Pathways mediating resolution of inflammation: when enough is too much

Apoptotic Cells Induce Immunosuppression through Dendritic Cells: Critical Roles of IFN-  and Nitric Oxide

(2014) G. Ren et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Protein-1 Inhibits Phagocytosis of Apoptotic Neutrophils through Binding to Phosphatidylserine

(2014) G. Liu et al.   JOURNAL OF IMMUNOLOGY

Resolvin D2 restores neutrophil directionality and improves survival after burns

(2013) Tomohiro Kurihara et al.   FASEB JOURNAL

Vitronectin Inhibits Efferocytosis through Interactions with Apoptotic Cells as well as with Macrophages

(2013) H.-B. Bae et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Type I IFN Drives Emergency Myelopoiesis and Peripheral Myeloid Expansion during Chronic TLR7 Signaling

(2013) M. B. Buechler et al.   JOURNAL OF IMMUNOLOGY

A Non-Lethal Traumatic/Hemorrhagic Insult Strongly Modulates the Compartment-Specific PAI-1 Response in the Subsequent Polymicrobial Sepsis

(2013) Pierre Raeven et al.   PLoS One

BLT1-dependent Alveolar Recruitment of CD4+CD25+Foxp3+Regulatory T Cells Is Important for Resolution of Acute Lung Injury

(2012) Luman Wang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulatory T Cells Reduce Acute Lung Injury Fibroproliferation by Decreasing Fibrocyte Recruitment

(2012) Brian T. Garibaldi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling

(2012) Z. Zaslona et al.   BLOOD

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Retraction notice to “Myeloid-derived suppressor cells accumulate in the liver site after sepsis to induce immunosuppression” Cellular Immunology 279 (2012) 12–20

(2012) Dongping Ren et al.   CELLULAR IMMUNOLOGY

The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment*

(2012) Andrew Labelle et al.   CRITICAL CARE MEDICINE

The function of neutrophils in sepsis

(2012) Melissa A. Kovach et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Myeloid-Derived Suppressor Cells Evolve during Sepsis and Can Enhance or Attenuate the Systemic Inflammatory Response

(2012) Laura Brudecki et al.   INFECTION AND IMMUNITY

Myeloid-derived suppressor cells control microbial sepsis

(2012) Marc Derive et al.   INTENSIVE CARE MEDICINE

Myeloid-derived suppressor cells in sepsis: friend or foe?

(2012) Alex G. Cuenca et al.   INTENSIVE CARE MEDICINE

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

(2012) S. Boettcher et al.   JOURNAL OF IMMUNOLOGY

Interleukin-7 Ameliorates Immune Dysfunction and Improves Survival in a 2-Hit Model of Fungal Sepsis

(2012) Jacqueline Unsinger et al.   JOURNAL OF INFECTIOUS DISEASES

Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis

(2012) Amiram Ariel et al.   JOURNAL OF PATHOLOGY

Cyclooxygenase Inhibition in Sepsis: Is There Life after Death?

(2012) David M. Aronoff   MEDIATORS OF INFLAMMATION

Unknown

(2012) Arnaud Friggeri et al.   MOLECULAR MEDICINE

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptome Kinetics of Circulating Neutrophils during Human Experimental Endotoxemia

(2012) Stan de Kleijn et al.   PLoS One

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae

(2012) David M. Aronoff et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Ketoprofen Impairs Immunosuppression Induced by Severe Sepsis and Reveals an Important Role for Prostaglandin E2

(2012) Ariane Rennó Brogliato et al.   SHOCK

Inhibition of neutrophil apoptosis by PAI-1

(2011) Jaroslaw W. Zmijewski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Increased susceptibility to Candida infection following cecal ligation and puncture

(2011) Christopher G. Davis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptomic analyses of murine resolution-phase macrophages

(2011) M. J. Stables et al.   BLOOD

C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients

(2011) A. C. Morris et al.   BLOOD

Macrophage polarization and bacterial infections

(2011) Jean-Louis Mège et al.   CURRENT OPINION IN INFECTIOUS DISEASES

In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site

(2011) Jessica M. Haverkamp et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunomodulatory therapy for sepsis: an update

(2011) Eirini Christaki et al.   Expert Review of Anti-Infective Therapy

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

B cells enhance early innate immune responses during bacterial sepsis

(2011) Kindra M. Kelly-Scumpia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cecal Ligation and Puncture-Induced Impairment of Innate Immune Function Does Not Occur in the Absence of Caspase-1

(2011) E. D. Murphey   JOURNAL OF IMMUNOLOGY

Unknown

(2011) Jochen Grommes et al.   MOLECULAR MEDICINE

Unknown

(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

Dysregulated Cytokine Expression by CD4+ T cells from Post-Septic Mice Modulates both Th1 and Th2-Mediated Granulomatous Lung Inflammation

(2011) William F. Carson et al.   PLoS One

The Outcome of Polymicrobial Sepsis Is Independent of T and B CellS

(2011) Markus Bosmann et al.   SHOCK

Neutralization of interleukin-10 or transforming growth factor-β decreases the percentages of CD4+CD25+Foxp3+ regulatory T cells in septic mice, thereby leading to an improved survival

(2011) Shuhichi Hiraki et al.   SURGERY

Neutrophil clearance: when the party is over, clean-up begins

(2011) Donna L. Bratton et al.   TRENDS IN IMMUNOLOGY

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

(2010) Charles N. Serhan   AMERICAN JOURNAL OF PATHOLOGY

HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrin

(2010) Arnaud Friggeri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Urokinase-Type Plasminogen Activator Inhibits Efferocytosis of Neutrophils

(2010) Yanping Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth

(2010) K. A. Cavassani et al.   BLOOD

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Prostaglandins antagonistically control Bax activation during apoptosis

(2010) L Lalier et al.   CELL DEATH AND DIFFERENTIATION

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) improves the innate immune response and enhances survival in murine polymicrobial sepsis

(2010) Katharina Cziupka et al.   CRITICAL CARE MEDICINE

Myeloid-derived suppressor cell heterogeneity and subset definition

(2010) Elisa Peranzoni et al.   CURRENT OPINION IN IMMUNOLOGY

Myeloid-derived suppressor cells in parasitic infections

(2010) Jo A. Van Ginderachter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Defect in efferocytosis leads to alternative activation of macrophages in Francisella infections

(2010) Chris A Mares et al.   IMMUNOLOGY AND CELL BIOLOGY

Characterization and Modulation of the Immunosuppressive Phase of Sepsis

(2010) J. T. Muenzer et al.   INFECTION AND IMMUNITY

Impact of nosocomial infections on clinical outcome and resource consumption in critically ill patients

(2010) Heinz Burgmann et al.   INTENSIVE CARE MEDICINE

New perspectives on immunomodulatory therapy for bacteraemia and sepsis

(2010) Steven M. Opal   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

(2010) Leif E. Sander et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sepsis Induces Early Alterations in Innate Immunity That Impact Mortality to Secondary Infection

(2010) M. J. Delano et al.   JOURNAL OF IMMUNOLOGY

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Critical care: advances and future perspectives

(2010) Jean-Louis Vincent et al.   LANCET

Critical care and the global burden of critical illness in adults

(2010) Neill KJ Adhikari et al.   LANCET

NEUTROPHIL PARALYSIS IN SEPSIS

(2010) José C. Alves-Filho et al.   SHOCK

Immunosuppression following surgical and traumatic injury

(2010) Fumio Kimura et al.   SURGERY TODAY

15-Epi-lipoxin A4Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

(2009) Driss El Kebir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression

(2009) Christian Meisel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macroscopic Postmortem Findings in 235 Surgical Intensive Care Patients with Sepsis

(2009) Christian Torgersen et al.   ANESTHESIA AND ANALGESIA

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis

(2009) Paul E. Stromberg et al.   FASEB JOURNAL

The role of T regulatory cells in human sepsis

(2009) Aharon Kessel et al.   JOURNAL OF AUTOIMMUNITY

CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

(2009) Franco R. D’Alessio et al.   JOURNAL OF CLINICAL INVESTIGATION

Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling

(2009) Alexandra I. Medeiros et al.   JOURNAL OF EXPERIMENTAL MEDICINE

E-Prostanoid 3 Receptor Deletion Improves Pulmonary Host Defense and Protects Mice from Death in Severe Streptococcus pneumoniae Infection

(2009) D. M. Aronoff et al.   JOURNAL OF IMMUNOLOGY

IL-15 Prevents Apoptosis, Reverses Innate and Adaptive Immune Dysfunction, and Improves Survival in Sepsis

(2009) S. Inoue et al.   JOURNAL OF IMMUNOLOGY

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

(2009) Miriam Beer Torchinsky et al.   NATURE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections

(2009) A. A. Navarini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MODULATION OF THE BCL-2 FAMILY BLOCKS SEPSIS-INDUCED DEPLETION OF DENDRITIC CELLS AND MACROPHAGES

(2009) Octavia M. Peck-Palmer et al.   SHOCK

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Novel biphasic role for lymphocytes revealed during resolving inflammation

(2008) R. Rajakariar et al.   BLOOD

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

Predictors of 30-Day Mortality and Hospital Costs in Patients With Ventilator-Associated Pneumonia Attributed to Potentially Antibiotic-Resistant Gram-Negative Bacteria

(2008) Katherine E. Kollef et al.   CHEST

Myeloperoxidase Delays Neutrophil Apoptosis Through CD11b/CD18 Integrins and Prolongs Inflammation

(2008) Driss El Kebir et al.   CIRCULATION RESEARCH

The Compensatory Anti-inflammatory Response Syndrome (CARS) in Critically Ill Patients

(2008) Nicholas S. Ward et al.   CLINICS IN CHEST MEDICINE

Gene-expression profiling of Gram-positive and Gram-negative sepsis in critically ill patients*

(2008) Benjamin M.P. Tang et al.   CRITICAL CARE MEDICINE

Apoptosis in Sepsis: Mechanisms, Clinical Impact and Potential Therapeutic Targets

(2008) Alfred Ayala et al.   CURRENT PHARMACEUTICAL DESIGN

Depletion of natural CD4+CD25+ T regulatory cells with anti-CD25 antibody does not change the course of Pseudomonas aeruginosa-induced acute lung infection in mice

(2008) Svetlana O. Carrigan et al.   IMMUNOBIOLOGY

Lymphocyte Apoptosis, Caspase Activation and Inflammatory Response in Septic Shock

(2008) G. Delogu et al.   INFECTION

Does severe non-infectious SIRS differ from severe sepsis?

(2008) Joel M. Dulhunty et al.   INTENSIVE CARE MEDICINE

Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients

(2008) Fabienne Venet et al.   INTENSIVE CARE MEDICINE

Reactivation of Cytomegalovirus Infection in Critically Ill Immunocompetent Patients—Reply

(2008) Ajit P. Limaye   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

(2008) Carmela De Santo et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular and cellular aspects of sepsis-induced immunosuppression

(2008) Tisha S. Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

(2008) Matthijs C Brouwer et al.   LANCET INFECTIOUS DISEASES

PAI-1 inhibits neutrophil efferocytosis

(2008) Y.-J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sepsis is Characterized by the Increases in Percentages of Circulating CD4+CD25+ Regulatory T Cells and Plasma Levels of Soluble CD25

(2008) Koji Saito et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Trypanosoma cruzi: The role of PGE2 in immune response during the acute phase of experimental infection

(2007) G.K. Abdalla et al.   EXPERIMENTAL PARASITOLOGY