Cathepsin B: Multiple roles in cancer

Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles

(2015) Ilaria Giusti et al.   NEOPLASIA

Cathepsin B Is the Driving Force of Esophageal Cell Invasion in a Fibroblast-Dependent Manner

(2015) Claudia D. Andl et al.   NEOPLASIA

The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis

(2013) Claudia Broder et al.   BIOCHEMICAL JOURNAL

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Contribution of the inflammasomes to autoinflammatory diseases and recent mouse models as research tools

(2013) Michael C. Heymann et al.   CLINICAL IMMUNOLOGY

Cathepsin B as a cancer target

(2013) Christopher S Gondi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Serine protease and ovarian paracrine factors in regulation of ovulation 

(2013) Yi-xun Liu   Frontiers in Bioscience-Landmark

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis

(2013) B. Ruffell et al.   GENES & DEVELOPMENT

Targeting therapy of hepatocellular carcinoma with doxorubicin prodrug PDOX increases anti-metastatic effect and reduces toxicity: a preclinical study

(2013) Qun Wang et al.   Journal of Translational Medicine

Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression

(2013) F Bengsch et al.   ONCOGENE

VEGF-initiated angiogenesis and the uPA/uPAR system

(2013) Johannes M. Breuss et al.   Cell Adhesion & Migration

Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration

(2012) Antje Schaefer et al.   BIOCHEMICAL JOURNAL

Structure–function relationships in calpains

(2012) Robert L. Campbell et al.   BIOCHEMICAL JOURNAL

Cysteine cathepsins are not critical for TRAIL- and CD95-induced apoptosis in several human cancer cell lines

(2012) Aleš Špes et al.   BIOLOGICAL CHEMISTRY

Cathepsin B Inhibition Limits Bone Metastasis in Breast Cancer

(2012) N. P. Withana et al.   CANCER RESEARCH

Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis

(2012) K Shchors et al.   ONCOGENE

At the Interface of Fibrinolysis and Inflammation: The Role of Urokinase-Type Plasminogen Activator in the Leukocyte Extravasation Cascade

(2012) Christoph A. Reichel et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

(2012) Gregg L. Semenza   TRENDS IN MOLECULAR MEDICINE

uPAR and cathepsin B shRNA impedes TGF-β1-driven proliferation and invasion of meningioma cells in a XIAP-dependent pathway

(2012) V R Gogineni et al.   Cell Death & Disease

Membrane-Anchored Serine Proteases in Vertebrate Cell and Developmental Biology

(2011) Roman Szabo et al.   Annual Review of Cell and Developmental Biology

Live-cell imaging of tumor proteolysis: Impact of cellular and non-cellular microenvironment

(2011) Jennifer M. Rothberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice

(2011) Aarthi Gopinathan et al.   GUT

SPARC Promotes Cathepsin B-Mediated Melanoma Invasiveness through a Collagen I/α2β1 Integrin Axis

(2011) María R. Girotti et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

uPAR and cathepsin B downregulation induces apoptosis by targeting calcineurin A to BAD via Bcl-2 in glioma

(2011) Rama Rao Malla et al.   JOURNAL OF NEURO-ONCOLOGY

Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes

(2011) J. Hu et al.   MOLECULAR CANCER RESEARCH

Protective role of cathepsin L in mouse skin carcinogenesis

(2011) Fernando Benavides et al.   MOLECULAR CARCINOGENESIS

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Effect of shRNA Mediated Down-Regulation of Annexin A2 on Biological Behavior of Human Lung Adencarcinoma Cells A549

(2011) Yue-xiang Wang et al.   PATHOLOGY & ONCOLOGY RESEARCH

uPAR/Cathepsin B Overexpression Reverse Angiogenesis by Rescuing FAK Phosphorylation in uPAR/Cathepsin B Down Regulated Meningioma

(2011) Reshu Gupta et al.   PLoS One

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration

(2011) Katarina Wolf et al.   TRENDS IN CELL BIOLOGY

Proteolytic networks in cancer

(2011) Steven D. Mason et al.   TRENDS IN CELL BIOLOGY

Balancing act: deubiquitinating enzymes in the nervous system

(2011) Sokol V. Todi et al.   TRENDS IN NEUROSCIENCES

The role of Sp1 and Sp3 in normal and cancer cell biology

(2010) Lin Li et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model

(2010) Benelita Tina Elie et al.   BIOCHIMIE

Drug resistant breast cancer cells overexpress ETS1 gene

(2010) Meltem Demirel Kars et al.   BIOMEDICINE & PHARMACOTHERAPY

Cathepsins (S and B) and their inhibitor Cystatin C in immune cells: Modulation by interferon-β and role played in cell migration

(2010) Elsebeth Staun-Ram et al.   JOURNAL OF NEUROIMMUNOLOGY

Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice

(2010) L Sevenich et al.   ONCOGENE

Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions

(2009) Elena I. Deryugina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

(2009) Farideh Sabeh et al.   JOURNAL OF CELL BIOLOGY

Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis

(2009) J Dennemärker et al.   ONCOGENE

Na+/H+Exchangers and RhoA Regulate Acidic Extracellular pH-Induced Lysosome Trafficking in Prostate Cancer Cells

(2009) Joshua J. Steffan et al.   TRAFFIC

Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model

(2008) Uta Schurigt et al.   BIOLOGICAL CHEMISTRY

Proteases and bone remodelling

(2008) S. Georges et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cysteine Cathepsins Trigger Caspase-dependent Cell Death through Cleavage of Bid and Antiapoptotic Bcl-2 Homologues

(2008) Gabriela Droga-Mazovec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice

(2008) O Vasiljeva et al.   ONCOGENE

The cathepsin family and their role in colorectal cancer

(2008) Doerthe Kuester et al.   PATHOLOGY RESEARCH AND PRACTICE

Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth

(2008) Elias Gounaris et al.   PLoS One

Membrane type 1-matrix metalloproteinase: Substrate diversity in pericellular proteolysis☆

(2007) M BARBOLINA et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cysteine cathepsin proteases as pharmacological targets in cancer

(2007) Carmela Palermo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES