The role of pannexin1 in the induction and resolution of inflammation

Diverse post-translational modifications of the pannexin family of channel-forming proteins

(2014) Silvia Penuela et al.   Channels

ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors

(2013) M. Alexandrina Timóteo et al.   BIOCHEMICAL PHARMACOLOGY

Purinergic receptor P2X7: A novel target for anti-inflammatory therapy

(2013) Nisha Mehta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

From Mechanosensitivity to Inflammatory Responses: New Players in the Pathology of Glaucoma

(2013) David Križaj et al.   CURRENT EYE RESEARCH

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

CD39 expression by hepatic myeloid dendritic cells attenuates inflammation in liver transplant ischemia-reperfusion injury in mice

(2013) Osamu Yoshida et al.   HEPATOLOGY

Histamine Induces ATP Release from Human Subcutaneous Fibroblasts, via Pannexin-1 Hemichannels, Leading to Ca2+Mobilization and Cell Proliferation

(2013) Ana Rita Pinheiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin 1 Channels Link Chemoattractant Receptor Signaling to Local Excitation and Global Inhibition Responses at the Front and Back of Polarized Neutrophils

(2013) Yi Bao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1

(2013) Junjie Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pathways mediating resolution of inflammation: when enough is too much

(2013) James N Fullerton et al.   JOURNAL OF PATHOLOGY

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

(2013) Luiz Alves et al.   MOLECULES

Is pannexin the pore associated with the P2X7 receptor?

(2013) A. V. P. Alberto et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Expression and localization of pannexin-1 hemichannels in human colon in health and disease

(2013) E. F. Diezmos et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The bizarre pharmacology of the ATP release channel pannexin1

(2013) Gerhard Dahl et al.   NEUROPHARMACOLOGY

Resolution of inflammation: Mechanisms and opportunity for drug development

(2013) Ana L. Alessandri et al.   PHARMACOLOGY & THERAPEUTICS

Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

(2013) Christopher Paustian et al.   PLoS One

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

(2013) Shu-Chen Hung et al.   PLoS One

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

(2013) Fenila Jacob et al.   Purinergic Signalling

P2X receptors as targets for the treatment of status epilepticus

(2013) David C. Henshall et al.   Frontiers in Cellular Neuroscience

Exploring the ATP-binding site of P2X receptors

(2013) Thierry Chataigneau et al.   Frontiers in Cellular Neuroscience

Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model

(2013) Hiromitsu Negoro et al.   Scientific Reports

ATP release and purinergic signaling in NLRP3 inflammasome activation

(2013) Aurélie Gombault et al.   Frontiers in Immunology

ATP-dependent recruitment, survival and differentiation of dendritic cell precursors in the tumor bed after anticancer chemotherapy

(2013) Yuting Ma et al.   OncoImmunology

The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats

(2012) Hans G. Folkesson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The biochemistry and function of pannexin channels

(2012) Silvia Penuela et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Immunoregulation through extracellular nucleotides

(2012) L. Vitiello et al.   BLOOD

Connexin and pannexin hemichannels in inflammatory responses of glia and neurons

(2012) Michael V.L. Bennett et al.   BRAIN RESEARCH

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration

(2012) Hiroki Kawamura et al.   IMMUNOLOGY

S-Nitrosylation Inhibits Pannexin 1 Channel Function

(2012) Alexander W. Lohman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient P2X 7 Receptor Activation Triggers Macrophage Death Independent of Toll-like Receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins

(2012) Peter J. Hanley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region

(2012) Joanna K. Sandilos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD73 Is Critical for the Resolution of Murine Colonic Inflammation

(2012) Margaret S. Bynoe et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Splice variants of the P2X7 receptor reveal differential agonist dependence and functional coupling with pannexin-1

(2012) X. J. Xu et al.   JOURNAL OF CELL SCIENCE

Purinergic Receptors Are Required for HIV-1 Infection of Primary Human Macrophages

(2012) J. E. Hazleton et al.   JOURNAL OF IMMUNOLOGY

TLR Agonists Stimulate Nlrp3-Dependent IL-1  Production Independently of the Purinergic P2X7 Receptor in Dendritic Cells and In Vivo

(2012) Y. He et al.   JOURNAL OF IMMUNOLOGY

Stretch of Atrial Myocytes Stimulates Recruitment of Macrophages via ATP Released Through Gap-Junction Channels

(2012) Sakiko Oishi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Genetic Ablation of Pannexin1 Protects Retinal Neurons from Ischemic Injury

(2012) Galina Dvoriantchikova et al.   PLoS One

ATP Release from Dying Autophagic Cells and Their Phagocytosis Are Crucial for Inflammasome Activation in Macrophages

(2012) Gizem Ayna et al.   PLoS One

Vesicular and conductive mechanisms of nucleotide release

(2012) Eduardo R. Lazarowski   Purinergic Signalling

New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors

(2012) Ross Corriden et al.   Purinergic Signalling

Moving through the gate in ATP-activated P2X receptors

(2012) Ruotian Jiang et al.   TRENDS IN BIOCHEMICAL SCIENCES

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

Adipocyte P2X7 receptors expression: A role in modulating inflammatory response in subjects with metabolic syndrome?

(2011) Stephanie Madec et al.   ATHEROSCLEROSIS

Pannexin channels are not gap junction hemichannels

(2011) Gina E. Sosinsky et al.   Channels

Pannexin1 Regulates α1-Adrenergic Receptor– Mediated Vasoconstriction

(2011) Marie Billaud et al.   CIRCULATION RESEARCH

Real-time Imaging Reveals That P2Y2and P2Y12Receptor Agonists Are Not Chemoattractants and Macrophage Chemotaxis to Complement C5a Is Phosphatidylinositol 3-Kinase (PI3K)- and p38 Mitogen-activated Protein Kinase (MAPK)-independent

(2011) Katrin Isfort et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

(2011) Claire Séror et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The P2X7 Receptor and Pannexin-1 Are Both Required for the Promotion of Multinucleated Macrophages by the Inflammatory Cytokine GM-CSF

(2011) I. Lemaire et al.   JOURNAL OF IMMUNOLOGY

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

(2011) K. Niemi et al.   JOURNAL OF IMMUNOLOGY

Involvement of Adenosine A2A Receptors in Engulfment-Dependent Apoptotic Cell Suppression of Inflammation

(2011) K. Koroskenyi et al.   JOURNAL OF IMMUNOLOGY

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

P2X7 Receptor–Pannexin 1 Hemichannel Association: Effect of Extracellular Calcium on Membrane Permeabilization

(2011) V. Poornima et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

(2011) Juan A. Orellana et al.   JOURNAL OF NEUROCHEMISTRY

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation

(2010) T. Müller et al.   ALLERGY

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

(2010) Nicolas Riteau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse

(2010) T. Woehrle et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules

(2010) Gloria Lopez-Castejón et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pannexin channels in ATP release and beyond: An unexpected rendezvous at the endoplasmic reticulum

(2010) Catheleyne D'hondt et al.   CELLULAR SIGNALLING

Pannexin 1 Constitutes the Large Conductance Cation Channel of Cardiac Myocytes

(2010) Marie-Cecile Kienitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular ATP May Contribute to Tissue Repair by Rapidly Stimulating Purinergic Receptor X7-Dependent Vascular Endothelial Growth Factor Release from Primary Human Monocytes

(2010) L. M. Hill et al.   JOURNAL OF IMMUNOLOGY

Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology

(2010) P. B. Ernst et al.   JOURNAL OF IMMUNOLOGY

Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors

(2010) Tobias Woehrle et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Connexin Channel-Dependent Signaling Pathways in Inflammation

(2010) K.E. Ludwig Scheckenbach et al.   JOURNAL OF VASCULAR RESEARCH

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

(2010) J. M. Garre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

(2010) M. Kronlage et al.   Science Signaling

Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet

(2009) Suzhao Li et al.   CIRCULATION RESEARCH

Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration

(2009) Filip Kukulski et al.   CYTOKINE

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis

(2009) J.-S. Frick et al.   JOURNAL OF IMMUNOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Molecular Mechanisms and Pathophysiology of Necrotic Cell Death

(2008) Nele Vanlangenakker et al.   CURRENT MOLECULAR MEDICINE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4+ T lymphocytes

(2008) Corinne Barat et al.   Retrovirology

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling