Deoxyribonucleotides as genetic and metabolic regulators

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

(2016) Sudha Mannava et al.   Aging-US

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

(2014) Cristina E. Requena et al.   BIOCHEMICAL JOURNAL

Protein and Nucleotide Biosynthesis Are Coupled by a Single Rate-Limiting Enzyme, PRPS2, to Drive Cancer

(2014) John T. Cunningham et al.   CELL

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

(2014) Sudha Mannava et al.   CELL CYCLE

Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)

(2014) Cristina Miazzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state

(2014) E. C. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of DNA synthesis facilitates expansion of low-complexity repeats

(2013) Andrei Kuzminov   BIOESSAYS

Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase

(2013) M. Xie et al.   CANCER RESEARCH

Reduction of dNTP levels enhances DNA replication fidelity in vivo

(2013) Luisa Laureti et al.   DNA REPAIR

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

(2013) A. Gupta et al.   GENETICS

Restricted 5′-End Gap Repair of HIV-1 Integration Due to Limited Cellular dNTP Concentrations in Human Primary Macrophages

(2013) Sarah K. Van Cor-Hosmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Allosteric Activation and Inhibition of the Deoxyribonucleoside Triphosphate Triphosphohydrolase fromEnterococcus faecalis

(2013) Ivan I. Vorontsov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1

(2013) Sarah M. Amie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-HIV Host Factor SAMHD1 Regulates Viral Sensitivity to Nucleoside Reverse Transcriptase Inhibitors via Modulation of Cellular Deoxyribonucleoside Triphosphate (dNTP) Levels

(2013) Sarah M. Amie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribonucleotides Are Signals for Mismatch Repair of Leading-Strand Replication Errors

(2013) Scott A. Lujan et al.   MOLECULAR CELL

Effect of dNTP pool alterations on fidelity of leading and lagging strand DNA replication in E. coli

(2013) Damian Gawel et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Mechanism of allosteric activation of SAMHD1 by dGTP

(2013) Xiaoyun Ji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pre-activation of the genome integrity checkpoint increases DNA damage tolerance

(2013) Olga Tsaponina et al.   NUCLEIC ACIDS RESEARCH

Structure-function analysis of ribonucleotide bypass by B family DNA replicases

(2013) A. R. Clausen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypermutability and error catastrophe due to defects in ribonucleotide reductase

(2013) D. Ahluwalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cost of rNTP/dNTP pool imbalance at the replication fork

(2013) N. Y. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

(2013) A. Allouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

(2013) E. Franzolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase

(2013) Chunfeng Zhu et al.   Nature Communications

Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

(2012) Sudha Mannava et al.   AMERICAN JOURNAL OF PATHOLOGY

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development

(2012) Martin A.M. Reijns et al.   CELL

Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ɛ

(2012) Jessica S. Williams et al.   DNA REPAIR

Novel mutator mutants of E. coli nrdAB ribonucleotide reductase: Insight into allosteric regulation and control of mutation rates

(2012) Deepti Ahluwalia et al.   DNA REPAIR

Mutational consequences of dNTP pool imbalances in E. coli

(2012) Roel M. Schaaper et al.   DNA REPAIR

Ribonucleotide incorporation, proofreading and bypass by human DNA polymerase δ

(2012) Anders R. Clausen et al.   DNA REPAIR

Endogenous DNA replication stress results in expansion of dNTP pools and a mutator phenotype

(2012) Marta B Davidson et al.   EMBO JOURNAL

dNTP pools determine fork progression and origin usage under replication stress

(2012) Jérôme Poli et al.   EMBO JOURNAL

Polynucleotide Phosphorylase Plays an Important Role in the Generation of Spontaneous Mutations in Escherichia coli

(2012) E. Becket et al.   JOURNAL OF BACTERIOLOGY

Replication Fork Collapse and Genome Instability in a Deoxycytidylate Deaminase Mutant

(2012) A. Sanchez et al.   MOLECULAR AND CELLULAR BIOLOGY

RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA

(2012) Federico Lazzaro et al.   MOLECULAR CELL

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

(2012) Joshua C. Saldivar et al.   PLoS Genetics

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases

(2011) Danielle L. Watt et al.   DNA REPAIR

Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ɛ

(2011) Alan B. Clark et al.   DNA REPAIR

Nucleoside Triphosphate Pool Asymmetry in Mammalian Mitochondria

(2011) Linda J. Wheeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

Mispaired rNMPs in DNA are mutagenic and are targets of mismatch repair and RNases H

(2011) Ying Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli

(2011) S. Gon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools

(2011) Olga Tsaponina et al.   PLoS Genetics

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

(2010) Chiara Rampazzo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Highly mutagenic and severely imbalanced dNTP pools can escape detection by the S-phase checkpoint

(2010) Dinesh Kumar et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

(2010) D. Kumar et al.   NUCLEIC ACIDS RESEARCH

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

(2010) S. A. Nick McElhinny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Mutator of Escherichia coli Carrying a Defect in the dgt Gene, Encoding a dGTP Triphosphohydrolase

(2008) D. Gawel et al.   JOURNAL OF BACTERIOLOGY

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase   replication fidelity

(2008) Z. F. Pursell et al.   NUCLEIC ACIDS RESEARCH

DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation

(2008) K. Hastak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The relationship between dNTP pool levels and mutagenesis in an Escherichia coli NDP kinase mutant

(2008) J. Nordman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA