Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis

(2011) Chris De Savi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Conformational flexibility and allosteric regulation of cathepsin K

(2010) Marko Novinec et al.   BIOCHEMICAL JOURNAL

Characterization of TIMP-3 in human articular talar cartilage

(2010) Kirsten J. Morris et al.   CONNECTIVE TISSUE RESEARCH

Paradoxical interactions between modifiers and elastase-2

(2010) Patricia Schenker et al.   FEBS Journal

Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

(2010) P.S. Chockalingam et al.   OSTEOARTHRITIS AND CARTILAGE

The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3

(2009) Linda Troeberg et al.   MATRIX BIOLOGY

Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor

(2009) M. Akiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases

(2008) Linda Troeberg et al.   FASEB JOURNAL

A Catalytic Role of Heparin within the Extracellular Matrix

(2008) Maria Mitsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY