Fighting against kidney diseases with small interfering RNA: opportunities and challenges

Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury

(2015) Jianping Peng et al.   KIDNEY INTERNATIONAL

Actively-targeted polyion complex micelles stabilized by cholesterol and disulfide cross-linking for systemic delivery of siRNA to solid tumors

(2014) Yusuke Oe et al.   BIOMATERIALS

Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies

(2014) Yan Deng et al.   GENE

Tubular p53 Regulates Multiple Genes to Mediate AKI

(2014) D. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Network analysis reveals roles of inflammatory factors in different phenotypes of kidney transplant patients

(2014) Duojiao Wu et al.   JOURNAL OF THEORETICAL BIOLOGY

Global CNS Transduction of Adult Mice by Intravenously Delivered rAAVrh.8 and rAAVrh.10 and Nonhuman Primates by rAAVrh.10

(2014) Bin Yang et al.   MOLECULAR THERAPY

The effect of FoxO1 on the proliferation of rat mesangial cells under high glucose conditions

(2014) F. Liu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Molecular Pathogenesis of Post-Transplant Acute Kidney Injury: Assessment of Whole-Genome mRNA and MiRNA Profiles

(2014) Julia Wilflingseder et al.   PLoS One

Managing renal transplant ischemia reperfusion injury: novel therapies in the pipeline

(2013) Jaclyn T. Powell et al.   CLINICAL TRANSPLANTATION

Investigating siRNA delivery to chronic myeloid leukemia K562 cells with lipophilic polymers for therapeutic BCR-ABL down-regulation

(2013) Juliana Valencia-Serna et al.   JOURNAL OF CONTROLLED RELEASE

Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA

(2013) Cheng Yang et al.   Journal of Translational Medicine

The siRNA cocktail targeting VEGF and HER2 inhibition on the proliferation and induced apoptosis of gastric cancer cell

(2013) Kun Liu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Small Interfering RNA Targeting Toll-Like Receptor 9 Protects Mice against Polymicrobial Septic Acute Kidney Injury

(2013) Lixia Liu et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Acetylation of histone H3 prevents resistance development caused by chronic mTOR inhibition in renal cell carcinoma cells

(2012) Eva Juengel et al.   CANCER LETTERS

siRNA Delivery: From Lipids to Cell-penetrating Peptides and Their Mimics

(2012) Matt Gooding et al.   Chemical Biology & Drug Design

Role of Renal DJ-1 in the Pathogenesis of Hypertension Associated With Increased Reactive Oxygen Species Production

(2012) Santiago Cuevas et al.   HYPERTENSION

Naked caspase 3 small interfering RNA is effective in cold preservation but not in autotransplantation of porcine kidneys

(2012) Cheng Yang et al.   JOURNAL OF SURGICAL RESEARCH

TGFBI-promoted Adhesion, Migration and Invasion of Human Renal Cell Carcinoma Depends on Inactivation of von Hippel-Lindau Tumor Suppressor

(2012) Donghao Shang et al.   UROLOGY

The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions

(2011) Bo Young Nam et al.   APOPTOSIS

Cell-to-cell and long-distance siRNA movement in plants: mechanisms and biological implications

(2011) Christopher Andrew Brosnan et al.   CURRENT OPINION IN PLANT BIOLOGY

RNA Interference in Fungi: Pathways, Functions, and Applications

(2011) Yunkun Dang et al.   EUKARYOTIC CELL

Targeted siRNA delivery to diseased microvascular endothelial cells-Cellular and molecular concepts

(2011) Piotr S. Kowalski et al.   IUBMB LIFE

Synthetic small interfering RNA down-regulates caspase-3 and affects apoptosis, IL-1β, and viability of porcine proximal tubular cells

(2011) Bin Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Systemic Administration of Combinatorial dsiRNAs via Nanoparticles Efficiently Suppresses HIV-1 Infection in Humanized Mice

(2011) Jiehua Zhou et al.   MOLECULAR THERAPY

RNA Interference and Cancer Therapy

(2011) Zhaohui Wang et al.   PHARMACEUTICAL RESEARCH

Immune Activation and Target Organ Damage Are Consequences of Hydrodynamic Treatment but Not Delivery of Naked siRNAs in Mice

(2011) Zsuzsanna Rácz et al.   Nucleic Acid Therapeutics

RNA interference for improving the outcome of islet transplantation

(2010) Feng Li et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of a software tool and criteria evaluation for efficient design of small interfering RNA

(2010) Aparna Chaudhary et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of the RNA-binding protein HuR in human renal cell carcinoma

(2010) Sabrina Danilin et al.   CARCINOGENESIS

Small RNA Regulators of T Cell-Mediated Autoimmunity

(2010) Lukas T. Jeker et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Promise and Challenge of RNA Interference–Based Therapy for Cancer

(2010) Fabio Petrocca et al.   JOURNAL OF CLINICAL ONCOLOGY

Analysis of Transcriptional Factors and Regulation Networks in Patients with Acute Renal Allograft Rejection

(2010) Duojiao Wu et al.   JOURNAL OF PROTEOME RESEARCH

siRNA-Based Therapy Ameliorates Glomerulonephritis

(2010) H. Shimizu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Naked Small Interfering RNA of Caspase-3 in Preservation Solution and Autologous Blood Perfusate Protects Isolated Ischemic Porcine Kidneys

(2010) Bin Yang et al.   TRANSPLANTATION

HuR expression is a marker of poor prognosis in renal cell carcinoma

(2010) Hanna Ronkainen et al.   TUMOR BIOLOGY

Leveraging therapeutic potential of multi-targeted siRNA inhibitors

(2009) Qing Ge et al.   Future Medicinal Chemistry

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury

(2009) B. A. Molitoris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

siRNA and Innate Immunity

(2009) Marjorie Robbins et al.   OLIGONUCLEOTIDES

The mitochondrial p53 pathway

(2008) Angelina V. Vaseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Evaluation and Initial Management of Acute Kidney Injury

(2008) J. Himmelfarb et al.   Clinical Journal of the American Society of Nephrology

RNA Silencing: Small RNA-Mediated Posttranscriptional Regulation of mRNA and the Implications for Heart Electropathophysiology

(2008) MICHAEL V. G. LATRONICO et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Guided Molecular Missiles for Tumor-Targeting Chemotherapy—Case Studies Using the Second-Generation Taxoids as Warheads

(2007) Iwao Ojima   ACCOUNTS OF CHEMICAL RESEARCH