Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer

(2015) Roland H. Stauber et al.   Oncotarget

Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

(2012) Philipp Thiel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors

(2012) Wajana L. Labisso et al.   CELL CYCLE

Histone deacetylase inhibitors block IFNγ-induced STAT1 phosphorylation

(2012) Torsten Ginter et al.   CELLULAR SIGNALLING

Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

(2011) Stefan Tenzer et al.   ACS Nano

A Pharmacologic Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth

(2011) D. Y. Chen et al.   CANCER RESEARCH

Interfering with protein-protein interactions: Potential for cancer therapy

(2011) Tomoyuki Tanaka et al.   CELL CYCLE

The heterodimerization domains of MLL—FYRN and FYRC—are potential target structures in t(4;11) leukemia

(2011) B Pless et al.   LEUKEMIA

HTRA proteases: regulated proteolysis in protein quality control

(2011) Tim Clausen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bioassays to Monitor Taspase1 Function for the Identification of Pharmacogenetic Inhibitors

(2011) Shirley K. Knauer et al.   PLoS One

The Importin-Alpha/Nucleophosmin Switch Controls Taspase1 Protease Function

(2011) Carolin Bier et al.   TRAFFIC

Binding Leverage as a Molecular Basis for Allosteric Regulation

(2011) Simon Mitternacht et al.   PLoS Computational Biology

Identification and Structure of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions

(2010) Rolf Rose et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Taspase1 Functions as a Non-Oncogene Addiction Protease that Coordinates Cancer Cell Proliferation and Apoptosis

(2010) D. Y. Chen et al.   CANCER RESEARCH

Patented inhibitors of p53–Mdm2 interaction (2006 – 2008)

(2010) Lutz Weber   EXPERT OPINION ON THERAPEUTIC PATENTS

Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer

(2010) Benjamin Schumacher et al.   FEBS LETTERS

Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

(2010) Giovanna Zinzalla et al.   Future Medicinal Chemistry

Cell-based Analysis of Structure-Function Activity of Threonine Aspartase 1

(2010) Carolin Bier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling

(2010) M. Molzan et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

(2010) Calvin K. Yip et al.   MOLECULAR CELL

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions

(2009) Michelle R Arkin et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Rationalizing the chemical space of protein–protein interaction inhibitors

(2009) Olivier Sperandio et al.   DRUG DISCOVERY TODAY

The structural basis of allosteric regulation in proteins

(2009) Roman A. Laskowski et al.   FEBS LETTERS

A phosphorylation-acetylation switch regulates STAT1 signaling

(2009) O. H. Kramer et al.   GENES & DEVELOPMENT

A Structural Rationale for Selective Stabilization of Anti-tumor Interactions of 14-3-3 proteins by Cotylenin A

(2009) Christian Ottmann et al.   JOURNAL OF MOLECULAR BIOLOGY

High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38α

(2009) Jeffrey R. Simard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human Cancer Protein-Protein Interaction Network: A Structural Perspective

(2009) Gozde Kar et al.   PLoS Computational Biology

Allosteric Regulation of Proteases

(2008) Patrick Hauske et al.   CHEMBIOCHEM

Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion

(2008) Lauren P. Saunders et al.   MOLECULAR CANCER THERAPEUTICS

Interaction of brefeldin A-inhibited guanine nucleotide-exchange protein (BIG) 1 and kinesin motor protein KIF21A

(2008) X. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA