HTRA proteases: regulated proteolysis in protein quality control

Structural and mechanistic insight into how antibodies inhibit serine proteases

(2010) Rajkumar Ganesan et al.   BIOCHEMICAL JOURNAL

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases

(2010) B Li et al.   CELL DEATH AND DIFFERENTIATION

Methylation Induced Gene Silencing of HtrA3 in Smoking-Related Lung Cancer

(2010) D. Beleford et al.   CLINICAL CANCER RESEARCH

Allostery and population shift in drug discovery

(2010) Gozde Kar et al.   CURRENT OPINION IN PHARMACOLOGY

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

Bacterial proteases from the intracellular vacuole niche; protease conservation and adaptation for pathogenic advantage

(2010) Wilhelmina M. Huston   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

High Temperature Requirement A3 (HtrA3) Promotes Etoposide- and Cisplatin-induced Cytotoxicity in Lung Cancer Cell Lines

(2010) Daniah Beleford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conversion of a Regulatory into a Degradative Protease

(2010) Sonja Hasenbein et al.   JOURNAL OF MOLECULAR BIOLOGY

High-temperature requirement factor A3 (Htra3): A novel serine protease and its potential role in ovarian function and ovarian cancers

(2010) Marissa A. Bowden et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Serine Protease HtrA1 Specifically Interacts and Degrades the Tuberous Sclerosis Complex 2 Protein

(2010) M. Campioni et al.   MOLECULAR CANCER RESEARCH

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

(2010) Melisa Merdanovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

(2010) Tobias Krojer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The thylakoid protease Deg1 is involved in photosystem-II assembly in Arabidopsis thaliana

(2010) Xuwu Sun et al.   PLANT JOURNAL

The Stromal Chloroplast Deg7 Protease Participates in the Repair of Photosystem II after Photoinhibition in Arabidopsis

(2010) X. Sun et al.   PLANT PHYSIOLOGY

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation

(2010) B. C. Lechtenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HAX-1: A multifunctional protein with emerging roles in human disease

(2009) Bengt Fadeel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Mitochondrial dysfunction in Parkinson's disease

(2009) Konstanze F. Winklhofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Selectivity profiling of DegP substrates and inhibitors

(2009) Patrick Hauske et al.   BIOORGANIC & MEDICINAL CHEMISTRY

HtrA Serine Proteases as Potential Therapeutic Targets in Cancer

(2009) Jeremy Chien et al.   CURRENT CANCER DRUG TARGETS

Serine Protease HtrA1 Associates with Microtubules and Inhibits Cell Migration

(2009) J. Chien et al.   MOLECULAR AND CELLULAR BIOLOGY

Evolutionary Expansion and Specialization of the PDZ Domains

(2009) O. Sakarya et al.   MOLECULAR BIOLOGY AND EVOLUTION

Peptidic small molecule activators of the stress sensor DegS

(2009) Patrick Hauske et al.   Molecular BioSystems

Role of DegP for two-partner secretion inBordetella

(2009) C. Baud et al.   MOLECULAR MICROBIOLOGY

Inhibition of Wnt signaling by Dishevelled PDZ peptides

(2009) Yingnan Zhang et al.   Nature Chemical Biology

Association of HTRA1 Mutations and Familial Ischemic Cerebral Small-Vessel Disease

(2009) Kenju Hara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control

(2009) Q.-T. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria

(2009) Pitter F. Huesgen et al.   RESEARCH IN MICROBIOLOGY

Proteases in bacterial pathogenesis

(2009) Hanne Ingmer et al.   RESEARCH IN MICROBIOLOGY

OMP Peptides Activate the DegS Stress-Sensor Protease by a Relief of Inhibition Mechanism

(2009) Jungsan Sohn et al.   STRUCTURE

Allosteric Activation of HtrA Protease DegP by Stress Signals during Bacterial Protein Quality Control

(2008) Michael Meltzer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging roles of serine proteinases in tissue turnover in arthritis

(2008) J. M. Milner et al.   ARTHRITIS AND RHEUMATISM

Structure and Function of the Virulence-Associated High-Temperature Requirement A ofMycobacterium tuberculosis†‡

(2008) Nilofar N. MohamedMohaideen et al.   BIOCHEMISTRY

HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival

(2008) S Launay et al.   CELL DEATH AND DIFFERENTIATION

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

(2008) N Moisoi et al.   CELL DEATH AND DIFFERENTIATION

Evolution of Peptidase Diversity

(2008) Michael J. Page et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The persisting challenge of selective and specific proteasome inhibition

(2008) Michael Groll et al.   JOURNAL OF PEPTIDE SCIENCE

Age-related macular degeneration

(2008) Hanna R Coleman et al.   LANCET

The Yeast HtrA Orthologue Ynm3 Is a Protease with Chaperone Activity that Aids Survival Under Heat Stress

(2008) Nirmala Padmanabhan et al.   MOLECULAR BIOLOGY OF THE CELL

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

(2008) Jyh-Rong Chao et al.   NATURE

Structural basis for the regulated protease and chaperone function of DegP

(2008) Tobias Krojer et al.   NATURE

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins

(2008) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

(2008) T. Krojer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA