Recent development of enterovirus A vaccine candidates for the prevention of hand, foot, and mouth disease

A virus-like particle vaccine protects mice against coxsackievirus A10 lethal infection

(2018) Yu Zhou et al.   ANTIVIRAL RESEARCH

The life cycle of non-polio enteroviruses and how to target it

(2018) Jim Baggen et al.   NATURE REVIEWS MICROBIOLOGY

Five-year immunity persistence following immunization with inactivated enterovirus 71 type (EV71) vaccine in healthy children: A further observation

(2018) Yuemei Hu et al.   Human Vaccines & Immunotherapeutics

A virus-like particle-based tetravalent vaccine for hand, foot, and mouth disease elicits broad and balanced protective immunity

(2018) Wei Zhang et al.   Emerging Microbes & Infections

Correlates of protection for inactivated enterovirus 71 vaccine: the analysis of immunological surrogate endpoints

(2017) Wenbo Zhu et al.   Expert Review of Vaccines

Intradermal injection of a fractional dose of an inactivated HFMD vaccine elicits similar protective immunity to intramuscular inoculation of a full dose of an Al(OH) 3 -adjuvanted vaccine

(2017) Min Li et al.   VACCINE

Impact of genetic changes, pathogenicity and antigenicity on Enterovirus- A71 vaccine development

(2017) Pinn Tsin Isabel Yee et al.   VIROLOGY

Pathologic and immunologic characteristics of coxsackievirus A16 infection in rhesus macaques

(2017) Jingjing Wang et al.   VIROLOGY

Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children

(2017) Kuan-Ying Arthur Huang et al.   Nature Communications

Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody

(2017) Longfa Xu et al.   Nature Communications

Effective in vivo therapeutic IgG antibody against VP3 of enterovirus 71 with receptor-competing activity

(2017) Qiang Jia et al.   Scientific Reports

Yeast-produced recombinant virus-like particles of coxsackievirus A6 elicited protective antibodies in mice

(2016) Yu Zhou et al.   ANTIVIRAL RESEARCH

Immunological and biochemical characterizations of coxsackievirus A6 and A10 viral particles

(2016) Chia-Chyi Liu et al.   ANTIVIRAL RESEARCH

Coxsackievirus A16-like particles produced in Pichia pastoris elicit high-titer neutralizing antibodies and confer protection against lethal viral challenge in mice

(2016) Chao Zhang et al.   ANTIVIRAL RESEARCH

2-Year Efficacy, Immunogenicity, and Safety of Vigoo Enterovirus 71 Vaccine in Healthy Chinese Children: A Randomized Open-Label Study

(2016) Mingwei Wei et al.   JOURNAL OF INFECTIOUS DISEASES

Hand, foot and mouth disease (HFMD): emerging epidemiology and the need for a vaccine strategy

(2016) S. Aswathyraj et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice

(2016) Lisheng Yang et al.   VACCINE

Inactivated coxsackievirus A10 experimental vaccines protect mice against lethal viral challenge

(2016) Chaoyun Shen et al.   VACCINE

Virus-like particle-based vaccine against coxsackievirus A6 protects mice against lethal infections

(2016) Chaoyun Shen et al.   VACCINE

Vesicular stomatitis virus-based vaccines expressing EV71 virus-like particles elicit strong immune responses and protect newborn mice from lethal challenges

(2016) Qin Yan et al.   VACCINE

Validation and evaluation of serological correlates of protection for inactivated enterovirus 71 vaccine in children aged 6-35 months

(2016) Pengfei Jin et al.   Human Vaccines & Immunotherapeutics

EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases

(2016) Qunying Mao et al.   Emerging Microbes & Infections

Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: a potential role of recombination in emergence and pathogenicity

(2015) Eleanor Gaunt et al.   JOURNAL OF GENERAL VIROLOGY

Epidemiological and etiological characteristics of hand, foot, and mouth disease in Wuhan, China from 2012 to 2013: Outbreaks of Coxsackieviruses A10

(2015) Qin Yang et al.   JOURNAL OF MEDICAL VIROLOGY

Considerations for developing an immunization strategy with enterovirus 71 vaccine

(2015) Li Li et al.   VACCINE

A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice

(2015) Liping Jiang et al.   VACCINE

Efficacy of a Trivalent Hand, Foot, and Mouth Disease Vaccine against Enterovirus 71 and Coxsackieviruses A16 and A6 in Mice

(2015) Elizabeth Caine et al.   Viruses-Basel

A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71

(2015) Longfa Xu et al.   Scientific Reports

Novel recombinant chimeric virus-like particle is immunogenic and protective against both enterovirus 71 and coxsackievirus A16 in mice

(2015) Hui Zhao et al.   Scientific Reports

A novel recombinant lineage’s contribution to the outbreak of coxsackievirus A6-associated hand, foot and mouth disease in Shanghai, China, 2012-2013

(2015) Xiaobo Feng et al.   Scientific Reports

Is a multivalent hand, foot, and mouth disease vaccine feasible?

(2015) Michel Klein et al.   Human Vaccines & Immunotherapeutics

Recombinant Adeno-Vaccine Expressing Enterovirus 71-Like Particles against Hand, Foot, and Mouth Disease

(2015) Yueh-Liang Tsou et al.   PLoS Neglected Tropical Diseases

Phylogenetic analysis of the major causative agents of hand, foot and mouth disease in Suzhou city, Jiangsu province, China, in 2012–2013

(2015) Chao Zhang et al.   Emerging Microbes & Infections

Achievements, challenges and prospects for the development of broadly protective multivalent vaccines and therapeutic antibodies against hand, foot and mouth disease

(2015) Ke Lyu et al.   Science Bulletin

Genotypes of the Enterovirus Causing Hand Foot and Mouth Disease in Shanghai, China, 2012-2013

(2015) Menghua Xu et al.   PLoS One

Review of Enterovirus 71 Vaccines

(2014) P. Chong et al.   CLINICAL INFECTIOUS DISEASES

Coxsackievirus A6 associated hand, foot and mouth disease in adults: Clinical presentation and review of the literature

(2014) Marigdalia K. Ramirez-Fort et al.   JOURNAL OF CLINICAL VIROLOGY

Protection from lethal challenge in a neonatal mouse model by circulating recombinant form coxsackievirus A16 vaccine candidates

(2014) J. Li et al.   JOURNAL OF GENERAL VIROLOGY

Cryo-Electron Microscopy Study of Insect Cell-Expressed Enterovirus 71 and Coxsackievirus A16 Virus-Like Particles Provides a Structural Basis for Vaccine Development

(2014) M. Gong et al.   JOURNAL OF VIROLOGY

An Inactivated Enterovirus 71 Vaccine in Healthy Children

(2014) Rongcheng Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China

(2014) Fengcai Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Comparison and Evolutionary Analyses of VP1 Nucleotide Sequences of New African Human Enterovirus 71 Isolates Reveal a Wide Genetic Diversity

(2014) Maël Bessaud et al.   PLoS One

Co-Circulation and Genomic Recombination of Coxsackievirus A16 and Enterovirus 71 during a Large Outbreak of Hand, Foot, and Mouth Disease in Central China

(2014) Weiyong Liu et al.   PLoS One

Long-Term Immunogenicity Studies of Formalin-Inactivated Enterovirus 71 Whole-Virion Vaccine in Macaques

(2014) Chia-Chyi Liu et al.   PLoS One

Neutralizing antibodies can initiate genome release from human enterovirus 71

(2014) Pavel Plevka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses

(2014) Yicun Cai et al.   VACCINE

Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases

(2014) Chia-Chyi Liu et al.   VACCINE

Protection against Lethal Enterovirus 71 Challenge in Mice by a Recombinant Vaccine Candidate Containing a Broadly Cross-Neutralizing Epitope within the VP2 EF Loop

(2014) Longfa Xu et al.   Theranostics

The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems

(2014) Wen Qi An et al.   Human Vaccines & Immunotherapeutics

Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice

(2014) Shiyang Sun et al.   Human Vaccines & Immunotherapeutics

Comparative study of the immunogenicity in mice and monkeys of an inactivated CA16 vaccine made from a human diploid cell line

(2014) Erxia Yang et al.   Human Vaccines & Immunotherapeutics

A Novel Universal Neutralizing Monoclonal Antibody against Enterovirus 71 That Targets the Highly Conserved “Knob” Region of VP3 Protein

(2014) Tanja K. Kiener et al.   PLoS Neglected Tropical Diseases

Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71

(2014) Minghao Dang et al.   Protein & Cell

Immunogenicity Studies of Bivalent Inactivated Virions of EV71/CVA16 Formulated with Submicron Emulsion Systems

(2014) Chih-Wei Lin et al.   Biomed Research International

Virus-like particles produced in Saccharomyces cerevisiae elicit protective immunity against Coxsackievirus A16 in mice

(2013) Hui Zhao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Clinicopathologic Analysis of Coxsackievirus A6 New Variant Induced Widespread Mucocutaneous Bullous Reactions Mimicking Severe Cutaneous Adverse Reactions

(2013) Wen-Hung Chung et al.   JOURNAL OF INFECTIOUS DISEASES

Is a monovalent vaccine against enterovirus 71 sufficient? A review of enterovirus 71 vaccine development based on enterovirus surveillance in Taiwan

(2013) Shu-Chun Chu et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

A Strain-Specific Epitope of Enterovirus 71 Identified by Cryo-Electron Microscopy of the Complex with Fab from Neutralizing Antibody

(2013) H. Lee et al.   JOURNAL OF VIROLOGY

Chimeric Virus-Like Particle Vaccines Displaying Conserved Enterovirus 71 Epitopes Elicit Protective Neutralizing Antibodies in Mice through Divergent Mechanisms

(2013) X. Ye et al.   JOURNAL OF VIROLOGY

Molecular epidemiology of Coxsackievirus A16 strains isolated from children in Yamagata, Japan between 1988 and 2011

(2013) Katsumi Mizuta et al.   MICROBIOLOGY AND IMMUNOLOGY

Epidemics and Frequent Recombination within Species in Outbreaks of Human Enterovirus B-Associated Hand, Foot and Mouth Disease in Shandong China in 2010 and 2011

(2013) Ting Zhang et al.   PLoS One

Formalin-Inactivated EV71 Vaccine Candidate Induced Cross-Neutralizing Antibody against Subgenotypes B1, B4, B5 and C4A in Adult Volunteers

(2013) Ai-Hsiang Chou et al.   PLoS One

Virus-like particles for enterovirus 71 produced from Saccharomyces cerevisiae potently elicits protective immune responses in mice

(2013) Hao-Yang Li et al.   VACCINE

Identification of conserved neutralizing linear epitopes within the VP1 protein of coxsackievirus A16

(2013) Jinping Shi et al.   VACCINE

Active immunization with a Coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infection

(2013) Yicun Cai et al.   VACCINE

A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine

(2013) Aristine Cheng et al.   VACCINE

Coxsackievirus A16

(2013) Qunying Mao et al.   Human Vaccines & Immunotherapeutics

A Neonatal Mouse Model of Coxsackievirus A16 for Vaccine Evaluation

(2012) Q. Mao et al.   JOURNAL OF VIROLOGY

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

(2012) Xiangxi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Circulation of Coxsackievirus A10 and A6 in Hand-Foot-Mouth Disease in China, 2009–2011

(2012) Qing-Bin Lu et al.   PLoS One

Immunological and Biochemical Characterization of Coxsackie Virus A16 Viral Particles

(2012) Pele Chong et al.   PLoS One

Cross-reactive neutralizing antibody epitopes against Enterovirus 71 identified by an in silico approach

(2012) K. Kirk et al.   VACCINE

Enterovirus type 71 neutralizing antibodies in the serum of macaque monkeys immunized with EV71 virus-like particles

(2012) Yu-Li Lin et al.   VACCINE

Vaccination with coxsackievirus B3 virus-like particles elicits humoral immune response and protects mice against myocarditis

(2012) L. Zhang et al.   VACCINE

A virus-like particle vaccine for coxsackievirus A16 potently elicits neutralizing antibodies that protect mice against lethal challenge

(2012) Qingwei Liu et al.   VACCINE

Progress on the research and development of human enterovirus 71 (EV71) vaccines

(2012) Zhenglun Liang et al.   Frontiers of Medicine

An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010

(2011) Sung-Hsi Wei et al.   BMC INFECTIOUS DISEASES

Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009

(2011) Shih-Hsuan Lo et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Generation of murine monoclonal antibodies which cross-neutralize human enterovirus genogroup B isolates

(2011) Hsuen-Wen Chang et al.   JOURNAL OF VIROLOGICAL METHODS

Development of a quantitative enzyme linked immunosorbent assay for monitoring the Enterovirus 71 vaccine manufacturing process

(2011) Chia-Chyi Liu et al.   JOURNAL OF VIROLOGICAL METHODS

Identification and characterization of a cross-neutralization epitope of Enterovirus 71

(2011) Chia-Chyi Liu et al.   VACCINE

Virology, epidemiology, pathogenesis, and control of enterovirus 71

(2010) Tom Solomon et al.   LANCET INFECTIOUS DISEASES

Forecasting the economic value of an Enterovirus 71 (EV71) vaccine

(2010) Bruce Y. Lee et al.   VACCINE

Attenuation of coxsackievirus B3 by VP2 mutation and its application as a vaccine against virus-induced myocarditis and pancreatitis

(2009) Jung-Hyun Park et al.   VACCINE

Identification of immunodominant VP1 linear epitope of enterovirus 71 (EV71) using synthetic peptides for detecting human anti-EV71 IgG antibodies in western blots

(2008) D.G.W. Foo et al.   CLINICAL MICROBIOLOGY AND INFECTION

Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge

(2008) Yao-Chi Chung et al.   VACCINE