期刊
AUTOPHAGY
卷 10, 期 2, 页码 192-200出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.26927
关键词
autophagy; tumor-associated macrophages; cancer; macrophage production; macrophage polarization
类别
资金
- Italian Ministry of Education, University and Research
- Cariparo Foundation
- University of Padova
Autophagy is a highly conserved homeostatic pathway that plays an important role in tumor development and progression by acting on cancer cells in a cell-autonomous mechanism. However, the solid tumor is not an island, but rather an ensemble performance that includes nonmalignant stromal cells, such as macrophages. A growing body of evidence indicates that autophagy is a key component of the innate immune response. In this review, we discuss the role of autophagy in the control of macrophage production at different stages (including hematopoietic stem cell maintenance, monocyte/macrophage migration, and monocyte differentiation into macrophages) and polarization and discuss how modulating autophagy in tumor-associated macrophages (TAMs) may represent a promising strategy for limiting cancer growth and progression.
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