Review: the Role and Mechanisms of Macrophage Autophagy in Sepsis

Targeting macrophage immunometabolism: Dawn in the darkness of sepsis

(2018) V. Kumar   INTERNATIONAL IMMUNOPHARMACOLOGY

IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential

(2018) Sonia Boulakirba et al.   Scientific Reports

Reciprocal role of SIRT6 and Hexokinase 2 in the regulation of autophagy driven monocyte differentiation

(2017) Ankita Singh et al.   EXPERIMENTAL CELL RESEARCH

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?

(2017) Martin Sebastian Winkler et al.   PLoS One

Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype

(2017) Haifa Xia et al.   Scientific Reports

Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages

(2016) Jacinta P. W. Lee et al.   Autophagy

The immune system's role in sepsis progression, resolution, and long-term outcome

(2016) Matthew J. Delano et al.   IMMUNOLOGICAL REVIEWS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regulation of inflammasomes by autophagy

(2016) Tatsuya Saitoh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Immune Cell Phenotype and Function in Sepsis

(2016) Thomas Rimmelé et al.   SHOCK

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

(2015) Abdullah A. Tarique et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

(2015) Sandrine Obba et al.   Autophagy

Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy

(2015) Kana Unuma et al.   Autophagy

MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation

(2015) Kuo-Ting Sun et al.   BONE

Autophagy Mediates Tolerance to Staphylococcus aureus Alpha-Toxin

(2015) Katie Maurer et al.   Cell Host & Microbe

Lipopolysaccharide Induces Autophagic Cell Death through the PERK-Dependent Branch of the Unfolded Protein Response in Human Alveolar Epithelial A549 Cells

(2015) Shaoying Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neuronal death after perinatal cerebral hypoxia-ischemia: Focus on autophagy—mediated cell death

(2015) C. Descloux et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Immunologic manifestations of autophagy

(2015) Vojo Deretic et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy Controls Acquisition of Aging Features in Macrophages

(2015) Amanda J. Stranks et al.   Journal of Innate Immunity

Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis

(2015) YunJie Su et al.   Journal of Neuroinflammation

Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction

(2015) Yan Zhang et al.   JOURNAL OF SURGICAL RESEARCH

Resolvin Infectious Inflammation by Targeting the Host Response

(2015) Craig R. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular features of macrophage activation

(2015) Joachim L. Schultze et al.   SEMINARS IN IMMUNOLOGY

Monocyte-mediated defense against bacteria, fungi, and parasites

(2015) Grégoire Lauvau et al.   SEMINARS IN IMMUNOLOGY

Macrophage migration inhibitory factor induces vascular leakage via autophagy

(2015) H.-R. Chen et al.   Biology Open

Signaling pathway of autophagy associated with innate immunity

(2014) Yi Xu et al.   Autophagy

Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity

(2014) Gur P. Kaushal et al.   Autophagy

Autophagy-mediated regulation of macrophages and its applications for cancer

(2014) Peiwen Chen et al.   Autophagy

Physalis angulata induces in vitro differentiation of murine bone marrow cells into macrophages

(2014) Bruno José da Silva et al.   BMC CELL BIOLOGY

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

(2014) Douglas R. Green et al.   CELL

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Natural Killer Cells in Sepsis

(2014) Evangelos J. Giamarellos-Bourboulis   CRITICAL CARE MEDICINE

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia

(2014) Alina Aguirre et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization

(2014) Min Yang et al.   Molecular Cancer

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Omega-3 Free Fatty Acids Suppress Macrophage Inflammasome Activation by Inhibiting NF-κB Activation and Enhancing Autophagy

(2014) Yolanda Williams-Bey et al.   PLoS One

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

(2014) Raja-Elie E. Abdulnour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) prevents lipopolysaccharide (LPS)-induced, sepsis-related severe acute lung injury in mice

(2014) Yuki Takaoka et al.   Scientific Reports

Targeting NFKB by autophagy to polarize hepatoma-associated macrophage differentiation

(2013) Chih-Peng Chang et al.   Autophagy

Autophagy Regulates Phagocytosis by Modulating the Expression of Scavenger Receptors

(2013) Diana L. Bonilla et al.   IMMUNITY

Autophagy activation by interferon-γ via the p38 mitogen-activated protein kinase signalling pathway is involved in macrophage bactericidal activity

(2013) Takeshi Matsuzawa et al.   IMMUNOLOGY

The Significance and Regulatory Mechanisms of Innate Immune Cells in the Development of Sepsis

(2013) Ying-Yi Luan et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Crosstalk between Autophagy and Inflammasomes

(2013) Jae-Min Yuk et al.   MOLECULES AND CELLS

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

(2013) Gina M. Howell et al.   PLoS One

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

(2013) Crystal Rocher et al.   PLoS One

Complete Activation of Autophagic Process Attenuates Liver Injury and Improves Survival in Septic Mice

(2013) Chih-Wen Lin et al.   SHOCK

Enhanced Liver Autophagic Activity Improves Survival of Septic Mice Lacking Surfactant Proteins A and D

(2013) Zhe Tang et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Inflammasome Components Coordinate Autophagy and Pyroptosis as Macrophage Responses to Infection

(2013) B. G. Byrne et al.   mBio

Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms

(2013) Maria Eugenia Mansilla Pareja et al.   Frontiers in Cellular and Infection Microbiology

Lc3 Over-Expression Improves Survival and Attenuates Lung Injury Through Increasing Autophagosomal Clearance in Septic Mice

(2012) Steven Lo et al.   ANNALS OF SURGERY

Proper macrophagic differentiation requires both autophagy and caspase activation

(2012) Arnaud Jacquel et al.   Autophagy

Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions

(2012) A. Jacquel et al.   BLOOD

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

Macrophage-Induced Tumor Angiogenesis Is Regulated by the TSC2-mTOR Pathway

(2012) W. Chen et al.   CANCER RESEARCH

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

(2012) C-P Chang et al.   CELL DEATH AND DIFFERENTIATION

The function of neutrophils in sepsis

(2012) Melissa A. Kovach et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An update

(2012) Angela Gauthier et al.   HEPATOLOGY RESEARCH

Autophagy as a macrophage response to bacterial infection

(2012) Lan Gong et al.   IUBMB LIFE

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(2012) Yinzhong Zhang et al.   MOLECULAR MEDICINE

Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition

(2012) Kevin Bray et al.   PLoS One

Carbon Monoxide Activates Autophagy via Mitochondrial Reactive Oxygen Species Formation

(2011) Seon-Jin Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hyperoxia-Induced LC3B Interacts with the Fas Apoptotic Pathway in Epithelial Cell Death

(2011) Akihiko Tanaka et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Complete Induction of Autophagy Is Essential for Cardioprotection in Sepsis

(2011) Chi-Hsun Hsieh et al.   ANNALS OF SURGERY

Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway

(2011) Paul Waltz et al.   Autophagy

TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS)

(2011) Ken-Ichi Fujita et al.   Autophagy

EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages

(2011) Wei Li et al.   BIOCHEMICAL PHARMACOLOGY

Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

(2011) Evie H. Carchman et al.   HEPATOLOGY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

(2011) Assaf D. Rubinstein et al.   MOLECULAR CELL

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Modulation of Dendritic Cell Differentiation in the Bone Marrow Mediates Sustained Immunosuppression after Polymicrobial Sepsis

(2010) E. Pastille et al.   JOURNAL OF IMMUNOLOGY

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Participation of Mammalian Target of Rapamycin Complex 1 in Toll-Like Receptor 2– and 4–Induced Neutrophil Activation and Acute Lung Injury

(2009) Emmanuel Lorne et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line

(2009) Pascal Colosetti et al.   Autophagy

Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia

(2009) N. Droin et al.   BLOOD

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Autophagy genes in immunity

(2009) Herbert W Virgin et al.   NATURE IMMUNOLOGY

The sepsis seesaw: tilting toward immunosuppression

(2009) Richard S Hotchkiss et al.   NATURE MEDICINE

Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo

(2009) M. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and cellular aspects of sepsis-induced immunosuppression

(2008) Tisha S. Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

(2008) Sudharsan Periyasamy-Thandavan et al.   KIDNEY INTERNATIONAL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE