Journal
VACCINE
Volume 28, Issue 49, Pages 7731-7736Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2010.09.065
Keywords
Enterovirus 71; Economics; Computer simulation; China; Vaccine
Categories
Funding
- National Institute of General Medical Sciences Models of Infectious Agent Disease Study (MIDAS) [1U54GM088491-0109]
- Bill and Melinda Gates Foundation
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Enterovirus 71 (EV71) is a growing public health concern, especially in Asia. A surge of EV71 cases in 2008 prompted authorities in China to go on national alert. While there is currently no treatment for EV71 infections, vaccines are under development. We developed a computer simulation model to determine the potential economic value of an EV71 vaccine for children (<5 years old) in China. Our results suggest that routine vaccination in China (EV71 infection incidence approximate to 10.04%) may be cost-effective when vaccine cost is $25 and efficacy >= 70% or cost is $10 and efficacy >= 50%. For populations with higher infection risk (>= 0.4%), a $50 or $75 vaccine would be highly cost-effective even when vaccine efficacy is as low as 50%. (C) 2010 Elsevier Ltd. All rights reserved.
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