siRNA Delivery: From Lipids to Cell-penetrating Peptides and Their Mimics

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interaction of Nucleic Acids with the Glycocalyx

(2012) Michael J. Palte et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pendant Polymer:Amino-β-Cyclodextrin:siRNA Guest:Host Nanoparticles as Efficient Vectors for Gene Silencing

(2012) Aditya Kulkarni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane

(2012) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding and transport of PAMAM-RGD in a tumor spheroid model: The effect of RGD targeting ligand density

(2011) Carolyn L. Waite et al.   BIOTECHNOLOGY AND BIOENGINEERING

Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule-Mediated Delivery of siRNA

(2011) Matt Gooding et al.   Chemical Biology & Drug Design

Scavenger receptor-mediated uptake of cell-penetrating peptide nanocomplexes with oligonucleotides

(2011) Kariem Ezzat et al.   FASEB JOURNAL

Mitochondria Associate with P-bodies and Modulate MicroRNA-mediated RNA Interference

(2011) Lue Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems

(2011) Olivia M. Merkel et al.   JOURNAL OF CONTROLLED RELEASE

Maximizing the Therapeutic Window of an Antimicrobial Drug by Imparting Mitochondrial Sequestration in Human Cells

(2011) Mark P. Pereira et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interaction of Cholesterol-Conjugated Ionizable Amino Lipids with Biomembranes: Lipid Polymorphism, Structure–Activity Relationship, and Implications for siRNA Delivery

(2011) Jingtao Zhang et al.   LANGMUIR

Efficient In Vivo Delivery of siRNA Into Brain Capillary Endothelial Cells Along With Endogenous Lipoprotein

(2011) Hiroya Kuwahara et al.   MOLECULAR THERAPY

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

(2011) Tore-Geir Iversen et al.   Nano Today

Polycationic amphiphilic cyclodextrin-based nanoparticles for therapeutic gene delivery

(2011) Alejandro Méndez-Ardoy et al.   Nanomedicine

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo

(2011) Samir EL Andaloussi et al.   NUCLEIC ACIDS RESEARCH

Anion mediated activation of guanidine rich small molecules

(2011) Abhigyan Som et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of Novel Peptides for Mitochondrial Drug Delivery: Amino Acids Featuring Delocalized Lipophilic Cations

(2011) Shana O. Kelley et al.   PHARMACEUTICAL RESEARCH

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Insight into the Cellular Uptake Mechanism of a Secondary Amphipathic Cell-Penetrating Peptide for siRNA Delivery

(2010) Karidia Konate et al.   BIOCHEMISTRY

Nucleic acid transfer with hemifluorinated polycationic lipids

(2010) Emmanuel Klein et al.   BIOMATERIALS

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

(2010) Ranit Kedmi et al.   BIOMATERIALS

Cationic lipid-mediated nucleic acid delivery: beyond being cationic

(2010) N. Madhusudhana Rao   CHEMISTRY AND PHYSICS OF LIPIDS

Lipid and polymeric carrier-mediated nucleic acid delivery

(2010) Lin Zhu et al.   Expert Opinion on Drug Delivery

Efficient and targeted delivery of siRNA in vivo

(2010) Min Suk Shim et al.   FEBS Journal

High-Density Lipoprotein Facilitates In Vivo Delivery of α-Tocopherol–Conjugated Short-Interfering RNA to the Brain

(2010) Yoshitaka Uno et al.   HUMAN GENE THERAPY

Dendrimer toxicity: Let's meet the challenge

(2010) Keerti Jain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

RNA interference in vitro and in vivo using an arginine peptide/siRNA complex system

(2010) Sung Wook Kim et al.   JOURNAL OF CONTROLLED RELEASE

Delivery of therapeutic shRNA and siRNA by Tat fusion peptide targeting bcr–abl fusion gene in Chronic Myeloid Leukemia cells

(2010) Yamini Arthanari et al.   JOURNAL OF CONTROLLED RELEASE

Chemical Fragments that Hydrogen Bond to Asp, Glu, Arg, and His Side Chains in Protein Binding Sites

(2010) A.W. Edith Chan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

(2010) Ashley Jarvis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

(2010) Thomas W Geisbert et al.   LANCET

Triazine Dendrimers as Nonviral Vectors for in Vitro and in Vivo RNAi: The Effects of Peripheral Groups and Core Structure on Biological Activity

(2010) Olivia M. Merkel et al.   MOLECULAR PHARMACEUTICS

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains

(2010) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-viral siRNA delivery into the mouse retina in vivo

(2010) Andrey Turchinovich et al.   BMC Ophthalmology

Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation

(2009) Sylvanie Malouitre et al.   BIOCHEMICAL JOURNAL

Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate

(2009) Peter Guterstam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Addressing the problem of cationic lipid-mediated toxicity: The magnetoliposome model

(2009) Stefaan J.H. Soenen et al.   BIOMATERIALS

TAT-mediated intracellular protein delivery to primary brain cells is dependent on glycosaminoglycan expression

(2009) Melissa J. Simon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Acetylation of PAMAM dendrimers for cellular delivery of siRNA

(2009) Carolyn L Waite et al.   BMC BIOTECHNOLOGY

Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides

(2009) Tsutomu Ishihara et al.   DRUG DELIVERY

Therapeutic opportunities of small interfering RNA

(2009) Bhoomika R. Goyal et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

MicroRNAs: Potential biomarkers for cancer diagnosis, prognosis and targets for therapy

(2009) William C.S. Cho   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Revised Role of Glycosaminoglycans in TAT Protein Transduction Domain-mediated Cellular Transduction

(2009) Jacob M. Gump et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism for HIV-1 Tat Insertion into the Endosome Membrane

(2009) Hocine Yezid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocation and Endocytosis for Cell-penetrating Peptide Internalization

(2009) Chen-Yu Jiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel lipidated sorbitol-based molecular transporters for non-viral gene delivery

(2009) Tomoko Higashi et al.   JOURNAL OF CONTROLLED RELEASE

DODAG; a versatile new cationic lipid that mediates efficient delivery of pDNA and siRNA

(2009) Mathieu Mével et al.   JOURNAL OF CONTROLLED RELEASE

Oxadiazolylindazole Sodium Channel Modulators are Neuroprotective toward Hippocampal Neurones

(2009) Lisa A. Clutterbuck et al.   JOURNAL OF MEDICINAL CHEMISTRY

General Synthetic Route to Cell-Permeable Block Copolymers via ROMP

(2009) Erin M. Kolonko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies

(2009) Christina B. Cooley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macromolecular Drug Delivery: Basic Principles and Therapeutic Applications

(2009) Mattias Belting et al.   MOLECULAR BIOTECHNOLOGY

First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder

(2009) Sancy A Leachman et al.   MOLECULAR THERAPY

Efficient siRNA delivery into primary cells by a peptide transduction domain–dsRNA binding domain fusion protein

(2009) Akiko Eguchi et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth

(2009) L. Crombez et al.   NUCLEIC ACIDS RESEARCH

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

(2009) W. G. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV TAT Forms Pores in Membranes by Inducing Saddle-Splay Curvature: Potential Role of Bidentate Hydrogen Bonding

(2008) Abhijit Mishra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells

(2008) Meredith F. Ross et al.   BIOCHEMICAL JOURNAL

Cholesterol domains in cationic lipid/DNA complexes improve transfection

(2008) Long Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cellular siRNA Delivery Mediated by a Cell-Permeant RNA-Binding Protein and Photoinduced RNA Interference

(2008) Tamaki Endoh et al.   BIOCONJUGATE CHEMISTRY

Modular Assembly Using Sequential Palladium Coupling Gives Easy Access to the SMoC Class of Cellular Transporters

(2008) Anne‐Sophie Rebstock et al.   CHEMBIOCHEM

Novel Guanidine-Containing Molecular Transporters Based on Lactose Scaffolds: Lipophilicity Effect on the Intracellular Organellar Selectivity

(2008) Goutam Biswas et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent progress in oligonucleotide therapeutics: antisense to aptamers

(2008) Douglas W Leaman   Expert Opinion on Drug Discovery

Safety-Related Regulatory Actions for Biologicals Approved in the United States and the European Union

(2008)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Not miR-ly small RNAs: Big potential for microRNAs in therapy

(2008) Tara M. Love et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Octaarginine- and Octalysine-modified Nanoparticles Have Different Modes of Endosomal Escape

(2008) Ayman El-Sayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Polymeric Domain That Promotes Cellular Internalization

(2008) Erin M. Kolonko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stimuli-Responsive Polyguanidino-Oxanorbornene Membrane Transporters as Multicomponent Sensors in Complex Matrices

(2008) Andreas Hennig et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Localization of Double-stranded Small Interfering RNA to Cytoplasmic Processing Bodies Is Ago2 Dependent and Results in Up-Regulation of GW182 and Argonaute-2

(2008) Aarti Jagannath et al.   MOLECULAR BIOLOGY OF THE CELL

A New Potent Secondary Amphipathic Cell–penetrating Peptide for siRNA Delivery Into Mammalian Cells

(2008) Laurence Crombez et al.   MOLECULAR THERAPY

Structure of the guide-strand-containing argonaute silencing complex

(2008) Yanli Wang et al.   NATURE

Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides

(2008) R. Juliano et al.   NUCLEIC ACIDS RESEARCH

The Homeodomain Derived Peptide Penetratin Induces Curvature of Fluid Membrane Domains

(2008) Antonin Lamazière et al.   PLoS One

The design of guanidinium-rich transporters and their internalization mechanisms

(2007) Paul A. Wender et al.   ADVANCED DRUG DELIVERY REVIEWS

Thermodynamic studies and binding mechanisms of cell-penetrating peptides with lipids and glycosaminoglycans

(2007) André Ziegler   ADVANCED DRUG DELIVERY REVIEWS

Binding and Clustering of Glycosaminoglycans: A Common Property of Mono- and Multivalent Cell-Penetrating Compounds

(2007) André Ziegler et al.   BIOPHYSICAL JOURNAL