Article
Genetics & Heredity
Hui-Ching Wang, Chien-Jung Chiang, Ta-Chih Liu, Chun-Chieh Wu, Yi-Ting Chen, Jan-Gowth Chang, Grace S. Shieh
Summary: This study identified novel immunohistochemical (IHC) prognostic markers for Asian oral squamous cell carcinoma (OSCC). Through multivariate analysis, significant IHC marker pairs were identified, improving the current state-of-the-art for identification of IHC markers.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Jiangbo Chen, Pin Gao, Lin Peng, Tianqi Liu, Fan Wu, Kai Xu, Lei Chen, Fei Tan, Pu Xing, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su
Summary: This study found that STK25 plays a crucial role in colorectal cancer and inhibits autophagy by activating the JAK2/STAT3 pathway, providing a potential indicator for therapies targeting CRC.
MOLECULAR CARCINOGENESIS
(2022)
Article
Oncology
Marko Hojnik, Snjezana Frkovic Grazio, Ivan Verdenik, Tea Lanisnik Rizner
Summary: The study found that AKR1B1 and AKR1B10 play protective roles in endometrioid endometrial cancer and have the potential as prognostic biomarkers. Patients with higher immunohistochemical levels of both AKR1B1 and AKR1B10 showed better survival rates. However, no significant differences were observed in patients with serous endometrial cancer.
Article
Pharmacology & Pharmacy
Balazs Gyorffy
Summary: This study established a comprehensive database of transcriptome-level data for lung cancer, which can be used to identify and rank the most promising biomarkers and therapeutic targets for different subtypes of lung cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Cell Biology
Xiang An, Wenlong Lin, Huan Liu, Weixiang Zhong, Xiuming Zhang, Yimin Zhu, Xiaojian Wang, Jun Li, Qinsong Sheng
Summary: The study found heterogeneous expression patterns of ACE2 protein in the gastrointestinal tract, with a punctate distribution in hepatic cells. Compared to adjacent non-tumor tissues, ACE2 protein expression was significantly increased in colon, stomach, and pancreatic cancer tissues but decreased in liver cancer tissues. The expression level of ACE2 protein was not correlated with patient survival in gastrointestinal cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Alexandra Daks, Alexey Petukhov, Olga Fedorova, Oleg Shuvalov, Alena Kizenko, Elizaveta Tananykina, Elena Vasileva, Oleg Semenov, Andrew Bottrill, Nickolai Barlev
Summary: Proteomic analysis revealed that the RING-finger protein Pirh2 interacts with a group of proteins related to RNA metabolism, including HuR. Pirh2 ubiquitinates HuR, leading to its degradation in response to heat shock, affecting the heat-shock response of cancer cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Anna Buchholz, Aurelia Vattai, Sophie Furst, Theresa Vilsmaier, Christina Kuhn, Elisa Schmoeckel, Doris Mayr, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene H. Heidegger
Summary: EP4 was found to be commonly expressed in vulvar cancer tissue, with significant correlations to tumor size and FIGO classification, as well as poorer overall survival and disease-free survival. EP4 was identified as an independent prognostic factor, and it was shown in vitro to attenuate viability and proliferation of vulvar cancer cells. Further research on the influence of EP4 in the tumor microenvironment and its potential as a therapeutic target is needed.
Article
Oncology
Georgia Levidou, Pawel Gajdzis, Nathalie Cassoux, Piotr Donizy, Christos Masaoutis, Malgorzata Gajdzis, Sophie Gardrat, Alexandros Pergaris, Eougken Danas, Jerzy Klijanienko, Stamatios Theocharis
Summary: HDACs, especially HDAC-2, may play a significant role in the development and progression of uveal melanoma, with potential implications for patient prognosis. This study evaluated the expression of HDAC-1, -2, -4, and -6 in UM cases and found associations with tumor characteristics and patient survival.
Article
Oncology
Sun-Young Jun, Seung-Mo Hong, Kee-Taek Jang
Summary: The expression of Cyclin D1 in small intestinal adenocarcinomas (SIACs) has not been comprehensively studied. This study found that Cyclin D1 is commonly overexpressed in SIACs, and high expression of Cyclin D1 is associated with favorable prognostic indicators.
Article
Oncology
Anna Buchholz, Aurelia Vattai, Sophie Fuerst, Theresa Vilsmaier, Alaleh Zati Zehni, Alexander Steger, Christina Kuhn, Elisa Schmoeckel, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene H. Heidegger
Summary: In recent years, vulvar cancer incidence has been increasing, but treatment options are limited. This study investigated the expression of EP1 in vulvar cancer and its correlation with clinicopathological parameters. The results suggest that EP1 expression is associated with tumor grading and may influence cell differentiation, providing important insights into the molecular mechanisms of carcinogenesis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mourad Assidi, Fatimah M. Yahya, Maryam H. Al-Zahrani, Razan Elkhatib, Ali Zari, Aisha Elaimi, Jaudah Al-Maghrabi, Ashraf Dallol, Abdelbaset Buhmeida, Muhammad Abu-Elmagd
Summary: This study investigated the expression pattern and methylation profiles of leptin (LEP) in ovarian cancer (OC), and found that high LEP protein expression is associated with better survival outcomes. The results suggest that LEP expression in OC may be regulated by promoter hypermethylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Salagacka-Kubiak, Dawid Zawada, Lias Saed, Radzislaw Kordek, Agnieszka Jelen, Ewa Balcerczak
Summary: ABCG2 is a cell membrane pump encoded by the ABCG2 gene, which can protect cells against compounds initiating and/or intensifying neoplasia and is considered a marker of cancer stem cells. Its prognostic significance in colorectal cancer remains unclear. Using publicly available data, ABCG2 was shown to be underexpressed in colon and rectum adenocarcinomas, and this downregulation could result from the methylation level of some sites of the ABCG2 gene. However, no association was found between ABCG2 expression level and survival of colorectal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yuexiang Liang, Jingli Cui, Fanghui Ding, Yiping Zou, Hanhan Guo, Quan Man, Shaofei Chang, Song Gao, Jihui Hao
Summary: The current TNM staging system for pancreatic ductal adenocarcinoma (PDAC) has shown inconsistent results in validating the revised definitions of T and N categories and stage groups. Thus, a new staging system incorporating various factors is proposed to improve the accuracy of prognosis assessment. This proposed staging system demonstrates superior prognostic performance compared to the TNM staging system, effectively stratifying survival and addressing the limitations of TNM staging in prognostication.
Article
Oncology
Jingwei Du, Jun Feng, Deyan Luo, Lijuan Peng
Summary: The meta-analysis results suggest that COX-2 overexpression is significantly associated with increased risk, worse clinicopathological progression, and poorer prognosis of laryngeal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Shinji Tsukamoto, Andreas F. Mavrogenis, Lucia Angelelli, Alberto Righi, Giuseppe Filardo, Akira Kido, Kanya Honoki, Yuu Tanaka, Yasuhito Tanaka, Costantino Errani
Summary: The 5-year disease-free survival rate for patients with localized extraskeletal osteosarcoma (ESOS) who underwent surgery combined with (neo)adjuvant chemotherapy was slightly higher than those who underwent surgery alone. Therefore, routine adjuvant chemotherapy for localized ESOS should be avoided.
Article
Biochemistry & Molecular Biology
Ping Gao, Ji-Han Xia, Csilla Sipeky, Xiao-Ming Dong, Qin Zhang, Yuehong Yang, Peng Zhang, Sara Pereira Cruz, Kai Zhang, Jing Zhu, Hang-Mao Lee, Sufyan Suleman, Nikolaos Giannareas, Song Liu, Teuvo L. J. Tammela, Anssi Auvinen, Xiaoyue Wang, Qilai Huang, Liguo Wang, Aki Manninen, Markku H. Vaarala, Liang Wang, Johanna Schleutker, Gong-Hong Wei
Article
Nursing
Markku H. Vaarala
JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
(2018)
Article
Medicine, General & Internal
Matthew R. Smith, Fred Saad, Simon Chowdhury, Stephane Oudard, Boris A. Hadaschik, Julie N. Graff, David Olmos, Paul N. Mainwaring, Ji Youl Lee, Hiroji Uemura, Angela Lopez-Gitlitz, Geralyn C. Trudel, Byron M. Espina, Youyi Shu, Youn C. Park, Wayne R. Rackoff, Margaret K. Yu, Eric J. Small
NEW ENGLAND JOURNAL OF MEDICINE
(2018)
Article
Urology & Nephrology
Panu P. Tonttila, Anne Ahtikoski, Mari Kuisma, Eija Paakko, Pasi Hirvikoski, Markku H. Vaarala
Article
Medicine, General & Internal
T. K. Choueiri, P. Tomczak, S. H. Park, B. Venugopal, T. Ferguson, Y. -H. Chang, J. Hajek, S. N. Symeonides, J. L. Lee, N. Sarwar, A. Thiery-Vuillemin, M. Gross-Goupil, M. Mahave, N. B. Haas, P. Sawrycki, H. Gurney, C. Chevreau, B. Melichar, E. Kopyltsov, A. Alva, J. M. Burke, G. Doshi, D. Topart, S. Oudard, H. Hammers, H. Kitamura, J. Bedke, R. F. Perini, P. Zhang, K. Imai, J. Willemann-Rogerio, D. I. Quinn, T. Powles
Summary: The study showed that adjuvant pembrolizumab therapy significantly improved disease-free survival compared to placebo among high-risk kidney cancer patients after surgery, with a positive impact on overall survival as well.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Lauri Laru, Hanna Ronkainen, Pasi Ohtonen, Markku H. Vaarala
Summary: This study shows that surgical treatment of metastatic renal cell cancer can significantly improve survival in patients with good and moderate performance status.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Urology & Nephrology
Erkkila Kaisa, Thea Veitonmaki, Otto Ettala, Hanna Ronkainen, Taina Isotalo, Timo Nykopp, Heikki Seikkula, Marjo Seppanen, Margus Tramberg, Christian Palmberg, Ansa Kilponen, Pogodin-Hannolainen Dimitri, Sirkku Mustonen, Harry Nisen
Summary: There is significant variation in Clavien-Dindo (CD) complication rates in urology, indicating the need for central review and detailed guidelines in the application of the CD system in kidney tumor surgery.
SCANDINAVIAN JOURNAL OF UROLOGY
(2021)
Article
Oncology
Lauri Laru, Hanna Ronkainen, Markku H. Vaarala
Summary: This study based on a nationwide cohort in Finland found that the overall survival of mRCC patients has improved since the introduction of targeted therapies, but remains poor for frail, elderly patients with impaired performance status.
INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Matthew R. Smith, Maha Hussain, Fred Saad, Karim Fizazi, Cora N. Sternberg, E. David Crawford, Evgeny Kopyltsov, Chandler H. Park, Boris Alekseev, Alvaro Montesa-Pino, Dingwei Ye, Francis Parnis, Felipe Cruz, Teuvo L. J. Tammela, Hiroyoshi Suzuki, Tapio Utriainen, Cheng Fu, Motohide Uemura, Maria J. Mendez-Vidal, Benjamin L. Maughan, Heikki Joensuu, Silke Thiele, Rui Li, Iris Kuss, Bertrand Tombal
Summary: Darolutamide, in combination with androgen-deprivation therapy and docetaxel, significantly increased overall survival among patients with metastatic hormone-sensitive prostate cancer compared to placebo plus androgen-deprivation therapy and docetaxel. The addition of darolutamide also led to improvement in secondary end points without notable differences in adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Aino Siltari, Jarno Riikonen, Juha Koskimaki, Tomi Pakarainen, Otto Ettala, Peter Bostrom, Heikki Seikkula, Andres Kotsar, Teuvo Tammela, Mika Helminen, Paavo Raittinen, Terho Lehtimaki, Mikkel Fode, Peter Ostergren, Michael Borre, Antti Rannikko, Timo Marttila, Arto Salonen, Hanna Ronkainen, Sven Loffeler, Teemu J. Murtola
Summary: This study aims to test the efficacy of statins in delaying castration resistance during androgen deprivation therapy for prostate cancer and explore its impact on prostate cancer mortality and lipid metabolism. In a randomized placebo-controlled trial, 400 men with primary metastatic or recurrent prostate cancer will be recruited and divided into two groups: one receiving statins and the other receiving placebo.
Article
Urology & Nephrology
Harry Nisen, Kaisa Erkkila, Otto Ettala, Hanna Ronkainen, Taina Isotalo, Timo Nykopp, Heikki Seikkula, Marjo Seppanen, Margus Tramberg, Christian Palmberg, Ansa Kilponen, Dimitri Pogodin-Hannolainen, Sirkku Mustonen, Thea Veitonmaki
Summary: This study applied and validated the intraoperative adverse incident classification (EAUiaiC) for kidney tumor surgery. The study found that bleeding was the most important adverse event in these surgeries, while bowel and ureter injuries were less common. The associations between adverse events and preoperative variables and postoperative outcome demonstrated the validity of the EAUiaiC classification.
SCANDINAVIAN JOURNAL OF UROLOGY
(2022)
Article
Oncology
Ilkka Nikulainen, Antti P. Salminen, Heikki Seikkula, Mikael Hogerman, Ileana Montoya Perez, Ilmari Koskinen, Jukka Sairanen, Jussi Nikkola, Teemu J. Murtola, Markku H. Vaarala, Senja Jousmaki, Timo K. Nykopp, Taina Isotalo, Timo Marttila, Abdiwahid Alibeto, Marjo Seppanen, Christian Palmberg, Peter J. Bostrom
Summary: This study analyzed population-based data from Finland to report short and long-term survival outcomes of patients undergoing radical cystectomy for bladder cancer. The results showed that the volume of surgical centers was not significantly associated with surgical mortality or long-term survival. Survival rates and disease-specific survival rates varied significantly based on the pTNM staging, and the presence of lymph node metastases had a significant impact on patient survival.
Article
Oncology
Thomas Powles, Piotr Tomczak, Se Hoon Park, Balaji Venugopal, Thomas Ferguson, Stefan N. Symeonides, Jaroslav Hajek, Howard Gurney, Yen-Hwa Chang, Jae Lyun Lee, Naveed Sarwar, Antoine Thiery-Vuillemin, Marine Gross-Goupil, Mauricio Mahave, Naomi B. Haas, Piotr Sawrycki, Joseph E. Burgents, Lei Xu, Kentaro Imai, David Quinn, Toni K. Choueiri
Summary: This study provides updated evidence supporting the use of adjuvant pembrolizumab monotherapy as a standard care for patients with clear cell renal cell carcinoma at an increased risk of recurrence after nephrectomy. It demonstrates improved disease-free survival and acceptable safety profile.
Article
Oncology
Antti P. Salminen, Ilmari Koskinen, Ileana Montoya Perez, Saija Hurme, Teemu J. Murtola, Markku H. Vaarala, Timo K. Nykopp, Marjo Seppanen, Taina Isotalo, Timo Marttila, Lasse Levomaki, Sebastian Becker, Mikael Anttinen, Tapani Liukkonen, Matti Saily, Dimitri Pogodin-Hannolainen, Jouko Viitanen, Christian Palmberg, Juhani Ottelinr, Jukka Sairanen, Otto O. Ettala, Peter J. Bostrom
EUROPEAN UROLOGY ONCOLOGY
(2018)