-Elaimy, Mohamed H. Mahmoud, Gamal Badr
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Immunology
Imam Hassouna, Hany Ibrahim, Faten Abdel Gaffar, Ibrahim El-Elaimy, Heba Abdel Latif
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Khaled Mohammed-Geba, Antonio Astola Gonzalez, Ruben Ayala Suarez, Asmaa Galal-Khallaf, Juan Antonio Martos-Sitcha, Hany Mohammed Ibrahim, Gonzalo Martinez-Rodriguez, Juan Miguel Mancera
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Public, Environmental & Occupational Health
Hany M. Ibrahim, Azza H. Mohamed, Ahmed A. El-Sharaawy, Hend E. El-Shqanqery
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2017)
Review
Immunology
Gwenoline Borhis, Maria Trovato, Nada Chaoul, Hany M. Ibrahim, Yolande Richard
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Medicine, Research & Experimental
Hany M. Ibrahim, Faten R. Abdel Ghaffar, Ibrahim A. El-Elaimy, Mona S. Gouida, Heba M. Abd El Latif
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Microbiology
Hany M. Ibrahim, Maki Nishimura, Sachi Tanaka, Walaa Awadin, Hidefumi Furuoka, Xuenan Xuan, Yoshifumi Nishikawa
Article
Veterinary Sciences
Yoshifumi Nishikawa, Houshuang Zhang, Hany M. Ibrahim, Kyoko Yamada, Hideyuki Nagasawa, Xuenan Xuan
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2010)
Article
Veterinary Sciences
Yoshifumi Nishikawa, Hany M. Ibrahim, Kyohko Kameyama, Ikumi Shiga, Jun Hiasa, Xuenan Xuan
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2011)
Article
Cell Biology
Hany M. Ibrahim, Ibrahim A. El-Elaimy, Heba M. Saad Eldien, Badr Mohamed Badr, Danny M. Rabah, Gamal Badr
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2013)
Article
Parasitology
Kyohko Kameyama, Maki Nishimura, Myagmarsuren Punsantsogvoo, Hany M. Ibrahim, Xuenan Xuan, Hidefumi Furuoka, Yoshifumi Nishikawa
Article
Parasitology
Hany M. Ibrahim, Paul F. Adjou Moumouni, Khaled Mohammed-Geba, Sherin K. Sheir, Ihab S. Y. Hashem, Shinuo Cao, Mohamad A. Terkawi, Ketsarin Kamyingkird, Yoshifumi Nishikawa, Hiroshi Suzuki, Xuenan Xuan
VETERINARY PARASITOLOGY
(2013)
Article
Virology
Maria Trovato, Hany M. Ibrahim, Stephane Isnard, Roger Le Grand, Nathalie Bosquet, Gwenoline Borhis, Yolande Richard
Summary: The study examined the impact of SIV infection and TT vaccination on the dynamics of B- and T-cells in macaque germinal centers, revealing abnormal helper functions of T-FH cells and reduced numbers of T-FR cells in the SIV infection group, which may limit the development of protective immunity.
Article
Biochemistry & Molecular Biology
Hany M. Ibrahim, Khaled Mohammed-Geba, Amr A. Tawfic, Mohammed A. El-Magd
Article
Parasitology
Hany M. Ibrahim, Gamalat Y. Osman, Azza H. Mohamed, Abduladeem G. M. Al-Selwi, Yoshifumi Nishikawa, Fathy Abdel-Ghaffar
VETERINARY PARASITOLOGY- REGIONAL STUDIES AND REPORTS
(2018)
