Review
Biochemistry & Molecular Biology
Anastasia V. Strokotova, Elvira V. Grigorieva
Summary: Glucocorticoids are commonly used to treat various diseases but can cause side effects. Recent studies suggest that the toxic effects of glucocorticoids on key extracellular components in the brain may be an underlying mechanism for these side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alyce J. Mayfosh, Tien K. Nguyen, Mark D. Hulett
Summary: The extracellular matrix plays crucial roles in maintaining tissue structure, immune defense, and acting as a reservoir for bioactive molecules, with heparan sulfate proteoglycans (HSPGs) and their component heparan sulfate being essential in these processes. Understanding the regulation of heparanase and its downstream targets is important for potential therapeutic strategies in inflammatory diseases, atherosclerosis, fibrosis, and cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Tien K. Nguyen, Stephanie Paone, Enoch Chan, Ivan K. H. Poon, Amy A. Baxter, Shane R. Thomas, Mark D. Hulett
Summary: Cardiovascular disease is the leading cause of death and disability worldwide, and atherosclerosis plays a crucial role in its development. Heparanase, as the only mammalian enzyme known to cleave heparan sulfate, has been found to be involved in various physiological and pathological processes, including inflammation and plaque formation. This review focuses on the emerging role of heparanase in atherosclerosis and provides an up-to-date overview of its functions.
Article
Biochemistry & Molecular Biology
Zuopeng Wu, Rebecca A. Sweet, Gerard F. Hoyne, Charmaine J. Simeonovic, Christopher R. Parish
Summary: It has been accepted for decades that T lymphocytes and metastasising tumour cells traverse basement membranes (BM) by deploying a battery of degradative enzymes, particularly proteases. However, recent studies suggest that there are other mechanisms that allow cell migration through basement membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Casper de Boer, Zachary Armstrong, Vincent A. J. Lit, Uri Barash, Gijs Ruijgrok, Ilanit Boyango, Merle M. Weitzenberg, Sybrin P. Schroder, Alexi J. C. Sarris, Nico J. Meeuwenoord, Pedro Bule, Yasmine Kayal, Neta Ilan, Jeroen D. C. Codee, Israel Vlodavsky, Herman S. Overkleeft, Gideon J. Davies, Liang Wu
Summary: Research has shown that by developing effective HPSE inhibitors, extracellular HPSE activity can be reduced, thereby reducing the aggressiveness of cancer and potentially controlling pathological HPSE-driven malignancies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Miriam Gross-Cohen, Sari Feld, Gil Arvatz, Neta Ilan, Israel Vlodavsky
Summary: Hpa2, a close homolog of heparanase, plays a role in a rare genetic disease called urofacial syndrome, indicating its importance in protein coding; despite lacking HS-degrading activity, it shows a high affinity to HS; experimental evidence shows that Hpa2 affects cell adhesion, migration, and colony morphology.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Lingjun Dong, Linhai Fu, Ting Zhu, Yuanlin Wu, Zhupeng Li, Jianyi Ding, Jiandong Zhang, Xiang Wang, Junjun Zhao, Guangmao Yu
Summary: This study aimed to investigate the expression pattern of collagen family genes in lung adenocarcinoma (LUAD) and develop a predictive signature based on collagen family. By analyzing samples from the TCGA cohort, a predictive model based on five collagen genes was created. The collagen signature was associated with extracellular matrix organization, ECM-receptor interaction, and activation of PI3K-Akts and AGE-RAGE signaling, as well as immune checkpoints, tumor mutation burden, and tumor purity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maxim O. Politko, Alexandra Y. Tsidulko, Oxana A. Pashkovskaya, Konstantin E. Kuper, Anastasia V. Suhovskih, Galina M. Kazanskaya, Lyubov S. Klyushova, Dmitry K. Sokolov, Alexander M. Volkov, Evgenii E. Kliver, Alexander A. Zheravin, Svetlana V. Aidagulova, Elvira V. Grigorieva
Summary: The study found that multiple irradiation affects the cellular and extracellular glycosylated components of normal brain tissue, resulting in changes in PGs and GAGs, and an increased adhesion and proliferation of GBM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Albina Fejza, Maurizio Polano, Lucrezia Camicia, Evelina Poletto, Greta Carobolante, Giuseppe Toffoli, Maurizio Mongiat, Eva Andreuzzi
Summary: The study suggests that EMILIN-2 plays a role in the response to PD-L1 inhibitors in melanoma patients, with its absence associated with increased PD-L1 expression and improved immunotherapy efficacy. EMILIN-2 regulates PD-L1 expression in melanoma cells through immune-dependent mechanisms, impacting treatment outcomes and angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Raghuram Koganti, Abdullah Memon, Deepak Shukla
Summary: Heparan sulfate is a glycosaminoglycan found in mammalian tissues that contributes to the structural integrity of the extracellular matrix and cell signaling, but is also exploited by viruses during infection. Loss or inhibition of heparan sulfate proteoglycans during infection can lead to significant decreases in viral entry and infectivity, affecting multiple viruses such as herpesviruses, HIV, dengue virus, HPV, and coronaviruses.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Chemistry, Multidisciplinary
Joseph Wakpal, Vishaka Pathiranage, Alice R. Walker, Hien M. Nguyen
Summary: This article describes a method for synthesizing a library of HS mimetics from natural aminoglycosides, reducing the number of steps compared to traditional methods. Computational modeling was used to identify a new class of trisaccharide compounds derived from tobramycin that mimic natural HS and have a strong binding to heparanase but a low affinity for off-target platelet factor-4 protein.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Immunology
Anne Mette Askehoj Romer, Marie-Louise Thorseth, Daniel Hargbol Madsen
Summary: During tumor growth, the extracellular matrix undergoes remodeling, with a tumor-specific ECM of higher collagen density being associated with poor prognosis in cancer. Recent studies suggest that collagen can influence the function and phenotype of tumor-infiltrating immune cells, potentially affecting cancer progression and immunotherapy efficacy. Knowledge of collagen's immune modulatory functions may help improve current cancer therapies and develop new treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Claire Deligne, Kim S. Midwood
Summary: The article discusses the interactions between tumor-associated macrophages and matrix molecules in the tumor microenvironment of breast cancer, and how these pathways can be targeted for new immunotherapies for hard to treat desmoplastic tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhenzhen Deng, Ning Wu, Qishan Suo, Jing Wang, Yang Yue, Lihua Geng, Quanbin Zhang
Summary: This study found that fucoidan (FPS1M) induced macrophages differentiation to the M1 phenotype, increasing the infiltration of M1 macrophages in tumor tissue and improving the sensitivity of tumor to chemotherapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Cell Biology
Hind Al Khashali, Jadziah Wareham, Ravel Ray, Ben Haddad, Kai-Ling Coleman, Robert Ranzenberger, Patrick McCombs, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans
Summary: This study investigates the roles of heparanase and IGFBP-3 in regulating the survival of non-small-cell lung cancer cells. The results suggest that inhibiting heparanase activity or expression decreases the levels of soluble HS fragments and reduces interactions between IGFBP-3 and HS. Additionally, blocking HA-CD44 signaling increases p53 activity and the levels of IGFBP-3. Silencing p53 leads to increased heparanase levels, while silencing IGFBP-3 blocks p53 activity and increases heparanase levels.
Article
Multidisciplinary Sciences
Immanuel Lerner, Osnat Bartok, Victoria Wolfson, Jerome S. Menet, Uri Weissbein, Shaked Afik, Daniel Haimovich, Chen Gafni, Nir Friedman, Michael Rosbash, Sebastian Kadener
NATURE COMMUNICATIONS
(2015)
Article
Oncology
Amichay Meirovitz, Esther Hermano, Immanuel Lerner, Eyal Zcharia, Claudio Pisano, Tamar Peretz, Michael Elkin
Article
Biochemistry & Molecular Biology
Immanuel Lerner, Eyal Zcharia, Tzahi Neuman, Esther Hermano, Ariel M. Rubinstein, Israel Vlodavsky, Michael Elkin
CELLULAR AND MOLECULAR LIFE SCIENCES
(2014)
Article
Oncology
Immanuel Lerner, Leah Baraz, Eli Pikarsky, Amichay Meirovitz, Evgeny Edovitsky, Tamar Peretz, Israel Vlodavsky, Michael Elkin
CLINICAL CANCER RESEARCH
(2008)
Meeting Abstract
Oncology
M. Elkin, I. Lerner, E. Bensoussan, V. Doviner, I. Vlodavsky
Article
Medicine, Research & Experimental
Immanuel Lerner, Esther Hermano, Eyal Zcharia, Dina Rodkin, Raanan Bulvik, Victoria Doviner, Ariel M. Rubinstein, Rivka Ishai-Michaeli, Ruth Atzmon, Yoav Sherman, Amichay Meirovitz, Tamar Peretz, Israel Vlodavsky, Michael Elkin
JOURNAL OF CLINICAL INVESTIGATION
(2011)
Article
Immunology
Amit Michaeli, Shaul Mezan, Andreas Kuehbacher, Doris Finkelmeier, Maayan Elias, Maria Zatsepin, Steven G. Reed, Malcolm S. Duthie, Steffen Rupp, Immanuel Lerner, Anke Burger-Kentischer
JOURNAL OF IMMUNOLOGY
(2018)
Review
Oncology
Israel Vlodavsky, Phillip Beckhove, Immanuel Lerner, Claudio Pisano, Amichai Meirovitz, Neta Ilan, Michael Elkin
CANCER MICROENVIRONMENT
(2012)
Article
Hematology
E Edovitsky, I Lerner, E Zcharia, T Peretz, I Vlodavsky, M Elkin
Article
Biochemistry & Molecular Biology
I Lerner, M Trus, R Cohen, O Yizhar, I Nussinovitch, D Atlas
JOURNAL OF NEUROCHEMISTRY
(2006)