Article
Biochemistry & Molecular Biology
Min Ji Lee, Jinkun Bae, Jung Ho Lee, Ye Jin Park, Han A. Reum Lee, Sehwan Mun, Yun-seok Kim, Chang June Yune, Tae Nyoung Chung, Kyuseok Kim
Summary: This study investigated the serial changes in endotoxin tolerance in a polymicrobial sepsis model. The results showed that endotoxin tolerance started at 6 hours after sepsis, reached its lowest point at 24 to 48 hours, and then started to recover. Endotoxin tolerance was more prominent in severe sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Seongmin Kim, Ji Heon Noh, Min Ji Lee, Ye Jin Park, Bo Mi Kim, Yun-Seok Kim, Sangik Hwang, Chungoo Park, Kyuseok Kim
Summary: The study demonstrates the beneficial effects of mitochondrial transplantation in a polymicrobial sepsis model. Transcriptomic changes after mitochondrial transplantation were identified, indicating the regulation of gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Zhiwen Cui, Lirui Wang, Hongbin Li, Min Feng
Summary: This study investigated the changes in immune and inflammatory responses in sepsis patients and their association with patient outcomes. The results showed that lymphocyte subset levels were reduced and the proportion of Tregs increased in sepsis patients, indicating immunosuppression. These findings can inform the development of therapeutic approaches to improve immune responses in sepsis patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biology
Ye Jin Park, Min Ji Lee, Jinkun Bae, Jung Ho Lee, Han A. Reum Lee, Sehwan Mun, Yun-seok Kim, Chang June Yune, Tae Nyoung Chung, Kyuseok Kim
Summary: Early administration of 0.2 mg/kg dexamethasone showed beneficial effects in a severe sepsis model, reducing kidney injury and bacterial burden, and lowering the levels of cytokines.
Review
Immunology
Li Li, Yuan-Qiang Lu
Summary: HMGB1 is a crucial player in the inflammatory response and immunosuppression of sepsis, mediating the release of inflammatory factors and potentially contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Wenqin Zhang, Minjie Luo, Yuexue Zhou, Jie Hu, Caiyan Li, Ke Liu, Meidong Liu, Yaxi Zhu, Huan Chen, Huali Zhang
Summary: The study demonstrates that the LXR agonist GW3965 improves survival in septic mice by reducing multi-organ injury and inflammatory cytokine levels, as well as decreasing MDSC abundance in spleen and enhancing bacteria clearance in tissues. GW3965 activates LXR beta and ABCA1 to induce apoptosis of spleen MDSCs, offering a potential approach to target sepsis-induced immunosuppression.
Article
Multidisciplinary Sciences
Pierre Bost, Francesco De Sanctis, Stefania Cane, Stefano Ugel, Katia Donadello, Monica Castellucci, David Eyal, Alessandra Fiore, Cristina Anselmi, Roza Maria Barouni, Rosalinda Trovato, Simone Caligola, Alessia Lamolinara, Manuela Iezzi, Federica Facciotti, Annarita Mazzariol, Davide Gibellini, Pasquale De Nardo, Evelina Tacconelli, Leonardo Gottin, Enrico Polati, Benno Schwikowski, Ido Amit, Vincenzo Bronte
Summary: COVID-19 patients show unique immune features, including lung accumulation of naive lymphoid cells, systemic expansion and activation of myeloid cells, and immune suppression. Loss of monocyte-driven and neutrophil-driven immune suppression may lead to fatal outcomes in severe patients. On the other hand, a lung CXCR6(+) effector memory T cell subset may be associated with better prognosis in severe COVID-19 patients.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Xiaohong Yuan, Yong Wu, Jia Lin, Qinyong Weng, Linqing Wu, Shu Yang, Xin Li, Ming Tan, Zhenxing Lin, Xiaolan Lian, Yuanzhong Chen
Summary: This study investigated the value of plasma fibronectin (pFN) in the diagnosis and prognosis of sepsis and found that pFN can more accurately reflect the severity and prognosis of advanced sepsis. The study also revealed that the absence of pFN alters the cytokine storm and phagocytic function of macrophages.
Review
Medicine, Research & Experimental
Arturo Cerbulo Vazquez, Lourdes Arriaga-Pizano, Eduardo Ferat-Osorio
Summary: Sepsis, caused by pathogen invasion and unregulated response, poses a threat to patient lives with increasing incidence and high mortality rates globally. Understanding the role of cells and inflammatory mediators in host responses is crucial for developing medical treatments to regulate immune responses.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Juveria Usmani, Tahira Khan, Razi Ahmad, Manju Sharma
Summary: Sepsis, a complex pathological reaction caused by host response to microbial invasion, cannot be solely controlled by antibiotics. Herbal plants have shown great potential in immunomodulation, making them a promising option for sepsis treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Jian Chen, Haiming Wei
Summary: Sepsis is a host immune disorder induced by infection, leading to multiple organ dysfunction syndrome with high morbidity and mortality. Despite significant progress in clinical diagnosis and treatment, there is still a lack of specific drugs for sepsis treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Xuzhe Fu, Zhi Liu, Yu Wang
Summary: Sepsis is a life-threatening disease caused by a systemic infection that triggers an imbalanced immune response. Immunosuppression plays a crucial role in sepsis, increasing the susceptibility to secondary infections and mortality. Research into immunosuppression brings new hope for sepsis treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
M. Malavika, S. Sanju, M. R. Poorna, Veeraraghavan Vishnu Priya, Neeraj Sidharthan, Praveen Varma, Ullas Mony
Summary: This review focuses on the role of myeloid derived suppressor cells (MDSCs) in infection, sepsis, and septic shock, and their contribution to lymphopenia and immune suppression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wanying Zhang, Xiangzhi Fang, Chenggang Gao, Chaoying Song, Yajun He, Ting Zhou, Xiaobo Yang, You Shang, Jiqian Xu
Summary: Sepsis is a life-threatening condition resulting from an uncontrolled host response to infection. Myeloid-derived suppressor cells (MDSCs), which consist of pathologically activated neutrophils and monocytes, play an important role in inhibiting innate and adaptive immune responses. This review explores the characteristics and suppressive mechanisms of MDSCs, and discusses their potential applications as biomarkers and targets for clinical treatment of sepsis.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Medicine, Research & Experimental
Ren-qi Yao, Zhi-xuan Li, Li-xue Wang, Yu-xuan Li, Li-yu Zheng, Ning Dong, Yao Wu, Zhao-fan Xia, Timothy R. Billiar, Chao Ren, Yong-ming Yao
Summary: In this study, the heterogeneity of immune cell subsets during sepsis was analyzed using single-cell RNA sequencing. A unique subcluster of dendritic cells called "mregDC" was identified and its presence and function in the disease were confirmed. Furthermore, the study found that the mregDC program was initiated through specific intracellular signaling pathways within 24 hours of septic challenge.
Article
Biochemistry & Molecular Biology
Hirofumi Kamata, Kazuko Yamamoto, Gregory A. Wasserman, Mary C. Zabinski, Constance K. Yuen, Wing Yi Lung, Adam C. Gower, Anna C. Belkina, Maria I. Ramirez, Jane C. Deng, Lee J. Quinton, Matthew R. Jones, Joseph P. Mizgerd
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2016)
Article
Gastroenterology & Hepatology
Alexander D. Zider, Radhika Zopey, Ronak Garg, Xiaoyan Wang, Tisha S. Wang, Jane C. Deng
LIVER INTERNATIONAL
(2016)
Article
Immunology
Stephen J. Gurczynski, Niket Nathani, Helen I. Warheit-Niemi, Elissa M. Hult, Amy Podsiad, Jane Deng, Rachel L. Zemans, Urvashi Bhan, Bethany B. Moore
MUCOSAL IMMUNOLOGY
(2019)
Article
Immunology
Upasana Kulkarni, Rachel L. Zemans, Candice A. Smith, Sherri C. Wood, Jane C. Deng, Daniel R. Goldstein
MUCOSAL IMMUNOLOGY
(2019)
Review
Immunology
Shigeo Hanada, Mina Pirzadeh, Kyle Y. Carver, Jane C. Deng
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Derek E. Dimcheff, Richard J. Schildhouse, Mark S. Hausman, Brenda M. Vincent, Erica Markovitz, Stephen W. Chensue, Jane Deng, Melissa McLeod, Danielle Hagan, Jon Russell, Suzanne F. Bradley
Summary: This study evaluated the seroprevalence of SARS-CoV-2 IgG antibody among employees of a Veterans Affairs healthcare system and found that employees who reported direct personal contact with COVID-19-positive persons outside work were more likely to have SARS-CoV-2 antibodies. The results suggest that employee exposure to SARS-CoV-2 outside of work may introduce infection into hospitals.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Editorial Material
Critical Care Medicine
Matthew K. Hensley, Jane C. Deng
Editorial Material
Medicine, General & Internal
Owen Albin, John P. Mills, Sanjay Saint, Michele Swanson, Jane C. Deng
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Judy Chen, Jane C. Deng, Daniel R. Goldstein
Summary: Aging leads to dysregulation of immune functions, resulting in reduced vaccine efficacy. This review discusses key factors contributing to the age-related decline in vaccine efficacy, such as alterations in lymph nodes, B and T cell compartments, and innate immune pathways. Furthermore, various methods to enhance vaccine efficacy in older adults are also explored. The review underscores the multifactorial defects that impair vaccine responses with aging.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Judy Chen, Jane C. Deng, Rachel L. Zemans, Karim Bahmed, Beata Kosmider, Min Zhang, Marc Peters-Golden, Daniel R. Goldstein
Summary: Aging impairs immune responses against influenza, and prostaglandin E-2 is identified as a factor that compromises host defense to influenza during aging.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Henry H. Gong, Matthew J. Worley, Kyle A. Carver, Daniel R. Goldstein, Jane C. Deng
Summary: In this study, the mechanisms underlying susceptibility to pulmonary vascular leakage in respiratory coronavirus infection were investigated using mice infected with murine hepatitis virus strain 1 (MHV-1). The susceptible mice displayed more severe lung injury and neutrophil influx compared to resistant mice. The susceptible mice also showed overexpression of primary granule protein genes in neutrophils and higher concentrations of myeloperoxidase and elastase protein in the bronchoalveolar spaces. Depletion of neutrophils mitigated lung injury in susceptible mice but had no effect in resistant mice, indicating that differences in neutrophil phenotypes and recruitment profiles contribute to lung immunopathology in susceptible mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jintao Xu, Bing He, Kyle Carver, Debora Vanheyningen, Brian Parkin, Lana X. Garmire, Michal A. Olszewski, Jane C. Deng
Summary: This study provides an in-depth analysis of neutrophil responses in COVID-19 patients and healthy controls, revealing distinct phenotypes of neutrophils during severe infections. The findings suggest that during severe infections, there is a loss of normal regulatory neutrophil phenotypes seen in healthy subjects, coupled with a decrease in appropriate cellular interactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Kathryn H. Melamed, Justin Williams, Xiaoyan Wang, Scott Hu, Christopher Nguyen, Jing Cui, Jane C. Deng
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2020)
Article
Microbiology
Lulan Wang, Su-Yang Liu, Hsiang-Wen Chen, Juan Xu, Maxime Chapon, Tao Zhang, Fan Zhou, Yao E. Wang, Natalie Quanquin, Guiqin Wang, Xiaoli Tian, Zhanlong He, Longding Liu, Wenhai Yu, David Jesse Sanchez, Yuying Liang, Taijiao Jiang, Robert Modlin, Barry R. Bloom, Qihan Li, Jane C. Deng, Paul Zhou, F. Xiao-Feng Qin, Genhong Cheng
CELL HOST & MICROBE
(2017)
Article
Respiratory System
Jason E. Prasso, Jane C. Deng
CLINICS IN CHEST MEDICINE
(2017)