期刊
EXPERIMENTAL PARASITOLOGY
卷 126, 期 4, 页码 582-591出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2010.06.011
关键词
Leishmania; Genome; Secretory pathway; Excreted/secreted proteins; Trypanosomatid
类别
资金
- NIH [T32 HL 0712, AI045540, AI067874, AI076233, AI048822, AI-30639]
- National Institutes of Health [R01 AI059451]
- Department of Veterans' Affairs
The parasitic protozoan, Leishmania, survives in harsh environments within its mammalian and sand fly hosts. Secreted proteins likely play critical roles in the parasite's interactions with its environment. As a preliminary identification of the spectrum of potential excreted/secreted (ES) proteins of Leishmania infantum chagasi (Lic), a causative agent of visceral leishmaniasis, we used standard algorithms to screen the annotated L infantum genome for genes whose predicted protein products have an N-terminal signal peptide and lack transmembrane domains and membrane anchors. A suite of 181 candidate ES proteins were identified. These included several that were documented in the literature to be released by other Leishmania spp. Six candidate ES proteins were selected for further validation of their expression and release by different parasite stages. We found both amastigote-specific and promastigote-specific released proteins. The ES proteins of Lic are candidates for future studies of parasite virulence determinants and host protective immunity. Published by Elsevier Inc.
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