The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1

Pannexin: From discovery to bedside in 11±4 years?

(2012) Gerhard Dahl et al.   BRAIN RESEARCH

ATP signaling is deficient in cultured pannexin1-null mouse astrocytes

(2012) Sylvia O. Suadicani et al.   GLIA

Loss of Pannexin 1 Attenuates Melanoma Progression by Reversion to a Melanocytic Phenotype

(2012) Silvia Penuela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus

(2012) Ketan Chu et al.   Journal of Neuroinflammation

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Anti-Prion Activity of Brilliant Blue G

(2012) Yoshifumi Iwamaru et al.   PLoS One

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

(2012) Donald E. Kimbler et al.   PLoS One

P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase1/2 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro

(2011) Chiara Traini et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

(2011) Claire Séror et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

(2011) Y. Qu et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G

(2011) S. Jo et al.   MOLECULAR PHARMACOLOGY

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

(2011) Joana Arbeloa et al.   NEUROBIOLOGY OF DISEASE

Minor contribution of ATP P2 receptors to electrically-evoked electrographic seizure activity in hippocampal slices: Evidence from purine biosensors and P2 receptor agonists and antagonists

(2011) Ján Lopatář et al.   NEUROPHARMACOLOGY

Targeting Pannexin1 Improves Seizure Outcome

(2011) Marcelo F. Santiago et al.   PLoS One

Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity

(2011) Feng Qiu et al.   Purinergic Signalling

EFFECT OF BRILLIANT BLUE G ON THE RETINAL GANGLION CELLS OF RATS

(2011) Aya Iriyama et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases

(2010) Takato Takenouchi et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

SCAM analysis of Panx1 suggests a peculiar pore structure

(2010) Junjie Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pannexin 1 Contributes to ATP Release in Airway Epithelia

(2009) George A. Ransford et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pannexin 1: The Molecular Substrate of Astrocyte "Hemichannels"

(2009) R. Iglesias et al.   JOURNAL OF NEUROSCIENCE

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP

(2008) Feng Qiu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels

(2008) S. Chaumont et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

(2008) R. J. Thompson et al.   SCIENCE