Elucidating the Genotype–Phenotype Relationships and Network Perturbations of Human Shared and Specific Disease Genes from an Evolutionary Perspective
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Title
Elucidating the Genotype–Phenotype Relationships and Network Perturbations of Human Shared and Specific Disease Genes from an Evolutionary Perspective
Authors
Keywords
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Journal
Genome Biology and Evolution
Volume 6, Issue 10, Pages 2741-2753
Publisher
Oxford University Press (OUP)
Online
2014-10-07
DOI
10.1093/gbe/evu220
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Note: Only part of the references are listed.- A general framework for estimating the relative pathogenicity of human genetic variants
- (2014) Martin Kircher et al. NATURE GENETICS
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- (2013) Sandip Chakraborty et al. Genome Biology and Evolution
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- (2013) Xiaotong Wang et al. Genome Biology and Evolution
- dbNSFP v2.0: A Database of Human Non-synonymous SNVs and Their Functional Predictions and Annotations
- (2013) Xiaoming Liu et al. HUMAN MUTATION
- Global versus Local Hubs in Human Protein–Protein Interaction Network
- (2013) Manjari Kiran et al. JOURNAL OF PROTEOME RESEARCH
- iPfam: a database of protein family and domain interactions found in the Protein Data Bank
- (2013) Robert D. Finn et al. NUCLEIC ACIDS RESEARCH
- DrugBank 4.0: shedding new light on drug metabolism
- (2013) Vivian Law et al. NUCLEIC ACIDS RESEARCH
- 3did: a catalog of domain-based interactions of known three-dimensional structure
- (2013) Roberto Mosca et al. NUCLEIC ACIDS RESEARCH
- Recent Adaptive Events in Human Brain Revealed by Meta-Analysis of Positively Selected Genes
- (2013) Yue Huang et al. PLoS One
- Target Essentiality and Centrality Characterize Drug Side Effects
- (2013) Xiujuan Wang et al. PLoS Computational Biology
- Biological function through network topology: a survey of the human diseasome
- (2012) V. Janjic et al. Briefings in Functional Genomics
- Novel insights through the integration of structural and functional genomics data with protein networks
- (2012) Declan Clarke et al. JOURNAL OF STRUCTURAL BIOLOGY
- Three-dimensional reconstruction of protein networks provides insight into human genetic disease
- (2012) Xiujuan Wang et al. NATURE BIOTECHNOLOGY
- SIFT web server: predicting effects of amino acid substitutions on proteins
- (2012) Ngak-Leng Sim et al. NUCLEIC ACIDS RESEARCH
- Ensembl 2013
- (2012) Paul Flicek et al. NUCLEIC ACIDS RESEARCH
- Insights into the Evolutionary Features of Human Neurodegenerative Diseases
- (2012) Arup Panda et al. PLoS One
- When orthologs diverge between human and mouse
- (2011) W. H. Gharib et al. BRIEFINGS IN BIOINFORMATICS
- Molecular Evolution, Mutation Size and Gene Pleiotropy: A Geometric Reexamination
- (2011) P. Razeto-Barry et al. GENETICS
- Substitution Patterns Are Under Different Influences in Primates and Rodents
- (2011) Yves Clément et al. Genome Biology and Evolution
- A systematic characterization of genes underlying both complex and Mendelian diseases
- (2011) Wenfei Jin et al. HUMAN MOLECULAR GENETICS
- Independent Effects of Alternative Splicing and Structural Constraint on the Evolution of Mammalian Coding Exons
- (2011) F.-C. Chen et al. MOLECULAR BIOLOGY AND EVOLUTION
- The quantitative proteome of a human cell line
- (2011) M. Beck et al. Molecular Systems Biology
- Comparative Network Analysis Reveals That Tissue Specificity and Gene Function Are Important Factors Influencing the Mode of Expression Evolution in Arabidopsis and Rice
- (2011) S. Movahedi et al. PLANT PHYSIOLOGY
- CAERUS: Predicting CAncER oUtcomeS Using Relationship between Protein Structural Information, Protein Networks, Gene Expression Data, and Mutation Data
- (2011) Kelvin Xi Zhang et al. PLoS Computational Biology
- Expression breadth and expression abundance behave differently in correlations with evolutionary rates
- (2010) Seung Park et al. BMC EVOLUTIONARY BIOLOGY
- Network properties of human disease genes with pleiotropic effects
- (2010) Sreenivas Chavali et al. BMC Systems Biology
- Understanding the Effect of Secondary Structures and Aggregation on Human Protein Folding Class Evolution
- (2010) Tina Begum et al. JOURNAL OF MOLECULAR EVOLUTION
- Network medicine: a network-based approach to human disease
- (2010) Albert-László Barabási et al. NATURE REVIEWS GENETICS
- DIMA 3.0: Domain Interaction Map
- (2010) Q. Luo et al. NUCLEIC ACIDS RESEARCH
- GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists
- (2009) Eran Eden et al. BMC BIOINFORMATICS
- Similarly Strong Purifying Selection Acts on Human Disease Genes of All Evolutionary Ages
- (2009) James J. Cai et al. Genome Biology and Evolution
- Nonlinear Dynamics of Nonsynonymous (dN) and Synonymous (dS) Substitution Rates Affects Inference of Selection
- (2009) Jochen B. W. Wolf et al. Genome Biology and Evolution
- Combining the interactome and deleterious SNP predictions to improve disease gene identification
- (2009) M.A. Care et al. HUMAN MUTATION
- Exploring the Differences in Evolutionary Rates between Monogenic and Polygenic Disease Genes in Human
- (2009) S. Podder et al. MOLECULAR BIOLOGY AND EVOLUTION
- Edgetic perturbation models of human inherited disorders
- (2009) Quan Zhong et al. Molecular Systems Biology
- CORUM: the comprehensive resource of mammalian protein complexes—2009
- (2009) Andreas Ruepp et al. NUCLEIC ACIDS RESEARCH
- Bi-Directional SIFT Predicts a Subset of Activating Mutations
- (2009) William Lee et al. PLoS One
- Structural imperatives impose diverse evolutionary constraints on helical membrane proteins
- (2009) A. Oberai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Human Gene Mutation Database: 2008 update
- (2009) Peter D Stenson et al. Genome Medicine
- An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data
- (2009) Daniel Ramsköld et al. PLoS Computational Biology
- Topological properties of protein interaction networks from a structural perspective
- (2008) Attila Gursoy et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Natural Selection on Genes that Underlie Human Disease Susceptibility
- (2008) Ran Blekhman et al. CURRENT BIOLOGY
- Alternative isoform regulation in human tissue transcriptomes
- (2008) Eric T. Wang et al. NATURE
- McKusick's Online Mendelian Inheritance in Man (OMIM(R))
- (2008) J. Amberger et al. NUCLEIC ACIDS RESEARCH
- Human Protein Reference Database--2009 update
- (2008) T. S. Keshava Prasad et al. NUCLEIC ACIDS RESEARCH
- A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes
- (2008) K. Lage et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Null mutations in human and mouse orthologs frequently result in different phenotypes
- (2008) B.-Y. Liao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional protein divergence in the evolution of Homo sapiens
- (2008) Nuria Lopez-Bigas et al. GENOME BIOLOGY
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