Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization

Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization

(2013) Donna M. Small et al.   INTERNATIONAL JOURNAL OF CANCER

Cathepsin B as a potential prognostic and therapeutic marker for human lung squamous cell carcinoma

(2013) Fengming Gong et al.   Molecular Cancer

Serum-Glucocorticoid Regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II–Induced Inflammation and Cardiac Fibrosis

(2012) Min Yang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

(2012) N. P. Withana et al.   CANCER RESEARCH

A Nonpeptidic Cathepsin S Activity-Based Probe for Noninvasive Optical Imaging of Tumor-Associated Macrophages

(2012) Martijn Verdoes et al.   CHEMISTRY & BIOLOGY

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

(2012) Lin Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cathepsin S dominates autoantigen processing in human thymic dendritic cells

(2012) Christina Stoeckle et al.   JOURNAL OF AUTOIMMUNITY

Cathepsin S Deficiency Results in Abnormal Accumulation of Autophagosomes in Macrophages and Enhances Ang II–Induced Cardiac Inflammation

(2012) Lili Pan et al.   PLoS One

The role of Cathepsin S as a marker of prognosis and predictor of chemotherapy benefit in adjuvant CRC: a pilot study

(2011) J A Gormley et al.   BRITISH JOURNAL OF CANCER

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

Antibody targeting of Cathepsin S induces antibody-dependent cellular cytotoxicity

(2011) Hang Fai Kwok et al.   Molecular Cancer

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Antibody Targeting of Cathepsin S Inhibits Angiogenesis and Synergistically Enhances Anti-VEGF

(2010) Claire Ward et al.   PLoS One

Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis

(2009) R. E. Burden et al.   CLINICAL CANCER RESEARCH

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells

(2009) Ludovic Gillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

(2009) G. Solinas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer

(2009) Hiroshi Kurahara et al.   JOURNAL OF SURGICAL RESEARCH

Endoplasmic reticulum stress and autophagy as targets for cancer therapy

(2008) Axel H. Schönthal   CANCER LETTERS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Cysteine cathepsin S as an immunomodulatory target: present and future trends

(2008) Suman Gupta et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival

(2008) Ivan Shabo et al.   INTERNATIONAL JOURNAL OF CANCER

Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum

(2008) Kenjiro Sakaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling

(2008) E. Schonteich et al.   JOURNAL OF CELL SCIENCE

Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas

(2008) Y Komohara et al.   JOURNAL OF PATHOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE